!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Estradiol
!smiles	CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
!drugbank_id	DB00783
!pubchem_cid	5757
!cell_type	Uterus - single injection of 400 ug/kg - 24 Hours after treatment
!organism	mouse
!end_metadata
CA2	0.238798
COL6A3	0.203842
LTBP4	-0.136295
DCN	-0.122024
SPARCL1	-0.120670
TPT1	-0.112455
RAN	0.110220
RPL13	-0.104174
COL6A2	0.102423
LGALS1	0.097508
LSP1	-0.095661
LCN2	0.093265
LDHA	0.088171
APP	-0.087651
ANXA2	0.084985
RPS3	-0.084036
LAPTM4A	-0.084030
IGFBP3	-0.083276
PLAT	-0.082731
BCAT1	0.082278
EEF2	-0.081968
APCDD1	-0.079735
EEF1A1	-0.077127
RPS23	-0.076860
LTF	0.076095
ID2	-0.075798
PLP2	0.074860
CD164	0.074670
EIF4A2	-0.074082
TUBB6	0.073512
DIO2	0.073457
ISLR	-0.072870
CLCA1	0.072629
LRRC59	0.072593
PLAC8	-0.072058
SOX17	-0.069861
RPS19	-0.069801
GSN	-0.069030
KCTD12	-0.068403
RPLP0	-0.068209
UQCRQ	0.067827
ITM2B	-0.067104
ACTG2	0.066958
RPS5	-0.065999
HK1	-0.065489
GNB2L1	-0.065472
ELF3	0.064299
CTSD	-0.064019
SERPING1	-0.063843
KRT7	0.063623
C3	0.063386
RHOB	-0.062684
RPL5	-0.061016
RPL19	-0.060498
CPE	-0.059735
PPP1R14B	0.059523
CCNB2	0.059207
TGFBI	-0.059123
PSMA3	0.057228
GSTM5	-0.057141
YBX1	0.056495
WDR92	-0.056195
ITM2C	-0.055301
RPL10A	-0.054748
PLTP	-0.054553
MYH11	-0.054254
COX6A1	0.054204
TACSTD2	0.054147
MDH2	0.053458
RPL7	-0.053075
NHP2	0.053039
RPL10	-0.052840
FMO1	-0.052513
CYC1	0.052101
SFRP2	-0.052063
TUBA1A	0.052015
GAS1	-0.051976
SRSF2	0.051924
RPS15A	-0.051916
TUBA1C	0.051906
LAMC2	0.051528
MYLK	-0.051299
HTRA1	0.051187
ENG	0.050959
DYNLL1	0.050685
UBC	-0.050359
B2M	-0.048548
NREP	-0.047757
PADI1	0.047359
RPL21	-0.047085
ERH	0.046647
ARHGDIA	0.046568
RPL3	-0.046450
KRT19	0.045970
RPS24	-0.045813
SNRPD2	0.045729
GNG5	0.045658
KRT8	0.045636
POSTN	-0.045600
APOE	-0.045535
ACAA2	-0.045506
CLDN7	0.045443
PPIA	0.045356
SLC35B1	0.045241
RPS12	-0.044894
IER3	0.043577
RPL28	-0.043524
SEC61A1	0.043294
RPS7	-0.043279
HIF1A	0.043269
YPEL3	-0.043229
PENK	-0.042920
GORASP2	0.042716
CDC20	0.042676
RPS27A	-0.042614
RABAC1	-0.042545
ACTA2	-0.042526
NPNT	-0.042380
ARPC2	0.042279
GAPDH	0.042165
MSX1	-0.042071
SERINC3	-0.042039
TAGLN2	0.041806
AP1S1	0.041764
TGFB1I1	-0.041236
SEC61G	0.041001
RPS28	-0.040919
COL3A1	-0.040867
PRKCDBP	0.040476
TIMM23	0.040309
ZBTB20	-0.040150
WFDC2	-0.040143
PADI2	0.039938
COL6A1	0.039893
HSP90B1	0.039876
MGP	-0.039769
CST3	-0.039307
PSMB3	0.039182
FAM213A	0.038970
TIMP3	-0.038944
ALDOA	0.038543
MDK	-0.038483
SVIL	-0.038341
PCNA	0.038308
PTP4A1	0.037975
SMDT1	0.037938
TXN	0.037905
H2AFX	0.037857
TUBB	0.037843
MORF4L1	-0.037773
TXNIP	-0.037457
GOLM1	0.037351
MAD2L1	0.037075
SERP1	0.036802
GSK3A	0.036741
WLS	-0.036685
IGF1	0.036414
SOCS2	0.036393
S100A6	0.036360
RIN2	-0.036300
UGDH	0.036205
KRTCAP2	0.035791
ATP5O	0.035783
NDUFA5	0.035631
SEC61B	0.035482
TPI1	0.035116
RPS10	-0.035030
ADH1C	0.034803
H19	-0.034768
SURF4	0.034298
SPTSSA	0.034168
BGN	-0.033964
ZFP36L1	-0.033962
FBLN2	0.033792
RPS26	-0.033447
ATP6V0C	0.033386
PLK2	0.033350
SESN1	-0.033318
TMEM97	0.033310
GADD45G	0.032944
RPS2	-0.032905
CLK1	-0.032817
TCF4	-0.032660
H2AFZ	0.032561
GTF2I	-0.032466
MRPL52	0.031882
HSPE1	0.031836
U2AF2	0.031819
RPL8	-0.031801
NDUFB5	0.031749
CALB1	-0.031663
UQCR10	0.031602
PGRMC1	-0.031503
FXYD1	-0.031485
TMEM123	-0.031264
HDGF	0.031167
FDPS	0.031071
POLR2L	0.030713
RAMP3	0.030639
FAM8A1	-0.030549
RECK	-0.030468
RARRES2	-0.030414
ANLN	0.030353
PRMT1	0.030077
PGK1	0.030058
LBP	-0.030012
NFIX	-0.029827
RNF167	-0.029795
MANF	0.029628
ACTG1	-0.029620
HDC	-0.029433
ALPL	0.029204
MAP1LC3B	-0.029171
TNXB	-0.029161
CSRP1	-0.029034
C20orf24	0.029031
PRDX1	0.029006
ID4	-0.028973
PPA1	0.028925
SPRR1A	0.028866
GABARAPL1	-0.028731
CTDSP2	-0.028526
MCAM	-0.028501
REV3L	-0.028414
CKS1B	0.028398
PNP	0.028385
RPL6	-0.028311
EID1	-0.028296
ENPP2	-0.028199
PLET1	0.028169
RBBP7	0.028133
TMED10	0.028118
CNN3	-0.028108
AMPD3	0.028093
CLIC4	-0.027979
MARCKSL1	-0.027955
GNG12	0.027769
IGFBP6	-0.027686
TMOD3	0.027655
AHNAK	-0.027623
COL4A2	0.027525
PSMD1	0.027496
IGF1R	-0.027468
LMNA	0.027436
BPIFB1	-0.027409
ARF4	0.027197
MFGE8	0.027092
PSMA6	0.027068
ACTA1	0.027057
REEP5	0.026979
RGS2	-0.026971
PSAT1	0.026961
NDP	-0.026935
PRNP	-0.026907
SMAD1	-0.026869
ANXA3	0.026677
MRPL18	0.026676
MAF1	-0.026653
PRC1	0.026453
CRIP1	0.026372
SEC13	0.026311
RPS11	-0.026240
DDX5	-0.026142
FKBP1A	0.026142
ARF1	0.026102
MEF2D	-0.026096
C9orf16	0.026095
IDI1	0.026080
RANBP1	0.025965
DPT	-0.025964
GJA1	0.025868
DBI	0.025759
TMEM14C	0.025750
RERE	-0.025745
CCT7	0.025711
CKS2	0.025671
OSTC	0.025594
RMND5A	-0.025489
RAMP1	-0.025342
GSPT1	0.025331
NSA2	-0.025043
AQP1	-0.025038
INHBB	0.024932
MYL12A	-0.024893
NDUFA11	0.024864
GPC3	-0.024859
SQLE	0.024849
PIGR	0.024827
PCBP1	0.024817
FTH1	-0.024767
CTSV	0.024614
MXD4	-0.024522
CDK1	0.024512
SUN2	-0.024458
SPOCK2	-0.024391
PPP4C	0.024145
C11orf31	0.024129
RBM3	0.024061
TRA2B	0.024054
CD74	-0.024044
HSD11B2	0.023870
AHCY	0.023690
GNAI3	0.023684
SMC4	0.023627
SCARB1	-0.023581
ALDH2	-0.023577
APLP2	-0.023554
SH3BGRL	-0.023354
HOXA11	-0.023289
PSMA2	0.023159
VMP1	0.023156
BRI3	-0.023070
SPTBN1	-0.023042
CEBPB	0.023024
DOCK9	-0.022977
LDLR	0.022951
YWHAG	0.022875
HMGCS1	0.022870
NDUFC1	0.022715
COPS6	0.022696
TAGLN	-0.022683
TXNRD1	0.022653
ARPC3	0.022621
PDXK	-0.022587
ISOC1	0.022427
DDB1	0.022311
FBLN1	-0.022289
CCNA2	0.022274
PTOV1	-0.022211
CDH5	-0.022208
PTGER4	-0.022182
HN1	0.022065
SPPL3	-0.021994
PTCH1	-0.021981
SQSTM1	-0.021980
UHRF1	0.021972
KIF22	0.021934
TSC22D1	-0.021913
NUMA1	-0.021830
G6PD	0.021799
FKBP11	0.021746
DDX17	-0.021715
TCN2	-0.021712
CAPNS1	0.021712
TIMM13	0.021602
CEACAM1	0.021580
RNF10	0.021565
PTTG1IP	-0.021549
MBTPS1	-0.021546
PRKAR1A	-0.021456
CD93	-0.021439
AP2M1	0.021433
KPNA2	0.021377
GJB2	0.021369
HNRNPD	0.021298
C5orf15	-0.021233
ID3	-0.021218
KDELR3	0.021093
PCBP2	-0.021052
KRT6B	0.021045
ZBTB16	-0.021008
SMTN	-0.020992
CALU	0.020972
CTPS1	0.020962
ERGIC3	-0.020934
C12orf57	-0.020741
HINT1	0.020656
MRPS34	0.020638
BZW2	0.020636
SRM	0.020623
CCT4	0.020518
FKBP2	0.020432
GNAS	-0.020409
IMPDH2	-0.020376
MTCH2	0.020334
PNO1	0.020237
TSPO	0.020184
PNRC2	-0.020161
ANXA1	0.020156
SSRP1	0.020119
CLPTM1	0.020089
ATP2A3	-0.020009
PSMB2	0.019966
TRIM28	0.019961
ECH1	-0.019952
HDAC5	-0.019950
PHB2	0.019928
AES	-0.019924
SLC25A39	0.019739
TXNDC5	0.019697
ACTB	-0.019650
MCM2	0.019556
SPARC	-0.019551
PPAP2B	-0.019502
MRPL51	0.019476
EIF4A3	0.019443
GDI1	-0.019433
PERP	0.019422
SAT1	0.019403
OAZ2	-0.019382
PSMB6	0.019343
GPX2	0.019308
CTSB	0.019291
PAPSS1	-0.019240
CACHD1	-0.019187
COX7B	0.019117
GLTSCR2	-0.019085
HSPA9	0.019010
CTSF	-0.018991
FZD2	-0.018899
UBE2N	0.018861
LRG1	0.018840
SLC25A36	-0.018747
SRSF6	0.018698
SPP1	0.018636
HNRNPA2B1	0.018612
LRRC58	-0.018603
CLU	0.018581
CRABP1	0.018565
ITGB1	-0.018532
PKD2	-0.018488
CPXM2	-0.018479
RPL27A	-0.018471
DAP	0.018459
SLC7A5	0.018429
KMT2E	-0.018410
HADH	-0.018391
RPS6KA4	0.018385
STOML2	0.018383
GDF10	-0.018380
C19orf10	0.018354
TRAM1	0.018312
TMED4	-0.018307
RPS4Y1	-0.018299
SGCE	-0.018297
TAF10	0.018269
SMAD4	-0.018249
MPRIP	-0.018247
WDR1	0.018224
NDUFAB1	0.018168
TK1	0.018151
MMP14	-0.018131
SLMAP	-0.018121
CCNB1	0.018093
ANGPTL2	-0.018077
MTHFD2	0.018068
FOXO3	-0.018034
GPI	0.018028
PKM	0.018021
DSTN	-0.017994
FCGBP	0.017977
CD9	-0.017976
ECT2	0.017972
SELT	0.017942
NDRG1	-0.017923
UQCRB	0.017890
EIF6	0.017864
KLF9	-0.017853
CLDN5	-0.017829
TMEM131	-0.017813
GRINA	-0.017721
NDUFS6	0.017712
SSR2	0.017711
ALAD	0.017693
RGS3	0.017586
PSMC6	-0.017584
RSU1	-0.017567
A2M	0.017561
PLS3	-0.017542
ACO2	0.017484
ATPIF1	0.017444
FRYL	-0.017432
BNIP3L	-0.017397
ALDH1A2	0.017371
COL4A1	0.017366
WDR6	-0.017346
CBX6	-0.017331
MINOS1	0.017307
ST5	-0.017245
ACTR3	0.017213
NDUFB8	0.017147
GSR	0.017126
COL1A2	-0.017123
INMT	-0.017120
KCNK1	0.017115
GPS1	0.017032
TRIO	-0.017016
ATF4	0.016995
THY1	-0.016980
IFITM3	-0.016947
CNIH1	0.016911
FKBP4	0.016881
PGAM1	0.016868
DKK3	-0.016821
COL5A1	0.016811
PRKCSH	0.016781
NDUFB2	0.016751
DENND5A	-0.016735
NOP2	0.016731
COX7A2	0.016729