!direction	-1
!num_genes	281
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Methotrexate
!smiles	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
!drugbank_id	DB00563
!pubchem_cid	126941
!cell_type	PBMC (peripheral blood mononuclear cells)
!organism	human
!end_metadata
HIST1H2AM	-0.091168
UTS2	-0.063758
HIST1H2BG	-0.058264
GZMK	-0.052172
CXCL10	-0.051515
IGJ	-0.047249
CXCR6	-0.047042
RC3H1	-0.044231
CCL4	-0.043250
DSP	-0.041969
HIST1H2AE	-0.041253
A2M-AS1	-0.039189
ANKRD20A11P	-0.038346
IL1B	-0.037836
CCR5	-0.037559
SPON2	-0.036470
CCL8	-0.036279
MIR181A2HG	-0.035930
HIST1H4C	-0.035756
EGR1	-0.035263
CCL2	-0.035064
MIR21	-0.035007
HCG27	-0.034745
EOMES	-0.034064
FLJ12120	-0.034017
PRDM1	-0.033999
GPR171	-0.033878
CST7	-0.033741
LAIR2	-0.033301
IGLV1-36	-0.033134
KLRC3	-0.032900
C15orf54	-0.032831
PSPH	-0.032519
FCGR3B	-0.032516
LOC145474	-0.032362
PROK2	-0.032238
PYHIN1	-0.031961
CDKN1C	-0.031616
VMP1	-0.031498
RTP4	-0.031140
TGFBR3	-0.031078
LOC285628	-0.031056
XIST	-0.030834
TCL1A	-0.030495
GZMA	-0.030338
CLHC1	-0.030148
IGLL3P	-0.029901
HIST1H2BN	-0.029833
GTF2H2B	-0.029829
AMFR	-0.029643
GCOM1	-0.029431
SLC35E2	-0.029281
GZMH	-0.029241
LTB4R2	-0.029039
CD160	-0.029037
OAS3	-0.028871
TAPT1-AS1	-0.028744
LAG3	-0.028447
HIST1H4F	-0.028056
NPIPB15	-0.028021
P2RY14	-0.027998
KCNJ2	-0.027908
ANXA3	-0.027723
PDK4	-0.027634
SUGCT	-0.027100
HLA-DPA1	-0.027025
IFIT3	-0.027015
LINC00936	-0.026782
PFKFB3	-0.026702
GPRASP2	-0.026626
ARL17A	-0.026626
GNLY	-0.026525
GBP2	-0.026205
NAIP	-0.026086
LINC00865	-0.026074
BZRAP1	-0.025628
FAM110D	-0.025502
GBP1	-0.025280
FFAR2	-0.025154
CCDC68	-0.025125
BEGAIN	-0.024808
CX3CR1	-0.024785
PRO1082	-0.024745
LRRC37A2	-0.024726
C8orf44	-0.024707
SOD3	-0.024693
MGC24103	-0.024467
TMEM151A	-0.024446
NAMPT	-0.024441
GBP5	-0.024405
LOC728613	-0.024369
CMPK2	-0.024351
ZCCHC18	-0.024324
CYP11B2	-0.024241
CMC1	-0.024171
LOC151174	-0.024147
FBXO6	-0.024058
CDKAL1	-0.023952
LOC153682	-0.023831
FASLG	-0.023740
TARP	-0.023738
IGLV2-23	-0.023698
ANKRD22	-0.023603
IL18R1	-0.023506
GTF2H2	-0.023455
MYOF	-0.023432
SERPING1	-0.023411
CXCL9	-0.023358
SCUBE1	-0.023346
MAP4K3	-0.023092
EMR3	-0.023010
USP53	-0.022977
AQP9	-0.022969
KLRF1	-0.022932
NUP43	-0.022916
KLRD1	-0.022868
C14orf79	-0.022699
CLEC1B	-0.022437
GNG2	-0.022408
RPS24	-0.022325
TCF7L2	-0.022321
IGKV1D-8	-0.022287
IFIT2	-0.022116
ITM2A	-0.022094
TNFRSF17	-0.022082
TRGV5	-0.022055
LOC100507281	-0.022017
IKZF3	-0.021913
CCZ1B	-0.021876
KIAA0101	-0.021848
IDO1	-0.021811
FAM129A	-0.021757
FNBP1	-0.021708
LINC00877	-0.021695
LOC200772	-0.021665
C10orf95	-0.021614
PRF1	-0.021490
IL18RAP	-0.021480
HCAR3	-0.021445
CD48	-0.021431
RSAD2	-0.021428
SLFN12	-0.021393
CTF1	-0.021343
TMEM176B	-0.021306
ARSA	-0.021285
CEP83-AS1	-0.021284
CLIC3	-0.021243
VPS37D	-0.021223
LOC643733	-0.021164
DYNLT1	-0.021137
THUMPD3-AS1	-0.021133
FAM179A	-0.021122
KIF5C	-0.021117
ISG15	-0.021115
SESN1	-0.021068
FLJ21369	-0.021064
ZNF785	-0.021055
CMTM8	-0.021036
HPGD	-0.021023
RGPD1	-0.021020
GBP3	-0.020787
SERPINB9P1	-0.020773
CHI3L2	-0.020761
HIST1H3G	-0.020756
ODF3B	-0.020548
LRRC75A	-0.020519
ZNF267	-0.020504
CCL5	-0.020484
FAM184B	-0.020470
LOC284454	-0.020469
LINC01355	-0.020328
CHP1	-0.020309
EXTL1	-0.020307
CLIC2	-0.020278
CA2	-0.020266
HDDC2	-0.020214
HERC5	-0.020213
IFI44L	-0.020183
TRBV25-1	-0.020175
CYP4F22	-0.020104
SERPINB9	-0.019960
LOC100270804	-0.019958
SUZ12P1	-0.019957
HAND2	-0.019900
LOC101927027	-0.019875
IFI6	-0.019864
LHB	-0.019860
LOC729732	-0.019856
DFNA5	-0.019802
ZNF702P	-0.019781
MLH3	-0.019758
SNAPC2	-0.019714
LAP3	-0.019701
FBLN2	-0.019694
IFI35	-0.019691
TCAP	-0.019558
ARHGAP15	-0.019536
USP30-AS1	-0.019536
TCF15	-0.019533
FCRLA	-0.019523
SLC7A10	-0.019497
NKAPP1	-0.019488
KLRG1	-0.019478
RAMP2-AS1	-0.019453
FAM129C	-0.019445
MYOG	-0.019422
CCDC71	-0.019376
MT2A	-0.019297
HEATR3	-0.019264
MS4A7	-0.019230
OASL	-0.019215
LOC157860	-0.019113
FPR1	-0.019111
TAF15	-0.019017
LRRN3	-0.018991
GUSBP3	-0.018969
TAP1	-0.018945
ADAT1	-0.018935
ABCA5	-0.018930
KLRK1	-0.018927
PCDH9	-0.018870
IFNG	-0.018869
GRASP	-0.018864
PTGER4	-0.018861
RUNX3	-0.018856
SMG1P5	-0.018816
TKTL1	-0.018813
IGLJ3	-0.018797
CD8A	-0.018766
ASAP1-IT1	-0.018745
MS4A4A	-0.018735
C11orf86	-0.018669
LINC00685	-0.018655
BCL2A1	-0.018614
AGO3	-0.018600
HYMAI	-0.018589
VRK2	-0.018527
SH2D1B	-0.018509
KLHL28	-0.018481
TRPM5	-0.018460
DDX6	-0.018454
LOC100131043	-0.018446
BARX1	-0.018435
CD38	-0.018431
GFOD1	-0.018429
ITPK1-AS1	-0.018404
PRLH	-0.018373
HIST1H3H	-0.018367
PPAPDC2	-0.018334
HIST1H4H	-0.018302
LOC100127972	-0.018294
HIST1H2BI	-0.018287
XAF1	-0.018244
DUOXA2	-0.018154
CD96	-0.018152
PYGM	-0.018069
CEP192	-0.018052
ADM	-0.018052
NKG7	-0.018016
NEIL1	-0.018007
LOC100134822	-0.017996
TNFAIP3	-0.017985
ICAM4	-0.017972
FRMD7	-0.017945
NHLH1	-0.017921
PCDHA10	-0.017914
TYMP	-0.017881
DKFZp779M0652	-0.017875
IL17RE	-0.017824
KLRB1	-0.017812
CCDC91	-0.017808
RGS1	-0.017795
LOC100134445	-0.017766
PVALB	-0.017760
VMO1	-0.017734
MATK	-0.017732
ARL16	-0.017709
NEAT1	-0.017701
IQCC	-0.017688
PHGR1	-0.017618
CECR5-AS1	-0.017617