!direction	-1
!num_genes	233
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	MLN4924
!smiles	C1CC2=CC=CC=C2C1NC3=NC=NC4=C3C=CN4C5CC(C(C5)O)COS(=O)(=O)N
!pubchem_cid	73014187
!cell_type	A375 melanoma cell line - 24 Hours
!organism	human
!end_metadata
SERPINA3	-0.159970
SLC26A2	-0.143962
LGALS1	-0.115530
IL13RA2	-0.100530
CDK2AP1	-0.097765
NACAP1	-0.095985
TSPAN13	-0.093077
S100A4	-0.087573
CD63	-0.083280
CTHRC1	-0.081537
TIMP1	-0.078281
HSPA8	-0.076179
TUBA1A	-0.072696
MARCKSL1	-0.071155
HLA-DRA	-0.068461
KPNA2	-0.068305
TRMT112	-0.064764
MIA	-0.064176
ATP5E	-0.062393
PFN1	-0.061469
DYNLT3	-0.060638
SYTL5	-0.058552
SPRY2	-0.058058
SRPX	-0.057818
WWTR1	-0.057609
LINC01419	-0.057407
ABHD17C	-0.056741
SDCBP	-0.056457
LOXL4	-0.055599
TIMP3	-0.055126
GNE	-0.053501
CKS2	-0.050158
SERPINE2	-0.050026
NGFRAP1	-0.049827
MAGEA4	-0.049219
MMADHC	-0.048932
IFITM3	-0.047020
MIR21	-0.046999
PPIB	-0.046963
MORF4L1	-0.046646
ALDH1A3	-0.046638
IRF2BPL	-0.046417
S100A6	-0.046309
SNRPB2	-0.045822
HLA-DRB1	-0.045811
ERRFI1	-0.045761
OAT	-0.044994
HAPLN1	-0.044397
TMSB10	-0.044287
PTTG1	-0.043522
GABARAP	-0.042786
DBI	-0.042717
COX7A2	-0.042291
SPARC	-0.041641
UBE2C	-0.041571
HMGN2	-0.041281
GNAS	-0.041189
VIM	-0.040181
NPTN	-0.039886
PRKAR1A	-0.039756
SPCS1	-0.039486
SH3BGRL3	-0.039152
ARL6IP1	-0.038948
HSP90B1	-0.037853
FLRT3	-0.037410
ARL6IP5	-0.037352
CCNB1	-0.036990
SH2B3	-0.036812
TNC	-0.035472
ISG20	-0.035463
RRAGA	-0.035417
PRC1	-0.035343
RPL39	-0.035248
OVOS2	-0.034802
ID1	-0.034556
ARPC1B	-0.033962
DYNLL1	-0.033879
YWHAZ	-0.033219
TRMT5	-0.032953
TUBB	-0.032780
PHLDA1	-0.031820
S100A13	-0.031778
TM9SF2	-0.031580
PXYLP1	-0.031280
ITGA6	-0.031227
LAPTM4A	-0.031227
PDHB	-0.031086
MANSC1	-0.030706
DUSP6	-0.030672
RNF145	-0.030568
IFNGR2	-0.030535
MYH10	-0.029858
MYL6	-0.029777
HMMR	-0.029571
ACSL3	-0.029468
TMBIM4	-0.029443
HLA-DPA1	-0.029413
S100A16	-0.029239
B2M	-0.029177
SLC5A3	-0.028925
RAB13	-0.028771
CD59	-0.028683
UBB	-0.028533
HPCAL1	-0.028527
EMP3	-0.028510
TUBB4B	-0.028043
CDK1	-0.028014
PDIA6	-0.027860
COX8A	-0.027688
RPS25	-0.027645
TMEM14A	-0.027641
CBX3	-0.027552
C16orf52	-0.027532
INHBA	-0.027509
ITM2B	-0.027293
MICU2	-0.027262
TOP2A	-0.026465
TFAP2B	-0.026408
MANF	-0.026302
TMEM230	-0.026221
ERBB3	-0.026190
NUF2	-0.026132
SOX11	-0.025973
ART3	-0.025682
HMGN1	-0.025625
LINC00326	-0.025625
SEPW1	-0.025517
LMNB1	-0.025503
C12orf57	-0.025442
INPP5F	-0.025427
CHMP2A	-0.025318
MAGED1	-0.025245
HMGB1	-0.025226
PRR11	-0.025060
PLIN2	-0.025018
MRPL51	-0.025017
YWHAE	-0.025012
SLMO2	-0.024988
STUB1	-0.024967
UBE2S	-0.024914
BTF3	-0.024893
UBE2E3	-0.024803
PLP1	-0.024501
ATRAID	-0.024454
DUT	-0.024403
PSMB4	-0.024260
TNFRSF21	-0.023998
ANXA1	-0.023988
PFN2	-0.023761
RPL3	-0.023641
CTSC	-0.023540
TMX4	-0.023503
RPL22L1	-0.023352
EID1	-0.023198
FGF13	-0.023137
HMGB2	-0.023102
SUCLG2	-0.022894
TGFBI	-0.022843
METTL23	-0.022835
ANLN	-0.022771
BTBD3	-0.022763
CD96	-0.022703
FAM83D	-0.022652
DNAJA1	-0.022532
TMEM59	-0.022451
LAMB1	-0.022447
ZCCHC24	-0.022368
MINPP1	-0.022323
ADD3	-0.022303
HNRNPA2B1	-0.022262
GBAS	-0.022225
CHSY1	-0.022206
HOXC6	-0.022128
TUBB3	-0.021999
ANP32A	-0.021947
AGPAT9	-0.021937
SSR4	-0.021768
HSPB1	-0.021668
HSP90AB1	-0.021651
CETN3	-0.021574
NDUFB10	-0.021521
WDR54	-0.021433
SNX10	-0.021362
COX7C	-0.021354
C1QBP	-0.021310
APOA1BP	-0.021218
HSBP1	-0.021003
LINC00493	-0.020957
CEMIP	-0.020858
ADI1	-0.020769
PTMA	-0.020654
MFAP2	-0.020526
SLC20A1	-0.020430
PAPSS1	-0.020413
TMEM258	-0.020411
ORMDL2	-0.020406
IFITM2	-0.020268
FXYD3	-0.020086
ANXA5	-0.020063
TRIB2	-0.019928
H2AFZ	-0.019926
ACADVL	-0.019876
SELK	-0.019870
C11orf31	-0.019723
MLLT11	-0.019681
APP	-0.019610
TMEM2	-0.019588
PCDHB5	-0.019515
TUBA1B	-0.019428
MEOX2	-0.019419
KIF20A	-0.019354
RPA3	-0.019311
TOP2B	-0.019277
CDKN1B	-0.019218
COX5B	-0.019068
TGFA	-0.019066
LINC00657	-0.019049
AURKA	-0.019025
TUBA1C	-0.019017
TCF7L2	-0.019016
SGK1	-0.018923
WBP5	-0.018817
EIF3E	-0.018789
ETFB	-0.018602
SH3KBP1	-0.018557
NDUFAB1	-0.018485
PRKAR2B	-0.018408
DPYSL2	-0.018349
HLA-A	-0.018318
GABARAPL2	-0.018253
EPS8	-0.018217
RPN2	-0.018194
TFAP2C	-0.018166