!direction	-1
!num_genes	214
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Methotrexate
!smiles	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
!drugbank_id	DB00563
!pubchem_cid	126941
!cell_type	PBMC
!organism	human
!end_metadata
ANXA1	-0.046007
SOCS3	-0.039411
DLGAP5	-0.038006
BRE-AS1	-0.037998
IL24	-0.037574
MTPN	-0.036967
CDC20	-0.036823
RRM2	-0.036543
DUSP4	-0.036180
LOC727820	-0.035871
PTENP1	-0.035728
PBK	-0.035563
CEP55	-0.035468
CCL20	-0.035295
CDKN3	-0.035055
THBD	-0.034893
KANSL1-AS1	-0.034885
CXCL3	-0.034289
LOC145474	-0.034034
GJB6	-0.033608
CDK1	-0.033202
IGKV1D-8	-0.033184
EIF3C	-0.032649
MELK	-0.032315
CAV1	-0.031845
OIP5	-0.031814
PLCG1-AS1	-0.031797
TMEM200B	-0.031309
RSPH10B2	-0.030993
EMC7	-0.030828
THOC7	-0.030258
GUK1	-0.030231
CCNA2	-0.029755
ADTRP	-0.029722
HP	-0.029505
USP3-AS1	-0.029310
HMMR	-0.029017
NDC80	-0.028844
CXCL8	-0.028731
PLBD1	-0.028722
NUF2	-0.028674
C15orf48	-0.028565
GPR84	-0.028315
CCNB1	-0.028177
DACT1	-0.028079
RNF182	-0.027887
KIF11	-0.027491
IDI2-AS1	-0.027438
APCDD1	-0.027313
SOCS2	-0.027171
CHN1	-0.027165
CCL4	-0.026982
ICOS	-0.026816
CCR10	-0.026657
GZMK	-0.026404
EEF1E1	-0.026252
NR4A2	-0.026208
GGH	-0.026087
CENPU	-0.025977
OLR1	-0.025941
EREG	-0.025778
MMP8	-0.025277
ST6GALNAC1	-0.025043
IGJ	-0.024987
KIF28P	-0.024949
TXN	-0.024948
TNFRSF17	-0.024891
MND1	-0.024848
ST8SIA1	-0.024527
PMCH	-0.024452
MZB1	-0.024108
CDO1	-0.024010
LYRM5	-0.023965
FAM46C	-0.023888
NFKBIZ	-0.023683
ZNF331	-0.023647
FABP5	-0.023637
TYMS	-0.023544
ARL2BP	-0.023494
WBP2	-0.023338
TPX2	-0.023322
APOBEC3B	-0.023270
HSP90B1	-0.023260
REL	-0.023239
MAD2L1	-0.023224
MIF-AS1	-0.023177
ADM	-0.023139
BRK1	-0.023096
CRISP3	-0.022992
RPLP2	-0.022865
NCAPG	-0.022830
RGS1	-0.022825
ACPP	-0.022822
IGLV1-36	-0.022809
ENO1-AS1	-0.022644
MRPL47	-0.022543
NUDT9P1	-0.022482
ZNF674-AS1	-0.022478
PRC1	-0.022461
ALG5	-0.022461
SEC11C	-0.022402
BBS12	-0.022386
IGLV1-44	-0.022300
SLC16A6	-0.022282
KISS1R	-0.022222
LOC100506083	-0.022128
TNNT1	-0.021990
CREM	-0.021981
PPIL1	-0.021780
PLEKHH1	-0.021696
ELANE	-0.021654
PARL	-0.021600
MS4A4A	-0.021536
RGPD1	-0.021530
PTTG1	-0.021460
ZNF165	-0.021443
G0S2	-0.021329
LINC00996	-0.021241
PKHD1L1	-0.021092
IGKV1OR2-108	-0.021087
C12orf45	-0.020892
LOC148413	-0.020755
SLC7A5	-0.020569
IGKV4-1	-0.020547
IER3IP1	-0.020432
F3	-0.020397
CCRL2	-0.020392
ANKRD19P	-0.020361
CHAC2	-0.020321
MRPS15	-0.020276
TTK	-0.020151
KIF20A	-0.020147
DDX50	-0.020095
LOC101929162	-0.020060
ELAC1	-0.020009
TMEM200A	-0.019991
GNPNAT1	-0.019886
THBS1	-0.019877
ERMN	-0.019848
RANBP1	-0.019799
TSIX	-0.019760
PIM2	-0.019738
IGLV1-40	-0.019705
GPR34	-0.019676
NEFL	-0.019671
NFIL3	-0.019657
BAG2	-0.019615
DTL	-0.019609
OR7E14P	-0.019510
BMP8B	-0.019504
RP9	-0.019489
MAT2B	-0.019455
KIAA0101	-0.019229
AREG	-0.019228
S100A12	-0.019210
BPI	-0.019152
DSC1	-0.019132
ATP6V0E1	-0.019103
C17orf75	-0.019001
LYRM4	-0.018945
IL1B	-0.018913
GLDC	-0.018891
PDE4B	-0.018887
OCIAD2	-0.018880
IGLV2-23	-0.018864
HYPK	-0.018863
OAZ3	-0.018862
ING2	-0.018858
EIF3F	-0.018828
EEF1D	-0.018827
BTBD18	-0.018779
ADSS	-0.018762
PLK2	-0.018735
DDIT4	-0.018694
RAI2	-0.018643
ITGA3	-0.018608
RAB32	-0.018577
FANK1	-0.018569
IGKC	-0.018569
OSTC	-0.018550
PAN3-AS1	-0.018543
DEPDC1B	-0.018502
LOC100129104	-0.018448
CYB5D1	-0.018411
DNAJC7	-0.018408
NME9	-0.018398
NAMPT	-0.018364
AQP9	-0.018338
CISD1	-0.018262
LAIR2	-0.018259
UHRF1	-0.018238
GUSBP5	-0.018221
MME	-0.018206
MCEMP1	-0.018143
GZMA	-0.018118
MZT1	-0.018093
PANK2	-0.018045
LILRA3	-0.017994
BIK	-0.017992
PLA2G7	-0.017972
GTSF1	-0.017966
LOC100507557	-0.017947
TCTEX1D2	-0.017938
SLC22A4	-0.017928
GADD45A	-0.017899
FAM177A1	-0.017745
DSC2	-0.017732
XIST	-0.017621
CDC45	-0.017590
S100A8	-0.017576
KIF18B	-0.017551
METTL9	-0.017534
SNRPE	-0.017524
PRIMPOL	-0.017511