BMS-387032 (BRD-K43389698)
Overview
- pert_id
- BRD-K43389698
- Name
- BMS-387032
- Synonyms
- S1145
- Collection
- BIOA
- Summary
- SNS-032 is a novel, potent and selective CDK inhibitor of CDK2, CDK7 and CDK9 with IC50 of 38 nM, 62 nM and 4 nM, respectively.
- MOA
- CDK inhibitor, cell cycle inhibitor, MCL1 inhibitor
- Target(s)
- CDK2, CDK7, CDK9
- Indication(s)
- Unknown
- Phase
- Phase 1
- Canonical SMILES
- CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1
- InChI key
- InChIKey=OUSFTKFNBAZUKL-UHFFFAOYSA-N
- InChI string
- InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)
- Molecular formula
- C17H24N4O2S2
- Molecular weight
- 380.528
External links
- PubChem
- 3025986
- Wikipedia
- http://www.selleckchem.com/products/SNS-032.html
- SEP-L1000
- BRD-K43389698
Predicted MOAs
| MOA | Probability |
|---|---|
| histamine receptor antagonist | 0.2689 |
| adrenergic receptor antagonist | 0.1886 |
| CDK inhibitor | 0.0924 |
| dopamine receptor antagonist | 0.0798 |
| PARP inhibitor | 0.0465 |
| HSP inhibitor | 0.0357 |
| calcium channel blocker | 0.0338 |
| Aurora kinase inhibitor | 0.0302 |
| PLK inhibitor | 0.0279 |
| tubulin polymerization inhibitor | 0.0250 |
Chemical structure
