!direction	-1
!num_genes	441
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Dactinomycin
!smiles	O=C1N[C@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)CC(=O)N([C@H](C(=O)O[C@@H]([C@@H]1NC(=O)c1c2nc3c(ccc(c3oc2c(c(=O)c1N)C)C)C(=O)N[C@H]1[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C(=O)[C@H]2N(C(=O)[C@H](NC1=O)C(C)C)CCC2)C)C)C(C)C)C
!drugbank_id	DB00970
!cell_type	wild type
!organism	mouse
!end_metadata
DUSP5	-0.167154
GADD45G	-0.154786
DUSP6	-0.150886
DUSP2	-0.128016
MYC	-0.123829
NR4A1	-0.117144
CSRNP1	-0.115921
IER5	-0.114711
NFKBIA	-0.112678
NFIL3	-0.109855
DUSP1	-0.109304
SOCS3	-0.108732
SNAI1	-0.105251
JUNB	-0.103994
IER3	-0.103021
JUN	-0.101786
IER2	-0.101643
NUAK2	-0.101270
ZFP36	-0.098932
SERTAD1	-0.097597
KLF10	-0.096605
BHLHE40	-0.096051
CYR61	-0.094457
PLEKHF1	-0.090378
ANKRD1	-0.084609
BTG2	-0.084321
CITED2	-0.082398
ARC	-0.082127
TNFAIP3	-0.080930
CLK1	-0.078494
SMAD7	-0.073713
TRIB1	-0.072254
GADD45B	-0.072191
FILIP1L	-0.072115
BMP4	-0.071161
FOSL2	-0.070394
FOS	-0.069478
DUSP10	-0.066027
ID1	-0.064387
DUSP4	-0.063931
EGR1	-0.062879
RAB9A	-0.062806
IRX3	-0.062758
CCNL1	-0.062708
CHAC1	-0.062646
EGR2	-0.062322
RND3	-0.062107
FOXG1	-0.060485
FOXC2	-0.059185
ID3	-0.058499
PHF13	-0.057443
TGIF1	-0.057112
PTGER4	-0.054901
CEBPB	-0.054762
CDC42EP3	-0.054069
GDNF	-0.053821
RHOB	-0.052277
TIPARP	-0.052005
CISH	-0.049870
VEGFA	-0.049425
MYL6	-0.049339
RNF19A	-0.049085
ZNF655	-0.048018
IFRD1	-0.046185
IRS1	-0.046109
PIM3	-0.045575
H1F0	-0.045284
HAS2	-0.045260
ZNF281	-0.045247
SGK1	-0.045192
PLK2	-0.045169
CSRNP2	-0.045024
NFKBIZ	-0.044893
MRGPRF	-0.044684
ADAMTS1	-0.044163
KCTD11	-0.043580
PHF23	-0.042626
PHLDA1	-0.041962
CNKSR3	-0.041786
PPP1R15B	-0.041378
ARRDC3	-0.041130
KLF2	-0.040811
FOXC1	-0.040024
FBXO30	-0.039712
ARID5B	-0.039604
ARID5A	-0.039371
NAB2	-0.038949
ERRFI1	-0.037946
KIAA1551	-0.037833
RPL12	-0.037227
ZSCAN25	-0.036841
ENC1	-0.036832
BRD2	-0.036701
KLF6	-0.036324
NOV	-0.034916
TOPORS	-0.034891
NRBF2	-0.034218
MCL1	-0.033795
ZNF623	-0.033511
ZNF25	-0.033447
AJUBA	-0.033374
BDNF	-0.033001
FOSB	-0.032770
ZBTB11	-0.032748
KDM3A	-0.032584
CDC42EP1	-0.032399
TMEM11	-0.032030
CLK4	-0.031955
OSER1	-0.031864
REL	-0.031749
PPP1R15A	-0.031718
C8orf4	-0.031622
ZBTB6	-0.031388
GTF2B	-0.031343
IRF2BP2	-0.031238
FBXO34	-0.030952
EP300	-0.030913
PAPOLG	-0.030742
NEDD9	-0.030721
FAM46B	-0.030585
MSL2	-0.030327
PCF11	-0.030222
IER5L	-0.030043
HMGCS1	-0.029978
BCAR1	-0.029913
EPC2	-0.029759
SNAI2	-0.029574
ITGA5	-0.029358
RNF34	-0.029354
ZNF280B	-0.029333
SNIP1	-0.029250
CBX4	-0.029213
ZNF622	-0.029117
RABGGTB	-0.028955
HIVEP1	-0.028681
IRF1	-0.028568
SKIL	-0.028307
ZNF131	-0.028278
SAP30	-0.028234
FEM1B	-0.027983
GEM	-0.027900
CTTNBP2NL	-0.027848
ZNF574	-0.027555
AMOTL2	-0.027282
FZD2	-0.027260
F3	-0.027108
ATF4	-0.027040
TRMT10C	-0.027034
MIER3	-0.027002
KBTBD2	-0.026987
STARD4	-0.026868
CDC42EP2	-0.026849
NANP	-0.026753
TP53INP1	-0.026620
USPL1	-0.026593
PPRC1	-0.026570
SLC38A2	-0.026465
C5orf51	-0.026261
SGK223	-0.026147
DDIT4	-0.026115
IRS2	-0.026074
SPRY2	-0.026036
C6orf141	-0.025708
GAS1	-0.025704
FOSL1	-0.025685
LMCD1	-0.025578
CLCF1	-0.025394
SNX18	-0.025374
ZBTB1	-0.025296
MAT2B	-0.025285
RUSC2	-0.025139
ZNF761	-0.024863
ADAMTS5	-0.024836
ZNF212	-0.024825
CLDN12	-0.024743
PLK3	-0.024708
SOCS5	-0.024698
KLF7	-0.024687
MED26	-0.024627
DYRK3	-0.024616
ZNF644	-0.024596
ZNF513	-0.024369
PIK3C3	-0.024359
FEM1C	-0.024347
SIAH2	-0.024223
DNAJB4	-0.024187
PER1	-0.024146
DCUN1D3	-0.024112
PDP1	-0.024088
SF3B3	-0.024088
SQLE	-0.023895
TGIF2	-0.023786
RGS16	-0.023766
TOB1	-0.023742
KANK1	-0.023724
CLP1	-0.023679
ZNF32	-0.023608
NUP62	-0.023544
STK40	-0.023526
TBX15	-0.023470
MED7	-0.023458
BTG1	-0.023345
LIPT1	-0.023259
ACAT2	-0.023165
C14orf169	-0.023134
ZSCAN21	-0.022957
CBLL1	-0.022650
BIRC2	-0.022368
JARID2	-0.022232
SDE2	-0.022217
ARGLU1	-0.022201
KLF4	-0.022135
MYL9	-0.022048
RBBP6	-0.022002
ZFP62	-0.021984
ING2	-0.021842
SMG8	-0.021730
NINL	-0.021687
RNF111	-0.021685
TBCC	-0.021520
ZNF778	-0.021509
MOGS	-0.021417
IL1RN	-0.021400
DACT1	-0.021231
TRAF5	-0.021152
EGR3	-0.021111
MAP3K8	-0.021080
S1PR1	-0.020957
FOXS1	-0.020829
FOXJ3	-0.020693
CTGF	-0.020692
NUFIP2	-0.020690
ADM	-0.020631
ARMCX1	-0.020585
EBAG9	-0.020572
ABL2	-0.020557
TAF1D	-0.020536
GATA2	-0.020444
ADNP2	-0.020375
HIAT1	-0.020312
CSTF2T	-0.020311
FBXL4	-0.020283
YTHDC1	-0.020221
TWIST1	-0.020216
ZBTB2	-0.020174
ZNF830	-0.020159
ZFX	-0.020134
HEXIM1	-0.020028
HES1	-0.020017
YTHDF2	-0.019907
RAB33B	-0.019900
USP42	-0.019819
PDCD2	-0.019813
KLF9	-0.019804
SLC3A2	-0.019762
ATF3	-0.019753
WSB1	-0.019668
SOCS1	-0.019651
SH3BP4	-0.019626
MAGI3	-0.019626
LDLR	-0.019612
RSPO2	-0.019590
S1PR2	-0.019535
ZNF189	-0.019532
LRIF1	-0.019523
PDCD4	-0.019267
CLPX	-0.019219
CEBPD	-0.019120
TSC22D2	-0.019043
ZFAND5	-0.019038
CACTIN	-0.019023
GNL3	-0.018988
C6orf120	-0.018955
KATNA1	-0.018952
C16orf72	-0.018942
ZFPM2	-0.018934
TMEM55B	-0.018930
PABPC1	-0.018891
RAD17	-0.018883
C15orf39	-0.018861
IFFO2	-0.018800
B4GALT3	-0.018690
EPM2AIP1	-0.018583
TIFA	-0.018577
UTP3	-0.018550
DLX1	-0.018446
MNT	-0.018402
ARID4B	-0.018381
CCL13	-0.018350
GAB1	-0.018291
ZSCAN26	-0.018273
CENPC	-0.018263
TP53BP2	-0.018207
ABT1	-0.018157
SLC30A6	-0.018152
TRIM59	-0.018096
ZCCHC7	-0.018076
MTMR12	-0.018068
FRAT2	-0.018023
ADPRM	-0.017992
RNF167	-0.017955
NR2F1	-0.017836
LPHN2	-0.017829
REV1	-0.017819
TRIM13	-0.017747
HPS6	-0.017746
SIRT1	-0.017691
GNB2L1	-0.017595
FZD1	-0.017589
ZNF217	-0.017584
FLCN	-0.017573
JMJD6	-0.017567
SMCR8	-0.017520
NSRP1	-0.017476
MARCH7	-0.017465
NDST2	-0.017404
BCL3	-0.017337
BRPF1	-0.017302
TADA2B	-0.017273
KIAA1143	-0.017228
CAMLG	-0.017157
EHMT1	-0.017132
DUSP16	-0.017116
ZNF175	-0.017105
ZBTB39	-0.017098
ZNF250	-0.017091
PLEKHG2	-0.017065
XBP1	-0.017045
RCHY1	-0.017029
AHCTF1	-0.017014
IGF2BP1	-0.017010
EHBP1	-0.016960
GYPC	-0.016958
NOC2L	-0.016942
MRPL22	-0.016939
KPNA2	-0.016930
RLF	-0.016895
CDCA4	-0.016894
IQCB1	-0.016891
LRIG2	-0.016826
IMP3	-0.016813
WASF1	-0.016807
ACSL3	-0.016799
EIF4A2	-0.016795
ELMSAN1	-0.016778
UBC	-0.016772
CDC5L	-0.016717
KCTD15	-0.016657
KTI12	-0.016623
TGFBR2	-0.016519
IRF2BPL	-0.016516
LIF	-0.016403
TMEM55A	-0.016362
FAM203A	-0.016337
UIMC1	-0.016320
NGLY1	-0.016303
CXCL2	-0.016302
IDI1	-0.016285
TOB2	-0.016250
MLLT11	-0.016237
STIL	-0.016184
UTP14C	-0.016170
FGF7	-0.016151
PIM1	-0.016146
SIMC1	-0.016142
IRAK2	-0.016090
FIZ1	-0.016029
SRSF7	-0.016029
LONRF1	-0.015998
NPAT	-0.015962
BBC3	-0.015956
LPAR6	-0.015937
INTS12	-0.015922
ZFYVE26	-0.015875
PPM1D	-0.015873
ZNF445	-0.015867
C12orf4	-0.015811
ASXL1	-0.015775
FLNB	-0.015732
FAT1	-0.015695
MVD	-0.015691
RRAD	-0.015676
CDH11	-0.015673
SETD2	-0.015664
CSF2	-0.015657
IPPK	-0.015646
AXIN1	-0.015599
PIK3R3	-0.015581
ZNF146	-0.015567
CAPRIN2	-0.015522
IFIT2	-0.015521
ZBTB43	-0.015515
WEE1	-0.015513
HLX	-0.015408
CFAP97	-0.015355
PCDH18	-0.015330
MPP5	-0.015324
MTERF2	-0.015310
C10orf88	-0.015263
FGD3	-0.015253
KLHL9	-0.015243
DBR1	-0.015236
ANKRD28	-0.015215
ATXN7	-0.015113
TJAP1	-0.015111
TANC1	-0.015101
VPS37C	-0.015065
CTU1	-0.015055
SMAD2	-0.015049
KMT2B	-0.015047
ZNF267	-0.015013
CEMIP	-0.015009
BACH1	-0.014992
ZNF384	-0.014986
RIN2	-0.014955
CCNL2	-0.014948
MKL1	-0.014938
ARID1A	-0.014928
GTF2H2	-0.014922
ZFP90	-0.014920
LURAP1L	-0.014911
SETD1A	-0.014909
MAD2L1BP	-0.014907
STARD13	-0.014892
LSS	-0.014888
RILPL2	-0.014884
USP38	-0.014868
TRAF2	-0.014849
TRIM28	-0.014820
EPC1	-0.014806
C11orf95	-0.014805
JMJD1C	-0.014791
PIK3R1	-0.014767
TJP1	-0.014743
LPIN1	-0.014741
ACBD3	-0.014686
PIK3R4	-0.014668
KDM6B	-0.014637
RABEP2	-0.014633
ITPKC	-0.014580
FAM76B	-0.014507