!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Mus musculus
!drug_name	Estradiol
!smiles	CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
!drugbank_id	DB00783
!pubchem_cid	5757
!cell_type	Thymus (of ovariectomized C57BL/6) - 6 Days
!organism	mouse
!end_metadata
TUBA1B	0.283964
EEF1A1	0.178127
RPL7A	0.161557
CD74	0.145406
RPL8	0.138237
RPS17	0.133128
RPL28	0.130631
ACTB	0.111940
RPL26	0.110949
RPS2	0.109438
RPS26	0.108205
RPS28	0.108103
RPL23	0.107203
RPS14	0.101728
FAU	0.099746
TPT1	0.099355
PRSS16	0.098181
RPL4	0.095272
PPIA	0.094554
RPL10A	0.093802
TMA7	0.088510
RPS15	0.087858
RPS29	0.087537
OAZ1	0.087223
RPL38	0.086373
CTSV	0.081027
RPLP2	0.080481
RPL10	0.076923
RPL19	0.076467
RPS5	0.074365
RPL37A	0.071749
RPL6	0.069461
DYNLL1	-0.069072
PTPRC	0.066339
B2M	0.065393
PSAP	0.064957
HLA-DRB5	0.063562
LBR	-0.063244
SEPP1	0.062950
SHISA5	0.062556
ACTG1	0.062035
SLC38A2	-0.061812
NPC2	0.061611
RPS3	0.060496
RPS21	0.059818
DDIT4	0.059588
FTH1	0.058450
LAPTM4A	0.058371
EEF2	0.057728
RPSA	0.056384
EIF5A	0.055830
HSPD1	-0.055060
RPS13	0.054903
THY1	0.054593
CRIP1	0.054510
DNAJA1	-0.054085
AP3S1	-0.053604
RPL7	0.053524
RPL3	0.053139
RPS12	0.052866
DNTT	0.051892
WASF2	0.051494
RPL13A	0.051481
PFN1	0.051470
RPS4Y1	0.049526
POLR2K	-0.049351
ETS2	-0.049060
SLC38A1	0.048992
ARPC2	0.048821
CYBA	0.047051
RPL9	0.046964
LCK	0.046652
CXCL12	0.046500
CDCA7	-0.046238
ZFP36L2	0.046226
TCF12	-0.045506
LIMD2	0.045435
CCT6A	-0.044959
SNX17	0.044779
DEK	-0.044197
CCL25	0.044117
HNRNPF	-0.043893
HLA-DQA1	0.042920
NDUFA13	0.042749
RPL11	0.042283
SLC25A3	0.041875
LAMP1	0.041758
ATP5G3	0.041564
CDK2AP1	-0.041296
RPS25	-0.041143
HSP90AA1	-0.041009
JUND	-0.040991
SEPW1	0.040567
EEF1G	0.040517
C11orf31	-0.040317
CD8A	-0.040240
CFL1	0.040172
NDUFS6	0.040039
RPL13	0.039849
RPL18	0.039459
RPL5	0.039434
CSTB	0.039353
TMBIM6	0.038972
FCGBP	0.038806
CD8B	0.038742
COX4I1	-0.037949
CHCHD2	0.037718
GRN	0.037636
KIAA0101	-0.037574
ATP5A1	0.037569
RCSD1	0.037554
EZH2	-0.037453
RPL22	-0.036928
VBP1	-0.036131
GCSH	0.036049
CNOT3	0.035623
TRIM59	-0.035595
HSPH1	-0.035272
CHORDC1	-0.035102
GAS6	0.035098
PSMB8	0.035052
PLAC8	0.034634
SPCS2	-0.034547
GNB2L1	0.034488
HMGCS1	-0.034423
PANK3	-0.034198
STMN1	0.034183
RAMP1	0.034084
SUMO2	-0.034035
COX7A2L	0.033866
SERINC3	0.033388
VDAC2	0.033253
MYB	0.032875
CST3	0.032835
IFITM3	0.032628
ATL2	-0.032193
RPS9	0.032135
SWI5	-0.032028
TFDP1	-0.031910
UQCRHL	-0.031905
NME2	0.031890
CPNE1	-0.031679
CAPZA2	0.031443
HMGB2	-0.031379
CALR	0.031137
LARP4B	0.031081
ARHGDIA	0.030859
RRM2	-0.030626
CYTIP	0.030250
EEF1E1	-0.029913
ATP5D	0.029885
RAC2	-0.029422
CCNG2	-0.029399
CNOT6	-0.029364
CSNK2B	-0.029154
PSMA2	-0.029102
RPL27A	-0.029067
DNAJB1	-0.029066
RAG1	-0.028907
PTPN18	0.028678
C1QA	0.028648
TSC22D3	0.028593
BCL11B	-0.028180
SASH3	0.027945
SELPLG	0.027931
HGS	0.027907
RPS7	0.027805
APOE	0.027710
ELAVL1	-0.027638
TAF9	-0.027584
CD3D	0.027487
MMADHC	-0.027476
C1QC	0.027422
HECTD1	0.027415
CORO1A	0.027272
TFG	0.027168
RPL14	0.027093
HLA-A	0.026968
RAP1B	-0.026952
HAT1	-0.026936
ITM2C	0.026764
ARID1A	-0.026670
POLR2I	-0.026636
SEP15	-0.026596
DNAJC7	0.026574
PITPNA	-0.026544
USMG5	-0.026424
ADCY6	-0.026384
KPNA2	-0.026277
APOBEC3B	0.026222
NDUFC2	-0.026196
MRPL24	-0.026055
EIF3D	-0.026037
CNOT1	-0.025914
RPL35	0.025871
SRRT	-0.025741
PPP1CA	-0.025713
CACYBP	-0.025687
FAM49B	-0.025619
MBNL1	0.025533
ABCG1	0.025521
SARAF	0.025479
TUBA1A	-0.025471
CTSC	0.025286
NUDT21	-0.025274
UCP1	0.025241
HSP90AB1	-0.025212
HLA-DQB1	0.025204
SCD	0.025180
IRF7	0.025015
PFDN6	-0.024916
SEPT7	-0.024893
MRFAP1	-0.024704
TRAT1	-0.024703
HP1BP3	0.024685
PSMB2	0.024652
LGALS3	0.024579
PSME2	0.024574
IGJ	0.024482
GSTP1	0.024351
TCP1	0.024337
UTP3	0.024271
DCK	-0.024170
HDAC7	-0.024165
NFKBIA	0.024163
RNF44	-0.023977
SNRNP27	-0.023867
CYC1	0.023750
PSME1	0.023736
PSMB7	-0.023683
MIF	0.023661
USP18	0.023450
RAG2	-0.023394
MRPL18	-0.023356
TNKS2	-0.023343
RPL12	-0.023341
CRIP3	0.023227
SNRPD1	-0.023196
PSMC4	-0.023154
IDI1	-0.023060
GPI	0.022996
DOCK2	-0.022828
RFWD2	-0.022645
NHP2L1	-0.022637
CLIC1	-0.022607
COPA	-0.022584
GAPDH	-0.022561
GPANK1	0.022521
PSMC3	-0.022486
UBE2E1	-0.022462
SNX3	0.022393
TIPIN	-0.022312
COPS3	-0.022281
DUT	-0.022240
CNPPD1	0.022233
SNRPD2	0.022230
COX7A2	0.022189
NDUFB11	0.022177
NEDD8	-0.022160
TRPC4AP	0.022137
RRM1	-0.022108
HNRNPUL1	0.022062
CTSB	0.021990
SFT2D1	-0.021979
PKM	0.021916
LAMTOR1	0.021855
CAPZA1	-0.021709
RPS19	-0.021696
SEPT9	0.021565
DBI	-0.021453
ITK	-0.021410
PPP2R1A	0.021334
EIF4H	0.021274
SPATS2	0.021259
IMMP1L	-0.021257
CMIP	0.021196
ELOVL5	0.021154
DYNLRB1	-0.021122
SQLE	-0.021101
MYL12B	-0.021096
C20orf24	0.021010
PSMC2	-0.020776
NRIP1	0.020744
AP1B1	-0.020738
ANAPC5	0.020724
RPL24	0.020698
GZMA	0.020662
IVNS1ABP	-0.020584
HELLS	-0.020584
LGALS1	0.020575
OSER1	-0.020551
PSMB9	0.020506
PABPC1	-0.020500
PRMT1	-0.020480
PSMA7	-0.020425
SPINT2	0.020409
SYVN1	-0.020371
PPP4C	-0.020309
SP1	0.020301
FKBP3	-0.020269
MGST2	0.020211
NDUFS8	0.020098
RBBP7	-0.020092
ATP5C1	0.020012
DESI1	0.019994
DDX19A	-0.019984
MAN2A1	0.019951
TOPBP1	-0.019949
CSNK1G2	0.019895
SRSF2	-0.019831
NT5C	0.019821
HDAC2	-0.019820
CCT8	-0.019789
E2F8	-0.019772
HNRNPH2	-0.019752
BCCIP	0.019650
ATAD2B	-0.019594
RERE	0.019594
LPL	0.019565
SOD1	-0.019540
LGALS3BP	0.019515
RBM38	-0.019505
G3BP1	-0.019468
SPO11	-0.019451
ZAP70	0.019440
IDH3G	0.019391
RNF145	-0.019372
SMC4	-0.019337
WDR78	-0.019212
ISG20	0.019207
FH	-0.019155
PDCD10	-0.019150
LAMTOR5	-0.019140
TOMM20	-0.019139
BIRC5	0.019139
ASF1B	-0.019129
TNIP1	0.019120
DDX6	0.019111
EDF1	-0.019059
GIMAP6	-0.019024
CYCS	-0.018995
STK38	-0.018947
ACTR3	-0.018926
COX19	0.018779
FBXL12	-0.018771
ICT1	0.018724
TMX1	-0.018652
SELK	-0.018644
EPC1	0.018600
EIF1B	-0.018593
MRPL30	-0.018592
LSM7	0.018565
TUBB	0.018564
YIPF1	0.018543
IFI30	0.018513
OSTC	-0.018464
TIMM23	0.018455
ROMO1	0.018431
CETN3	-0.018419
FKBP1A	-0.018397
DNAJC15	-0.018393
STAG2	-0.018380
ATP6AP2	0.018306
HINT1	-0.018293
TMEM261	-0.018275
BRD2	0.018271
NOP10	-0.018246
YWHAH	-0.018225
MPEG1	0.018218
SRSF1	-0.018187
NUP107	-0.018175
MSH6	-0.018133
PLEC	0.018114
UBALD1	-0.018082
CSTF3	-0.018032
IL2RG	0.018024
HNRNPM	-0.018020
HAX1	0.017953
ATP5F1	0.017944
NUDT5	-0.017926
SHFM1	-0.017917
MAD2L1	-0.017898
PTTG1	0.017877
MRTO4	-0.017856
CENPA	0.017835
CPSF7	-0.017816
MAT2B	-0.017801
LYPLA2	0.017604
GTF2H4	-0.017592
IQGAP1	0.017590
PPP1R8	-0.017562
ENPEP	0.017550
ST13	-0.017480
MATR3	-0.017431
DARS	-0.017396
GPSM3	0.017395
HNRNPH1	-0.017384
RPS18	0.017383
FAM76B	-0.017372
CDK2	-0.017154
MOB4	-0.017131
SLA	-0.017067
CCT5	0.017040
S100A10	-0.017003
CLEC7A	0.016986
PRC1	-0.016983
HIAT1	-0.016973
LGALS9B	0.016970
CCND3	-0.016952
GNB2	-0.016921
KCNN4	0.016865
GLCCI1	0.016854
STIP1	-0.016745
CCT2	0.016736
CHCHD1	-0.016722
ESYT1	0.016720
CHIC2	-0.016691
LAPTM4B	0.016663
SRSF7	-0.016646
CDC6	-0.016624
PGK1	0.016615
IKZF1	-0.016614
FAM120A	-0.016545
ZMPSTE24	0.016533
DGKZ	-0.016478
FDPS	-0.016461
RHOH	-0.016459
HMGN1	-0.016443
AKIRIN1	-0.016438
MNS1	-0.016434
YPEL3	0.016294
SRP14	-0.016286
SDHB	0.016286
PIAS4	0.016254
APEX1	0.016251
SMARCD2	-0.016212
PDIA3	0.016207
C1QBP	0.016188
AHSA1	-0.016165
CA6	0.016122
BANF1	-0.016113
DNAJB9	-0.016090
CNN3	0.016075
NDUFV3	0.015988
ATP6V1G1	-0.015976
TUBA4A	0.015961
HLA-G	0.015900
ITGAL	-0.015896
PDS5A	-0.015862
CCL5	0.015848
PARP14	0.015848
CSNK1A1	0.015847
DDOST	0.015827
ACADVL	0.015813
MED10	-0.015803
API5	-0.015800
GMNN	-0.015797
MGEA5	-0.015792
CTDSP1	0.015689
U2AF2	-0.015679
ANXA5	-0.015647
ETS1	0.015639
RPS27A	-0.015544
NDUFA3	0.015527
MRPL32	-0.015524
CFD	0.015515
SUB1	-0.015509
RGCC	-0.015498
TRIOBP	0.015493
EIF4G3	-0.015485
PSENEN	-0.015483
LSM5	-0.015453
NDUFB8	0.015451
SMC2	-0.015444
TOP1	-0.015440
IFNGR1	0.015419
UBD	0.015380
LAMP2	0.015350
RRAGA	0.015340
ACADM	0.015332
MROH1	0.015327
IL17RB	0.015326
PLEKHB1	0.015322
GIT2	0.015315
NABP1	-0.015312
PPP1CB	-0.015304
MAST3	-0.015304
EXT2	0.015301
C5orf24	-0.015268
ABLIM1	-0.015264
MAZ	-0.015239
CTSH	0.015233
KCNA3	-0.015221
FXR2	0.015163
MOB1A	-0.015159
NXF1	-0.015111
NUSAP1	-0.015104
TFAM	-0.015089
ZBTB18	-0.015006
CDC42SE2	-0.014962