!direction	-1
!num_genes	334
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Metoprolol
!smiles	CC(C)NCC(COC1=CC=C(C=C1)CCOC)O
!drugbank_id	DB00264
!pubchem_cid	4171
!cell_type	colon
!organism	human
!end_metadata
FOS	-0.130187
XIST	-0.119049
EGR1	-0.116334
NR4A1	-0.088770
GCG	-0.080059
LOC284454	-0.070125
OLFM4	-0.069276
ERAP1	-0.055352
KRBOX1	-0.054647
MARS2	-0.051783
ADAMDEC1	-0.051466
NR4A2	-0.051280
IGJ	-0.050837
CXCL3	-0.049487
RGS1	-0.047457
SST	-0.047125
C8orf4	-0.044388
CXCL1	-0.044255
CD69	-0.044087
LINC00261	-0.043937
EGR2	-0.040707
ZFP36	-0.040080
LINC01405	-0.039033
CCL8	-0.038829
IER2	-0.037439
DUSP1	-0.037361
KCTD12	-0.037185
TUSC3	-0.037002
HBB	-0.036856
MAB21L2	-0.036783
ERAP2	-0.036716
ODC1	-0.035834
SAMD10	-0.035833
PSMG1	-0.035537
CCDC58	-0.035494
LEPREL1	-0.034816
NUPR1L	-0.034575
RBM48	-0.034569
C1D	-0.034275
MAD2L1	-0.034051
FHDC1	-0.033825
C3orf14	-0.033731
KCNMB4	-0.033002
GBP3	-0.031657
WBP5	-0.031362
RRS1	-0.031338
PNP	-0.031226
FMOD	-0.031077
CBWD3	-0.030924
SQLE	-0.030661
HAPLN1	-0.030542
LOC642236	-0.030257
CXCL2	-0.029855
GGH	-0.029205
DCUN1D5	-0.029126
DPP10-AS1	-0.028956
CYR61	-0.028887
SPINK1	-0.028848
C11orf96	-0.028586
SELK	-0.028549
SNHG5	-0.028237
C9orf43	-0.028231
ADAMTS1	-0.028078
IER3	-0.028036
CFD	-0.028029
ARHGAP15	-0.028022
SCUBE2	-0.027960
CDR1	-0.027898
GDF15	-0.027841
LXN	-0.027805
GATM	-0.027791
VMP1	-0.027613
KCNE3	-0.027442
FAM21EP	-0.027220
MRPS21	-0.027053
PTGS2	-0.026996
EEF1E1	-0.026873
RLN2	-0.026682
AGR2	-0.026679
ABHD10	-0.026636
PHF5A	-0.026527
TEX10	-0.026391
SPINK2	-0.026368
NOS2	-0.026339
ZNF367	-0.026322
ARHGEF40	-0.026320
SI	-0.026276
TIMM21	-0.026096
ECHDC1	-0.026030
DICER1	-0.025962
MFAP4	-0.025936
PIM3	-0.025927
ZNF165	-0.025817
PITHD1	-0.025736
SGK1	-0.025542
TRIB1	-0.025452
PBK	-0.025394
DUSP5	-0.025186
CNIH3	-0.025183
S100B	-0.025174
TOP2A	-0.025129
DLL1	-0.025006
KIF18A	-0.024958
LOXL1-AS1	-0.024769
MYB	-0.024757
TSPAN11	-0.024664
EYA1	-0.024614
LYAR	-0.024546
KIAA1324L	-0.024515
MMACHC	-0.024458
INPP1	-0.024095
CBWD6	-0.024092
ENC1	-0.024037
POLR1B	-0.024027
GJB2	-0.024008
RGMB	-0.023958
TTF2	-0.023925
PARPBP	-0.023649
TPSB2	-0.023468
TMEM67	-0.023415
HEYL	-0.023414
FOXJ2	-0.023344
ANG	-0.023290
GPR110	-0.023262
ID1	-0.023248
RPF2	-0.023158
ZNF671	-0.023146
RPS5	-0.023109
E2F8	-0.023090
IGKC	-0.022950
MESDC1	-0.022919
C11orf73	-0.022896
HSPA5	-0.022873
TOMM70A	-0.022873
GFAP	-0.022799
HMGN5	-0.022792
DNA2	-0.022744
TCF21	-0.022710
CCNJ	-0.022703
PLP1	-0.022690
CRCT1	-0.022674
OIP5	-0.022639
LINC00115	-0.022622
MLLT4-AS1	-0.022550
PPAT	-0.022518
SPC25	-0.022463
TEX30	-0.022402
PTBP1	-0.022337
GLRX2	-0.022290
FRZB	-0.022286
KRT10	-0.022274
TMEM200A	-0.022136
MSH2	-0.022097
TMBIM4	-0.022064
FGFRL1	-0.022014
ETS2	-0.021993
CREB5	-0.021985
WDR3	-0.021978
KLF2	-0.021928
PLK3	-0.021927
EXOSC3	-0.021903
C3orf33	-0.021875
OSTC	-0.021830
LINC01351	-0.021791
GNL3	-0.021784
SRSF8	-0.021733
ALG5	-0.021729
PRNP	-0.021708
TNFAIP6	-0.021689
PDS5A	-0.021676
H2AFZ	-0.021675
CDC73	-0.021622
TRMT10C	-0.021594
ARMCX3	-0.021526
SERP1	-0.021509
PDGFRB	-0.021461
RLIM	-0.021459
PROCR	-0.021398
MSH6	-0.021271
MRPL1	-0.021268
TCEAL8	-0.021257
HIF1A	-0.021233
KRTAP5-8	-0.021199
UGT2B11	-0.021135
FGF14-AS2	-0.021110
RAB1A	-0.021095
CDH13	-0.021056
FGFBP2	-0.021000
RHOBTB3	-0.020981
LGALS2	-0.020946
MFSD6L	-0.020941
PCDH20	-0.020939
CBWD2	-0.020901
CPAMD8	-0.020809
MIPEP	-0.020752
MNX1-AS1	-0.020747
MTERF3	-0.020739
RHAG	-0.020736
TCP1	-0.020669
SAP30	-0.020668
VHL	-0.020560
SMC4	-0.020496
SPOCK1	-0.020489
RAB27A	-0.020442
RAD51AP1	-0.020435
NCAM2	-0.020403
ESCO2	-0.020397
DIMT1	-0.020394
GCNT2	-0.020378
POU2AF1	-0.020338
PHLDA2	-0.020324
MRPL17	-0.020261
KIAA0895	-0.020235
WIPI1	-0.020228
LINC01116	-0.020220
SET	-0.020203
HSPH1	-0.020180
MGAT2	-0.020130
BRCA2	-0.020106
TFB2M	-0.020081
OXCT1	-0.020062
GEMIN4	-0.020020
ZBTB1	-0.020001
CCT2	-0.019986
CDCA7	-0.019951
TFAM	-0.019915
HBEGF	-0.019886
LINC00621	-0.019867
ZFP36L2	-0.019846
MRPL50	-0.019818
NEIL3	-0.019801
HMGCS1	-0.019792
CCDC144B	-0.019781
PCSK9	-0.019700
MTFR2	-0.019697
DCAF13	-0.019692
DKC1	-0.019691
TXNDC9	-0.019680
SCGB2A1	-0.019638
EIF1AX	-0.019629
MAGOH	-0.019608
PHTF1	-0.019605
SDHD	-0.019571
DDX21	-0.019551
JUNB	-0.019532
GLRB	-0.019440
GPATCH4	-0.019437
JUN	-0.019436
PLEKHG4	-0.019412
TPO	-0.019402
RARRES1	-0.019377
SAMHD1	-0.019362
ZNHIT6	-0.019345
DNAJA1	-0.019340
NFKBIZ	-0.019304
IRF4	-0.019296
NUP35	-0.019281
DRG1	-0.019279
HEPACAM2	-0.019271
NIFK	-0.019254
IMPACT	-0.019250
CCNH	-0.019194
RACGAP1	-0.019193
ZNF649	-0.019186
ACAT2	-0.019177
CHSY1	-0.019170
TGFB2-OT1	-0.019159
SLC12A2	-0.019125
NCKAP1	-0.019105
PLAT	-0.019099
CARD16	-0.019072
CASP1	-0.019052
ZNF623	-0.019035
MRPS17	-0.018912
ZNF432	-0.018866
CAB39L	-0.018853
PARK7	-0.018845
BYSL	-0.018843
UBE2J2	-0.018834
SARAF	-0.018809
SUMO1P3	-0.018804
DNALI1	-0.018783
WDR43	-0.018756
KIF13A	-0.018738
LCMT2	-0.018699
PASD1	-0.018672
PRMT6	-0.018652
BRIX1	-0.018623
HNRNPDL	-0.018606
DNAJB11	-0.018580
PDCD2	-0.018569
ERLEC1	-0.018560
CDC26	-0.018548
C11orf74	-0.018513
CD48	-0.018488
CGREF1	-0.018410
SPAG16	-0.018393
TSPAN15	-0.018392
UBE3D	-0.018379
CAPRIN1	-0.018356
FMN2	-0.018332
INSL5	-0.018321
TYMSOS	-0.018319
GNE	-0.018319
PBRM1	-0.018311
CTGF	-0.018302
REG4	-0.018289
TIMM23	-0.018253
PDIA6	-0.018248
C7orf62	-0.018212
OCA2	-0.018203
HPS6	-0.018202
MTFMT	-0.018193
PLAG1	-0.018155
POLR3K	-0.018149
PLA2G2A	-0.018136
TM9SF3	-0.018122
SRP9	-0.018112
H2AFX	-0.018093
PRSS36	-0.018075
COX18	-0.018023
GTPBP4	-0.018019
MND1	-0.017998
IDO1	-0.017992
MPLKIP	-0.017990
SRSF2	-0.017969
ZNF684	-0.017962
AFMID	-0.017961
ANO5	-0.017956
TFRC	-0.017943
POLB	-0.017941
LTV1	-0.017908
SPRY1	-0.017908
CKAP4	-0.017887