!direction	-1
!num_genes	203
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Methotrexate
!smiles	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
!drugbank_id	DB00563
!pubchem_cid	126941
!cell_type	HT29 colon adenocarcinoma cell line
!organism	human
!end_metadata
HAPLN1	-0.269591
S100A4	-0.226563
TMEM167A	-0.216142
DHFR	-0.202119
AKR1B10	-0.151277
DKK1	-0.122934
AKR1C2	-0.111473
ZCCHC9	-0.101051
AKR1C3	-0.098867
UQCRFS1	-0.086835
TMSB10	-0.083509
SLC25A6	-0.083390
FDFT1	-0.077253
COX6B1	-0.077242
EDIL3	-0.075325
AKR1C1	-0.072409
GPI	-0.071511
CCNG1	-0.069397
NDUFS6	-0.067548
ECHS1	-0.064651
PODXL	-0.061728
OAT	-0.059777
CAPNS1	-0.058271
USMG5	-0.055621
OCIAD2	-0.053580
GSTO1	-0.052881
EEF1A2	-0.049745
RPS14P3	-0.049549
TSPAN13	-0.048796
PGAM1	-0.048365
BZW2	-0.047323
S100A11	-0.044013
ALDOA	-0.043923
TMED7	-0.043715
NDUFA4	-0.043478
DSTN	-0.043395
TAF7	-0.041365
XRCC4	-0.039443
RPL12	-0.038808
CHMP2A	-0.038177
MSN	-0.037657
SPINK1	-0.035429
CLPTM1L	-0.035107
PSMD2	-0.034774
CD55	-0.034492
PRDX5	-0.033780
C14orf2	-0.033594
ID1	-0.032727
SSR2	-0.032725
MRPL36	-0.032511
CMBL	-0.032169
CLDN2	-0.031828
AP2S1	-0.031739
SNRPD2	-0.031470
ITM2B	-0.031418
CRIP2	-0.031295
RGS2	-0.031269
RPA3	-0.031263
TOMM20	-0.031029
SMNDC1	-0.030975
WDR54	-0.030535
OST4	-0.030524
MRPS30	-0.030309
HIST1H2BK	-0.029972
ATF4	-0.029757
EPHX1	-0.029555
NDUFV2	-0.028844
UFD1L	-0.028777
IARS2	-0.028530
ANXA5	-0.028491
P4HB	-0.028414
RPS4X	-0.028386
CALB2	-0.028143
CRIP1	-0.027770
PDIA6	-0.027663
FXYD3	-0.027663
DHX32	-0.027236
CD99	-0.027189
CAPN2	-0.026979
NDUFB5	-0.026699
CKMT2-AS1	-0.026514
RPL3	-0.026014
RPS23	-0.025947
CAV1	-0.025876
ETFB	-0.025657
NME7	-0.025411
SNRPB	-0.025198
ADAM9	-0.024848
UBA2	-0.024693
DAP	-0.024636
LASP1	-0.024418
FXYD5	-0.024418
ANKRD27	-0.024382
AGPAT5	-0.024297
MRPL3	-0.024249
ZDHHC6	-0.024178
TYMS	-0.024088
PPP1R1B	-0.024024
LTA4H	-0.023589
ATP1B1	-0.023436
MORC4	-0.023079
LAPTM4A	-0.022917
COTL1	-0.022910
S100A16	-0.022556
EIF2A	-0.022547
HIF1A	-0.022495
PAM	-0.022350
CKB	-0.022317
PHB2	-0.022211
OSTC	-0.022031
TWSG1	-0.021873
ATRAID	-0.021782
PTTG1	-0.021688
ID2	-0.021411
C12orf57	-0.021326
EPB41L4A-AS1	-0.021319
TCEAL4	-0.021066
KPNA2	-0.021033
SLK	-0.020955
HPCAL1	-0.020923
UPF2	-0.020670
BCCIP	-0.020650
RAB25	-0.020550
ZDHHC16	-0.020514
GLRX3	-0.019939
RPS7	-0.019934
UQCR10	-0.019909
PLOD2	-0.019803
PGM1	-0.019690
MRPL33	-0.019570
ARL6IP1	-0.019432
PSMD11	-0.019345
EIF1AX	-0.019055
AFG3L2	-0.018972
KIAA1191	-0.018922
AP2M1	-0.018918
TRIM28	-0.018865
CAV2	-0.018846
RPS2	-0.018822
KIAA1598	-0.018804
CBWD1	-0.018803
SPINT2	-0.018693
S100A10	-0.018495
SGK223	-0.018391
ABLIM1	-0.018322
CD59	-0.018243
VDAC3	-0.018180
SEC61G	-0.018143
MXI1	-0.018139
ALDH3A2	-0.018114
ANXA10	-0.018039
ZNF511	-0.018036
CYP3A5	-0.017861
TUBB2A	-0.017719
SYT13	-0.017692
YES1	-0.017530
ALDH3A1	-0.017521
PLEK2	-0.017503
MSH3	-0.017428
IGFBP7	-0.017363
UGDH	-0.017219
LINC00493	-0.017173
TMEM258	-0.017139
PCBP1	-0.016930
EIF3A	-0.016885
TSPAN1	-0.016865
PPP1CB	-0.016862
ACADM	-0.016860
NEK7	-0.016849
TSC22D1	-0.016802
EIF2S3	-0.016754
COPB1	-0.016608
USP14	-0.016573
MDH1	-0.016459
SFXN3	-0.016449
ODC1	-0.016421
PSMG1	-0.016340
ARMCX6	-0.016325
ATP5I	-0.016324
GAPDH	-0.016232
ANXA2R	-0.016230
NHP2	-0.016121
AMIGO2	-0.016088
RPL23	-0.016070
EIF1	-0.016068
TPT1	-0.016001
MTIF2	-0.015983
SH3KBP1	-0.015898
NEAT1	-0.015895
RPLP0	-0.015884
QPCT	-0.015867
CCNI	-0.015829
TM9SF3	-0.015783
TOB1	-0.015758
EIF5	-0.015745
RTN4	-0.015745
PFN2	-0.015704
MTHFD2	-0.015611
YWHAQ	-0.015581
RBBP7	-0.015507
SLC25A1	-0.015422
HERPUD1	-0.015257
COX3	-0.015160