!direction	-1
!num_genes	174
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	rat
!drug_name	Irinotecan
!smiles	CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
!drugbank_id	DB00762
!pubchem_cid	60838
!cell_type	jejunum
!organism	rat
!end_metadata
DBP	-0.090721
CYP1A1	-0.078769
ATP8B1	-0.063669
PMP22	-0.054342
AQP3	-0.054038
CYP4B1	-0.053573
ONECUT2	-0.049575
SLC16A10	-0.047794
FOSB	-0.043789
ABCC2	-0.043335
ENTPD5	-0.042674
PCK1	-0.042077
SAMD8	-0.041304
SLC5A1	-0.040499
TMEM120A	-0.040347
MME	-0.039849
ALPI	-0.039643
SLC16A3	-0.039474
TPPP	-0.037704
PRSS35	-0.036924
TNFRSF21	-0.036776
FAM160B1	-0.034139
PHOSPHO1	-0.033920
SLC2A5	-0.033042
NT5E	-0.032028
ACTA1	-0.031330
ABHD2	-0.031215
PDZK1	-0.030960
PCDH1	-0.030781
HOPX	-0.030674
GPD2	-0.029952
LPIN2	-0.029747
GPRC5A	-0.029730
EEPD1	-0.029633
DGKH	-0.029415
CNDP2	-0.029378
CREB3L2	-0.028995
LPAR6	-0.028991
SLC5A12	-0.028949
SLC25A10	-0.028807
ACSL3	-0.028691
PPARGC1A	-0.028045
ANGPTL4	-0.027992
CCNG2	-0.027794
BCMO1	-0.027671
NUAK2	-0.027492
PER2	-0.027482
APLP1	-0.027327
CEMIP	-0.027188
FA2H	-0.027166
MXD1	-0.027067
SLC43A2	-0.026948
TREH	-0.026785
CDCA8	-0.026102
ACE	-0.025978
ABCB1	-0.025921
JAG1	-0.025860
SGK2	-0.025803
PPARG	-0.025784
RPS6KA5	-0.025674
NFE2L2	-0.025578
TIFAB	-0.025439
CLDN7	-0.025389
SLC20A1	-0.025333
AGPAT1	-0.025237
ATF3	-0.025187
RAPGEF2	-0.024618
POR	-0.024466
GHRL	-0.024459
DGAT2	-0.024420
RAPGEF5	-0.024343
PTPRO	-0.024343
TXNRD1	-0.024221
ALDH1A1	-0.024142
SLC40A1	-0.024049
PPP1R1B	-0.023823
DNMBP	-0.023790
TASP1	-0.023725
PRKG2	-0.023606
TRIM25	-0.023585
RAB30	-0.022977
STARD13	-0.022921
ALDH1B1	-0.022868
TNFRSF1A	-0.022833
SLC4A7	-0.022706
ACSF2	-0.022650
PARP8	-0.022632
MPP5	-0.022631
GNA11	-0.022426
ROCK2	-0.022423
GDNF	-0.022416
TMEM45B	-0.022369
CLIC5	-0.022100
LPGAT1	-0.022056
ALDH3A2	-0.021939
LIPA	-0.021902
SAMHD1	-0.021798
FCHSD2	-0.021653
RIPK4	-0.021643
SLC15A1	-0.021508
STK17B	-0.021498
LNX1	-0.021460
KLK3	-0.021453
ROPN1L	-0.021442
TRDMT1	-0.021321
CBL	-0.021309
GPD1	-0.021294
MSL2	-0.021241
C15orf60	-0.021170
KCNK10	-0.021096
GP2	-0.021087
LAMA2	-0.021084
DLL1	-0.021026
TSPAN7	-0.020894
EFCAB14	-0.020762
SLC22A5	-0.020705
SLC28A2	-0.020668
DSG2	-0.020647
SEC31A	-0.020640
PUSL1	-0.020614
SLC4A10	-0.020580
GRAMD1B	-0.020572
PEX11G	-0.020514
FMO4	-0.020512
MYC	-0.020370
CIDEB	-0.020212
NHLRC2	-0.020166
CUEDC1	-0.020141
EZR	-0.020113
SCEL	-0.020110
POU2F1	-0.019972
LAMB3	-0.019964
SLC6A8	-0.019907
CDC14A	-0.019907
AQP7	-0.019904
TOMM40	-0.019816
WDR19	-0.019766
GATA5	-0.019723
PELI1	-0.019667
TBC1D10A	-0.019601
LPAR3	-0.019593
ZSWIM6	-0.019505
PGGT1B	-0.019471
EPHX1	-0.019460
CRY1	-0.019393
ANK3	-0.019251
RPS6KA1	-0.019189
CPT2	-0.018973
PRKAA2	-0.018960
SCFD1	-0.018927
HIC1	-0.018891
SUSD2	-0.018884
PEX3	-0.018880
DUOX2	-0.018864
FLNB	-0.018845
LPHN2	-0.018795
IGSF9	-0.018768
MARCH3	-0.018722
GCNT3	-0.018710
IGSF3	-0.018679
EPN1	-0.018633
SLC9A3R1	-0.018521
CCK	-0.018504
MTHFD2L	-0.018336
UNC5CL	-0.018281
FCGBP	-0.018274
VDR	-0.018207
WASF2	-0.018191
CDA	-0.018157
MYPN	-0.018117
GUCY2C	-0.018070
PTPLAD1	-0.018070
CCND2	-0.018014
TPPP3	-0.017988