!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Vemurafenib
!smiles	CCCS(=O)(=O)Nc1ccc(c(c1F)C(=O)c1c[nH]c2c1cc(cn2)c1ccc(cc1)Cl)F
!drugbank_id	DB08881
!cell_type	SW1736  thyroid cancer cell line (vemurafenib-refractory cell line) - 6 Hours
!organism	human
!end_metadata
CTGF	-0.079738
FOSL1	-0.077993
LMO1	0.077283
SPRY2	-0.075936
CYR61	-0.073157
EMP1	-0.070835
THBS1	-0.067562
DDIT4	0.066985
NNMT	0.065772
LDLR	-0.065268
ANKRD1	-0.059902
TMEM158	-0.059743
ETV5	-0.058893
EVA1A	-0.055430
RGS4	-0.055209
F3	-0.054981
LINC00704	-0.053581
SLCO4A1	-0.052372
TMEM200A	-0.052257
FJX1	-0.052073
MYC	-0.051236
CEMIP	-0.051204
NUPR1	0.050742
BCL3	0.049125
IL6	-0.048556
TFAP2C	-0.047879
ELF3	0.046964
LAMA5	0.046931
PHLDA1	-0.046803
CITED2	0.046388
SHISA2	-0.045719
STX1A	-0.045486
PLLP	-0.045392
C1orf106	-0.045016
SLC20A1	-0.044575
SPRED1	-0.044307
LIF	-0.044270
ACTBL2	0.043829
CFB	0.043452
PLAT	-0.043260
ASNS	0.043206
MLPH	-0.042538
ABCA1	0.041912
CEBPD	0.041239
CBLB	0.041099
RARRES3	0.040732
SLC25A19	-0.040575
IL1B	-0.039690
EPHA2	-0.039563
LXN	0.039286
ARID5B	0.038829
DNAJB6	-0.038675
MRTO4	-0.038591
BCL2L1	-0.038313
G0S2	-0.038092
ALDH1A3	-0.037803
GFPT2	0.037627
PLAU	-0.037161
EFNA1	0.037094
CCND1	-0.036744
AKR1C3	0.036610
CD44	-0.035779
MIR221	-0.035727
IFITM1	0.035495
LRIG1	-0.035203
ARHGAP22	-0.035183
CLDN1	-0.035092
TOR3A	-0.034743
SFXN1	-0.034726
NFIL3	0.034717
ID3	0.034575
AGPAT9	-0.034546
SNORD36C	-0.034542
PHLDA2	-0.034530
CTH	0.034516
NOLC1	-0.034430
IFI44L	0.034389
DDX21	-0.034344
CEBPB	0.034178
LPXN	-0.033913
UCK2	-0.033583
CSF2	-0.033554
BYSL	-0.033505
IER3	-0.033390
TNFRSF11B	-0.033325
TRIM22	0.033220
UBASH3B	-0.033114
NFE2	0.032786
PTGIS	0.032428
TRIB2	-0.032281
MKX	0.032187
RRS1	-0.032029
IRF9	0.032012
LIPG	0.031808
BLACAT1	-0.031800
TXNIP	0.031766
BMP2	0.031561
ADM2	0.031449
LRP8	-0.030940
NIP7	-0.030908
RRM2	-0.030714
CCND3	-0.030665
JUN	-0.030553
A4GALT	0.030549
PHF21A	0.030392
STAT2	0.030305
LMO4	0.030288
ASAP3	0.030255
MXD4	0.029954
IRAK2	-0.029953
EXOSC4	-0.029943
EIF5A2	-0.029874
SNORA24	-0.029796
OASL	0.029766
FKBP4	-0.029759
ASAP2	-0.029708
KAL1	0.029675
GPR3	-0.029561
SH3PXD2A	-0.029557
TGFBR2	-0.029489
PDXP	-0.029420
PAPLN	0.029341
IFI16	0.029335
BCL6	0.029249
ITGA2	-0.029206
SLC2A3	-0.029085
PDGFRB	0.029029
LRRFIP1	-0.028978
DEFB1	0.028942
DUSP6	-0.028875
DDIT3	0.028774
BHLHE41	0.028566
VASN	0.028532
CXCL8	-0.028501
LTBP2	-0.028414
GPT2	0.028396
FILIP1L	0.028388
CDC42EP2	-0.028343
PPRC1	-0.028237
TFRC	-0.027949
C1QTNF5	0.027858
PCK2	0.027649
CABLES1	-0.027489
TNFAIP2	0.027381
MICAL2	-0.027361
BRIX1	-0.027360
EPSTI1	0.027347
SSPN	0.027327
DKK1	-0.027307
AEN	-0.027190
LRRN4	-0.027184
FAM46A	0.027166
TTLL12	-0.027157
WARS	0.027138
NXT1	-0.027052
KCNJ2	-0.027044
SAMD3	-0.027020
KLHDC8B	0.026997
SAMD9	0.026988
MPP4	-0.026984
C9orf89	-0.026945
FHOD3	-0.026935
RAB40B	0.026849
SLIT2	-0.026799
SPSB3	0.026612
FAM174B	-0.026552
KCNK3	-0.026539
LYAR	-0.026498
TRIB3	0.026492
SERPINE1	-0.026387
CNIH3	-0.026251
ETV4	-0.026210
PPIF	-0.026108
PAQR4	-0.026043
STAMBPL1	-0.026037
ODC1	-0.025933
IFI44	0.025865
NREP	0.025803
FGFBP1	-0.025752
CIRBP	0.025724
ENC1	-0.025715
IFNGR1	0.025708
SLC25A22	-0.025542
YPEL5	0.025498
EIF2B2	-0.025471
HMGCS1	0.025451
TNFRSF10A	-0.025434
NOC3L	-0.025324
TIMM8A	-0.025231
SH2B3	-0.025225
KCNN4	-0.025181
GABBR2	-0.025150
BGN	0.025102
MTHFR	0.025086
HSPH1	-0.024986
MARS	0.024960
RCL1	-0.024874
ULBP1	0.024872
CTPS1	-0.024817
CHST7	-0.024801
SNORD13	0.024784
CDCA7	-0.024738
ZFP90	0.024623
PUS7	-0.024484
APOBEC3B	0.024468
MX2	0.024453
DKC1	-0.024418
GAS1	0.024379
KLK5	0.024361
TNIP1	-0.024321
EXOSC2	-0.024287
RNF165	-0.024091
PRMT3	-0.023968
SCHIP1	-0.023942
PLEKHS1	0.023918
NIFK	-0.023915
DDIAS	-0.023897
NOG	-0.023882
DUSP5	-0.023874
IMP4	-0.023869
TSPAN18	-0.023844
ELOVL6	-0.023824
BLOC1S1	0.023750
GTPBP4	-0.023742
SNHG17	-0.023722
SLC1A5	0.023695
AAMDC	0.023664
PDCD2L	-0.023618
BCAR3	-0.023616
MALL	-0.023587
DENND5B	0.023556
ERRFI1	-0.023529
JAG1	0.023528
HK2	-0.023496
NDUFS4	0.023436
ARSJ	-0.023420
PARP9	0.023381
ZNF581	0.023362
PARP14	0.023333
TNFRSF21	-0.023311
RFWD3	-0.023284
PTGER4	-0.023278
IDH1	0.023269
MCM4	-0.023255
ZMYND19	-0.023084
SERTAD4	-0.023062
DFFB	-0.023045
MX1	0.022933
DEPTOR	-0.022898
XDH	-0.022860
COA5	0.022856
ICAM1	-0.022851
VAV3	0.022836
KLHL36	-0.022804
RSRP1	0.022742
DNASE2	0.022740
IFIT2	0.022713
APOBEC3G	-0.022708
LMNB1	-0.022648
TSC22D3	0.022589
TGFA	-0.022566
GEMIN4	-0.022556
CARD10	-0.022535
C10orf2	-0.022501
CCT6B	0.022492
CD24	0.022467
MMD	-0.022462
CCL2	0.022441
MN1	0.022424
DCTPP1	-0.022420
CDT1	-0.022395
MB21D1	-0.022394
RILPL1	-0.022318
JUNB	0.022300
ULK1	0.022298
LTB	-0.022238
ANKRA2	0.022224
NEDD4L	-0.022220
MRPL14	-0.022159
NOP16	-0.022147
TNFRSF12A	-0.022145
IRS1	-0.022124
SPRY1	-0.022025
HEG1	0.022016
YRDC	-0.022009
SHMT2	0.022007
MCM10	-0.021984
SLC19A1	-0.021978
NT5E	-0.021958
TXLNG	-0.021930
CDC45	-0.021926
SLC35G1	-0.021910
SIRPD	-0.021904
ARL4C	-0.021891
DHRS3	0.021866
IMP3	-0.021864
MAT2A	-0.021860
NCLN	-0.021859
MYO10	-0.021770
HBP1	0.021765
LPL	-0.021729
CYSRT1	-0.021725
STMN3	-0.021661
ADAM8	-0.021621
PTRH2	-0.021617
NPAS2	-0.021612
MAFF	-0.021589
HINT2	0.021588
GADD45A	-0.021578
EHD1	-0.021573
CXCL1	-0.021525
SPRED2	-0.021524
CYP24A1	-0.021514
RSL24D1	0.021479
IFNGR2	-0.021443
MPP6	-0.021437
C1RL	0.021434
WBSCR22	-0.021416
ADRB2	-0.021339
SNAI1	0.021323
C5orf34	0.021318
HMOX1	0.021310
ALDH1A1	0.021306
CYB5D2	0.021271
GFOD1	0.021261
FEZ1	-0.021256
DDAH1	-0.021211
FAM57A	-0.021199
FOXO4	0.021193
GCC1	0.021176
E2F3	-0.021171
CDCA4	-0.021133
ISG15	0.021126
PIR	0.021085
KIF20A	0.021083
EIF4A1	-0.021041
SNAP25	-0.021035
CD83	-0.021000
ARHGEF5	0.020991
ZNF446	0.020970
CCDC86	-0.020906
FAM129B	-0.020883
SNORA61	-0.020878
CHSY1	-0.020849
NUDT14	0.020832
TRIM6	0.020813
VGF	-0.020808
SPATA5L1	-0.020753
DPF2	0.020731
POLR3E	-0.020730
REEP3	-0.020721
NR2C2AP	-0.020667
CCNB2	0.020653
SLC1A3	-0.020640
MOB3A	-0.020601
PMEPA1	-0.020539
SARS	0.020519
UBIAD1	-0.020518
SNORD104	-0.020513
ANKMY2	0.020486
KLHL14	0.020475
SMCO4	-0.020455
SLFN11	-0.020440
TOMM40	-0.020406
FMNL2	-0.020286
FAM60A	-0.020258
EFHD2	-0.020217
GRWD1	-0.020205
ORAI1	-0.020202
PPIL1	-0.020195
SLC30A1	-0.020173
CDC25C	0.020163
ATG14	0.020159
PES1	-0.020153
SLC15A3	0.020147
UNG	-0.020123
ZNF358	0.020117
CRACR2B	-0.020083
PGBD3	0.020075
FAM206A	0.020054
TFPI2	-0.019941
THEM6	-0.019933
CALM1	-0.019930
HEATR1	-0.019894
DAB2	0.019886
URB2	-0.019865
SLBP	-0.019858
NSUN2	-0.019851
FEN1	-0.019849
LOC100129550	0.019838
AHSA1	-0.019757
CEP44	0.019752
RPL13A	0.019737
PRKAB2	0.019719
POLR1E	-0.019711
SCG2	-0.019706
RRP1B	-0.019697
HERC6	0.019688
TMEM59	0.019685
MTHFD2	0.019684
C15orf52	-0.019664
ACOT13	0.019659
CCDC23	0.019632
STK39	-0.019614
RABEPK	-0.019605
GBP2	0.019599
RRP15	-0.019594
MYO1B	-0.019580
THAP10	-0.019574
APEX2	-0.019574
AP5S1	0.019551
TMEM187	0.019545
HPCAL1	-0.019511
EI24	-0.019510
NIPAL3	0.019457
SIRPB1	-0.019443
NAA60	-0.019433
NDFIP2	-0.019431
IFIT3	0.019405
KLC1	-0.019400
AMOT	0.019393
SCNN1A	0.019375
HNRNPAB	-0.019363
ARMC4	0.019342
MTMR11	0.019333
HSPA1B	-0.019312
CCDC53	0.019311
SRSF1	-0.019246
DUS3L	-0.019216
LYPD6B	-0.019213
LYRM5	0.019209
RHBDD2	0.019183
NOP58	-0.019177
CRTC1	-0.019154
AGMAT	-0.019148
AJAP1	-0.019143
MIR1282	-0.019138
SOWAHC	-0.019129
MRPL17	-0.019124
PPP1R14C	-0.019101
POLE2	-0.019096
HDAC6	0.019082
C20orf194	0.019081
CHAF1A	-0.019071
MGP	0.019064
WFS1	0.019053
MLLT11	0.019017
CEP70	0.019016
PRR7	-0.019006
DSCC1	-0.018986
NIPAL1	-0.018984
KIAA0020	-0.018984
GINS3	-0.018967
PLAUR	-0.018935
ACOX2	-0.018926
CLIC3	0.018911
HIBADH	0.018910
RGS2	0.018903
PFKL	0.018889
SRA1	-0.018883
ALDH1B1	-0.018866
SNORD57	-0.018862
SPARC	0.018843
MSH6	-0.018824
EFNA4	0.018808
NDUFA11	0.018765
DDB2	0.018754
SIX5	0.018750
GLIPR1	-0.018725
CNTNAP1	0.018703
LINC00493	0.018702
STK19	0.018697
CCDC88C	-0.018686
RHBDF1	-0.018672
RAB5B	0.018659
GLT8D2	0.018599
TRAPPC6A	0.018577
SRM	-0.018568
HCFC1R1	0.018567
TENM4	-0.018565
PIM1	0.018542
MEF2BNB-MEF2B	0.018529
PXYLP1	-0.018509
HS3ST1	-0.018505
PTPRE	-0.018498
KLHL42	-0.018498
CBX4	0.018470
ANGPTL2	-0.018463
SOX4	0.018406
MICA	-0.018397
MARCH4	-0.018387
TMEM185B	-0.018356
FIS1	0.018349
CCT2	-0.018330
FRG1	0.018325
IFI35	0.018321
PUS1	-0.018311
PNO1	-0.018285
HSPA8	-0.018274
ZNF121	-0.018252