!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Estradiol
!smiles	CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
!drugbank_id	DB00783
!pubchem_cid	5757
!cell_type	NA
!organism	human
!end_metadata
PLAC1	0.120835
IL17RB	0.088158
HCAR3	-0.087342
PALMD	-0.080056
HCK	0.077517
MME	-0.077265
WISP2	0.076458
EGR3	0.074103
CYP26B1	0.071503
OLFML3	0.070879
TNFRSF11B	-0.069499
ABHD2	0.068982
ELF5	-0.066486
SGK1	0.063298
MYBL1	0.063173
FRK	0.060407
RET	0.059785
CELSR2	0.059048
CERK	-0.056613
FAM110B	-0.056538
PLCL1	0.056506
CDH18	-0.056503
KIAA0226L	0.056467
NAV2	0.055811
IGFBP4	0.054901
TIPARP	0.054345
CXCL12	0.053918
RAPGEFL1	0.053323
PRSS23	0.053182
TBX3	-0.053119
BLNK	-0.052370
IER3	-0.052210
PLAT	0.051895
RAB31	0.051378
KMO	-0.051212
MAMLD1	0.050572
SYBU	0.048966
GRB14	-0.048830
ST6GALNAC5	-0.048772
KCNJ8	-0.048166
BFSP2	0.047867
NPY5R	0.047225
NR3C1	-0.047078
CALCR	0.046653
SLC47A1	0.046571
HOXC5	0.046114
PDLIM3	0.045951
NR5A2	0.045809
FOS	0.045217
ANXA9	0.045182
PGR	0.044194
DRAM1	-0.043980
TPD52L1	0.043723
FOXC1	0.043588
IL1R1	-0.043536
LIMA1	-0.042983
SHH	0.042909
COL21A1	0.042863
AGTR1	-0.042738
PLK2	-0.042706
SGCG	-0.042481
LMCD1	-0.042296
ISG20	0.042022
SLC22A5	0.041677
PITPNC1	0.041556
ANKRD11	0.041239
TMEM45A	-0.041125
CXCR4	-0.040989
NXPH3	0.040880
GHR	-0.040659
HEY1	-0.040576
NT5DC3	0.040277
SLC22A4	0.040248
PTCD2	0.040204
ATP8A2	-0.039962
RNF43	-0.039858
KIAA0922	-0.039626
HIST1H4D	-0.039457
METTL1	0.039433
TCF7L1	-0.039017
CA5B	-0.038956
SLC19A2	0.038852
ERBB4	-0.038744
AGO4	-0.038713
HIST1H2BG	-0.038311
UPK1A	-0.038074
SEMA3E	-0.038031
SLC29A1	0.037997
ANKRD36B	0.037846
TNS3	-0.037837
EFNA1	-0.037827
BIK	-0.037573
CAV1	0.037501
RAB30	0.037470
TSPAN12	-0.037341
PAPSS2	0.037210
DDX10	0.037121
ABCA12	-0.036935
RPRM	-0.036935
ATP8A1	-0.036603
PTGER2	-0.036461
ACSS3	-0.036126
HESX1	-0.036040
RHOH	-0.036019
HOMER2	0.035874
PMAIP1	0.035812
SOX5	0.035776
EFEMP1	-0.035456
METTL8	0.035412
TMA16	0.035296
AIM1	-0.035245
KYNU	-0.035172
OLFML2A	0.034897
LRP8	0.034833
CTNND2	-0.034794
CITED1	0.034791
STON1	-0.034704
LRRFIP2	0.034676
SOCS2	-0.034546
STYK1	0.034540
FHL2	0.034516
SLC7A5	0.034344
HEY2	0.034019
FKBP4	0.034001
ACKR3	-0.033928
DIO1	0.033915
HIPK2	0.033862
ANXA3	-0.033533
FKBP5	0.033434
NUAK1	-0.033308
PMP22	-0.033129
TPK1	-0.033029
KAL1	-0.033017
MICB	0.032920
SLC35E2	0.032859
NEAT1	0.032721
TGFB3	-0.032684
DEPTOR	0.032607
NOTCH2NL	0.032476
CHST8	0.032464
MARK1	-0.032399
FAM134B	-0.032213
CXXC4	-0.032160
LYPD3	-0.032139
LAD1	0.032085
ELF1	0.032068
KANSL1L	-0.032068
KCNJ13	-0.032029
C3orf52	0.031913
CTF1	-0.031816
ITPR1	-0.031759
ARSJ	0.031753
EFHD1	-0.031701
FAM216A	0.031677
HSPB6	-0.031528
HOPX	-0.031432
ZNF750	-0.031371
FBN2	-0.031335
FJX1	0.031232
RND1	-0.031205
RLN2	0.031204
SLC6A6	0.031135
PTGES	0.031091
C11orf63	-0.031068
GNAI1	-0.031025
PTGER3	0.031000
FAM189A2	0.030982
TMEM164	0.030921
NBEA	-0.030911
PLA2G16	0.030776
SPRY1	-0.030655
SLIT2	-0.030637
GTF2IRD1	-0.030598
ST8SIA4	-0.030541
NMRK1	0.030508
TIAM1	0.030488
SASH1	-0.030483
DOCK4	0.030434
CYBRD1	-0.030301
UGT2B15	0.030166
LIN7A	-0.030019
FAM105A	-0.029934
HELLS	0.029906
BHLHB9	-0.029885
KITLG	-0.029879
MB	-0.029863
TIPIN	0.029830
CADM1	0.029821
PYCRL	0.029750
NKAIN1	0.029738
C10orf2	0.029723
TPST1	-0.029688
LINC00341	0.029679
PPP2R2A	0.029658
PPIF	0.029639
SACS	0.029525
BTG2	-0.029432
DDX21	0.029394
PRLR	0.029374
UTRN	-0.029313
MAN1A1	0.029267
PSD3	-0.029256
LITAF	-0.029175
TMEM135	-0.029163
ASB9	-0.029082
CD55	-0.028964
GREB1	0.028937
P4HA2	0.028922
TSEN2	0.028844
ELOVL2	0.028751
PDZK1	0.028738
P2RY2	0.028644
PCP4	0.028643
SDC2	0.028630
MAPK8	-0.028625
KRT23	-0.028533
MITF	0.028528
ARID5B	-0.028475
SHROOM2	-0.028444
SLC12A5	-0.028429
CA12	0.028355
HOXC4	0.028343
RCBTB2	-0.028139
HOXC6	0.028099
ZC4H2	-0.028094
KIAA0513	-0.028089
PDE5A	-0.028085
LIF	0.028033
MUC1	-0.027978
ABCC5	-0.027940
CUEDC1	0.027896
HSPB8	0.027734
CCNT1	0.027720
LIMCH1	-0.027552
STK16	-0.027493
NELL2	-0.027489
FHIT	-0.027451
PDZD2	-0.027416
HAS2	0.027409
TIMP3	-0.027344
HIST1H2AI	-0.027311
SLC9A3R1	0.027270
MCM10	0.027269
WFS1	0.027267
JAM2	-0.027183
TRMT2B	-0.027155
DHRS11	0.027148
HIST1H2AC	-0.027111
SYNDIG1	0.027111
CAPN15	0.027110
KLF4	0.027011
TFPI	-0.026985
ID3	-0.026938
CLMN	-0.026910
CYFIP2	-0.026896
TDRD1	0.026826
PARD6B	0.026824
ALDOC	0.026759
GPR65	0.026675
NPY1R	0.026638
CAMTA1	0.026636
FAM120C	0.026545
PARP8	-0.026502
LRIG1	0.026314
UGT8	0.026074
APOLD1	-0.026059
BAMBI	-0.026019
PCTP	-0.026002
NAA15	0.025995
UGDH	0.025933
PAIP2B	-0.025809
ABCG1	-0.025804
AKR1C2	0.025693
PKP2	-0.025655
KCNK15	0.025550
C14orf132	0.025514
B4GALT2	0.025509
MMD	-0.025503
CCNG2	-0.025458
ZNF280D	-0.025452
KCNK5	0.025332
ZNF10	-0.025294
ENPP2	0.025285
CLSTN2	-0.025264
MIR22HG	0.025255
TNIK	0.025246
SIDT1	-0.025227
ZNF185	0.025222
TRMT2A	0.025209
CBX4	-0.025201
TGFBI	-0.025197
MYOF	0.025191
HDAC5	-0.025180
CLN3	-0.025177
WWC1	0.025141
IL6ST	0.025112
URB2	0.025098
PYCR1	0.025088
TFAP2C	0.025045
NBL1	0.025042
ACADSB	-0.025001
DACH1	-0.024997
ELF3	-0.024932
FGF13	-0.024871
FZD4	-0.024840
KPNA5	-0.024761
SSBP2	-0.024742
PCOLCE2	0.024724
SLC16A6	0.024719
MICAL2	0.024705
MCOLN3	-0.024685
NVL	-0.024539
PCDHB8	0.024525
NRIP1	0.024525
ING4	-0.024477
GSAP	-0.024466
ABCB4	-0.024457
FAM63A	0.024452
DTL	0.024450
PMCH	0.024417
ZNF124	0.024349
MIA3	-0.024348
TNFSF10	0.024307
MAN2C1	0.024268
RAB40C	0.024251
C11orf24	0.024230
GNA14	0.024209
RBBP7	0.024180
SLC7A1	0.024166
AEN	0.024114
NOLC1	0.024105
STC2	0.024060
PIM1	0.024032
HHAT	-0.024032
CYP4F11	0.023997
RPP25	0.023983
RNASEL	0.023944
DUSP10	-0.023845
BCAR3	-0.023831
C11orf95	-0.023829
TRIM68	-0.023825
SLC9A1	-0.023731
PLCB4	-0.023730
NOC3L	0.023723
CERS4	-0.023696
PELI1	0.023674
GPR37	-0.023642
PRPS1	-0.023632
RASSF2	0.023630
EPB41L5	-0.023607
MED24	0.023606
CCDC28A	-0.023563
TAF4B	0.023523
ZNF37BP	-0.023434
JAK2	0.023425
DNAJC22	-0.023422
PUS7	0.023365
ABCE1	0.023360
MBOAT2	-0.023348
ZNF345	-0.023320
SUSD4	0.023314
PCDH8	-0.023246
TAZ	0.023243
EPS8	-0.023216
HIST1H3H	-0.023205
EFNB2	-0.023130
SLC26A2	0.023127
GALNT10	-0.023110
KCTD12	0.023104
PCYT2	0.023103
ZDHHC7	-0.023024
CDC42EP1	0.023006
RARRES2	0.022996
SLC16A4	-0.022966
ESF1	0.022939
GPR126	-0.022902
NR1H3	-0.022898
SNX24	0.022881
MIOS	-0.022852
MAP6D1	0.022807
TUBBP5	0.022742
RUNDC3B	-0.022719
LPHN2	-0.022549
PRSS8	-0.022498
MCM6	0.022468
UGT2B17	0.022460
LINC00963	-0.022400
SMG1	0.022384
AHNAK2	-0.022369
HIST2H2BE	-0.022369
RAMP3	0.022308
PTPRE	0.022268
FLNB	0.022238
TMLHE	0.022237
DGCR11	0.022233
CDH3	-0.022227
ID1	-0.022211
MET	0.022199
ARMC6	0.022195
WDR62	0.022115
COA7	0.022112
FICD	0.022112
NADSYN1	0.022105
PDSS1	0.022084
FABP5	0.022064
RBM41	0.022052
HILPDA	-0.021976
ZNF652	-0.021956
AUNIP	0.021949
LIFR	-0.021943
FAM57A	0.021923
SPIN1	0.021914
RBM47	-0.021903
ERMAP	-0.021882
DDIT4	-0.021862
MSMB	0.021798
EGR2	0.021792
NR3C2	-0.021784
SIK1	-0.021763
THAP9-AS1	0.021728
HLA-DMA	-0.021710
SERPINF1	0.021659
PLAGL1	0.021657
NT5E	-0.021628
SERPINA1	0.021599
MRTO4	0.021583
MACF1	0.021559
NCS1	0.021517
TMEM51	0.021516
HIST1H2BC	-0.021479
SELENBP1	-0.021419
LTBP2	0.021413
KIAA0355	-0.021361
ZNF271	-0.021348
ITGA2	0.021338
FAM169A	0.021302
TOX3	-0.021266
SERPINB1	-0.021249
AMIGO2	-0.021235
SENP2	-0.021171
RND3	-0.021171
ZNF442	0.021170
ZNF480	0.021114
RTN1	-0.021111
COL16A1	0.021073
PIK3IP1	-0.021024
HIST1H4E	-0.021015
ARHGAP11A	-0.021013
VCAN	0.021012
ALDH4A1	-0.021007
NAB2	0.020897
CDC6	0.020860
LINC00339	-0.020848
UNC119	0.020813
MBTPS2	0.020806
PCDH9	-0.020785
DIAPH2	-0.020736
SLC16A7	0.020732
CTPS1	0.020698
MED9	-0.020698
NOL6	0.020684
TRAM2	-0.020683
RMND1	-0.020666
PPAP2C	-0.020629
PHACTR4	-0.020625
DHCR7	0.020602
PAQR4	0.020599
ARHGEF40	-0.020585
MGP	0.020581
SEMA3B	0.020466
CTR9	0.020452
TBX2	0.020451
PTPRK	-0.020446
HIST1H3B	-0.020416
SERPINA3	0.020371
LINC00342	0.020370
MYC	0.020345
CTGF	-0.020343
AMD1	0.020288
GPR87	0.020282
IPO4	0.020275
KIR2DL5A	-0.020247
OSBP2	0.020228
PHLDA1	0.020178
RAB27B	-0.020141
MEIS2	-0.020112
FKBP1B	-0.020095
WASF2	-0.020092
TBC1D31	-0.020050
FMO5	-0.020043
OSGIN1	0.020031
DYNLT3	0.020029
TBC1D19	-0.019936
ARHGEF26	-0.019919
TCERG1	0.019896
GNAZ	0.019887
OSTF1	0.019879
SLC12A2	-0.019870
ETV6	0.019842
ZNF225	-0.019836