!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	curcumin
!smiles	COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
!pubchem_cid	969516
!cell_type	U937 monoctyes exposed to oxidative stress - 4 Hours
!organism	human
!end_metadata
ISG15	0.256447
CCL8	0.161240
IL1B	0.147149
MMP7	0.145014
CCL7	0.140308
NDUFA1	-0.133721
LYZ	-0.124553
IFIT3	0.122775
CAPG	-0.113029
FTL	0.108171
CXCL10	-0.107969
TYROBP	-0.107842
ALOX5AP	-0.102628
CCL1	-0.101734
IER3	0.101130
IFIT1	0.099261
TPSB2	-0.097307
IFI6	0.093543
TDO2	0.093130
BCL2A1	0.091719
HMOX1	-0.089594
S100A9	-0.088080
MT1HL1	0.086352
RPL34	-0.083942
BCAP31	-0.083246
PIM1	0.082441
RPS14P3	-0.078507
TIMP1	0.076337
S100A11	-0.073977
HMGN2	0.073136
RPS10	0.072764
SHFM1	-0.071693
H2AFZ	0.071292
NDUFB9	0.070790
MMP1	0.070693
RSAD2	-0.069092
IER2	0.068698
TRIB3	0.067956
HIF1A	-0.067451
RPL39	0.065113
RPL36A	0.064977
TUBB	0.064431
PCBP1	-0.062559
GPX1	-0.062248
FABP4	-0.062024
MCEMP1	0.061867
UQCRH	-0.061810
FABP5	0.061393
SRP14	-0.060467
COX1	0.059942
SEC11A	-0.059672
IFIT2	-0.059341
EMP3	0.059217
MAPK6	0.059071
RPS18	0.058358
ISG20	-0.057493
MT2A	0.056953
PSMA4	-0.056933
PLIN2	0.056750
RPL41	0.056592
PRDX1	-0.056341
NPC2	-0.055973
RPS25	0.055755
EEF1A1	0.055582
PPIB	-0.055446
TPT1	0.054957
MMP9	-0.054397
IFI30	0.054232
CCL5	-0.053996
COX2	0.053847
S100A8	-0.053035
SOD2	-0.052939
CXCL8	0.052884
MYD88	0.052856
TMSB10	0.052133
PSAP	-0.051374
DYNLL1	0.051162
TPSAB1	-0.050809
RGS2	0.050457
RPL12	-0.050358
SEC61G	-0.050156
TM9SF2	-0.049781
TBCA	-0.049510
FAU	-0.049310
CLEC5A	0.049307
PPIA	0.049096
OST4	-0.048909
B2M	0.048372
LDHA	-0.048345
GAPDH	0.048021
CCL4	0.047699
SPP1	0.047096
ND2	0.046425
RPS8	0.046321
BEX1	0.046250
TMBIM6	-0.045923
ANXA2P2	0.045188
ACTG1	0.044959
CHIT1	-0.044805
CCL2	0.044749
CXCL11	-0.044636
FTH1P5	0.044231
PSMD14	-0.043999
NSMAF	0.043940
RPS3	0.043697
SSR4	-0.043592
SLC7A7	-0.043230
RPSA	0.043142
TMEM123	0.042420
CHCHD2	-0.042390
ERH	-0.042318
RPL35	-0.041459
RPS4X	0.041278
CD52	0.041176
TALDO1	-0.041128
RPLP0	0.041063
TMEM258	-0.040756
ATP6	0.040247
RPL13A	0.039966
SUCNR1	0.039433
TAP1	-0.039407
IL6	-0.039013
NKG7	-0.038948
SERPINB2	0.038642
APOC2	-0.038184
HLA-A	-0.038134
ARF4	-0.037446
S100A4	0.037116
NARS	0.037004
MT1E	0.036845
FCGR2B	-0.036793
NDRG1	-0.036708
HLA-G	-0.036671
CD83	0.036572
HSPB1	-0.036293
ATP6V0B	-0.036246
IFI44L	-0.036206
CES1	-0.036173
IFI27	-0.035984
IFITM1	-0.035971
TNFAIP6	-0.035917
GLO1	0.035719
TNFSF10	-0.035666
FFAR2	-0.035636
SNHG6	-0.035581
FCAR	0.035407
ISCU	-0.035394
ARL6IP1	-0.035164
NQO1	-0.034768
TDP2	-0.034579
SLC38A2	0.034507
IRS2	-0.034433
RPL23A	0.034370
ARL6IP5	-0.034186
PTDSS1	0.034076
TM2D2	-0.033708
DAD1	-0.033406
THBD	0.033306
TMEM158	-0.033187
SAT1	-0.033030
WDR82	0.033011
UBC	0.032859
GADD45B	-0.032763
MRFAP1	-0.032752
RPL8	0.032536
AHRR	0.032454
PDK1	-0.032448
SF3B5	-0.032348
RPL24	-0.032264
COX7C	-0.032195
MORF4L1	-0.032159
TNFSF13B	-0.031933
NDUFA4	-0.031917
NPC1	0.031611
BLOC1S2	-0.031403
PROCR	-0.031132
PSMD8	-0.030836
SNX3	-0.030827
TMA7	-0.030625
S100A10	-0.030234
PPP1R18	0.029928
S100P	0.029868
RPL6	-0.029691
HSPA8	0.029674
PSMB3	-0.029580
GAS5	-0.029367
UBA52	-0.029299
SUGT1	-0.029237
SPPL2A	-0.029196
FLNA	0.029157
RPS11	0.028990
TMEM230	-0.028953
TRAM1	-0.028858
PFKFB3	-0.028702
CD63	-0.028697
SNRPD2	-0.028632
SELK	-0.028590
STAT1	0.028549
IL4I1	-0.028524
TKT	-0.028494
MMP12	-0.028421
PEA15	0.028220
SCP2	-0.028209
ABRACL	-0.028135
IL7R	-0.028013
PTTG1IP	-0.027989
LPXN	0.027934
PCNA	0.027898
FGR	0.027885
PSME1	0.027658
EIF3H	-0.027622
EIF3I	-0.027567
BZW1	-0.027535
GARS	0.027452
RPL10A	-0.027265
PSAT1	0.027256
SRXN1	0.027201
OAZ1	0.027167
ATF3	0.027150
TXNIP	-0.027087
MYL12A	-0.027063
SNHG1	-0.027003
ETHE1	0.026919
RPS29	-0.026753
MT1H	0.026686
EIF4A3	0.026685
GBE1	-0.026684
NACAP1	-0.026575
CXCL6	-0.026564
VIMP	-0.026424
KDELR2	-0.026415
FCGR2C	-0.026399
TTC19	0.026260
ATP5J	-0.026118
DUSP6	0.026007
LSM7	0.025986
CTSD	-0.025957
RPL11	-0.025955
LINC00657	0.025926
ANXA2	0.025677
CALM2	0.025653
SRGN	-0.025608
HLA-C	0.025574
HSPE1	-0.025492
EIF5	-0.025460
PPIF	-0.025430
TUBA4A	-0.025394
CD163	-0.025296
MGLL	-0.025291
SEP15	0.025235
SLC17A5	0.025235
TRMT112	-0.025168
PPP1R15A	0.025143
MX2	0.024935
MXD1	-0.024898
TUBA1C	0.024739
DTX3L	0.024712
RPL27	0.024649
LIMS1	0.024635
RPS20	0.024571
C6orf62	0.024551
TPM4	-0.024536
HSPA6	-0.024488
TXN	-0.024453
NCF1C	-0.024339
RPS23	0.024236
PLSCR1	0.024132
ODC1	0.024103
TM4SF1	0.024079
HNRNPC	-0.024014
UXT	-0.023968
RPL23	-0.023920
JUND	0.023789
TCEB2	-0.023731
FCER2	0.023705
MMP8	-0.023692
FCER1G	0.023676
HERPUD1	0.023601
ARPC5	-0.023590
RBBP7	0.023503
EMC4	-0.023482
IER5	0.023437
VIM	0.023323
TPD52L2	-0.023319
CHSY1	-0.023249
CHI3L1	0.023174
RPS27	0.023162
ZFAS1	-0.023143
CLIC1	-0.023089
RCBTB2	-0.022873
OSBPL8	0.022792
SLC7A11	0.022767
PDIA6	-0.022756
MTCH1	-0.022727
RPS28	0.022715
ARPC2	0.022637
OLIG1	-0.022555
MT1X	0.022529
UBL5	-0.022511
NME1	0.022500
GPNMB	-0.022406
TAF7	-0.022392
SRSF2	-0.022288
SQLE	0.022236
ABHD17C	0.022199
LYN	-0.022021
DYNLT1	-0.021974
HCAR3	-0.021954
GABARAP	-0.021934
HADHB	0.021920
CSTA	0.021905
HSP90B1	-0.021729
RPL28	0.021726
LAPTM4A	-0.021699
CD14	-0.021697
SLA	-0.021692
RABAC1	-0.021676
LY6E	-0.021643
RPS27L	-0.021629
CYTIP	0.021628
ERP29	-0.021596
PSMA6	-0.021555
TOR1B	-0.021540
OSTC	-0.021493
ADI1	-0.021489
YWHAG	0.021436
SLC1A4	0.021426
LAMP2	-0.021396
RGS16	-0.021378
PLAU	-0.021338
FAM96A	-0.021278
ETFA	-0.021264
ZC3HAV1	0.021165
CORO1C	-0.021164
TMED2	-0.021128
SERTAD2	0.021061
DPM1	0.020953
CLEC2B	-0.020915
SERP1	-0.020850
HUWE1	0.020843
IFI16	0.020801
NPTN	-0.020776
HEXA	-0.020712
AQP9	0.020694
ADM	-0.020666
MTHFD2	0.020586
SNRPG	-0.020557
PTMA	0.020537
CSGALNACT2	0.020490
MORF4L2	-0.020469
HLA-F	-0.020444
GM2A	-0.020440
EIF2AK2	0.020381
RPS26	-0.020258
VKORC1	-0.020073
MMP3	-0.020066
EMR1	-0.020037
ATP6V1E1	-0.020013
SERF2	-0.020007
FXYD5	-0.019995
MAN2B1	-0.019931
COX3	0.019871
LYSMD2	-0.019847
PSMD11	-0.019841
TRIM25	0.019694
TGFBR1	0.019671
OLR1	-0.019627
CD99	-0.019564
EIF4A2	-0.019558
PNN	-0.019534
CXCR4	-0.019516
PRDX5	-0.019421
SNHG5	0.019417
NFE4	0.019364
SLC20A1	0.019357
EEF1D	-0.019341
CD36	0.019287
INSIG1	0.019264
COX6C	0.019212
SNRPB2	0.019145
ITM2B	-0.019135
NAMPT	0.019126
HMGB2	0.019095
CXCL3	-0.019095
VAT1	0.019065
KIAA0101	0.019022
RPL4	0.019014
MIR22HG	-0.019009
RPL7L1	0.018970
ITGB2	0.018928
MGAT4B	0.018924
H3F3B	0.018917
RPS24	0.018867
FUCA2	-0.018776
GBP1	-0.018775
FN1	-0.018693
CDKN1A	0.018632
GPR183	-0.018614
CITED2	0.018582
NUDT19	0.018559
LASP1	0.018552
RPL36	-0.018550
TMCO1	-0.018472
MOB4	-0.018447
TRIM22	-0.018443
PSMB4	-0.018437
MIR21	-0.018385
RILPL2	-0.018272
HNRNPH1	0.018269
MIR155HG	0.018244
RRM2	0.018244
HCK	-0.018223
TRMT5	0.018221
EMP1	-0.018169
ATP6V1B2	0.018105
TXNDC12	-0.018090
SEC61B	-0.018052
C20orf24	-0.017973
ATP5J2	-0.017919
CKS2	0.017914
RAB13	-0.017886
PSMA1	0.017851
TUBB4B	0.017833
PSMA3	-0.017798
LOC100129361	-0.017747
RNF149	-0.017740
TNFRSF10B	0.017697
SNX10	-0.017694
TMED3	-0.017573
HDAC1	0.017564
MRPL32	-0.017563
SAMD9	-0.017563
CPOX	-0.017526
SRPK1	-0.017506
PSMB1	-0.017451
ASAH1	-0.017427
CEBPB	0.017426
SHISA5	0.017397
PLAUR	0.017379
ATP6V0D2	-0.017379
NACA	-0.017355
C16orf54	-0.017347
HPCAL1	-0.017264
BAMBI	-0.017259
PSMC6	-0.017239
NDUFS2	0.017214
EID1	-0.017202
MESDC1	0.017145
ATP6V1F	-0.017142
TOP1	-0.017140
TMEM14B	-0.017134
NAP1L1	-0.017125
RASSF2	0.017123
DUSP10	-0.017121
ENC1	-0.017116
COPS5	-0.017090
C3AR1	-0.017062
EGR1	0.017058
RPS15	0.017030
LRIF1	0.016996
IRAK1	0.016995
UBE2L6	0.016991
RAB1A	0.016988
USP18	-0.016941
PYGL	0.016907
RPS6	-0.016881
DEDD2	0.016845
RPL37A	0.016818
DBI	-0.016716
DNAJA1	-0.016707
SNRPC	-0.016648
MRPS24	-0.016635
GPR34	-0.016629
RSRC2	-0.016625
MT1F	0.016575
ATP1B3	0.016570
IFI44	-0.016526
UBE2Z	-0.016517
KPNA2	0.016446
RPS21	-0.016441
CD163L1	-0.016415
HLA-B	0.016296
HIST1H2AC	0.016290
GNA15	-0.016281
TUBB6	0.016262
COX5B	-0.016234
MLKL	-0.016206
ACSL1	0.016109
SLC1A5	0.016108
SOD1	-0.016106
METTL9	0.016082
UPP1	-0.016053
LDHB	0.016050
MMP10	-0.016038
ATP5I	-0.016019
EIF2S1	-0.016008
GLB1	-0.015989
SF3B6	-0.015980
AGPAT9	-0.015960
KARS	-0.015879