!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Tretinoin
!smiles	CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
!drugbank_id	DB00755
!pubchem_cid	444795
!cell_type	ME180 squamous cell carcinoma cell line - 6 hours 10μM
!organism	human
!end_metadata
MIR877	0.058148
HPGD	-0.053666
EPB41L3	-0.052242
CXCL8	0.050991
CCL20	0.050744
SERTAD4-AS1	0.047238
RELB	0.046044
MT4	-0.045369
SAMD9	-0.044272
TCHHL1	-0.042838
TNFSF10	-0.040812
SCD	-0.039567
FOSL1	0.039510
ATP7A	-0.039416
CYR61	0.037392
KLHL24	-0.037288
STXBP3	-0.036984
CEP70	-0.036581
CYP26A1	-0.036306
SDPR	-0.035907
KRTAP3-1	0.035853
KRT1	-0.035596
ACAP2	-0.035456
TMED10	-0.035344
PCMTD1	-0.035327
WNT7A	0.035164
XRN1	-0.034163
GLIPR1	0.033737
EEF1A2	0.033559
DSG1	-0.033326
PTHLH	0.033317
PLAT	0.032739
TBL1XR1	-0.032668
APOD	-0.032570
CHD9	-0.032518
KTN1	-0.032354
DAAM1	-0.031901
LRRC75B	0.031897
KRT84	-0.031680
EVA1A	0.031679
MOB3B	-0.031600
GAL	0.031440
SCOC	-0.031358
CRCT1	0.031321
LIN54	-0.031319
DOCK8	-0.031245
KIF20B	-0.031214
FOXN2	-0.031139
F3	0.031075
TMEM74B	0.030937
CYB5R2	0.030850
SC5D	-0.030790
MIS18BP1	-0.030735
MTBP	-0.030730
FAM102B	-0.030555
PELI2	-0.030375
PHLDA2	0.030349
PLA2G4F	-0.030285
TMEM123	-0.030249
NEK6	0.030200
CENPF	-0.029939
LPAR6	-0.029732
MISP	0.029667
ASF1A	-0.029587
ZBED2	0.029275
CENPE	-0.029200
LCP1	0.029179
ZNF770	-0.029174
KRT23	0.029080
HLTF	-0.029045
SMARCAD1	-0.029019
NRIP1	-0.028909
NFE2L2	-0.028908
LPIN1	-0.028861
MKLN1	-0.028856
ROR2	0.028662
COBLL1	-0.028485
CDK19	-0.028361
SHOC2	-0.028299
KLF9	-0.028132
U2SURP	-0.028078
SPOCD1	0.027944
PTAR1	-0.027914
TNFAIP3	0.027907
RB1CC1	-0.027894
HMMR	-0.027890
DLGAP5	-0.027884
RPTN	-0.027838
IFI27	0.027794
MYEOV	0.027770
ATAD2	-0.027753
ASPM	-0.027638
TTK	-0.027512
KIF14	-0.027185
CDC42EP5	0.027162
ABCA1	-0.027145
RRP9	0.027145
TP53INP1	-0.026955
ANLN	-0.026933
THBS1	0.026913
LSM8	-0.026879
TRIM2	-0.026846
FST	0.026814
COG6	-0.026810
PUS7L	-0.026744
FAM214A	-0.026731
SERPINB13	-0.026707
HMOX1	-0.026693
VPS9D1-AS1	0.026671
NTF3	0.026609
GJB4	0.026608
TTC37	-0.026608
TGFB3	-0.026598
TOP2A	-0.026542
CKAP2	-0.026482
STAT4	-0.026426
DPYSL3	0.026370
RBPMS2	0.026349
BATF3	0.026324
SNX2	-0.026315
CCDC14	-0.026293
PTBP3	-0.026204
MTHFD1L	0.026193
PDCD4	-0.026102
ZNF845	-0.026090
IGFL1	0.026073
PCM1	-0.026058
CYP26B1	-0.026015
TRAPPC8	-0.026005
NRG4	-0.025975
ORC3	-0.025966
SAMD4A	0.025879
CEMIP	0.025848
PCMTD2	-0.025832
CD70	0.025812
SERPINB2	0.025738
CEP44	-0.025702
KRTAP3-2	0.025689
SPDYE2B	0.025687
VCPIP1	-0.025626
PRUNE2	-0.025551
LRFN4	0.025488
TRMT61A	0.025483
TRIM31	-0.025473
RRP12	0.025468
MPHOSPH9	-0.025460
ZNF239	0.025451
RPRML	0.025434
ADAP2	0.025429
LAMC2	0.025413
KLHL9	-0.025384
CUL5	-0.025379
OSTM1	-0.025349
SNRK	-0.025319
NEK1	-0.025308
CKAP2L	-0.025289
RBM47	-0.025275
ANXA2R	-0.025268
KIF11	-0.025240
IGF2BP3	-0.025234
LIPG	0.025126
PHIP	-0.025094
OSBP2	0.025087
CXADR	-0.025022
ARHGAP20	-0.025010
ZNF260	-0.025009
FSTL3	0.025005
PUM2	-0.025005
TTC14	-0.024993
SNX4	-0.024985
GNA13	-0.024985
ZNF680	-0.024964
HIF1A	-0.024940
ATP10B	-0.024937
TRIP11	-0.024885
PABPC4L	-0.024875
SCAPER	-0.024758
CLCA2	-0.024735
TNFRSF10A	0.024723
SLC39A2	-0.024710
RALGAPA1	-0.024648
DOCK11	-0.024636
ZMYND15	0.024590
DOPEY1	-0.024568
LOC100129550	-0.024542
RTP4	-0.024532
UBL3	-0.024500
NDFIP1	-0.024448
CXorf57	-0.024391
IFT74	-0.024357
PLS1	-0.024340
ZMYM4	-0.024339
CNTRL	-0.024306
ANKRD12	-0.024299
PIK3C2A	-0.024255
RB1	-0.024214
ZBTB33	-0.024169
FJX1	0.024157
NKD2	0.024156
DEK	-0.024046
GMFB	-0.024008
TNFRSF12A	0.024005
ZNF484	-0.023993
RBM27	-0.023976
CD200R1	-0.023963
TAF2	-0.023952
CPNE3	-0.023915
IGFBP5	-0.023912
MTX3	-0.023844
NEMF	-0.023835
LANCL1	-0.023833
SLCO4A1	0.023825
KIF5B	-0.023796
DDN	0.023774
BAZ2B	-0.023734
PAFAH1B1	-0.023734
JMJD4	0.023711
ZMYM1	-0.023653
COL4A1	0.023644
ZNF518B	-0.023642
GBP2	0.023608
RAPGEF5	-0.023585
TMEM158	0.023546
PREPL	-0.023523
HBA2	0.023475
REEP3	-0.023445
EGFL6	-0.023401
RAB8B	-0.023380
CAMK2N2	0.023344
CA2	-0.023324
CEP128	-0.023315
PAPD4	-0.023304
PELI1	-0.023261
TLE4	-0.023254
DENND4C	-0.023218
EFCAB14	-0.023159
ZBTB21	-0.023154
HOXA13	-0.023139
MYO9A	-0.023101
PGM2	-0.023080
RAB18	-0.023026
EDN1	0.022965
BLM	-0.022910
CLPSL2	0.022891
SH2D3A	0.022871
RBFA	0.022862
PSG5	-0.022849
KAL1	-0.022829
STMN3	0.022811
AKAP11	-0.022802
RPA3OS	-0.022801
TMTC3	-0.022790
KNTC1	-0.022736
MAL	-0.022717
RAI14	-0.022710
MARCH7	-0.022696
TOP2B	-0.022649
C10orf2	0.022646
FZD9	0.022622
BCO1	-0.022616
LOC646626	0.022614
ARL6IP5	-0.022598
METTL7A	-0.022586
GOLGA4	-0.022537
SPG11	-0.022488
ETV4	0.022479
HBB	0.022452
ARID2	-0.022435
FAM171A1	0.022413
NDC80	-0.022402
BMPR2	-0.022393
FAIM3	0.022392
JAK2	-0.022377
ZNF614	-0.022369
CYBRD1	-0.022359
ZFX	-0.022358
HSDL2	-0.022333
SUZ12	-0.022325
CAT	-0.022320
RDH13	0.022298
GPSM2	-0.022282
OXR1	-0.022280
ZSCAN31	-0.022277
ARPC3	0.022262
FAM76B	-0.022255
C5orf51	-0.022241
TBK1	-0.022220
DUSP1	0.022185
IRS1	0.022170
KIAA1551	-0.022142
VGF	0.022109
DUSP5	0.022091
NUSAP1	-0.022042
CEP55	-0.022029
ZNF518A	-0.022005
GHR	-0.021979
WNT10B	0.021914
FAR1	-0.021884
ZNF148	-0.021877
CENPK	-0.021863
PDS5B	-0.021856
ELF1	-0.021836
CSRNP1	0.021828
CXorf28	-0.021817
C10orf67	0.021813
PAPOLA	-0.021784
MAFB	-0.021772
ATF7IP2	-0.021772
MAP4K5	-0.021769
PDIK1L	-0.021730
TRIM47	0.021728
FAM49A	-0.021701
RP2	-0.021691
CHURC1	-0.021672
PDGFD	-0.021657
PRR7	0.021648
MAP4K3	-0.021639
NCAPG	-0.021571
ELOVL6	-0.021560
TBC1D31	-0.021551
CAP2	-0.021551
CAND1	-0.021531
CCP110	-0.021512
PARP14	-0.021491
VMA21	-0.021480
SNX13	-0.021422
TXNDC16	-0.021412
AHI1	-0.021406
XPO1	-0.021338
HECTD1	-0.021320
SKAP2	-0.021286
ZHX1	-0.021274
AEBP2	-0.021256
SNCAIP	-0.021232
PSEN2	0.021204
JMJD1C	-0.021191
HES4	0.021169
KCTD3	-0.021160
RAB22A	-0.021154
UBXN4	-0.021123
LOXL3	0.021113
RBM25	-0.021104
SVEP1	0.021095
GLTP	-0.021028
CD2AP	-0.021028
DIP2B	-0.021009
BCYRN1	0.020996
IFIT2	-0.020975
STC2	0.020974
DTX3L	-0.020972
FEZ1	0.020967
C2CD5	-0.020958
ZNF324B	0.020942
RAP2A	-0.020910
DPY19L4	-0.020886
HBA1	0.020872
FA2H	-0.020862
SLMAP	-0.020835
ECT2	-0.020833
PCF11	-0.020828
FZD6	-0.020815
PJA2	-0.020808
SSR1	-0.020802
ANKIB1	-0.020802
NBN	-0.020780
SECISBP2L	-0.020774
RDX	-0.020703
AMOT	-0.020685
CUL2	-0.020681
CDH2	0.020673
UFSP1	0.020668
GLB1L2	0.020628
MAP3K8	-0.020619
GCA	-0.020576
CEP152	-0.020575
GPNMB	-0.020571
HELZ	-0.020549
MYLIP	-0.020543
AGGF1	-0.020532
PODXL2	0.020524
SLC30A7	-0.020524
MARCKSL1	0.020523
CPD	-0.020520
ARSK	-0.020461
VTA1	-0.020430
DDIAS	-0.020421
USPL1	-0.020354
LCOR	-0.020335
RALGPS1	-0.020297
CD3EAP	0.020288
TRMT1	0.020268
TMEM150A	0.020264
C14orf79	0.020262
DSG3	-0.020259
MORC3	-0.020247
TLR3	-0.020241
NAB1	-0.020238
DUSP6	0.020231
CERS6	-0.020218
RAB10	-0.020209
DHX29	-0.020208
TTC33	-0.020158
ADAMTS1	0.020158
TMX3	-0.020146
C10orf99	-0.020117
CASC5	-0.020100
SMC2	-0.020083
C5orf24	-0.020071
RGPD8	-0.020070
PVT1	0.020046
CENPQ	-0.020026
TOPBP1	-0.020008
NPR3	-0.020006
YTHDC2	-0.019981
FABP4	0.019979
NLE1	0.019954
WDFY1	-0.019941
UBE2Q2	-0.019940
INSIG1	-0.019924
PLAUR	0.019915
KRT80	0.019901
IDH1	-0.019866
CEP192	-0.019858
NKTR	-0.019843
SERTAD4	0.019836
UBLCP1	-0.019807
PLK4	-0.019798
FAM111A	-0.019774
PPWD1	-0.019770
FAM117B	-0.019733
VAMP7	-0.019730
KIDINS220	-0.019716
CLDND1	-0.019681
DNAJC13	-0.019654
NREP	-0.019638
C4orf33	-0.019626
CSTF2T	-0.019608
CYSRT1	-0.019606
ZYX	0.019599
KRT7	0.019592
SLC30A10	-0.019575
PIGK	-0.019564
SIPA1L2	-0.019563
DEPDC1B	-0.019563
C19orf24	0.019559
TAX1BP1	-0.019554
LRRC58	-0.019552
HCAR2	-0.019540
CTDSPL2	-0.019539
ATAD3A	0.019526
CCDC15	-0.019522
BMI1	-0.019521
ANKRD50	-0.019512
ITGAV	-0.019498
ARL5B	-0.019495
KBTBD8	-0.019481
CPA2	0.019439
RIF1	-0.019421
STAU2	-0.019418
SMEK2	-0.019387
C3orf58	-0.019384
TRAF2	0.019379
IBTK	-0.019376
SMC6	-0.019373
ALKBH2	0.019362
LTN1	-0.019339
FUBP3	-0.019328
CNTLN	-0.019321
GPC3	0.019312
EML4	-0.019308
KIT	-0.019305
CPTP	0.019297
KRTDAP	-0.019269
PES1	0.019265
EPM2AIP1	-0.019259
NPAT	-0.019237
CBR4	-0.019223
C6orf15	-0.019219
SCNN1A	-0.019218
CEP135	-0.019188
STX19	-0.019176
FRMD6	-0.019168
CSE1L	-0.019165
FHL3	0.019154
TRIM22	-0.019144
SEMA4D	-0.019136
NMRK1	-0.019135
MAP3K1	-0.019118
TNC	0.019110
NETO2	-0.019106
CCDC85B	0.019102
PLD6	0.019101
EPHA2	0.019084
FAM181B	0.019070
CBLC	0.019065
ACTA2	0.019040
PTPLB	-0.019039
LRP3	0.019032
MRTO4	0.019029
MXRA5	-0.019009