PIFITHRIN-ALPHA (BRD-K66874953)
Overview
- pert_id
- BRD-K66874953
- Name
- pifithrin-alpha
- Synonyms
- pifithrin; S2929
- Collection
- BIOA
- Summary
- Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.
- MOA
- TP53 inhibitor
- Target(s)
- TP53
- Indication(s)
- Unknown
- Phase
- Preclinical
- Canonical SMILES
- Cc1ccc(cc1)C(=O)Cn2c3CCCCc3sc2=N
- InChI key
- InChIKey=OLTZHXYLLRJLST-UHFFFAOYSA-N
- InChI string
- InChI=1S/C16H18N2OS/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17/h6-9,17H,2-5,10H2,1H3
- Molecular formula
- C16H18N2OS
- Molecular weight
- 286.392
External links
- PubChem
- 4817
- Wikipedia
- http://www.millipore.com/catalogue/item/506132-5MG&cid=BIOS-A-LINS-1212-1204-RC
- SEP-L1000
- BRD-K66874953
Predicted MOAs
| MOA | Probability |
|---|---|
| cyclooxygenase inhibitor | 0.3364 |
| dopamine receptor antagonist | 0.2254 |
| adrenergic receptor antagonist | 0.1155 |
| histamine receptor antagonist | 0.0808 |
| calcium channel blocker | 0.0617 |
| Aurora kinase inhibitor | 0.0282 |
| PI3K inhibitor | 0.0165 |
| mTOR inhibitor | 0.0148 |
| EGFR inhibitor | 0.0099 |
| PARP inhibitor | 0.0097 |
Chemical structure
