GSK-461364 (BRD-K92428232)
Overview
- pert_id
- BRD-K92428232
- Name
- GSK-461364
- Synonyms
- S2193
- Collection
- BIOA
- Summary
- GSK461364 inhibits purified Plk1 with Ki of 2 nM.
- MOA
- PLK inhibitor
- Target(s)
- PLK1
- Indication(s)
- Unknown
- Phase
- Phase 1
- Canonical SMILES
- C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F
- InChI key
- InChIKey=ZHJGWYRLJUCMRT-QGZVFWFLSA-N
- InChI string
- InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1
- Molecular formula
- C27H28F3N5O2S
- Molecular weight
- 543.604
External links
- PubChem
- 15983966
- Wikipedia
- http://www.selleckchem.com/products/GSK461364.html
- SEP-L1000
- BRD-K92428232
Predicted MOAs
| MOA | Probability |
|---|---|
| PLK inhibitor | 0.8640 |
| dopamine receptor antagonist | 0.0216 |
| topoisomerase inhibitor | 0.0176 |
| adrenergic receptor antagonist | 0.0157 |
| HSP inhibitor | 0.0099 |
| cyclooxygenase inhibitor | 0.0074 |
| histamine receptor antagonist | 0.0072 |
| tubulin polymerization inhibitor | 0.0065 |
| PI3K inhibitor | 0.0046 |
| calcium channel blocker | 0.0045 |
Chemical structure
