PD-173074 (BRD-K97764662)
Overview
- pert_id
- BRD-K97764662
- Name
- PD-173074
- Synonyms
- S1264
- Collection
- BIOA
- Summary
- PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM.
- MOA
- FGFR inhibitor, VEGFR inhibitor
- Target(s)
- FGFR1, FGFR2, FGFR3, FGFR4, FLT1, FLT4, KDR, PDGFRA, PDGFRB
- Indication(s)
- Unknown
- Phase
- Preclinical
- Canonical SMILES
- CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)c3cc(OC)cc(OC)c3
- InChI key
- InChIKey=DXCUKNQANPLTEJ-UHFFFAOYSA-N
- InChI string
- InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
- Molecular formula
- C28H41N7O3
- Molecular weight
- 523.67
External links
- PubChem
- 1401
- Wikipedia
- http://www.selleckchem.com/products/PD-173074.html
- SEP-L1000
- BRD-K97764662
Predicted MOAs
| MOA | Probability |
|---|---|
| tubulin polymerization inhibitor | 0.4811 |
| adrenergic receptor antagonist | 0.1578 |
| Aurora kinase inhibitor | 0.0498 |
| PLK inhibitor | 0.0340 |
| topoisomerase inhibitor | 0.0298 |
| dopamine receptor antagonist | 0.0262 |
| CDK inhibitor | 0.0205 |
| EGFR inhibitor | 0.0195 |
| mTOR inhibitor | 0.0186 |
| histamine receptor antagonist | 0.0160 |
Chemical structure
