!direction	-1
!num_genes	254
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Lapatinib
!smiles	CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
!drugbank_id	DB01259
!pubchem_cid	208908
!cell_type	lapatinib sensitive and lapatinib resistant ErbB2-positive breast cancer cells
!organism	human
!end_metadata
HSPB1	-0.167693
S100A9	-0.155926
RPS13	-0.146495
RPL39	-0.124989
H3F3A	-0.102449
RPS4X	-0.088086
RPL22	-0.086641
EEF1A2	-0.082482
PPA1	-0.082198
UQCRHL	-0.081684
RPL35A	-0.080642
S100A8	-0.075344
TMSB10	-0.074895
RPL8	-0.073010
MDH2	-0.072498
MYL6	-0.065606
TRAM1	-0.063303
HIST1H2BK	-0.062458
RN7SL1	-0.062377
GLTSCR2	-0.061400
H3F3AP4	-0.061061
TPT1	-0.060004
SRRM2	-0.059515
ACTG1	-0.058133
NCCRP1	-0.057493
EIF4A2	-0.056550
ATP5H	-0.054639
NFKBIA	-0.053991
MAL2	-0.051954
GPX4	-0.050949
RPS10	-0.050193
SAT1	-0.049537
LDHA	-0.048210
RPL38	-0.048165
ZMPSTE24	-0.047587
RPL13AP3	-0.047393
UBA52	-0.046896
SSU72	-0.046857
RPS16	-0.046448
AURKAIP1	-0.046430
RPS21	-0.046247
UQCRH	-0.046141
ACTB	-0.044149
NDUFA3	-0.043090
RPS11	-0.043079
HSD17B7	-0.042166
TMEM59	-0.041938
PSMB10	-0.041073
CDKN2AIPNL	-0.040465
SLC25A51	-0.040359
CAP1	-0.039579
PPIAL4B	-0.038633
CDC42EP4	-0.038295
TAP1	-0.037435
PSMA5	-0.036333
PTPRF	-0.035817
ATP5B	-0.035091
ATP6V1F	-0.034732
MRPS17	-0.034589
RSL24D1	-0.034133
NDUFB5	-0.033543
RPL30	-0.032711
RPL5	-0.032228
VPS35	-0.031670
RPS14	-0.031606
DBI	-0.031549
ZNF549	-0.031511
RPS18	-0.031235
SLIRP	-0.031198
RBM22	-0.031190
PTBP1	-0.031128
PURB	-0.030926
B4GALT5	-0.030549
COPS5	-0.030301
NDUFS3	-0.030280
PGRMC1	-0.030006
MBD4	-0.029910
LAMA5	-0.029893
IMP3	-0.029188
CAPZA2	-0.029087
ZNF486	-0.029066
SEP15	-0.028913
PFN1	-0.028769
TMEM17	-0.028592
EFNA1	-0.028556
FERMT2	-0.028397
IGFBP5	-0.028282
RPL18	-0.028251
CYC1	-0.028028
HIST2H2AA3	-0.027371
EBNA1BP2	-0.027324
EPRS	-0.027200
AMY1C	-0.027148
ATP5F1	-0.026451
NLRP8	-0.026314
NOL11	-0.026138
PSMA6	-0.026112
RPL6	-0.026071
SRRT	-0.025946
TACSTD2	-0.025913
ZC2HC1A	-0.025898
CLIC1	-0.025754
WASL	-0.025737
KRT7	-0.025309
IL18	-0.025265
RPL9	-0.025247
SERBP1	-0.025219
EIF3E	-0.025188
KAT2A	-0.025048
CYP1B1	-0.024941
MRPL13	-0.024894
MRPS22	-0.024713
CFD	-0.024602
TBATA	-0.024529
MAGT1	-0.024323
CPNE3	-0.024161
HNRNPAB	-0.023905
MRPL32	-0.023741
PSME1	-0.023626
MYL12A	-0.023616
DDX5	-0.023566
LACTB2	-0.023499
GPR56	-0.023344
PSMC2	-0.023244
RPL12	-0.023132
ZNF217	-0.023121
RPL36	-0.023091
AOC4P	-0.023009
UFC1	-0.022977
DENND2D	-0.022941
ATP5O	-0.022862
DUSP19	-0.022806
EIF3K	-0.022781
PGAP3	-0.022555
MSH3	-0.022503
SRP9	-0.022474
EIF3L	-0.022338
USP49	-0.022264
SRSF2	-0.022177
ELF3	-0.022158
ITPR3	-0.022151
CLEC2D	-0.022056
TAX1BP1	-0.021926
ADM	-0.021888
CPE	-0.021834
ARPC1A	-0.021826
SNRPG	-0.021730
RPSA	-0.021724
SUMO3	-0.021719
DDIT4	-0.021638
C8orf76	-0.021528
MTSS1	-0.021484
ATP5J2	-0.021407
NDUFA13	-0.021371
PON2	-0.021329
RPL7	-0.021301
RDH10	-0.021292
CD2BP2	-0.021279
ATP6V1B1	-0.021256
ALPP	-0.021244
GGA1	-0.021115
FBLN1	-0.021005
KPNB1	-0.020987
NSA2	-0.020851
TYMP	-0.020833
RPS20	-0.020800
HSPH1	-0.020770
HSP90AA1	-0.020564
VIPR1	-0.020563
SSBP1	-0.020522
FAF2	-0.020399
FAM213A	-0.020284
CALM2	-0.020270
THOC7	-0.020259
MKRN1	-0.020127
ZNF14	-0.020102
ZNF704	-0.020024
NDUFS5	-0.019876
MRPS24	-0.019773
PPP1CC	-0.019751
CITED4	-0.019701
IER3	-0.019661
PUF60	-0.019605
RPL23AP64	-0.019570
OVOL2	-0.019539
GABPB2	-0.019440
BRD2	-0.019411
RARS	-0.019317
NOL7	-0.019316
CDC20	-0.019162
PTGES3	-0.019057
CYBA	-0.018990
DUSP1	-0.018981
MAT2A	-0.018840
SGCE	-0.018724
TCEB1	-0.018587
AHCYL1	-0.018468
DDX21	-0.018460
YWHAQ	-0.018383
WWC1	-0.018383
PALLD	-0.018364
CX3CL1	-0.018114
CRYZ	-0.018085
MRPL37	-0.018053
SARAF	-0.018033
SNX3	-0.017964
TRIP6	-0.017862
KHDRBS1	-0.017736
UHMK1	-0.017670
CCR6	-0.017575
ARGLU1	-0.017537
CTGF	-0.017477
ORM1	-0.017463
PTPLB	-0.017391
HIST1H2BD	-0.017349
PSMB4	-0.017313
BLZF1	-0.017310
NOA1	-0.017307
RAB10	-0.017205
CCDC6	-0.017061
CKMT1A	-0.017050
NOP56	-0.017010
SHFM1	-0.017006
HIST1H1C	-0.016983
NDUFS4	-0.016959
NFKB1	-0.016823
NPM3	-0.016693
DKC1	-0.016651
CD24	-0.016639
IDH3B	-0.016605
BTF3	-0.016574
DDX56	-0.016491
CTNNA1	-0.016478
CLINT1	-0.016390
TFAM	-0.016274
PIEZO1	-0.016213
PTMA	-0.016208
EPCAM	-0.016199
PSME2	-0.016108
HARS	-0.016101
GAR1	-0.015967
SLC25A3	-0.015936
DMC1	-0.015908
EID2B	-0.015880
SHROOM3	-0.015741
SPPL2A	-0.015725
EIF4A3	-0.015677
MRPL15	-0.015650
CAMK2G	-0.015645
KPNA4	-0.015601
ANXA1	-0.015526
CPD	-0.015461
ZNF69	-0.015448
GNB1	-0.015437