!direction	-1
!num_genes	297
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Methotrexate
!smiles	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
!drugbank_id	DB00563
!pubchem_cid	126941
!cell_type	HT29
!organism	human
!end_metadata
TM4SF4	-0.156708
IFI27	-0.138292
ALDH1A1	-0.137439
HLA-C	-0.114002
B2M	-0.113323
HLA-B	-0.102189
VBP1	-0.092160
HLA-A	-0.090784
TSPAN8	-0.090059
SSR4	-0.089542
MMP7	-0.086327
CD24	-0.077845
IFITM2	-0.070942
BCAP31	-0.070407
RPL30	-0.066667
IFITM3	-0.065927
IRAK1	-0.061510
EIF3H	-0.059733
RRM2	-0.059484
DKC1	-0.058120
PABPC3	-0.056392
MRPL13	-0.055806
DNAJA1	-0.055602
LYZ	-0.054505
YWHAZ	-0.053527
RPL8	-0.053525
NOP10	-0.049650
KRT8	-0.048785
KLK6	-0.048755
UBE2C	-0.046812
PTMA	-0.046287
KRT18	-0.046057
RPN2	-0.045916
ZWINT	-0.045698
HLA-G	-0.045628
HMGN1	-0.045493
COX2	-0.045447
EIF6	-0.044499
ISG15	-0.044306
RPS6	-0.044120
UBE2S	-0.043258
LGALS4	-0.042967
EIF3E	-0.042945
CDH1	-0.041065
CRABP2	-0.040928
MT1E	-0.040909
GTF3C6	-0.040458
PSME2	-0.039346
RAN	-0.038947
FAM96A	-0.037942
ACTN4	-0.037668
HSPE1	-0.037613
PTGES3	-0.037207
RPL4	-0.036996
PROM1	-0.036825
SEPW1	-0.036677
SNHG6	-0.036462
BST2	-0.036148
LAPTM4B	-0.036101
KRT20	-0.036011
LCN2	-0.035865
LAP3	-0.035835
CTSH	-0.034992
HSPH1	-0.034883
MAPRE1	-0.034775
LGALS3BP	-0.034301
HSPA8	-0.034038
GINS1	-0.034008
NMI	-0.033738
RPF2	-0.033663
HMGN2	-0.033331
FAM60A	-0.033262
YBX1	-0.033016
FABP5	-0.032855
MAL2	-0.032813
CD164	-0.032594
PTPLAD1	-0.032505
TXNIP	-0.032464
HEBP2	-0.032445
PLSCR1	-0.032269
KIAA0101	-0.031357
MRPS21	-0.030926
PLS1	-0.030397
TOMM5	-0.029927
TATDN1	-0.029891
EIF3J	-0.029684
DYNLL1	-0.029611
VAMP7	-0.029608
RPL10	-0.029601
PPIB	-0.029505
NGRN	-0.029205
HDAC1	-0.028774
COX5A	-0.028752
LDHB	-0.028238
ANXA4	-0.028132
ANXA13	-0.028067
LY6E	-0.028027
ALYREF	-0.028017
S100A6	-0.027659
CSE1L	-0.027630
HSP90AB1	-0.027509
FMR1	-0.027269
SUMO2	-0.027264
IPO7	-0.027203
NDUFB9	-0.027182
STIP1	-0.027052
PSMA4	-0.027000
PTS	-0.026876
RAD21	-0.026844
AURKA	-0.026760
PRR13	-0.026682
HMGN3	-0.026292
CCT3	-0.025980
CYC1	-0.025885
PABPC1	-0.025659
NUSAP1	-0.025596
VIMP	-0.025584
NOP58	-0.025562
ENOPH1	-0.024975
PRC1	-0.024830
ANP32B	-0.024818
PTDSS1	-0.024734
ATP6AP1	-0.024595
MRPL17	-0.024470
BRCC3	-0.024464
FAM84B	-0.024424
UBB	-0.024387
ATAD2	-0.024367
MT1HL1	-0.024353
ASUN	-0.024268
CDK1	-0.024235
NELFCD	-0.024188
MRPL15	-0.024024
UHRF1	-0.023932
RPS20	-0.023522
GNL3	-0.023513
COX6C	-0.023355
LAMP1	-0.023143
MEST	-0.023129
IMPA1	-0.023023
MAPK6	-0.023018
TPX2	-0.022992
MT2A	-0.022963
PSMA7	-0.022943
GTF3A	-0.022807
YWHAB	-0.022770
LYPLA1	-0.022669
RRM1	-0.022586
SNRPA1	-0.022559
IFITM1	-0.022517
COPS5	-0.022377
NSA2	-0.022329
HPRT1	-0.022326
KNSTRN	-0.022291
OIP5	-0.022253
TRMT5	-0.021891
GPX1	-0.021855
IER3	-0.021811
MRPS35	-0.021680
ADRM1	-0.021659
CTPS1	-0.021639
AQP3	-0.021538
ANLN	-0.021501
CTNNAL1	-0.021461
MORF4L1	-0.021431
HLA-F	-0.021415
PSMB8	-0.021233
EIF2S2	-0.021109
SLC25A32	-0.021082
RFK	-0.020844
BUB1B	-0.020793
C1QBP	-0.020694
UBE2T	-0.020682
FBL	-0.020615
PPIF	-0.020463
DDX39A	-0.020443
SRP14	-0.020391
SLIRP	-0.020386
MTHFD1	-0.020256
FAM122B	-0.020219
AHSA1	-0.020140
LYSMD2	-0.020075
PAICS	-0.020057
FUNDC2	-0.019995
CXorf40A	-0.019958
CCT2	-0.019950
GDI2	-0.019949
ANP32A	-0.019873
IFI6	-0.019819
ESRP1	-0.019751
IDH3G	-0.019749
SERPINA1	-0.019631
NCAPG2	-0.019631
FANCI	-0.019578
SORD	-0.019564
MRPL27	-0.019506
PNRC2	-0.019420
KLK11	-0.019370
CXorf40B	-0.019296
CENPW	-0.019227
GCNT3	-0.019179
CKS1B	-0.019031
NDUFAB1	-0.018836
KIF5B	-0.018773
GMDS	-0.018758
UCHL3	-0.018742
ZNF706	-0.018733
PITPNB	-0.018651
TCEB1	-0.018588
DYNLRB1	-0.018565
IARS	-0.018437
RPL9	-0.018375
TMEM54	-0.018374
CETN2	-0.018240
CYFIP1	-0.018148
TUBA4A	-0.018131
SIGMAR1	-0.018048
RAB11A	-0.018025
EEF1A1	-0.018012
ETFA	-0.017993
ZWILCH	-0.017989
EEF1D	-0.017988
POLR2K	-0.017951
EREG	-0.017934
PTPRK	-0.017913
TUBA1C	-0.017758
KARS	-0.017748
NAE1	-0.017740
H2AFZ	-0.017736
LACTB2	-0.017724
SLC1A1	-0.017723
PSMA1	-0.017720
NDUFB2	-0.017627
PRSS2	-0.017568
OAZ1	-0.017507
CBFB	-0.017499
EMC4	-0.017479
MRPL42	-0.017384
NPTN	-0.017328
IFNGR1	-0.017325
SNX3	-0.017305
PSME1	-0.017191
TAF1D	-0.017155
ATIC	-0.017143
TUBA1B	-0.017114
DSCC1	-0.016947
RPS27L	-0.016942
RUVBL2	-0.016941
EZH2	-0.016902
ATP6V0B	-0.016899
CDKN2A	-0.016834
REPIN1	-0.016819
CYSTM1	-0.016805
PRPS1	-0.016764
BANF1	-0.016733
CHORDC1	-0.016612
ARPC1B	-0.016611
RPL24	-0.016609
MRPL16	-0.016507
RNF139	-0.016489
C12orf75	-0.016403
DCTPP1	-0.016383
ARHGAP18	-0.016325
H3F3B	-0.016256
RPS12	-0.016230
LBR	-0.016188
CIRH1A	-0.016176
VMA21	-0.016168
PFDN2	-0.016162
PTTG1IP	-0.016135
FAM91A1	-0.016107
CHCHD3	-0.016095
TPD52L2	-0.016057
TSG101	-0.015992
PLP2	-0.015918
SRSF2	-0.015887
SOD1	-0.015854
CFL1	-0.015844
HEXB	-0.015833
ENC1	-0.015816
CKS2	-0.015802
MELK	-0.015798
CDCA7	-0.015768
HMGB3	-0.015739
PIGP	-0.015737
MCM7	-0.015692
TRMT11	-0.015586
HSP90AA1	-0.015490
SEC11A	-0.015480
NMB	-0.015465
SERPINB1	-0.015400
CEACAM6	-0.015379
GGCT	-0.015343
MUC13	-0.015341
RBMX	-0.015246
ERMP1	-0.015190
CCT6A	-0.015131