!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Temozolomide
!smiles	CN1C(=O)N2C=NC(=C2N=N1)C(=O)N
!drugbank_id	DB00853
!pubchem_cid	5394
!cell_type	U87
!organism	human
!end_metadata
SERPINB2	-0.064385
TXNIP	0.057334
IGFBP3	0.056361
CDKN1A	0.047928
DAPK3	-0.045732
HMOX1	-0.045414
TGFA	0.041914
PRR7	-0.036931
VTRNA2-1	-0.036505
PREX1	-0.035826
FLNA	-0.035028
LIF	-0.034950
ACTA2	0.034886
IL1B	-0.034816
DUSP6	-0.034386
RNY4	-0.033791
SLC16A6	-0.033699
RNA28S5	-0.033100
AMY1C	-0.032986
CXADR	0.032848
GNAI2	-0.032725
ZP1	0.032495
ARHGDIA	-0.031992
DRD5	0.031636
PEBP1	-0.031205
PPP1R15A	-0.031110
SPATC1L	-0.030997
HS1BP3	-0.030823
CA9	0.030823
CLCN7	-0.030760
PTGS2	-0.030726
SGTA	-0.030678
STOM	0.030386
FAM210B	-0.030279
PFKFB4	0.030193
NOV	-0.029850
RND3	-0.029468
KIF2C	0.029415
TRIM22	0.028973
RRAGD	-0.028721
DSCC1	0.028510
AKR1C3	0.028336
MAP1S	-0.028112
SPAG4	0.028016
ZNF395	0.027978
CCNB2	0.027885
SSNA1	-0.027779
ALDOC	0.027551
NPC1	-0.027200
IGFBP1	-0.027075
ADAMTS1	-0.027046
COL7A1	0.026952
SYNC	-0.026857
RRP12	-0.026825
GRINA	-0.026772
SPRY2	-0.026705
AQP9	-0.026679
RRM2	0.026584
RASSF7	0.026541
WBP2	-0.026538
HNRNPA3P1	-0.026366
RPS28	-0.026320
TRIM47	-0.026206
ID3	0.026148
GCNT3	-0.026139
BLK	-0.026113
TTC28-AS1	0.025998
MEG3	0.025917
TRAPPC5	-0.025719
CDK2	0.025564
RNPEPL1	-0.025274
SPDL1	0.025254
PPDPF	-0.025241
ID2	0.025224
LOC340357	-0.025218
NDUFAB1	-0.025217
CHCHD10	-0.025046
CD99L2	0.024924
TRUB2	-0.024681
RDH5	0.024653
ERO1L	0.024636
AGTRAP	-0.024573
RNA18S5	0.024554
CEBPZ	-0.024544
SLC38A6	-0.024488
TFPI2	-0.024486
IGF2BP1	-0.024315
PNLIPRP3	-0.024268
VTI1B	-0.024214
RPS4Y1	-0.024212
C19orf70	-0.024120
UBE2T	0.024041
ATF7	0.024019
PGM1	0.024013
RWDD2B	-0.024012
JOSD2	-0.023959
JUN	-0.023902
CLPTM1	-0.023890
NBAS	0.023876
MAP3K11	-0.023848
NDRG1	0.023831
AEN	0.023669
ZNF337	0.023625
SNX27	0.023584
RRM2B	0.023581
MPDU1	0.023574
CDH4	-0.023560
NUTM2A	0.023464
SERTAD1	0.023449
C12orf45	0.023419
CPT1C	0.023408
FANCI	0.023370
TMEM223	-0.023349
CSF3	-0.023292
GDF15	0.023276
SPRYD3	0.023246
CHIC2	-0.023206
NAGLU	-0.023153
PLEKHO1	-0.023114
ADAM9	0.023053
YEATS4	-0.023004
SNHG7	-0.022995
RAD23A	-0.022975
DKC1	-0.022950
RRS1	-0.022924
PTTG1	0.022920
DIMT1	-0.022904
CLIC1	0.022895
CDT1	0.022867
TBX2	-0.022855
RANGAP1	0.022708
LXN	0.022694
DCAF8	0.022646
MIR877	-0.022605
PPP1R14A	0.022495
TWF2	-0.022466
PPP1R14B	-0.022466
ID1	0.022437
CEND1	-0.022388
CXCL2	-0.022298
MRPL12	-0.022273
FTH1	-0.022192
PRDX4	0.022189
RCC2	0.022181
EXOSC4	-0.022176
COG4	0.022142
RAB6B	0.022098
MFAP1	0.022088
SUGCT	0.022068
SECTM1	0.022050
SESN1	0.022023
CDC42EP2	0.021975
CLEC4M	0.021972
KTI12	-0.021950
MRPS30	-0.021904
APBB1IP	-0.021862
TRIM68	0.021857
SHC3	-0.021831
DDB2	0.021824
DAO	0.021751
GFER	-0.021734
ADAMTS8	0.021645
SPOCD1	-0.021644
C12orf5	0.021642
MIR659	0.021628
PPM1J	-0.021526
MIR134	0.021499
CRYZ	-0.021495
CARHSP1	0.021457
DPCD	0.021444
HLA-H	0.021413
TTC17	0.021407
QSOX2	0.021378
DDIT4	0.021347
TMEFF2	0.021333
PAQR3	-0.021299
E2F2	0.021297
DAW1	-0.021265
INSIG1	-0.021231
PMVK	0.021181
KIF20A	0.021166
LYSMD2	-0.021156
HSPB6	-0.021135
ERGIC1	-0.021133
PLEKHN1	-0.021114
KRT10	-0.021097
HS6ST2-AS1	0.021088
IRS1	-0.021086
PLOD1	0.021084
MGME1	0.021044
RRAS	0.021029
SNORD19B	-0.021003
FADS3	-0.020963
NFKBIB	-0.020928
BIVM	-0.020870
PA2G4	-0.020817
OAZ2	0.020801
UBXN1	0.020757
NUDT1	0.020679
LTBR	-0.020647
C5orf15	0.020590
KIAA1522	-0.020568
FTH1P3	-0.020547
TMEM45A	0.020527
SYNCRIP	-0.020506
TMEM63B	-0.020488
IER2	-0.020482
PRR11	0.020479
GUCD1	0.020474
UTP18	-0.020471
DNAH7	-0.020465
EVI5L	0.020423
FAM212B	0.020414
XPC	0.020380
MTMR11	0.020377
C2CD2	-0.020374
MSX1	-0.020287
QTRT1	-0.020284
CMBL	0.020281
IL11	0.020262
PLAU	-0.020252
DHCR7	-0.020231
SIK1	-0.020195
PGM5-AS1	0.020191
MKL2	-0.020179
IGFBP6	-0.020068
TFAP2E	0.020042
DAGLB	0.020029
DDX39A	-0.019996
RBM42	-0.019979
SERPINA3	0.019961
PACS1	-0.019943
PTMS	-0.019883
FCRLB	-0.019857
RASD2	0.019845
CCL8	-0.019823
FETUB	0.019814
DGCR6L	0.019808
CST3	-0.019797
YTHDF2	-0.019777
GPNMB	-0.019766
CCDC60	-0.019759
SDF2L1	-0.019758
THPO	-0.019728
MTDH	-0.019680
HIRIP3	0.019672
CDC42EP4	0.019663
BNIP3	0.019662
NRIP1	-0.019654
PRDM15	-0.019653
TNP1	0.019594
MUM1	0.019543
OR8K3	-0.019534
HPS6	0.019488
SLC25A13	-0.019478
KANK2	0.019463
ACAA2	0.019458
TNFRSF9	-0.019442
MAP3K14	-0.019440
SYNJ2BP	0.019426
STT3A	0.019410
HEMK1	0.019403
MT1M	-0.019401
GPR135	-0.019374
GPI	0.019328
MIR1282	-0.019324
DUSP5	-0.019323
EMP3	-0.019297
MMP1	-0.019280
WDR54	0.019276
STAC2	-0.019261
RBM4B	0.019260
SCIN	0.019248
THBS3	-0.019237
FAM53C	0.019213
PTPMT1	-0.019196
MIR578	-0.019185
DLX3	0.019168
SRM	-0.019140
SCAP	0.019137
TPM4	-0.019135
PEPD	-0.019130
VPS51	0.019117
PCNX	0.019111
TBC1D17	-0.019081
TRMT1	-0.019071
RNASE6	0.019068
RPS19BP1	-0.019045
POF1B	0.019029
HLA-B	0.019019
TMEM205	0.018993
ARC	-0.018987
TAOK1	-0.018971
EHBP1L1	-0.018953
DCUN1D3	0.018934
CLN3	-0.018930
TARS	-0.018896
CCDC124	-0.018892
MMP3	-0.018856
LOC100130093	-0.018848
MIR658	-0.018822
KPNB1	-0.018811
COPG2	-0.018803
FPR1	0.018782
SLC25A10	0.018776
CCDC107	-0.018765
SMOC1	0.018758
KIAA0196	-0.018755
POLR3D	-0.018755
RHNO1	0.018736
TAP1	0.018719
CAMTA2	-0.018714
MTA1	-0.018705
C19orf60	-0.018692
VAT1	-0.018690
TNC	-0.018686
HKDC1	-0.018677
LMAN2	0.018669
C17orf74	-0.018662
WBSCR22	0.018646
METRN	-0.018635
ZNF593	-0.018614
EHD1	-0.018613
SGSM2	0.018572
HSPBP1	-0.018550
DNAJC5G	-0.018544
EMC2	-0.018544
KRT36	-0.018538
PEX11G	0.018531
ALKBH7	-0.018512
TRIM8	0.018484
PTGES	-0.018473
CNTNAP3	-0.018468
U2AF1	-0.018443
ABCA11P	0.018439
ASB16	0.018427
KIF4A	0.018417
SLC11A2	-0.018362
DUSP1	0.018354
MXD4	0.018343
PKHD1L1	-0.018342
ANKRD34A	-0.018331
KRT75	-0.018276
RXRB	0.018242
HSPA4L	0.018236
ENO2	0.018223
TROAP	0.018219
KLHDC3	0.018203
SPNS3	-0.018175
C17orf53	0.018155
NDUFB10	-0.018148
MAP2K2	-0.018146
PCDHGA12	-0.018132
SLC35E4	-0.018130
HSD17B8	0.018104
HLA-DMA	0.018102
LOC283332	-0.018099
TSFM	0.018089
CYB5A	0.018075
DOK1	-0.018051
ACTN4	-0.018035
HSD17B14	-0.018021
ESRRA	-0.018020
RERG-AS1	-0.017996
GRAMD2	-0.017994
DNAJC24	-0.017975
NARF	0.017953
TTYH3	-0.017952
GSTO1	-0.017940
PPP6R1	-0.017928
MYO1F	-0.017901
TGM4	-0.017854
SLC1A3	0.017854
FAM131A	0.017842
FAM86HP	-0.017829
PLB1	0.017810
HACL1	0.017808
MIF4GD	0.017804
STX4	-0.017792
ABHD5	-0.017784
C1orf123	0.017760
KCTD8	-0.017751
NFIX	-0.017727
PRKAR1B	-0.017725
RAB3IL1	-0.017723
NIPA1	0.017686
PIN1	0.017672
MIR1185-1	-0.017648
AP5S1	-0.017642
PTDSS2	-0.017639
CKAP4	0.017630
FAM214B	-0.017609
TST	0.017606
CHD1L	0.017575
POLD4	0.017573
PTGES3	0.017569
NUSAP1	0.017557
VPS4A	-0.017556
BTG2	0.017555
SPTAN1	0.017553
GRHPR	-0.017551
NCAN	0.017541
FAM111A	0.017517
PTMA	0.017517
RPS6KA4	-0.017502
DIRC1	0.017494
CFP	-0.017476
TSR3	-0.017475
MRPL15	-0.017460
TMUB1	-0.017447
ENDOG	-0.017431
FUNDC1	0.017424
FAM183CP	0.017424
CACNA1C-AS4	0.017417
GAGE2E	0.017387
MBOAT7	-0.017384
FOXO1	0.017370
IGFBP7	0.017348
USP39	0.017335
GOLGA6L6	0.017324
BLCAP	0.017307
TMEM192	-0.017302
TARM1	0.017296
CAGE1	-0.017293
TRPC4	-0.017293
TMEM59	0.017254
CBX1	-0.017253
RPS3	0.017232
LINC00200	-0.017212
NLGN2	0.017211
TATDN1	-0.017205
PFKFB3	0.017203
MRPL34	-0.017194
AGK	-0.017175
MGAT4B	-0.017155
USF2	-0.017122
PLAGL2	0.017104
ASH2L	0.017104
KARS	-0.017093
RSPRY1	0.017087
PSMD3	0.017074
MSANTD3	-0.017052
NSFP1	-0.017050
ZCCHC9	-0.017033
ARHGEF5	-0.017031
KRTAP1-5	-0.017028
FAM86C1	-0.017026
SERPINE1	-0.017017
BRF2	-0.017013
MAP3K9	0.017000
TNP2	-0.016990
IMP4	-0.016985
ADAMTS15	-0.016970
LOC100128573	-0.016961
ARL8B	-0.016946
CALM3	0.016938
FAM162A	0.016926
CYBA	-0.016923
KCTD11	0.016918
TRIM51	-0.016916
MITD1	-0.016912
PLOD2	0.016907
CBX5	-0.016903
FGF2	-0.016899
TDRP	-0.016896
GGT3P	-0.016886
LASP1	0.016879
LRRTM4	0.016858
SPC24	0.016855
CALR	-0.016844
LOC730101	0.016841
NDUFB7	0.016829
C1QBP	-0.016829
FADD	-0.016819
TAL2	-0.016793
BUB1B	-0.016793
NISCH	0.016769
CHST10	-0.016761
ST8SIA2	-0.016743
ZNF768	-0.016727
COPB1	-0.016724
UBALD1	-0.016721
SH3BP5L	-0.016716
FEN1	0.016705
DHX30	-0.016694
B3GNT3	0.016688
FHL3	0.016682
SAT2	-0.016681
H3F3C	0.016681
PAPPA	-0.016680
STX5	0.016655
PRDM13	-0.016640
TMEM89	-0.016639
MIR609	-0.016635
BRI3	-0.016628
SCAF1	-0.016626
SLC31A1	-0.016613
MRPL32	0.016604
ZNF699	0.016585
CRIP3	-0.016580