!direction	-1
!num_genes	247
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Lapatinib
!smiles	CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
!drugbank_id	DB01259
!pubchem_cid	208908
!cell_type	lapatinib-sensitive ErbB2-positive cells treated with 1 uM lapatinib
!organism	human
!end_metadata
TUBA1B	-0.200870
S100A9	-0.164132
RPS12	-0.160757
SNAR-A1	-0.154067
S100A8	-0.145258
H2AFZ	-0.144226
TUBA1C	-0.140201
LDHA	-0.117762
SLIRP	-0.117220
DHRS2	-0.102953
UQCRHL	-0.102537
OAZ1	-0.102433
ATP5EP2	-0.093939
H19	-0.083667
MIF	-0.082516
ENO1	-0.080633
PRDX1	-0.068947
SNRPG	-0.068061
MT2A	-0.067447
C20orf24	-0.067028
TUBB	-0.066826
TUBA1A	-0.065354
TOMM40	-0.063751
EBNA1BP2	-0.063150
RPL8	-0.061721
MT1A	-0.060391
NDUFA4	-0.060205
NOL7	-0.059565
CDC20	-0.059228
RPL13AP3	-0.059211
UQCRQ	-0.057588
NME1	-0.056738
AURKAIP1	-0.055798
TXN	-0.054973
MT1X	-0.054941
ID3	-0.054893
HSP90AA1	-0.053844
CALM2	-0.053819
UBA52	-0.053627
NDUFS5	-0.053197
HNRNPA2B1	-0.052645
AP2S1	-0.052169
CCND1	-0.051389
SOD1	-0.050933
ATP5H	-0.049163
TMEM147	-0.048716
ATP5J2	-0.048700
SNRPF	-0.047744
SRSF2	-0.046794
COX8A	-0.046393
HNRNPD	-0.046258
TPI1	-0.045753
ODC1	-0.045469
COX7A2	-0.043722
HSPA1A	-0.042974
PFN1	-0.042863
PSMA6	-0.042708
MDH2	-0.042542
CEBPB	-0.042482
RPS7	-0.041822
PGRMC1	-0.041784
TXNDC17	-0.041754
ACTB	-0.041643
ORM1	-0.041260
CKS2	-0.040958
GPX4	-0.040765
HSPE1	-0.040735
TRMT112	-0.040425
AURKA	-0.040267
HIST1H4C	-0.040115
RPS17	-0.039558
STRA13	-0.039514
TOP2A	-0.039466
UQCC2	-0.038376
SNRPD2	-0.037726
CHCHD10	-0.036436
RPS21	-0.036147
SDF2L1	-0.035670
SEC61G	-0.035445
RPL24	-0.035277
PRDX4	-0.034774
ATAD2	-0.034222
NDUFS8	-0.034139
ZMPSTE24	-0.033868
ATP5L	-0.033589
POLE3	-0.033510
RPS26P11	-0.033493
DNAJA1	-0.033293
YWHAH	-0.033211
CPS1	-0.033115
NOP56	-0.032750
BOLA3	-0.032742
HNRNPAB	-0.032260
RPS10	-0.032050
YWHAQ	-0.031856
GALK1	-0.031812
TCEB1	-0.031652
MALSU1	-0.031651
PTGES3	-0.031374
ECT2	-0.031296
PARK7	-0.031078
TMEM14B	-0.030299
NDUFAB1	-0.030226
IMP3	-0.029997
GAPDH	-0.029880
PTTG1	-0.029632
YBX1	-0.029375
MCM6	-0.029226
HMGN1	-0.029205
CMC2	-0.029205
SNRPA1	-0.029195
RANBP1	-0.029170
HSPA8	-0.029140
BOLA2	-0.028931
SNRPB	-0.028794
COX7C	-0.028750
CFL1	-0.028711
GLO1	-0.028558
UQCRH	-0.028317
TUBB4B	-0.027746
DNMT1	-0.027367
PSMB6	-0.027342
EFHD1	-0.027289
KRT81	-0.026905
NUDC	-0.026777
ATOX1	-0.026442
SSU72	-0.026280
IMP4	-0.026218
PTBP1	-0.026149
EIF4A1	-0.025745
CSE1L	-0.025437
SLC25A39	-0.025389
DNAJB11	-0.025257
CDCA5	-0.025137
PPIAL4B	-0.025133
MAL2	-0.025013
PUF60	-0.024961
PNP	-0.024805
CKS1B	-0.024719
NEDD8	-0.024553
APOA1BP	-0.024492
HES4	-0.024238
RPA3	-0.024216
TRA2B	-0.024067
DUSP23	-0.024049
DDT	-0.023868
CCDC109B	-0.023595
NDUFA3	-0.023425
MRPL41	-0.023388
COX7B	-0.023382
DDX39A	-0.023349
DEK	-0.023303
HSP90B1	-0.023258
MRPL36	-0.023086
TK1	-0.023049
CYB5B	-0.022959
MCM7	-0.022951
DNAJC9	-0.022880
TMX2	-0.022632
MANF	-0.022630
PSMB3	-0.022557
SAE1	-0.022479
FH	-0.022427
CNIH4	-0.022390
TFRC	-0.022333
PSMA5	-0.022147
UBE2C	-0.022111
NPM3	-0.021951
SHFM1	-0.021720
KPNA2	-0.021419
LSM5	-0.021341
UBE2T	-0.021294
GLRX5	-0.021274
FAM83D	-0.021225
BOP1	-0.020875
COX6C	-0.020675
PARP1	-0.020646
HSPA1B	-0.020532
MRPL18	-0.020432
CDC45	-0.020359
TMSB4X	-0.020348
PTMA	-0.020254
HSPD1	-0.020209
NXT1	-0.020017
CDK1	-0.019993
CRELD2	-0.019968
LAGE3	-0.019769
SSBP1	-0.019673
PTTG3P	-0.019669
NUSAP1	-0.019574
SLC16A3	-0.019507
SRRT	-0.019375
MRPL12	-0.019366
CISD1	-0.019280
POMP	-0.019177
EIF5A	-0.019165
TYMS	-0.019124
ALDOC	-0.019109
LDHB	-0.019077
YWHAB	-0.019064
MRPL51	-0.019050
COX17	-0.018973
CCT7	-0.018967
TOMM5	-0.018908
EPCAM	-0.018894
HSPH1	-0.018850
CCND3	-0.018683
ATP5I	-0.018592
F12	-0.018589
ANP32B	-0.018528
SRSF6	-0.018526
DKC1	-0.018458
GLDC	-0.018457
RPS24	-0.018304
CCNB2	-0.018256
KPNB1	-0.018227
SEPT9	-0.018179
SQLE	-0.018129
RPL39L	-0.018077
PSMD14	-0.018042
SRP14	-0.017965
AHSA1	-0.017834
NDUFA12	-0.017803
FAU	-0.017729
PAQR4	-0.017618
MRPS28	-0.017618
MSH6	-0.017614
JMJD8	-0.017602
PRC1	-0.017501
LDLR	-0.017484
S100A16	-0.017453
LSM3	-0.017398
C9orf142	-0.017337
RPS14	-0.017174
ACAT1	-0.017019
ROMO1	-0.016865
PDCD5	-0.016679
TIMM21	-0.016627
TSPAN13	-0.016576
MFSD3	-0.016461
SLC25A5	-0.016323
EEF1A1	-0.016281
C19orf70	-0.016239
MRPS6	-0.016122
CALM1	-0.016108
LACTB2	-0.016023
EEF1E1	-0.015952