!direction	-1
!num_genes	274
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	rat
!drug_name	Estradiol
!smiles	CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
!drugbank_id	DB00783
!pubchem_cid	5757
!cell_type	ischemic cerebral cortex
!organism	rat
!end_metadata
ND5	-0.410428
PKM	-0.208042
ND2	-0.202837
RPS14	-0.169822
MBP	-0.166203
CKB	-0.133985
STXBP1	-0.130337
CCK	-0.125127
COX8A	-0.117855
COX4I1	-0.109360
ALDOA	-0.106107
TUBA1B	-0.104366
PRKAR1B	-0.103185
EEF1A2	-0.096109
ATP6V0C	-0.088596
CTXN1	-0.088181
ATP1B1	-0.087028
TAGLN3	-0.082183
TTR	-0.080147
OLFM1	-0.076444
TPI1	-0.075699
PPIA	-0.075059
ND1	-0.074591
COX3	-0.074028
PABPC4	-0.070482
MDH1	-0.068789
PSAP	-0.063860
ALDOC	-0.063002
FAU	-0.062721
GAPDH	-0.062257
SEPW1	-0.058333
RPL22	-0.057593
LDHA	-0.057341
RAB3A	-0.055165
APP	-0.055118
CAP2	-0.054706
STX1A	-0.053505
COX6A1	-0.053183
TUBB	-0.052988
BCAT1	-0.052780
SNRPN	-0.052640
ENO1	-0.052607
UQCR11	-0.052418
GNAS	-0.052347
CHN1	-0.051634
NELL2	-0.049786
YWHAH	-0.049478
ATP1A3	-0.049083
UBC	-0.048517
DYNLL1	-0.048344
RPS10	-0.047576
AKR1A1	-0.047059
EIF4A2	-0.046969
MAP1A	-0.046747
ENO2	-0.046650
BSG	-0.044090
FAIM2	-0.044000
MGST3	-0.042523
VAMP2	-0.042397
SYN1	-0.041585
LDHB	-0.041387
VSNL1	-0.039928
IQSEC1	-0.039817
SLC25A3	-0.038784
GPX4	-0.038121
ADCY2	-0.036227
RPLP0	-0.036188
UCHL1	-0.035999
PPP1CA	-0.035742
SLC25A5	-0.035430
NEFL	-0.034935
MFGE8	-0.034821
SV2B	-0.034206
PSMB5	-0.034034
RPS16	-0.033791
TUBA4A	-0.033148
ND4	-0.032259
RPS26	-0.031903
BIN1	-0.031725
STMN1	-0.031499
RPS3	-0.031329
SPARCL1	-0.031201
CDC37	-0.030576
COPZ1	-0.030517
MAP1LC3A	-0.030238
TOM1L2	-0.030072
SPTBN2	-0.030001
SLC25A4	-0.029958
NDUFA8	-0.029549
RPL31	-0.028909
RPS9	-0.028564
CPLX1	-0.028475
INF2	-0.028169
CSNK2B	-0.028148
YWHAZ	-0.028040
ENPP2	-0.027646
SYP	-0.027525
SCN1B	-0.026975
RPL9	-0.026921
RPS21	-0.026688
GNB1	-0.026595
TMEM59	-0.026317
CAPNS1	-0.026287
RPS15A	-0.025830
TMBIM6	-0.025750
LPHN1	-0.025682
CFL1	-0.024975
STX1B	-0.024962
CNTNAP1	-0.024933
RPL28	-0.024859
GLS	-0.024834
NPY	-0.024688
ATP5H	-0.024309
AP2M1	-0.024245
RPL10	-0.024042
REEP2	-0.024020
NDUFB2	-0.023802
ATP2A2	-0.023338
DYNLRB1	-0.022911
ARF5	-0.022836
APOD	-0.022667
MDH2	-0.021742
CYC1	-0.021408
CAMK2N1	-0.021406
TSPAN17	-0.021079
KLC1	-0.020925
APLP2	-0.020571
RPS13	-0.020414
ATP6V0A1	-0.020387
INA	-0.020343
ATP2B2	-0.020266
SYNJ1	-0.020066
ACTB	-0.020039
PRKCB	-0.019907
ALKBH7	-0.019668
GABBR2	-0.019517
PLEKHM2	-0.019427
KCNH1	-0.019367
PIP5K1C	-0.019143
MATK	-0.019093
GAS7	-0.018526
STMN4	-0.018497
DNM1	-0.018344
SYT11	-0.018311
DGKZ	-0.018199
LZTS1	-0.017864
PAK1	-0.017809
MRFAP1	-0.017624
NDRG4	-0.017558
UNC50	-0.017558
HIBADH	-0.017380
RASGRF1	-0.017221
DDN	-0.017081
SST	-0.017012
SYT17	-0.016876
RPN2	-0.016872
GIT1	-0.016743
NDUFB9	-0.016646
COX7B	-0.016396
ATP5D	-0.016303
PLP1	-0.015931
NEK7	-0.015829
MAPK8IP2	-0.015654
PI4KA	-0.015632
RPS24	-0.015627
OAZ1	-0.015539
SUB1	-0.015522
CTSD	-0.015289
RPS25	-0.015280
STARD3	-0.015244
SVOP	-0.015189
SNN	-0.015057
CADPS	-0.015021
ATP6V1B2	-0.014990
RALGDS	-0.014893
ENSA	-0.014700
NDUFB8	-0.014692
LGALS3BP	-0.014665
FKBP2	-0.014662
ELAVL4	-0.014613
HIVEP2	-0.014561
PSMC3	-0.014547
CDK16	-0.014542
PGAM1	-0.014494
PPP1R1A	-0.014490
ITPKA	-0.014413
HPCA	-0.014404
GABRD	-0.014266
SH3GL2	-0.014243
CLIP2	-0.014140
HNRNPK	-0.013931
CST3	-0.013910
GDI1	-0.013880
MATR3	-0.013876
RPL36AL	-0.013861
CUTA	-0.013857
AKT1	-0.013787
NDUFB4	-0.013676
RPL10A	-0.013639
NDUFV3	-0.013502
NUCB1	-0.013502
NCKAP1	-0.013445
GABARAP	-0.013442
CAMKK1	-0.013418
TAF10	-0.013385
OLA1	-0.013345
RPL7A	-0.013273
CADPS2	-0.013253
FEZ1	-0.013236
HRAS	-0.013211
NGFR	-0.013107
MAPT	-0.013085
ARFGAP2	-0.012962
DLST	-0.012948
FRMD5	-0.012908
ATN1	-0.012810
SYT5	-0.012771
ATP9B	-0.012740
PSMB1	-0.012617
MAL	-0.012481
RPL18A	-0.012445
RPS23	-0.012398
APH1A	-0.012359
INO80E	-0.012044
SNCB	-0.012027
TMEM205	-0.011921
GAP43	-0.011839
NEFH	-0.011819
FASN	-0.011588
BAG6	-0.011549
PSMD11	-0.011519
FABP3	-0.011516
UQCC2	-0.011484
LGALS1	-0.011444
FURIN	-0.011441
THY1	-0.011362
PRKCG	-0.011258
LYZ	-0.011226
UQCRFS1	-0.011205
GRID1	-0.011043
HDLBP	-0.011041
PARK7	-0.011019
PEX1	-0.010993
COPS7A	-0.010900
NRN1	-0.010868
PSMD2	-0.010843
FAM195B	-0.010838
PVALB	-0.010823
GIPR	-0.010804
SNAP91	-0.010788
GTF3C1	-0.010764
GJB1	-0.010745
CCNG1	-0.010724
SERBP1	-0.010699
EAF1	-0.010689
VTN	-0.010639
SLC4A3	-0.010636
TNK2	-0.010606
PCOLCE	-0.010505
PSME2	-0.010466
PFN1	-0.010445
RPL11	-0.010426
RXRB	-0.010370
MIF	-0.010366
GOT1	-0.010341
NSFL1C	-0.010329
CDK5	-0.010275
SDC4	-0.010119
RPL6	-0.010068
CDC34	-0.010038
CAMKV	-0.010027
PLLP	-0.009968
ADRBK1	-0.009847
FAAH	-0.009829