!direction	-1
!num_genes	239
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Pimecrolimus
!smiles	CCC1C=C(CC(CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC1=O)O)C)C(=CC4CCC(C(C4)OC)Cl)C)O)C)OC)OC)C)C
!drugbank_id	DB00337
!pubchem_cid	17753757
!cell_type	skin
!organism	human
!end_metadata
S100A7	-0.243200
COX1	-0.182330
SERPINB4	-0.173182
S100A8	-0.167163
GJB2	-0.147187
SERPINB3	-0.129538
SFN	-0.122300
CA2	-0.115212
AQP3	-0.109992
PTMA	-0.108179
KRT14	-0.106160
NACAP1	-0.104040
IVL	-0.087986
CEBPB	-0.086763
ND2	-0.080299
MMP12	-0.079950
RPS4X	-0.076131
FGFBP1	-0.069560
SPRR2G	-0.069322
KRT5	-0.069080
TUBB2A	-0.068315
NDRG1	-0.067695
HLA-A	-0.065876
KRT2	-0.065421
TUBA1C	-0.062586
KRT10	-0.059626
KRT1	-0.058840
SERPINB5	-0.058672
PDLIM1	-0.058502
RPS18	-0.054629
RPS29	-0.054301
ODC1	-0.049249
TUBA1A	-0.047769
ACTG1	-0.046877
HIF1A	-0.046842
GJA1	-0.044970
TUBA1B	-0.043878
RPL27	-0.043078
ATP1B3	-0.042230
IRF2BPL	-0.041132
CFL1	-0.041095
CFD	-0.040502
EIF4A3	-0.039786
MKNK2	-0.039404
DEFB4A	-0.039319
EMP2	-0.039198
LYPD3	-0.039114
NDEL1	-0.038368
FAU	-0.037992
MALAT1	-0.037875
S100A9	-0.037259
IER2	-0.037177
CDH3	-0.036530
SLC16A14	-0.035728
VDAC2	-0.035689
KLF10	-0.035663
MRFAP1	-0.035604
SRSF2	-0.034807
IGFBP3	-0.034273
RPLP0	-0.033943
ATP6	-0.033646
RPL21	-0.033615
SGK1	-0.033314
DBI	-0.032646
HAS3	-0.032308
COX2	-0.032089
ALDH9A1	-0.031941
PDZK1IP1	-0.031399
KTN1	-0.031330
NOP58	-0.031207
YBX3	-0.031027
JUND	-0.030707
NELL2	-0.030555
RPS25	-0.030480
DYNLL1	-0.030088
ZNF721	-0.029550
CCL2	-0.029521
XIST	-0.029318
S100A7A	-0.028484
DDX21	-0.028483
ATP5I	-0.028371
CHSY1	-0.028309
DSG3	-0.028282
TYRP1	-0.028258
IL36G	-0.028230
DCD	-0.028174
RTN4	-0.028040
PPP1R3C	-0.027905
ZG16B	-0.027665
GGCT	-0.027637
RPS16	-0.027513
ZFP36	-0.027312
SERINC5	-0.027163
SCO2	-0.026892
RPL37A	-0.026839
INPP1	-0.026566
NNMT	-0.026447
WFDC12	-0.026344
IER3	-0.026331
CXADR	-0.026301
METRNL	-0.026163
TUBB4B	-0.025909
FAM110C	-0.025908
PIM3	-0.025694
RARS	-0.025281
B2M	-0.025138
PMS2P9	-0.025099
RPL23A	-0.025022
MYADM	-0.024955
RPL7L1	-0.024633
ZDHHC11	-0.024424
EPPK1	-0.024250
RPL39	-0.023873
HSPA1A	-0.023867
EEF1D	-0.023822
ATP5E	-0.023822
RASGRP1	-0.023696
GLTSCR2	-0.023330
HLA-C	-0.022683
PPP4R1	-0.022665
NDUFS6	-0.022488
ZFP36L2	-0.022122
JUP	-0.022092
SPRR2B	-0.022088
TNFSF10	-0.022017
OLFM4	-0.021900
KIAA0247	-0.021878
UAP1	-0.021570
CTSC	-0.020988
GTF2H3	-0.020833
CMBL	-0.020595
PITPNB	-0.020574
RPS2	-0.020573
SDR16C5	-0.020424
SOX7	-0.020359
ATP5A1	-0.020033
CXCL10	-0.020033
RPS11	-0.019985
IFITM3	-0.019953
RNF144B	-0.019857
VPS51	-0.019835
LUM	-0.019716
EEF1B2	-0.019685
DSC1	-0.019671
GNG12	-0.019619
NAA50	-0.019596
RPL41	-0.019431
PMP22	-0.019427
GNA15	-0.019358
CD24	-0.019308
C3	-0.019202
TACSTD2	-0.019183
YWHAG	-0.019054
TXN	-0.019032
CD55	-0.018998
OAT	-0.018797
ALDH2	-0.018791
EMP1	-0.018764
TNFRSF1A	-0.018676
MYL12B	-0.018616
BZW2	-0.018577
CDIPT	-0.018555
HMGCR	-0.018468
PRR11	-0.018405
EHF	-0.018398
MT1E	-0.018386
C15orf48	-0.018216
LRRFIP1	-0.018206
CDK2AP1	-0.018169
MAPK6	-0.018165
KRT16	-0.018130
IFI16	-0.018076
SARAF	-0.017947
CSNK1A1	-0.017868
TRIM28	-0.017841
CD47	-0.017700
CEBPD	-0.017597
KLF4	-0.017592
DUOX1	-0.017527
LTF	-0.017514
EMB	-0.017420
DSC3	-0.017351
HSP90AA1	-0.017288
TSTA3	-0.017171
RNF19A	-0.016989
HNRNPA1	-0.016987
JUNB	-0.016963
PSME2	-0.016890
RAB10	-0.016820
STAT3	-0.016753
DUSP7	-0.016738
NAMPT	-0.016647
CRABP2	-0.016619
RNF149	-0.016440
CCL19	-0.016347
RPLP1	-0.016253
TUBB6	-0.015966
RAP1B	-0.015898
RRAGC	-0.015863
CCDC152	-0.015835
PLIN3	-0.015796
POLB	-0.015781
RAN	-0.015772
DUSP1	-0.015735
CBR3	-0.015727
S100A16	-0.015670
SEPT9	-0.015654
RAB24	-0.015648
ISG15	-0.015605
CEBPA	-0.015600
GOLPH3	-0.015513
GGH	-0.015403
SERPINB13	-0.015309
TMBIM1	-0.015304
SEMA4B	-0.015301
TGM3	-0.015213
MIR22HG	-0.015115
UQCRFS1	-0.015098
ADAR	-0.015084
NMI	-0.015026
MIR21	-0.014943
PAK6	-0.014898
AHR	-0.014820
LIMA1	-0.014538
MAT2A	-0.014506
ZNF160	-0.014502
ARPC5L	-0.014485
CKB	-0.014434
SYTL1	-0.014264
CD44	-0.014215
ENDOU	-0.014092
DDR1	-0.014055
NCL	-0.014054
PUF60	-0.014053
HINT3	-0.014039
EGR1	-0.014021
CHI3L2	-0.013951
TIAM1	-0.013897
SDC1	-0.013892