!direction	-1
!num_genes	360
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Rattus norvegicus
!drug_name	orotic acid
!smiles	C1=C(NC(=O)NC1=O)C(=O)O
!pubchem_cid	967
!cell_type	Livers ( from outbred Wistars - fed a diet with 1% orotic acid) - 1 Day
!organism	rat
!end_metadata
RPL23	-0.261652
VTN	-0.225112
RPS13	-0.160594
HP	-0.156812
SLC27A2	-0.154091
UPB1	-0.152093
PON1	-0.138352
TMEM205	-0.130872
ARG1	-0.125495
CTH	-0.124827
RPS29	-0.115549
APOA2	-0.115532
ASS1	-0.115086
COX1	-0.109013
GSTM5	-0.107933
THRSP	-0.104110
FTH1	-0.097060
ATP5B	-0.094323
HMGCS1	-0.091268
PAH	-0.083787
METTL7B	-0.083438
ALDH1L1	-0.082470
DDT	-0.080628
KHK	-0.079270
CYB5A	-0.078997
GPX1	-0.077164
MIF	-0.076565
BAAT	-0.075027
SCD	-0.074442
HSD11B1	-0.073852
PIGR	-0.073337
PCBD1	-0.071907
RPL19	-0.069022
TTC36	-0.068872
ATP5O	-0.066896
CDO1	-0.066319
RPS12	-0.065187
CLU	-0.064951
TDO2	-0.064773
RPS26	-0.064729
RPS16	-0.064607
HPX	-0.063597
CPS1	-0.062171
SERPING1	-0.061570
COX8A	-0.060419
AHSG	-0.059845
ALDOB	-0.059492
EPHX1	-0.058903
GLUD1	-0.057862
SOD1	-0.057797
HRSP12	-0.057749
B2M	-0.057624
RPL5	-0.056564
MST1	-0.055389
SDC4	-0.055245
ADH1C	-0.054173
HAAO	-0.054048
PTTG1IP	-0.053547
RPS27A	-0.051167
RPL9	-0.050153
RBP1	-0.049891
RPL31	-0.049742
RPL30	-0.049552
TTR	-0.049426
PLIN2	-0.049042
POMP	-0.047657
GSTM1	-0.047484
RPS23	-0.047233
FAH	-0.046578
CYP2E1	-0.046405
CYP1A2	-0.046358
ACLY	-0.046256
MGST1	-0.045502
PAPSS2	-0.045475
HPD	-0.045267
NDUFA8	-0.045211
FABP6	-0.044616
CPQ	-0.044514
ACADM	-0.044342
KYNU	-0.043895
ND4	-0.043705
NUP88	-0.043486
ATP5C1	-0.042773
C9	-0.041616
SLC10A1	-0.041242
TSC22D1	-0.041054
LAMP2	-0.041027
PROS1	-0.040949
UGT2B28	-0.040928
GPX4	-0.040694
PRDX1	-0.040215
SPP2	-0.040174
GSTK1	-0.039949
ETNK2	-0.039795
SORD	-0.039734
CSAD	-0.038962
ALDH2	-0.038957
MSMO1	-0.038730
GPT	-0.038420
COX7A2	-0.038379
GAMT	-0.038041
APOH	-0.037885
RPS11	-0.037516
FTL	-0.036907
AKR1D1	-0.036709
SQLE	-0.036630
NDUFC1	-0.036069
RPL35	-0.035865
CFB	-0.035752
GNMT	-0.035718
RPL27A	-0.034982
RPLP2	-0.034969
CTDSP1	-0.034858
YWHAB	-0.034593
RPL24	-0.034584
COX4I1	-0.034521
ACAA2	-0.034477
AGXT2	-0.034423
RPSA	-0.034119
APOB	-0.033450
SNRNP70	-0.033439
ATP5G2	-0.033303
PAICS	-0.033277
DBI	-0.032826
TMBIM6	-0.032786
COX5A	-0.032701
KLKB1	-0.032419
GSTA5	-0.032414
DHCR7	-0.032233
CA3	-0.032186
HSD3B7	-0.032050
ACADL	-0.031884
PROC	-0.031774
CYP7A1	-0.031295
DDC	-0.031219
DPYS	-0.031005
OAZ1	-0.030994
AK4	-0.030802
HSD17B6	-0.030608
ADK	-0.030498
ABCB11	-0.030456
PABPC4	-0.030307
UQCR11	-0.030090
NDUFB3	-0.029968
C8B	-0.029914
CAT	-0.029797
AUH	-0.029711
ERRFI1	-0.029081
RPS4Y1	-0.028748
APOC4	-0.028702
SLC22A18	-0.028606
ABCC6	-0.028281
ITIH3	-0.028085
SERPIND1	-0.028066
MARC2	-0.028028
OAT	-0.027569
CES1	-0.027471
RBP4	-0.027273
CST3	-0.027203
ACSL5	-0.027169
GSTM2	-0.027120
PSAP	-0.026700
COX6A1	-0.026634
NDUFB9	-0.026631
LIPC	-0.026378
HIBADH	-0.026334
LAMP1	-0.026067
ALAD	-0.025986
SIGMAR1	-0.025839
G0S2	-0.025587
PGRMC1	-0.025480
NDUFB8	-0.025458
BSG	-0.025308
RPL11	-0.025219
ETFA	-0.025006
PSMA6	-0.024994
MAN2B1	-0.024577
EBP	-0.024330
SPINT2	-0.024252
NDUFS7	-0.023911
RPS5	-0.023484
CYP27A1	-0.023483
MGST3	-0.023280
HSPE1	-0.022748
RPS6	-0.022468
EIF5	-0.021660
ACY1	-0.021596
ATRN	-0.021469
CD74	-0.021247
HPN	-0.020908
CREG1	-0.020797
GCKR	-0.020721
CISH	-0.020406
SEC61B	-0.020298
EHHADH	-0.020259
DIO1	-0.020054
OTC	-0.020044
RPS21	-0.019966
DARS	-0.019834
HSPD1	-0.019833
TALDO1	-0.019562
NDUFV2	-0.019514
PGK1	-0.019460
HSPA9	-0.019360
AMBP	-0.019216
ATP5A1	-0.019003
RPL8	-0.018910
CTSB	-0.018865
PEMT	-0.018783
NDUFB4	-0.018692
ST6GAL1	-0.018673
RPL28	-0.018672
MAP3K1	-0.018649
DDRGK1	-0.018634
NDRG2	-0.018316
SUB1	-0.018277
NPHP1	-0.018218
RPS7	-0.018129
NDUFV3	-0.018002
RPL27	-0.017825
CYC1	-0.017726
PPIA	-0.017678
RGN	-0.017673
NDUFA4	-0.017431
PCYT2	-0.017339
CD63	-0.017233
ACAT2	-0.017166
GLS2	-0.017059
ID2	-0.017046
TUBA1C	-0.016929
SLC22A1	-0.016635
NME2	-0.016418
RPS8	-0.016395
NR1H4	-0.016144
CTSS	-0.015960
PYGL	-0.015846
NDUFB6	-0.015665
ZFP36L1	-0.015635
SDCBP	-0.015584
HACL1	-0.015537
ALAS1	-0.015379
DUSP1	-0.015348
AES	-0.015289
UGT1A1	-0.015264
HSD17B13	-0.015255
RPL17	-0.015198
ASGR2	-0.015170
NDUFA9	-0.015137
CA5A	-0.015039
PXMP2	-0.015018
CYTB	-0.014889
TECR	-0.014846
DMBT1	-0.014827
PTPLAD1	-0.014682
SLC25A3	-0.014647
AMY2B	-0.014613
FAU	-0.014600
ACAT1	-0.014484
DLST	-0.014378
DAK	-0.014287
DAD1	-0.014200
MAOB	-0.014036
FIS1	-0.014025
GRB14	-0.013764
IVD	-0.013702
IDH1	-0.013610
GDA	-0.013532
SLCO2A1	-0.013388
MAOA	-0.013387
MRFAP1	-0.013253
SLC26A1	-0.013227
FABP7	-0.013060
MTCH2	-0.012848
NINJ1	-0.012718
PTP4A1	-0.012653
CP	-0.012623
TST	-0.012548
NQO1	-0.012537
GRINA	-0.012442
RPL10A	-0.012387
RPL13A	-0.012322
IDI1	-0.012313
BHLHE40	-0.012299
ECHS1	-0.012233
ADIPOR2	-0.012228
AQP9	-0.012204
LITAF	-0.012142
RPL22	-0.011985
GNPTG	-0.011908
BCKDHB	-0.011893
ALDH1A1	-0.011781
FUCA1	-0.011758
AADAT	-0.011754
SERPINA6	-0.011720
F2	-0.011692
FAAH	-0.011628
SERPINA10	-0.011607
CLTA	-0.011565
MPC1	-0.011410
FDFT1	-0.011358
EIF4A2	-0.011356
DECR2	-0.011166
MYRF	-0.011139
ALPL	-0.011116
NME1	-0.011088
CAPNS1	-0.011071
NDUFB2	-0.011063
TXN2	-0.011040
AIFM1	-0.010969
INHBE	-0.010963
HSD17B12	-0.010961
PCCA	-0.010929
RPL18	-0.010866
MGST2	-0.010862
PSMC1	-0.010845
DAO	-0.010835
CHKA	-0.010798
APH1A	-0.010774
NR1H3	-0.010746
CNN3	-0.010717
CLEC4F	-0.010710
ADD1	-0.010706
MPST	-0.010678
SCLY	-0.010670
SLC41A2	-0.010639
RPS15A	-0.010616
FGB	-0.010608
CXXC5	-0.010547
RPS15	-0.010417
ADH5	-0.010403
ZFAND6	-0.010348
CNPY2	-0.010295
ADRA1B	-0.010195
GCHFR	-0.010188
SDHA	-0.010118
DDX3X	-0.010032
PHB	-0.010020
FGGY	-0.009972
RPL18A	-0.009862
PDLIM1	-0.009810
HADHA	-0.009794
UGT2B17	-0.009792
COX7B	-0.009752
RPS10	-0.009638
SYNGR2	-0.009626
RDH16	-0.009500
SDS	-0.009390
NDUFA3	-0.009364
GSTO1	-0.009310
DNAJA1	-0.009234
RPL36AL	-0.009230
PPAP2B	-0.009186
CFD	-0.009155
GRK6	-0.009069
PDK2	-0.008925
PGAM1	-0.008911
CYP51A1	-0.008888
F9	-0.008879
ACP2	-0.008808
FOXA2	-0.008807