TRICHOSTATIN-A (BRD-K68202742)
Overview
- pert_id
- BRD-K68202742
- Name
- trichostatin-a
- Synonyms
- S1045
- Collection
- BIOA
- Summary
- Trichostatin A (TSA) is an HDAC inhibitor with IC50 of ~1.8 nM.
- MOA
- HDAC inhibitor
- Target(s)
- HDAC1, HDAC10, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9
- Indication(s)
- Unknown
- Phase
- Preclinical
- Canonical SMILES
- C[C@H](/C=C(C)/C=C/C(=O)NO)C(=O)c1ccc(cc1)N(C)C
- InChI key
- InChIKey=RTKIYFITIVXBLE-QEQCGCAPSA-N
- InChI string
- InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
- Molecular formula
- C17H22N2O3
- Molecular weight
- 302.368
External links
- PubChem
- 444732
- Wikipedia
- http://en.wikipedia.org/wiki/Trichostatin_A
- SEP-L1000
- BRD-K68202742
Predicted MOAs
| MOA | Probability |
|---|---|
| HDAC inhibitor | 0.9961 |
| retinoid receptor agonist | 0.0003 |
| RAF inhibitor | 0.0003 |
| PARP inhibitor | 0.0002 |
| NFkB pathway inhibitor | 0.0002 |
| histamine receptor antagonist | 0.0002 |
| estrogen receptor agonist | 0.0002 |
| protein synthesis inhibitor | 0.0002 |
| PLK inhibitor | 0.0002 |
| MEK inhibitor | 0.0002 |
Chemical structure
