PHA-793887 (BRD-K64800655)
Overview
- pert_id
- BRD-K64800655
- Name
- PHA-793887
- Synonyms
- S1487
- Collection
- BIOA
- Summary
- PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM, respectively.
- MOA
- CDK inhibitor
- Target(s)
- CDK1, CDK2, CDK4, CDK5, CDK7, CDK9
- Indication(s)
- Unknown
- Phase
- Phase 1
- Canonical SMILES
- CC(C)CC(=O)Nc1n[nH]c2c1CN(C(=O)C1CCN(C)CC1)C2(C)C
- InChI key
- InChIKey=HUXYBQXJVXOMKX-UHFFFAOYSA-N
- InChI string
- InChI=1S/C19H31N5O2/c1-12(2)10-15(25)20-17-14-11-24(19(3,4)16(14)21-22-17)18(26)13-6-8-23(5)9-7-13/h12-13H,6-11H2,1-5H3,(H2,20,21,22,25)
- Molecular formula
- C19H31N5O2
- Molecular weight
- 361.482
External links
- PubChem
- 46191454
- Wikipedia
- http://www.selleckchem.com/products/PHA-793887.html
- SEP-L1000
- BRD-K64800655
Predicted MOAs
| MOA | Probability |
|---|---|
| CDK inhibitor | 0.7160 |
| dopamine receptor antagonist | 0.0436 |
| Aurora kinase inhibitor | 0.0417 |
| adrenergic receptor antagonist | 0.0196 |
| EGFR inhibitor | 0.0144 |
| tubulin polymerization inhibitor | 0.0128 |
| PI3K inhibitor | 0.0120 |
| PARP inhibitor | 0.0114 |
| NFkB pathway inhibitor | 0.0106 |
| cyclooxygenase inhibitor | 0.0106 |
Chemical structure
