PIK-75 (BRD-M16762496)
Overview
- pert_id
- BRD-M16762496
- Name
- PIK-75
- Synonyms
- S1205
- Collection
- BIOA
- Summary
- PIK-75 is a selective and competitive inhibitor of p110α with IC50 of 5.8 nM and also potently inhibits DNA-PK with IC50 of 2 nM.
- MOA
- DNA protein kinase inhibitor, PI3K inhibitor
- Target(s)
- PIK3CA, PIK3CB, PIK3CD, PIK3CG, PRKDC
- Indication(s)
- Unknown
- Phase
- Preclinical
- Canonical SMILES
- CI.CN(N=Cc1cnc2ccc(Br)cn12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O
- InChI key
- InChIKey=HFUAOBLWRUIXKP-MYHMWQFYSA-N
- InChI string
- InChI=1S/C16H14BrN5O4S.CH3I/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16;1-2/h3-10H,1-2H3;1H3/b19-9+;
- Molecular formula
- C17H17BrIN5O4S
- Molecular weight
- 594.221
External links
- PubChem
- 73707389
- Wikipedia
- https://www.caymanchem.com/app/template/Product.vm/catalog/10009210
- SEP-L1000
- BRD-M16762496
Predicted MOAs
| MOA | Probability |
|---|---|
| cyclooxygenase inhibitor | 0.2576 |
| CDK inhibitor | 0.1682 |
| calcium channel blocker | 0.1625 |
| MEK inhibitor | 0.1095 |
| PI3K inhibitor | 0.0829 |
| HDAC inhibitor | 0.0400 |
| RAF inhibitor | 0.0296 |
| EGFR inhibitor | 0.0235 |
| histamine receptor antagonist | 0.0223 |
| HSP inhibitor | 0.0220 |
Chemical structure
