!direction	-1
!num_genes	281
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	MEK inhibitor (MEKi : AZD6244)
!smiles	CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
!pubchem_cid	10127622
!cell_type	SW480 cancer cells
!organism	human
!end_metadata
DUSP6	-0.169696
IER3	-0.113608
EGR1	-0.093667
SOX9	-0.079823
PCNA	-0.079336
CDCA7L	-0.069996
LPCAT2	-0.066449
MALL	-0.065324
ZNF367	-0.063680
DPYSL2	-0.063330
RRM2B	-0.057147
SLC16A1	-0.054499
FGF19	-0.053630
NGFR	-0.053144
EN2	-0.052581
DCLK1	-0.052574
CTNNAL1	-0.051740
UNG	-0.050939
KLF10	-0.050849
DUT	-0.050237
METTL9	-0.050090
NUDT15	-0.049430
AKAP12	-0.048509
SMURF2	-0.048383
NET1	-0.048264
EPHA2	-0.047951
LINC00341	-0.047413
ANKRD1	-0.047236
RMI1	-0.047196
GLRX	-0.046782
POC1B	-0.046716
UHRF1	-0.045842
RBBP8	-0.045120
H2AFZ	-0.044094
WNT5A	-0.043878
C1QBP	-0.043700
KIF11	-0.043309
DNMBP	-0.042935
LYRM1	-0.042574
RFC4	-0.041719
SAT1	-0.041386
HMGA1	-0.041386
ETV3	-0.041379
OSBPL3	-0.041335
SLC39A10	-0.041303
AP1S2	-0.041261
ITGB5	-0.040468
MCM7	-0.040369
PRIM1	-0.040072
SLC20A1	-0.039908
CHST11	-0.039385
SEH1L	-0.039358
ZWINT	-0.039175
RAD51AP1	-0.038896
DUSP5	-0.038682
LIMS3	-0.038493
APOBEC3C	-0.038456
STARD4	-0.038245
CPOX	-0.037876
PALD1	-0.037865
TNS4	-0.037695
ETV5	-0.037437
DCUN1D3	-0.037133
YAP1	-0.036860
CDC7	-0.036772
CXCR4	-0.036734
GMNN	-0.036605
TBC1D4	-0.035932
FAM101B	-0.035703
SH3KBP1	-0.035657
RMI2	-0.035528
PIM1	-0.035341
NEIL3	-0.035140
RAB8A	-0.035134
IGFBP3	-0.035063
IER2	-0.034919
UBE2C	-0.034448
CCND1	-0.034356
FEN1	-0.034353
TINAGL1	-0.033786
CKS1B	-0.033766
STARD7	-0.033591
UBE2T	-0.033555
NRARP	-0.033547
IL17RD	-0.033446
DCK	-0.033066
TMEM163	-0.033055
ANLN	-0.032985
ERRFI1	-0.032903
KDM3B	-0.032707
ASF1B	-0.032694
CORO1C	-0.032675
MCM6	-0.032662
MSL2	-0.032448
MMD	-0.032201
NCAPD2	-0.032105
ALDH1A3	-0.032049
LOC284023	-0.031871
SLC16A6	-0.031862
GINS1	-0.031780
POLA1	-0.031766
FABP5	-0.031564
NELL2	-0.031533
ACYP1	-0.031384
SMC2	-0.031061
EPAS1	-0.030999
SERPINE1	-0.030837
SORBS1	-0.030700
DHFR	-0.030553
ANXA6	-0.030336
PTPRN2	-0.030199
DBF4	-0.030093
CDK1	-0.029796
UXS1	-0.029708
SPIN1	-0.029659
PDGFA	-0.029631
AFAP1L2	-0.029534
TYMS	-0.029385
GOLPH3	-0.029240
AURKA	-0.029139
CYB5B	-0.029103
EBNA1BP2	-0.029025
H1F0	-0.028989
FAM171B	-0.028950
MCM2	-0.028819
CDCA4	-0.028676
GALNT4	-0.028652
INTS2	-0.028618
GLUD1	-0.028515
DNAJB1	-0.028480
FGF13	-0.028462
MELK	-0.028164
LSM5	-0.028108
KCNJ5	-0.028046
IGFBP4	-0.028042
USP1	-0.027997
ITGA6	-0.027983
SPC25	-0.027816
KIAA0101	-0.027795
GJB1	-0.027750
MGAT5	-0.027641
TMA7	-0.027534
HAT1	-0.027453
LTA4H	-0.027415
GLRX5	-0.027311
FAM102B	-0.027288
EMP1	-0.027250
TIAM1	-0.027210
IPO5	-0.027186
MRGBP	-0.027124
TMEM194A	-0.027050
NCAPG2	-0.027022
PTGES3	-0.026954
ACN9	-0.026751
EDAR	-0.026682
GLOD4	-0.026673
TGFBI	-0.026656
SRSF2	-0.026653
IPO7	-0.026497
RPA3	-0.026393
SPIN4	-0.026330
PPP1R2	-0.026302
ZIC2	-0.026281
TNFRSF1B	-0.026261
YBX1	-0.026237
DHRS3	-0.026229
MRPL18	-0.026171
RRM2	-0.026029
ABLIM1	-0.026027
HMGB1	-0.025982
IER5	-0.025950
SPRY2	-0.025919
C16orf54	-0.025910
SCD	-0.025879
SRRM1	-0.025875
ADORA2B	-0.025787
RANBP1	-0.025705
RFWD3	-0.025648
PBK	-0.025643
PLS1	-0.025589
ABHD3	-0.025518
PARP4	-0.025459
E2F7	-0.025390
APOBEC3G	-0.025340
DDX5	-0.025109
POMP	-0.025058
HSD17B11	-0.025025
EIF4A3	-0.024936
CCNG1	-0.024915
EXOSC8	-0.024833
SLC25A32	-0.024793
DCBLD2	-0.024741
LOC100130468	-0.024695
NAA20	-0.024653
DNAJB6	-0.024585
SKA2	-0.024564
MAFF	-0.024493
RRM1	-0.024434
COA6	-0.024387
MSH2	-0.024245
UBR7	-0.024143
CDCA5	-0.024120
PMAIP1	-0.024014
HSPH1	-0.023990
RPS7	-0.023975
EIF4B	-0.023958
FBXO5	-0.023899
ILF2	-0.023887
VRK1	-0.023812
RFC3	-0.023765
ATOX1	-0.023744
MAGOH	-0.023666
TRIP13	-0.023655
TMEM47	-0.023603
NCAPG	-0.023580
ETV4	-0.023578
AATF	-0.023386
TIPARP	-0.023313
DPY30	-0.023275
RHNO1	-0.023263
NXT1	-0.023221
NUP107	-0.023049
TPST1	-0.023024
CCDC43	-0.022913
MCM3	-0.022908
HIST1H3C	-0.022892
MND1	-0.022756
ATF1	-0.022721
LSM4	-0.022665
LSM12	-0.022663
SLC38A2	-0.022661
SPRY4	-0.022608
NIP7	-0.022534
BNIP3L	-0.022530
UQCRH	-0.022393
SNRPG	-0.022336
PTMA	-0.022271
NME1	-0.022252
FAM60A	-0.022068
PRKCI	-0.022031
NCAPH	-0.022017
ANP32B	-0.021855
SLC35F2	-0.021783
PCBP1	-0.021730
COX20	-0.021633
ASAP2	-0.021632
SEPT10	-0.021557
CHEK1	-0.021539
CDK8	-0.021461
BUB1B	-0.021384
EGR3	-0.021339
ADNP	-0.021155
GSTO1	-0.021143
RFC5	-0.021052
SDCBP	-0.020987
TOP2A	-0.020987
HSP90AB1	-0.020973
KIAA1524	-0.020973
UBA2	-0.020935
TMEM243	-0.020908
PIH1D1	-0.020846
BTBD11	-0.020828
PKIG	-0.020790
GPR137B	-0.020771
ERH	-0.020635
SLBP	-0.020529
EZH2	-0.020522
SUDS3	-0.020492
CBFB	-0.020370
NUP35	-0.020361
ARHGAP12	-0.020358
NDC80	-0.020337
CCP110	-0.020318
HJURP	-0.020275
C6orf211	-0.020205
AHCY	-0.020188
HIST1H2BJ	-0.020179
GABPA	-0.020161
SAV1	-0.020144
GLI3	-0.020130
CEP78	-0.020039