!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!ligand_name	estradiol
!ligand_id	CHEBI:23965
!cell_type	estrogen receptor (ER)-positive MCF7 breast cancer cells
!organism	human
!end_metadata
SLC7A5	0.199484
S100A7	0.143747
LXN	-0.121727
DKK1	-0.119853
ID1	-0.119698
TUBB	0.115570
RAN	0.100048
NME1	0.099654
TUBB4B	0.094970
NHP2	0.092743
YBX1	0.091422
HSPA8	0.090847
BCAS3	-0.090259
MRPL3	0.090062
TPD52L1	0.088392
UBE2S	0.086695
PTP4A1	0.085724
DHRS2	0.085036
BAMBI	-0.080438
PTTG1	0.079895
BASP1	-0.077506
SLC9A3R1	0.076687
CCT2	0.075234
SLIRP	0.074087
RPL39	-0.073755
DDIT4	-0.073259
EMG1	0.072091
TFF1	0.071776
CD24	-0.071638
TUBA1A	0.071310
PLEKHF2	-0.069557
HSPE1	0.068480
LDHA	0.067174
KARS	0.066719
HSP90AA1	0.066574
TUBA1B	0.065583
IARS	0.065444
ASS1	0.063967
GATA3	-0.062782
RPS26	0.062635
SIAH2	0.062436
TUBB3	0.062261
SLC3A2	0.062054
MIF	0.061603
EIF4A1	0.060816
TXNIP	-0.060371
NOP58	0.059818
MIR21	-0.059461
MRPL36	0.058722
TUBA1C	0.058688
KPNA2	0.057967
C1QBP	0.057651
CCT7	0.056891
HSPB1	0.055926
NQO1	-0.055749
PNRC1	-0.055383
HSP90AB1	0.055377
C20orf24	0.055252
PPT1	-0.054649
DDX21	0.054390
TSTD1	-0.053636
USMG5	0.053604
ADIRF	-0.052805
ETFA	-0.052624
ID3	-0.052528
RPL22L1	0.051706
NPM1	0.051564
FBP1	-0.051483
PPIB	0.050759
KRT8	0.050609
BOLA3	0.050007
ID2	-0.049610
VAMP8	-0.049602
PHB2	0.048608
TCN1	0.048570
UBE2T	0.048105
PSMB5	0.048033
SNRPF	0.047532
AHSA1	0.047374
STIP1	0.047288
IRF2BPL	-0.047234
PSME1	-0.047226
UBE2C	0.047146
CCT6A	0.046868
TUBB6	0.046641
PKIB	0.046209
ND2	0.046186
HIF1A	0.045914
TRIM28	0.045727
SMIM15	0.045707
DYNLT3	0.045505
DNAJA1	0.045086
SERPINA3	0.045040
FDFT1	0.043652
SLC26A2	0.043582
MRPS23	0.043287
HSPB8	0.043201
MLPH	-0.043125
PRELID1	0.042905
DSP	-0.042903
MT2A	0.042431
MRPL15	0.042359
PTGES3	0.042168
FAM102B	-0.042165
FBL	0.042061
ZNF217	-0.041948
TMSB10	-0.041900
ILF2	0.041656
CDC20	0.041647
ANP32B	0.041470
MYEOV2	0.041428
CD63	-0.041393
PSMA6	0.041277
DYNLL1	0.041267
PRC1	0.041266
CCNB1	0.040951
TMEM64	0.040550
CCT5	0.040481
SLC35A1	-0.040031
CTSD	0.039925
SAT1	-0.039765
HNRNPAB	0.039658
MYO1B	-0.039588
GPR160	-0.039537
KRT19	0.039411
KRT18	0.039388
GSTM3	-0.039348
CSTA	-0.039295
ISG15	-0.039201
TFRC	0.039124
SYTL2	-0.038962
HMGB1	0.038961
REEP5	-0.038939
MB	-0.038759
NOP10	0.038619
FKBP4	0.038474
MAPK6	0.038436
TPBG	0.038403
MRFAP1	0.038283
CYC1	0.038261
PLP2	0.038212
POLR2G	0.038091
TSKU	0.037841
EEF1B2	0.037280
CKS1B	0.037137
COX7A2	-0.036961
PPIF	0.036937
PKM	0.036818
TUBB2A	0.035968
NPY1R	0.035826
ARMCX6	0.035698
DDX39A	0.035363
DNAJC1	-0.035285
HLA-A	-0.035267
HILPDA	-0.035138
CCT3	0.035093
PSMC3	0.035055
KYNU	-0.035020
RPS18	-0.034881
HSPH1	0.034850
TOMM5	0.034743
BTG1	-0.034642
CDKN3	0.034593
CMC2	0.034445
ISOC1	-0.034422
YWHAG	0.034417
SNHG19	-0.034339
CA12	0.034170
ZFP36L2	-0.034086
MRPL16	0.034056
CLU	-0.033962
GABARAP	-0.033858
SEPP1	-0.033776
PSAP	-0.033591
ENO1	-0.033399
GLA	0.032993
OSBPL9	-0.032980
ATP1B1	-0.032932
UBL3	0.032848
NDUFB9	0.032843
DCTPP1	0.032825
SMIM14	-0.032773
RRM2	0.032703
TMEM150C	-0.032517
PRMT1	0.032406
PNPT1	0.032396
ITM2B	-0.032367
STARD10	0.032314
CELSR2	0.032292
FAM96B	0.032165
TMA7	0.032101
ISCU	0.032100
CCT4	0.032043
GLO1	0.032003
PDIA6	0.031882
RUVBL1	0.031820
SLC12A2	-0.031698
IFIT1	-0.031506
LOC100129361	-0.031490
PIK3R3	-0.031489
IFITM3	-0.031435
ABCE1	0.031241
HSPA5	0.031235
JTB	0.031210
SNRPG	0.031133
G6PD	0.031071
FTL	0.030992
IMP4	0.030915
S100A9	0.030804
BAG3	-0.030778
MAD2L1	0.030763
MREG	0.030728
STUB1	0.030690
RPL24	0.030640
SNRNP25	0.030563
GREB1	0.030556
NGFRAP1	-0.030485
PBK	0.030480
ADIPOR2	-0.030316
LYSMD2	0.030146
EIF3D	0.030137
FAU	0.030094
RPL19	0.030093
RPL8	0.030082
TOP2B	-0.030013
GABARAPL2	-0.029850
FAM84B	-0.029813
HIST1H2AC	-0.029788
XPOT	0.029477
EIF4H	0.029399
CKS2	0.029302
SNHG1	0.029177
PSMD8	0.029155
DNAJB11	0.028768
UBC	-0.028637
PHB	0.028578
NAA20	0.028539
RPL17	0.028412
H2AFZ	0.028357
CDK2AP1	0.028356
SYTL5	0.028339
VIMP	0.028205
LAPTM4A	-0.028182
SOCS2	-0.027898
ATP5G3	0.027870
IFITM1	-0.027855
PEG10	0.027653
ARL6IP1	0.027539
TMEM59	-0.027537
BANF1	0.027519
NCL	0.027445
CDKN1B	-0.027406
LAPTM4B	0.027359
CHSY1	0.027263
SH3YL1	-0.027162
SGCG	-0.027031
PAICS	0.026981
RNASEH2A	0.026975
ADRM1	0.026973
RPS14P3	0.026964
PARK7	0.026950
KLHDC2	-0.026946
RRS1	0.026936
PRSS23	0.026840
BRIP1	0.026789
COX2	-0.026550
ALYREF	0.026545
EGR3	0.026443
ATP1B3	0.026407
DEK	0.026384
MARCKSL1	0.026365
SNRPD3	0.026338
RPS7	0.026307
TFAP2C	0.026252
TCERG1	0.026179
CERS2	-0.025920
RPF2	0.025912
CCT8	0.025875
CXXC5	0.025838
SEC61G	0.025826
ETF1	0.025794
NAA50	0.025728
MSMO1	0.025711
CIRH1A	0.025691
SNRPD2	0.025674
CEBPB	0.025666
NMD3	-0.025622
PRMT5	0.025609
WSB2	-0.025566
H3F3B	0.025540
RPL7L1	0.025505
SRSF2	0.025496
SF3B5	0.025494
UQCRFS1	0.025475
RACGAP1	0.025429
RPL3	-0.025394
RAB31	0.025323
TRIM37	-0.025173
CANX	0.025084
IGFBP4	0.024853
CACYBP	0.024805
EFNA1	-0.024755
GEMIN5	0.024692
DPM1	-0.024645
DHCR7	0.024642
BRK1	-0.024604
DTX3L	-0.024393
SLC38A2	0.024390
HADHB	-0.024328
NARS	0.024302
NDUFB10	0.024236
NSA2	0.024189
TPX2	0.024109
SRM	0.024107
FTH1P5	-0.024034
GGCT	0.024002
MRFAP1L1	-0.024000
HMCN1	-0.023994
DDR1	-0.023993
ENOPH1	0.023958
GRB14	-0.023919
TPT1	-0.023885
RAD51C	0.023870
ATP5B	0.023749
NDUFA4	-0.023742
TOB1	0.023704
NCOA4	-0.023669
NUP107	0.023648
NRIP1	0.023646
CYCS	0.023571
GTF3C6	0.023553
PSMB6	0.023551
NDUFS3	0.023547
COX6C	0.023401
CBWD1	0.023394
AGR2	-0.023355
YPEL5	-0.023348
VDAC1	0.023313
SSR1	0.023284
OSTC	0.023100
EIF5	0.023072
COA4	0.023066
PRR13	0.023065
CNBP	0.023064
TMEM147	0.023021
ATIC	-0.022927
PSMB3	0.022912
SLC25A5	0.022878
UFD1L	0.022858
PDCD10	0.022836
PRDX4	0.022818
HSP90B1	0.022666
FABP5	0.022636
PABPC3	-0.022576
PRDX6	0.022534
EIF3I	0.022516
AMD1	0.022494
TIMM10	0.022485
DANCR	0.022451
NDUFAF2	0.022380
TMEM30A	-0.022342
S100A13	-0.022328
CAPNS1	-0.022273
LITAF	-0.022258
TCEAL1	-0.022250
RCN2	0.022229
HIST1H2BD	-0.022187
PPP3CA	-0.022166
PSMD12	0.022159
RXRA	-0.022089
GNAS	-0.022069
PA2G4	0.022059
NME7	-0.022030
CDK1	0.022028
SSB	0.021973
DRG1	0.021963
TMBIM4	-0.021923
SNRPB	0.021910
TMED2	0.021847
DSTN	-0.021832
EBPL	0.021825
CPNE3	0.021809
MYL12A	-0.021761
C14orf2	0.021722
UBE2M	0.021708
MRPS24	0.021677
SEC13	0.021675
PSMD14	0.021633
PSMG1	0.021626
NOL11	0.021600
MAL2	-0.021585
RBL2	-0.021581
PFDN2	0.021536
ODC1	0.021528
PSMC1	0.021440
TPI1	0.021335
RARS	0.021318
DPY30	0.021295
BLVRB	0.021271
LMNB1	0.021264
ARNT2	-0.021245
ATP5G1	0.021223
RNPS1	0.021162
MANF	0.021156
PRR11	0.021141
MRPL14	0.021139
HIST1H3H	-0.021136
MRPL51	0.021100
NDUFB1	-0.021025
CCNG2	-0.020981
CSE1L	0.020962
NDUFA12	0.020931
PSMB7	0.020925
PFN1	0.020885
DKC1	0.020867
KNSTRN	0.020861
GRPEL1	0.020719
GRN	-0.020717
RBM24	0.020699
MAP1LC3B	-0.020692
MRPL22	0.020661
SFN	0.020625
ATP5I	0.020574
EIF3E	0.020545
PRPF4	0.020529
MRPL37	0.020518
ZDHHC7	-0.020484
TXN	0.020467
XRCC5	0.020457
SNHG16	0.020441
C2orf69	0.020382
CCNG1	-0.020369
PNMA1	0.020335
POLE3	0.020322
HSPD1	0.020230
COMT	-0.020149
NR3C1	-0.020128
NRAS	0.020057
CALM1	0.020036
ANP32E	0.020018
ANK3	-0.019973
HSPA9	0.019934
MYO6	-0.019932
NUP35	0.019921
HEBP1	-0.019913
STOM	-0.019856
PPA1	0.019849
MRPL33	-0.019827
TAGLN2	0.019826
CCND1	0.019796
SH3BGRL	-0.019745
SPCS1	0.019714
POP5	0.019703
CRELD2	0.019676
ABHD17C	-0.019668
TRMT10C	0.019630
CIB1	-0.019628
RPS17	0.019622
ZG16B	-0.019594
TSPYL4	-0.019592
EIF2A	0.019588
PSMA7	0.019574
BZW1	-0.019515
RPSA	0.019485
RET	0.019476
SRSF3	0.019473
PGR	0.019441
MRPL42	0.019407
TMEM205	-0.019371
PMP22	-0.019359
UBE2L6	-0.019357
ADM	-0.019326
PPP1R3C	-0.019286
DYNLT1	-0.019269
FAM83D	0.019259
HLA-C	-0.019256
GBAS	-0.019234
TYMS	0.019231
ATOX1	-0.019207
ABAT	0.019148
CHCHD3	0.019144
NOLC1	0.019125
PSMD2	0.019119
TOP1	0.019119
RAB1A	-0.019095
HIST1H1C	-0.019086
CTSA	-0.019083
HSPA4	0.019070
TRMT112	0.019047
TM7SF2	-0.019030
RAB9A	-0.019017
BUB1B	0.018988
NCOA3	-0.018987
TACSTD2	-0.018961
DHX40	-0.018959
HAT1	0.018931
MRPL17	0.018838
ZWILCH	0.018778
TMEM106C	-0.018728
S100A10	-0.018711