!direction	-1
!num_genes	418
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Rattus norvegicus
!drug_name	orotic acid
!smiles	C1=C(NC(=O)NC1=O)C(=O)O
!pubchem_cid	967
!cell_type	Livers ( from inbred Kyotos - fed a diet with 1% orotic acid) - 1 Day
!organism	rat
!end_metadata
PABPC4	-0.212450
KNG1	-0.188044
VTN	-0.181231
RPS29	-0.177527
COMT	-0.166966
APOE	-0.154340
MGST1	-0.149174
GC	-0.140333
FABP1	-0.139410
HSD11B1	-0.126578
CLU	-0.124568
ADH1C	-0.124342
GPX1	-0.122594
PCBD1	-0.117220
MPC1	-0.116721
PON1	-0.110875
CYP2E1	-0.109488
ITIH3	-0.108697
APOH	-0.108049
GSTM5	-0.105487
C9	-0.105335
APOA1	-0.104415
MGST3	-0.101870
PIGR	-0.100181
INSIG1	-0.099993
PPIA	-0.099868
ACAA2	-0.097509
ATP6	-0.095015
F2	-0.094059
RPS21	-0.092551
EPHX1	-0.092147
RPS12	-0.087347
GSTA5	-0.086889
ARG1	-0.083850
GSTM1	-0.083821
GAMT	-0.083093
COX4I1	-0.083015
AGT	-0.079678
UBC	-0.077445
HPX	-0.077230
SULT2A1	-0.077176
ASS1	-0.076985
THRSP	-0.073685
HPD	-0.072151
BSG	-0.070796
ZFP36L1	-0.069338
TECR	-0.068816
CYP1A2	-0.068735
ECHS1	-0.067794
RBP4	-0.067190
ALDH2	-0.067019
PEMT	-0.066803
TST	-0.066707
CTH	-0.066489
COX8A	-0.065864
SOD1	-0.065270
CPS1	-0.064653
BHMT	-0.063014
SERPINA6	-0.062884
ALDOB	-0.060540
FAU	-0.060516
GPX4	-0.058462
APOA2	-0.057062
FTL	-0.057054
SORD	-0.056998
ATP5B	-0.056810
RPL18A	-0.056509
UGT2B28	-0.056500
RPS13	-0.055992
KHK	-0.055416
TMEM205	-0.054739
HAAO	-0.053618
UPB1	-0.053076
FBP1	-0.052775
PCYT2	-0.052649
NDUFB9	-0.051436
CTSS	-0.050581
RPS16	-0.050257
RPS26	-0.049999
ATP5G2	-0.049600
APOC4	-0.049375
HRSP12	-0.049307
PAH	-0.048874
ALDH1L1	-0.048676
APOM	-0.048649
RPL19	-0.047565
F10	-0.047086
COX6A1	-0.046298
NDUFA4	-0.045851
AMBP	-0.045430
CDO1	-0.045051
NDUFB8	-0.044846
RPL26	-0.044834
ATP5O	-0.044326
GNMT	-0.044072
SULT1B1	-0.044057
AFM	-0.043646
POMP	-0.043478
COX7A2	-0.043008
RPL27A	-0.042965
OAZ1	-0.042947
PAICS	-0.042917
SERPIND1	-0.042890
RPL31	-0.042227
HMGCS1	-0.041532
COX3	-0.041397
DDT	-0.041167
RPS25	-0.040506
CA3	-0.040301
APCS	-0.040133
TTC36	-0.039807
AHCY	-0.039629
SDC4	-0.039324
LDHA	-0.039047
HMGCS2	-0.038711
RPL9	-0.038654
NDUFB2	-0.038543
SPP2	-0.038532
CYB5A	-0.038506
FTH1	-0.037720
RPL27	-0.037254
SERPINA3	-0.037064
B2M	-0.036996
GSTO1	-0.036983
NDUFC1	-0.036471
TPT1	-0.036210
HSPD1	-0.036151
AKR1D1	-0.035923
NEDD8	-0.035613
TDO2	-0.035152
RPS14	-0.035105
ERRFI1	-0.035094
HSD17B13	-0.034808
CLEC4F	-0.034591
ACADM	-0.034575
SULT1E1	-0.034457
FGG	-0.034292
RPL23	-0.034036
UGT2B17	-0.033255
APOB	-0.033171
COX7B	-0.033139
CYP27A1	-0.033138
NME2	-0.032636
MGST2	-0.032518
SLC25A5	-0.032515
TAT	-0.032505
PHB2	-0.032123
RPLP0	-0.032114
RPL24	-0.032097
PCK1	-0.032000
ABCB11	-0.031979
HPN	-0.031941
RPL35	-0.031630
CYC1	-0.031486
TPI1	-0.031297
CD63	-0.031191
MIF	-0.031143
PPDPF	-0.031117
PXMP2	-0.031105
SERPING1	-0.030946
NDUFB4	-0.030733
SDS	-0.030307
PSAP	-0.030251
DBI	-0.029839
RPL18	-0.029697
GHR	-0.029333
PROS1	-0.029276
TTR	-0.029185
RPL11	-0.029117
ATP5H	-0.029091
SLC37A4	-0.028858
HIBADH	-0.028837
RPL22	-0.028728
RPL10	-0.028719
SLC22A7	-0.028710
RPS6	-0.028421
FAH	-0.028406
SCD	-0.028238
LAMP1	-0.028199
PGRMC1	-0.028045
CSAD	-0.028033
GSTK1	-0.027879
SIGMAR1	-0.027628
CTSH	-0.027499
RPS11	-0.027068
DAO	-0.027001
GLUD1	-0.026859
MARC2	-0.026446
NDUFA8	-0.026064
AKR1A1	-0.026001
FMO1	-0.025806
SLCO2A1	-0.025378
PRDX1	-0.024774
CAT	-0.024720
ACOX2	-0.024297
CFB	-0.024202
ALAD	-0.024140
RPL12	-0.024099
RPS27L	-0.023970
QDPR	-0.023846
RPL30	-0.023822
MBL2	-0.023652
ABCC6	-0.023620
CISH	-0.023361
HSPE1	-0.023129
PSMB4	-0.023109
RPL5	-0.023003
MDH1	-0.022630
SNRNP70	-0.022627
MAOB	-0.022566
FABP6	-0.022443
NDUFB3	-0.022371
RPL13A	-0.022190
RBP1	-0.022101
PTGR1	-0.021914
RPL15	-0.021869
RPSA	-0.021814
DECR1	-0.021700
PEBP1	-0.021664
CP	-0.021492
ST6GAL1	-0.021483
GJB1	-0.021430
CPQ	-0.021412
LIPA	-0.021343
ACSL5	-0.021342
SEPP1	-0.021298
UQCR11	-0.021142
NDUFV3	-0.020830
CST3	-0.020466
NDUFA3	-0.020448
PPIF	-0.019748
TMBIM6	-0.019621
RPS8	-0.019606
IGFBP1	-0.019529
IFITM3	-0.019469
AQP9	-0.019051
COX5A	-0.018855
NDUFB10	-0.018644
PLG	-0.018323
RPS4Y1	-0.018301
HAO2	-0.018122
DHCR7	-0.018114
SERPINA10	-0.017906
ENO1	-0.017493
CTDSP1	-0.017443
AK3	-0.017217
DDC	-0.017165
RPS7	-0.017154
OPLAH	-0.017065
KYNU	-0.017063
ADH5	-0.017000
GRN	-0.016875
HSD17B4	-0.016781
IVD	-0.016720
PROC	-0.016637
DUSP1	-0.016309
NPHP1	-0.016217
ACLY	-0.016025
YBX1	-0.015998
HAGH	-0.015854
SEPHS2	-0.015828
OAT	-0.015810
AQP8	-0.015733
DIO1	-0.015667
MPST	-0.015582
ACADL	-0.015568
NDUFS7	-0.015519
FUCA1	-0.015459
ENPP3	-0.015459
NDUFAB1	-0.015442
COX1	-0.015402
NQO1	-0.015272
GCHFR	-0.015262
PSMA6	-0.015253
DNAJA1	-0.015204
JUN	-0.015152
KLKB1	-0.015063
HSP90AB1	-0.015058
KMO	-0.015008
GOT2	-0.014887
UQCRFS1	-0.014848
CNN3	-0.014806
RPS10	-0.014605
CTSC	-0.014543
PGAM1	-0.014474
PSMB3	-0.014403
EHHADH	-0.014226
RPS27A	-0.014082
CLTA	-0.014042
HIGD2A	-0.014024
PSMB5	-0.014014
TXN2	-0.013940
CD81	-0.013931
CDC37	-0.013922
OTC	-0.013902
PEX14	-0.013897
ITIH4	-0.013829
GABARAPL2	-0.013823
ABHD14B	-0.013710
PDYN	-0.013698
GRPEL1	-0.013620
LCAT	-0.013573
GPT	-0.013540
C1QB	-0.013524
HSD17B10	-0.013487
PGK1	-0.013480
UBXN1	-0.013443
EGR1	-0.013431
SLC22A1	-0.013349
RGN	-0.013323
PRDX2	-0.013279
FIS1	-0.013230
ADK	-0.013070
CA5A	-0.013042
CTSD	-0.013036
GSTM2	-0.012998
PSMB8	-0.012981
RPS23	-0.012945
KLF9	-0.012896
BCKDHA	-0.012863
IDH1	-0.012655
AZGP1	-0.012515
NDUFA6	-0.012425
PARK7	-0.012418
ETNK2	-0.012298
SUCLG1	-0.012297
HADHA	-0.012279
ASGR1	-0.012218
GRB2	-0.012194
CYBA	-0.012166
ACADS	-0.012134
LEP	-0.012127
TALDO1	-0.011996
SLC25A10	-0.011894
BAAT	-0.011804
ACY1	-0.011773
ATP5A1	-0.011739
HSD3B7	-0.011660
TTPA	-0.011657
ATP5D	-0.011603
NDUFS8	-0.011571
ASGR2	-0.011455
TMEM47	-0.011408
ATP5F1	-0.011312
RPL39	-0.011240
PSMB2	-0.011087
SLC6A13	-0.011080
AP2M1	-0.011078
RBCK1	-0.010993
NDUFV2	-0.010927
LAMP2	-0.010909
GAPDH	-0.010818
RPS3	-0.010658
HSP90AA1	-0.010647
PRDX6	-0.010592
TUBA1B	-0.010477
ABAT	-0.010355
AUH	-0.010329
FOXA2	-0.010262
RPL28	-0.010178
ND1	-0.010162
ATRN	-0.010129
CYTB	-0.010071
CYP51A1	-0.010020
RABAC1	-0.009977
CITED2	-0.009965
DECR2	-0.009965
DAD1	-0.009875
KCNH3	-0.009866
PDK2	-0.009818
PSMB9	-0.009741
PSMB1	-0.009700
MRFAP1	-0.009700
GDA	-0.009416
RPL17	-0.009394
ACAT1	-0.009273
C8B	-0.009271
HADHB	-0.009233
RPL37	-0.009181
PRKCG	-0.009142
SCAMP2	-0.009120
RPL10A	-0.009118
NDUFB6	-0.009100
TSPO	-0.009053
ACP2	-0.009017
GCKR	-0.009016
IDH2	-0.008990
APMAP	-0.008945
PHB	-0.008889
CTSV	-0.008858
CHURC1	-0.008817
RPS9	-0.008795
HBP1	-0.008548
PDHA1	-0.008536
TSPAN3	-0.008522
CSTB	-0.008483
GRK6	-0.008463
TIMP2	-0.008324
DLST	-0.008311
C3	-0.008305
NAPA	-0.008296
MAP3K1	-0.008199
ATP5C1	-0.008123
NDUFA5	-0.008113
BCKDHB	-0.008101
MAOA	-0.008028
RAF1	-0.008018
AES	-0.007995
PPP2R5A	-0.007945
SLC25A30	-0.007871
PRODH2	-0.007864
RPLP2	-0.007849
CELA1	-0.007819
COX2	-0.007784
CHKA	-0.007771
ACOX1	-0.007641
NR1H2	-0.007615
ACAT2	-0.007607