GSK-1059615 (BRD-K06750613)
Overview
- pert_id
- BRD-K06750613
- Name
- GSK-1059615
- Synonyms
- S1360
- Collection
- BIOA
- Summary
- GSK1059615 is a novel and dual inhibitor of PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR with IC50 of 0.4 nM, 0.6 nM, 2 nM, 5 nM and 12 nM, respectively.
- MOA
- PI3K inhibitor
- Target(s)
- PIK3CG
- Indication(s)
- Unknown
- Phase
- Phase 1
- Canonical SMILES
- O=C1NC(=O)C(S1)=Cc1ccc2nccc(-c3ccncc3)c2c1
- InChI key
- InChIKey=QDITZBLZQQZVEE-YBEGLDIGSA-N
- InChI string
- InChI=1S/C18H11N3O2S/c22-17-16(24-18(23)21-17)10-11-1-2-15-14(9-11)13(5-8-20-15)12-3-6-19-7-4-12/h1-10H,(H,21,22,23)/b16-10-
- Molecular formula
- C18H11N3O2S
- Molecular weight
- 333.364
External links
- PubChem
- 23582824
- Wikipedia
- http://www.selleckchem.com/products/GSK1059615.html
- SEP-L1000
- BRD-K06750613
Predicted MOAs
| MOA | Probability |
|---|---|
| PI3K inhibitor | 0.9733 |
| PARP inhibitor | 0.0047 |
| cyclooxygenase inhibitor | 0.0045 |
| PLK inhibitor | 0.0020 |
| dopamine receptor antagonist | 0.0016 |
| calcium channel blocker | 0.0014 |
| CDK inhibitor | 0.0013 |
| topoisomerase inhibitor | 0.0011 |
| tubulin polymerization inhibitor | 0.0010 |
| mTOR inhibitor | 0.0009 |
Chemical structure
