!direction	-1
!num_genes	259
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Lapatinib
!smiles	CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
!drugbank_id	DB01259
!pubchem_cid	208908
!cell_type	SKBR3 parental and resistant (SKBR3-R) cell lines
!organism	human
!end_metadata
HSPB1	-0.157402
RPL19	-0.145920
RPS13	-0.125839
H3F3A	-0.124869
RPS4X	-0.114029
RPL22	-0.106401
S100A9	-0.103785
EEF1A2	-0.101871
MYL6	-0.083062
ACTG1	-0.080939
RPS16	-0.079609
H3F3AP4	-0.077872
SSU72	-0.077346
NFKBIA	-0.072790
HIST1H4C	-0.071508
EIF4A2	-0.068073
RPS25	-0.065891
HIST1H2BK	-0.064608
TRAM1	-0.064398
SAT1	-0.063500
TMSB10	-0.063130
TMEM59	-0.062413
PPA1	-0.061726
RPL8	-0.060187
TPT1	-0.059722
PSMB10	-0.058244
EPRS	-0.058213
GLTSCR2	-0.058003
PPIAL4B	-0.057895
EIF3E	-0.057756
CCNI	-0.056059
GPX4	-0.054430
GNB2L1	-0.053368
JUND	-0.052594
MRPL37	-0.050370
YWHAQ	-0.050108
ATP6V1B1	-0.049931
CTNNA1	-0.049901
ACTB	-0.049454
RPL35A	-0.048742
UBA52	-0.048481
NDUFB5	-0.047803
RPL4	-0.047205
CNDP2	-0.046962
MYH9	-0.046508
NCCRP1	-0.046147
RPS5	-0.045913
EIF3L	-0.044920
C8orf76	-0.044761
MAL2	-0.044262
TAP1	-0.043468
RPL6	-0.041759
ENO1	-0.041308
GARS	-0.040399
TAX1BP1	-0.040079
CAPZA2	-0.039602
FBLN1	-0.039329
ZC2HC1A	-0.037684
LDHA	-0.037470
CD81	-0.037374
ATP5B	-0.037265
RPL27	-0.036749
VTCN1	-0.036652
H2AFZ	-0.036638
FERMT2	-0.036615
LAMA5	-0.036546
DDIT4	-0.036526
CEBPB	-0.036189
PURB	-0.035591
PGRMC2	-0.035000
RPL12	-0.034954
EFNA1	-0.034858
TUBA1B	-0.034390
RSL24D1	-0.034200
TKT	-0.034119
CLIC1	-0.033655
NCOA4	-0.033639
MSH3	-0.033473
RBM22	-0.033466
PPP1CC	-0.032566
VPS35	-0.032358
ACTN1	-0.031925
RPL17	-0.031417
RPS9	-0.031202
UBB	-0.030902
RPL18	-0.030549
MTSS1	-0.030458
ZNF217	-0.030452
CDC42EP4	-0.030297
PGRMC1	-0.030269
TACSTD2	-0.029864
ELF3	-0.029530
NOL7	-0.028852
SLC25A5	-0.028721
CPNE3	-0.028692
HIST2H2AA3	-0.028571
HIST1H1C	-0.028371
S100A8	-0.028277
CFD	-0.028249
TYMP	-0.028197
CYP1B1	-0.027774
EIF4G2	-0.027701
MRPS24	-0.027617
EIF3H	-0.027574
FBXO32	-0.027562
RHPN2	-0.027491
RDH10	-0.027379
DERL1	-0.027301
PSME1	-0.027216
NOA1	-0.026873
CLINT1	-0.026873
IGFBP5	-0.026779
CYC1	-0.026619
SARAF	-0.026603
EIF3M	-0.026537
VIPR1	-0.026488
TRPM4	-0.026036
IMPDH2	-0.025945
PMPCB	-0.025935
MKRN1	-0.025859
ARPC1A	-0.025781
PSMA5	-0.025445
B4GALT5	-0.025270
SHROOM3	-0.025108
SQSTM1	-0.025093
CITED4	-0.024610
EBNA1BP2	-0.024502
BOP1	-0.024443
SNX3	-0.024436
ACLY	-0.024107
RPL15	-0.024094
FBXL20	-0.023958
BTF3	-0.023820
RPL30	-0.023628
GPR56	-0.023541
AMY1C	-0.023517
EIF4A3	-0.023483
DENND2D	-0.023368
RAB25	-0.023130
IER3	-0.023126
WASL	-0.023101
PTBP1	-0.022852
YBX3	-0.022842
CCDC6	-0.022612
RPL5	-0.022585
UHMK1	-0.022574
FAF2	-0.022513
FTL	-0.022453
RPS27	-0.022427
NFKB1	-0.022414
DYNLL1	-0.022172
EIF3D	-0.022103
PSMA6	-0.021993
CCT8	-0.021838
CNN3	-0.021773
ITPR3	-0.021673
CLEC2D	-0.021329
SERBP1	-0.021278
ZNF704	-0.020818
POLR1D	-0.020538
ATP6V1F	-0.020468
VPS51	-0.020432
NDUFS3	-0.020400
NUCB1	-0.020375
MAT2A	-0.020336
AURKAIP1	-0.020225
EIF4B	-0.020193
RPS2	-0.020133
CAP1	-0.020014
RPL13AP6	-0.019922
PTPRF	-0.019790
MRPS17	-0.019758
JUP	-0.019729
ATP5H	-0.019719
EEF2	-0.019707
TFAP2C	-0.019677
ZMPSTE24	-0.019601
PALLD	-0.019592
OAZ1	-0.019504
ATP5F1	-0.019458
ADM	-0.019385
RPS21	-0.019275
OVOL2	-0.019273
CD2BP2	-0.019262
PSMC2	-0.019258
HNRNPAB	-0.019047
SGCE	-0.018984
NOL11	-0.018908
CCDC109B	-0.018830
TFAM	-0.018736
CDC20	-0.018728
ILF2	-0.018700
CPE	-0.018667
ZBED1	-0.018635
APEX1	-0.018505
RPS20	-0.018163
TNS3	-0.018059
RAB10	-0.018007
HDAC1	-0.017958
ULK1	-0.017753
ZYG11B	-0.017750
RSPRY1	-0.017546
RPS10	-0.017528
PGM1	-0.017516
CSF1R	-0.017455
ATP6V0E1	-0.017374
BAIAP2L1	-0.017372
IMPA2	-0.017357
KPNB1	-0.017357
EIF1	-0.017325
GNB1	-0.017299
DAZAP2	-0.017257
RPL36	-0.017253
CDC37	-0.017187
PABPC1	-0.017151
PGAP3	-0.017144
COPS5	-0.017119
PCNP	-0.017096
TRIM2	-0.017095
PTPRK	-0.017094
TUG1	-0.017032
DARS	-0.016992
RN7SL1	-0.016844
BRD2	-0.016842
LGALS3BP	-0.016726
COBL	-0.016699
RPL23A	-0.016660
HSPA8	-0.016560
NIFK	-0.016432
MFSD10	-0.016413
DDX21	-0.016270
PCBP2	-0.016237
YWHAZ	-0.016223
ANP32B	-0.016205
SNRPA1	-0.016190
IARS2	-0.016126
CEBPD	-0.015970
CX3CL1	-0.015967
SS18L2	-0.015954
SERPINE1	-0.015947
SNRPD2	-0.015910
PTPLB	-0.015901
UQCRH	-0.015805
PUF60	-0.015772
MAL	-0.015766
HIST2H2AC	-0.015702
SIX4	-0.015668
HMGN1	-0.015498
SUMO3	-0.015462
EIF4H	-0.015438
NSA2	-0.015400
CARHSP1	-0.015393
MED1	-0.015337
GPX2	-0.015267
GLTP	-0.015239
PSMB4	-0.015227
ADCY3	-0.015199
UFC1	-0.015193
RPL9	-0.015190