!direction	-1
!num_genes	227
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Estradiol
!smiles	CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
!drugbank_id	DB00783
!pubchem_cid	5757
!cell_type	MCF7 cells depleted of ERK1 - 4 Hours after treatment
!organism	human
!end_metadata
TNFRSF11B	-0.085329
ID3	-0.084196
C8orf4	-0.076669
EFNA1	-0.076047
DKK1	-0.075242
ARID5B	-0.075132
DUSP10	-0.073246
CCNG2	-0.072850
RNF43	-0.072298
FAM13A	-0.065355
PDP1	-0.061198
MMD	-0.058570
GATA3	-0.058002
ARL4A	-0.057122
CLDN1	-0.056004
ID1	-0.054810
PPP1R3C	-0.052708
HILPDA	-0.052265
TRIB1	-0.052045
RWDD2A	-0.051523
GCNT1	-0.051295
TGFB2	-0.050443
DDIT4	-0.050234
HMOX1	-0.049808
VEGFC	-0.047215
INTS6	-0.045967
HEY1	-0.045544
SESN1	-0.044940
HCAR3	-0.043904
BLNK	-0.040662
ASCL1	-0.039376
NKX2-2	-0.039115
IRX5	-0.039086
FFAR2	-0.038459
TRAF5	-0.038455
RASL11B	-0.038204
EGLN3	-0.037962
EFNA4	-0.037942
ADM	-0.037364
ARHGAP32	-0.036708
TRIM36	-0.036666
GRAMD3	-0.036560
ERF	-0.036360
CXCR4	-0.036214
TOB2	-0.036139
CEP83	-0.036112
KLF5	-0.035941
CBR4	-0.035909
SERTAD3	-0.035739
KCNJ3	-0.035329
LMO3	-0.035245
HHEX	-0.034894
ST8SIA4	-0.034516
SEMA4C	-0.034297
ZBED8	-0.034223
ENC1	-0.034070
HIVEP2	-0.033996
IRS1	-0.033362
ZNF184	-0.033071
PNRC1	-0.032959
KDM6A	-0.032956
ZNF750	-0.032558
NEDD9	-0.032237
S100PBP	-0.032031
ZFC3H1	-0.031791
RND3	-0.031766
HIVEP1	-0.031372
SOX4	-0.031309
PLK2	-0.031169
GRB14	-0.030940
MTCL1	-0.030329
CDKN1B	-0.030256
SPRY1	-0.030217
JRKL	-0.030013
SOX9	-0.029989
DLX2	-0.029691
FZD4	-0.029584
GUSBP3	-0.028910
CGA	-0.028733
RPRM	-0.028375
LPIN2	-0.028364
ACVR2A	-0.028078
CREB5	-0.027848
GABBR1	-0.027204
RAB9A	-0.027152
CSRNP2	-0.027129
ACTG2	-0.026581
FZD2	-0.026405
WEE1	-0.026261
USP2	-0.026203
GBP1	-0.025939
SNX16	-0.025900
KIAA0922	-0.025694
TNFRSF21	-0.025250
ZNF217	-0.025205
MYO1E	-0.025066
CXCL3	-0.025058
CASP8AP2	-0.025009
REL	-0.024882
ACVR1	-0.024840
LOC100272216	-0.024780
RNF39	-0.024739
GSAP	-0.024724
CLK4	-0.024710
RNF146	-0.024638
DSE	-0.024614
VAV3	-0.024581
SCYL3	-0.024579
BIK	-0.024526
WDR47	-0.024497
NR2F1	-0.024359
GAS1	-0.024341
ZNF606	-0.024252
IER2	-0.024235
ID2	-0.024114
C3orf52	-0.024046
RSRP1	-0.024042
TIMP2	-0.024004
RAB20	-0.023929
CLDND1	-0.023917
CCR1	-0.023897
PLEKHF2	-0.023801
MGLL	-0.023721
TRIB2	-0.023659
FURIN	-0.023538
FRAT1	-0.023449
CTGF	-0.023389
SLC35C1	-0.023296
PAWR	-0.023252
IRF6	-0.023248
AMIGO2	-0.023081
CHD1	-0.023061
SOX2	-0.022957
GNAI1	-0.022880
ITGB6	-0.022810
ARHGAP12	-0.022749
TRIM45	-0.022714
RELB	-0.022686
TRIM62	-0.022576
MED23	-0.022392
JUNB	-0.022289
TM4SF1	-0.022259
TGIF1	-0.022258
DNAJB2	-0.022240
ZKSCAN4	-0.021860
SETD1B	-0.021810
PPP1R12A	-0.021801
OASL	-0.021748
TRIM68	-0.021726
EIF2AK3	-0.021632
LIMK2	-0.021614
CHORDC1	-0.021542
PIK3IP1	-0.021477
ZNF280D	-0.021472
UNC5C	-0.021450
FAM46A	-0.021386
MAPK7	-0.021378
E2F8	-0.021306
NEIL3	-0.021229
GTF2E1	-0.021142
SEC14L5	-0.021043
ZCCHC24	-0.021031
SH3BP4	-0.021009
INSIG2	-0.020968
ZBTB10	-0.020923
ETAA1	-0.020901
BTBD3	-0.020771
FOXA1	-0.020723
GGNBP2	-0.020698
LMO4	-0.020696
FAM69A	-0.020690
CXCL2	-0.020645
BBS10	-0.020570
ZNF292	-0.020509
WWTR1	-0.020499
GADD45A	-0.020483
AHR	-0.020257
ATXN2	-0.020253
CDK17	-0.020252
CASD1	-0.020193
KITLG	-0.020183
SAMD4A	-0.020062
PIK3R3	-0.019887
NFRKB	-0.019819
C19orf40	-0.019804
TMEM39B	-0.019774
KLF6	-0.019740
CDC42EP4	-0.019711
BRWD1	-0.019692
MISP	-0.019632
IFNGR1	-0.019591
BCOR	-0.019550
ATF3	-0.019454
ZNF329	-0.019409
FAM110B	-0.019338
ZFP36L2	-0.019283
KDM3A	-0.019203
LIN37	-0.019183
SATB1	-0.019131
PEX13	-0.019122
BTG2	-0.019095
PPWD1	-0.018979
OSER1	-0.018895
ID4	-0.018873
RLF	-0.018732
FERMT2	-0.018725
PIKFYVE	-0.018684
PCP4	-0.018636
PLEKHO1	-0.018624
ZCCHC6	-0.018528
KIAA0907	-0.018506
LARP6	-0.018493
SH2D4A	-0.018450
ZNF85	-0.018440
ESRRG	-0.018405
BRD2	-0.018395
TFAP2A	-0.018348
RNF19B	-0.018188
FOXJ2	-0.018169
DMTF1	-0.018128
CARD14	-0.018097
MIR22HG	-0.018093
PPP1R15A	-0.018069
CALHM2	-0.018062
MEX3C	-0.018061
CPB1	-0.018052
A2M	-0.018002