BELINOSTAT (BRD-K17743125)
Overview
- pert_id
- BRD-K17743125
- Name
- belinostat
- Synonyms
- PXD-101; S1085
- Collection
- BIOA
- Summary
- Belinostat (PXD101) is a novel HDAC inhibitor with IC50 of 27 nM in HeLa cell extracts.
- MOA
- HDAC inhibitor
- Target(s)
- HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9
- Indication(s)
- peripheral T-cell lymphoma (PTCL)
- Phase
- Launched
- Canonical SMILES
- ONC(=O)/C=C/c1cccc(c1)S(=O)(=O)Nc2ccccc2
- InChI key
- InChIKey=NCNRHFGMJRPRSK-MDZDMXLPSA-N
- InChI string
- InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+
- Molecular formula
- C15H14N2O4S
- Molecular weight
- 318.348
External links
- PubChem
- 6918638
- Wikipedia
- http://en.wikipedia.org/wiki/Belinostat
- SEP-L1000
- BRD-K17743125
Predicted MOAs
| MOA | Probability |
|---|---|
| HDAC inhibitor | 0.9892 |
| glucocorticoid receptor agonist | 0.0012 |
| tubulin polymerization inhibitor | 0.0012 |
| PLK inhibitor | 0.0009 |
| cyclooxygenase inhibitor | 0.0008 |
| HSP inhibitor | 0.0006 |
| dopamine receptor antagonist | 0.0005 |
| mTOR inhibitor | 0.0005 |
| RAF inhibitor | 0.0005 |
| NFkB pathway inhibitor | 0.0005 |
Chemical structure
