!direction	-1
!num_genes	291
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Rattus norvegicus
!drug_name	Pioglitazone
!smiles	CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
!drugbank_id	DB01132
!pubchem_cid	4829
!cell_type	17 months
!organism	rat
!end_metadata
RPL13A	-0.119847
SERBP1	-0.108688
ITIH3	-0.106524
FOXG1	-0.100998
VDAC3	-0.098821
YWHAG	-0.096260
RNF44	-0.094438
CTSS	-0.091855
WASF1	-0.090157
BRSK1	-0.089836
NEDD8	-0.076245
RPS19	-0.075563
RPS27A	-0.074945
GSTO1	-0.073915
RPL5	-0.072840
RPL27	-0.071687
GRINA	-0.070684
BHLHE22	-0.067394
NME2	-0.066395
OCIAD1	-0.066039
CTTNBP2	-0.063869
NDRG2	-0.063848
RPL19	-0.062146
UQCRB	-0.059907
TMEM130	-0.059815
RPS7	-0.056843
PRKCG	-0.056462
BSG	-0.054794
DDN	-0.054428
RPS4Y1	-0.053887
TUSC3	-0.053488
S100B	-0.052567
TSPYL1	-0.051749
CDO1	-0.051657
GPM6A	-0.051091
CHCHD10	-0.051004
BCAS1	-0.050360
AP2M1	-0.049939
COX7A2	-0.049821
RPL21	-0.049471
GFAP	-0.048929
NOP10	-0.048767
RPS3	-0.048250
CMPK1	-0.048008
MOCS2	-0.047990
RPS12	-0.047603
DDX5	-0.047309
POLR2K	-0.047038
SOD1	-0.046685
RPS8	-0.046347
COX4I1	-0.046082
RPS6	-0.046069
HSP90B1	-0.045807
SLC22A17	-0.045331
PGBD5	-0.045308
HSPA5	-0.044740
GABRG2	-0.044585
OLFM1	-0.044580
RTN1	-0.043554
RPL23	-0.043371
RPL38	-0.043279
PTGES3	-0.043158
FTL	-0.042842
SLC25A3	-0.042590
ZCCHC18	-0.041942
CSE1L	-0.041653
POMP	-0.039845
ACOT7	-0.039774
MOBP	-0.039735
UBE2V2	-0.039712
HMGCS1	-0.039622
S100A13	-0.039562
HPCA	-0.039331
PCP4	-0.038671
RPL30	-0.038025
SLC30A3	-0.037965
FABP7	-0.037275
KLHL7	-0.037053
GLO1	-0.036932
PTBP2	-0.036536
ATP5F1	-0.036474
NCKAP1	-0.036450
PYGB	-0.036127
LRRN2	-0.035487
FAM107A	-0.035426
RPS9	-0.035353
VGF	-0.035194
NCL	-0.034885
NPTX1	-0.034719
MICU3	-0.034219
GDI1	-0.034104
ARL15	-0.033941
RPS5	-0.033835
PHYHIP	-0.033833
PSMA7	-0.033749
PLCXD3	-0.033611
PDIA6	-0.033607
USMG5	-0.033603
SCN3B	-0.033489
SCPEP1	-0.033226
PPP1CA	-0.033144
EGR1	-0.033062
GRIA3	-0.033006
MAT2B	-0.032976
RBM39	-0.032922
PPP3CA	-0.032749
CELF5	-0.032424
DOCK4	-0.032306
CHMP5	-0.032278
TAGLN3	-0.031835
ALCAM	-0.031744
MAP2	-0.031718
NCDN	-0.031622
RBBP7	-0.031478
CHMP2A	-0.031449
OMG	-0.030917
YWHAE	-0.030756
ALDOA	-0.030751
SPTBN2	-0.030727
ITFG1	-0.030173
RPSA	-0.030128
ILDR2	-0.030037
FAM120A	-0.029867
PGK1	-0.029851
SEC61A2	-0.029635
MMD2	-0.029356
SLC38A10	-0.029318
CAMK2A	-0.029169
SUGT1	-0.029119
ARAF	-0.029084
PTP4A1	-0.028819
PPP1R9B	-0.028243
NAPA	-0.028086
HNRNPAB	-0.027894
PCDH8	-0.027783
PLCB1	-0.027777
NAPB	-0.027632
CHGA	-0.027482
RPS25	-0.027464
CAMKK1	-0.027457
UQCR11	-0.027184
ID2	-0.027173
IQUB	-0.026851
NDUFA12	-0.026774
TCP11L2	-0.026758
ACO2	-0.026721
AIG1	-0.026703
EIF5A	-0.026617
RPL31	-0.026192
YPEL4	-0.026190
GLYR1	-0.025998
RPL4	-0.025731
TSC2	-0.025577
NADK2	-0.025544
BAI2	-0.025479
JPH3	-0.025468
SORBS2	-0.025432
EIF4A2	-0.025418
UFC1	-0.025332
PRPF19	-0.025277
CHGB	-0.025203
CAMK2B	-0.025194
FTH1	-0.025167
GSTM2	-0.025098
CDC37	-0.025042
PDE2A	-0.024860
SLC6A1	-0.024846
GAA	-0.024833
SNN	-0.024820
ATP1B2	-0.024778
TRAPPC2	-0.024736
EZR	-0.024502
DCTN3	-0.024420
SLC12A5	-0.024370
COA5	-0.024288
NDFIP2	-0.024227
POLR2C	-0.024225
IDH2	-0.024115
APOE	-0.024056
MRPS25	-0.024026
BTG3	-0.023937
PRKCZ	-0.023921
RPL7A	-0.023841
PLCG1	-0.023838
TFG	-0.023764
HIBADH	-0.023689
PGPEP1	-0.023659
PDIA3	-0.023616
NDUFC2	-0.023568
TCP1	-0.023517
RAP1GAP2	-0.023495
CYP46A1	-0.023478
RPS26	-0.023473
ZNF330	-0.023049
CLDN10	-0.023012
CASC4	-0.022975
MAP3K12	-0.022936
ESD	-0.022676
PTGS2	-0.022343
RNF112	-0.022325
PIN1	-0.022175
CHN1	-0.022165
C11orf73	-0.022148
KCTD4	-0.022111
RBM3	-0.022056
RELL2	-0.022040
RGS10	-0.021964
FGF13	-0.021955
NAA38	-0.021904
CUL4A	-0.021899
PTPRZ1	-0.021829
PDAP1	-0.021715
ENO2	-0.021598
WFS1	-0.021595
CALCOCO1	-0.021562
SRSF1	-0.021438
ABHD17A	-0.021397
WDR13	-0.021272
NEK7	-0.021269
CAMTA2	-0.021232
CNOT7	-0.021194
PPP1CB	-0.021179
CETN2	-0.021080
SAT1	-0.021050
GABARAPL1	-0.021023
DNAJC6	-0.021007
NRN1	-0.020949
HGS	-0.020921
HSD17B12	-0.020883
HYPK	-0.020876
BTG1	-0.020860
IPO7	-0.020840
PSMA6	-0.020736
ZEB1	-0.020729
PCBP2	-0.020688
SIRT5	-0.020624
CACYBP	-0.020619
TRAPPC3	-0.020491
SWAP70	-0.020488
SERINC1	-0.020397
ATP5H	-0.020313
CISD1	-0.020298
ALKBH3	-0.020274
PAPD5	-0.020256
RPL7	-0.020240
MEF2C	-0.020228
DNAJA1	-0.020211
GSTM3	-0.020179
RPL27A	-0.020058
HNRNPH3	-0.019984
FAM3C	-0.019862
STXBP6	-0.019786
PIP5K1C	-0.019738
SNRPN	-0.019730
PRMT8	-0.019727
MEX3B	-0.019639
PCGF6	-0.019512
RTFDC1	-0.019496
KLHL9	-0.019476
RPL9	-0.019357
TAF9B	-0.019312
SERPINE2	-0.019300
PKIG	-0.019297
BAP1	-0.019286
MAP2K1	-0.019248
ANKRD27	-0.019172
PCGF1	-0.019171
RPL36AL	-0.019128
HNRNPU	-0.019091
CD81	-0.019060
TMX1	-0.018991
NOL4	-0.018940
RAB18	-0.018936
PAM16	-0.018904
MVB12B	-0.018903
ACSBG1	-0.018862
PITPNM2	-0.018753
ARPC5	-0.018753
TLE1	-0.018741
CLTA	-0.018738
RASGRF1	-0.018710
ETFB	-0.018684
CCDC53	-0.018660
RANBP6	-0.018630
TBCA	-0.018434
ACTR6	-0.018423
XBP1	-0.018353
GLRX3	-0.018338
ARL3	-0.018295
DARS	-0.018203
CACNA2D1	-0.018192