LOVASTATIN (BRD-K09416995)
Overview
- pert_id
- BRD-K09416995
- Name
- lovastatin
- Synonyms
- NP-001236; MK-803; mevacor; altocor; altoprev; S2061
- Collection
- BIOA
- Summary
- Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM, used for lowering cholesterol (hypolipidemic agent).
- MOA
- HMGCR inhibitor
- Target(s)
- HDAC2, HMGCR, ITGAL, NR1I2
- Indication(s)
- coronary heart disease, myocardial infarction, hypercholesterolemia
- Phase
- Launched
- Canonical SMILES
- CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12
- InChI key
- InChIKey=PCZOHLXUXFIOCF-BXMDZJJMSA-N
- InChI string
- InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
- Molecular formula
- C24H36O5
- Molecular weight
- 404.54
External links
- PubChem
- 53232
- Wikipedia
- http://en.wikipedia.org/wiki/Lovastatin
- SEP-L1000
- BRD-K09416995
Predicted MOAs
| MOA | Probability |
|---|---|
| glucocorticoid receptor agonist | 0.8832 |
| protein synthesis inhibitor | 0.0226 |
| cyclooxygenase inhibitor | 0.0148 |
| retinoid receptor agonist | 0.0109 |
| NFkB pathway inhibitor | 0.0067 |
| PI3K inhibitor | 0.0060 |
| estrogen receptor agonist | 0.0055 |
| mTOR inhibitor | 0.0049 |
| tubulin polymerization inhibitor | 0.0042 |
| HSP inhibitor | 0.0041 |
Chemical structure
Diagnoses (based on Mount Sinai EHR)
Top diagnoses associated with lovastatin:
Co-prescribed Drugs (based on Mount Sinai EHR)
Top coprescribed drugs of lovastatin:
Age Distribution (based on Mount Sinai EHR)
Probability distribution for the prescription of lovastatin across different ages: