!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Morphine
!smiles	CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O
!drugbank_id	DB00295
!pubchem_cid	5288826
!cell_type	Striatum - 129P3/J mice - Chronic morphine treatment
!organism	mouse
!end_metadata
TTR	-0.334171
PTGDS	0.147981
CST3	-0.129251
PFDN6	-0.110779
FAM71F1	-0.088765
NNAT	-0.087790
SLC17A7	0.087753
ZBTB16	0.087012
TUSC2	-0.075585
CA2	-0.074498
PSAP	-0.071709
FABP7	-0.069298
ZIC1	-0.069271
RPS15	-0.069234
CCK	0.068259
PLP1	-0.067114
APOE	-0.066907
C8orf46	0.066539
ADORA2A	-0.065951
GNG7	-0.065282
NRN1	0.063203
CALR	-0.061923
BSG	-0.061778
PCP4	-0.060491
ID4	-0.059023
ZCCHC12	-0.059013
RPS12	-0.058063
CNP	-0.056741
CKB	-0.056563
TMA7	-0.056437
CTRB2	-0.055990
SP4	-0.055642
WFIKKN1	-0.055466
OLFM1	0.055193
CHGB	0.053870
SCN1B	0.052936
ZBTB18	0.050367
RPL26	-0.050143
TUBB2B	-0.050122
HSPA5	-0.049344
SLC2A1	0.049331
RPL4	-0.049204
RPL3	-0.048986
LOC728392	-0.048670
SYNPR	-0.048460
TTC9B	0.047768
FABP5	-0.047690
PLIN4	0.047437
QDPR	-0.047013
NPTX1	0.046770
PDE1B	-0.046648
HIST1H1C	-0.046300
TMEM130	-0.046288
TFG	-0.045886
RNF145	-0.045118
GSTP1	-0.044713
RPL10	-0.044645
ANKRD63	-0.044019
PLTP	-0.043686
CALB2	-0.043470
TSC22D3	0.043451
HAP1	-0.042969
TMEM178A	0.042108
HPCA	-0.042030
ADCY1	0.041839
TIMM8B	-0.041823
B3GNT1	-0.041645
TUBA1A	-0.041300
MEIS2	-0.041140
MEF2C	0.041099
KCNJ11	-0.040863
EFHD2	0.040793
EFNB3	-0.040495
GJA1	-0.040490
UNC80	0.040329
CAMK2G	0.040261
RPL11	-0.040184
PPP5C	0.040000
PHACTR3	0.039853
PGRMC1	-0.039814
LRRC19	-0.039800
NCDN	-0.039756
CADPS	0.039683
GPR17	-0.039456
CIRBP	0.039400
HIST1H2BI	-0.039340
KLHDC1	-0.039188
IMP4	-0.039062
ATP6V1G2	0.038962
SNCB	0.038962
VAT1L	-0.038944
MGLL	0.038903
HMGN1	-0.038812
RPL28	-0.038719
RPL13	-0.038659
EEF1B2	-0.038465
CADPS2	0.038243
OSBPL1A	0.038214
CD81	-0.038099
SYNE1	0.038014
NEFL	0.038006
PBX3	-0.037832
RPL7A	-0.037790
ELOVL2	-0.037662
LACE1	-0.037254
CHCHD10	-0.037102
SV2B	0.037071
HSPA8	-0.036944
GABRA1	0.036843
ZMPSTE24	-0.036802
LGALS2	-0.036680
WIPF3	0.036603
NDUFA1	-0.036595
STX1A	0.036391
FARP1	-0.036024
APOD	0.035940
BAIAP3	-0.035849
RXRG	-0.035709
CACHD1	-0.035418
TRIM46	-0.035339
EGR1	0.035080
RPS7	-0.035070
PCSK1N	-0.034778
MANF	-0.034745
DRD2	-0.034729
PRICKLE2	0.034615
OSBPL8	-0.034608
PPP1CA	-0.034507
GAP43	-0.034335
CAMK1G	0.034225
LOH12CR1	-0.034091
CTXN1	-0.034056
IGFBP6	0.034014
MGP	0.033997
ARL3	-0.033814
LAMP5	0.033533
COX6B1	-0.033507
GSTM3	0.033466
SGK1	0.033300
GNB2	-0.033275
RGS10	-0.033199
BTBD10	0.033189
SESN3	-0.033179
RPS5	-0.033124
PISD	-0.033084
BASP1	0.033004
FOXG1	-0.032998
SOX2	-0.032903
MAN1A1	-0.032739
GAA	-0.032732
HIST1H2BO	-0.032628
INA	0.032403
CALY	-0.032289
PRMT2	-0.032285
LZTS3	-0.032123
NGEF	-0.032095
LY6H	-0.032019
NGFRAP1	-0.032004
NAP1L5	-0.031863
ITM2C	-0.031789
NECAB2	-0.031760
CSDC2	-0.031722
CHORDC1	-0.031706
SYN1	0.031508
STMN1	0.031459
RPL27	-0.031458
RPS11	-0.031444
NREP	-0.031228
CNIH2	-0.031009
NAPB	0.030938
SNAP47	0.030920
HSPH1	-0.030779
NACA	-0.030763
PCDH8	-0.030652
RIMS1	0.030577
INSIG1	0.030481
YWHAH	0.030391
PSD	0.030221
CEP170B	0.030147
KCTD12	-0.030116
GPR6	-0.030004
ENC1	0.029988
ITPR1	0.029966
ATP5B	-0.029948
TCTE1	0.029913
SPOCK1	0.029891
NPY	0.029880
PPAP2B	-0.029853
RCAN2	0.029739
SPNS2	0.029648
DDX3X	0.029584
RPS26	-0.029553
NOV	0.029368
PMP2	-0.029289
RAB3A	0.029170
YWHAQ	-0.029072
GPR155	-0.028889
FAU	-0.028864
RPL18A	-0.028705
DNAJA1	-0.028621
ROMO1	-0.028195
ABHD3	-0.028190
HNRNPUL1	0.028131
CTGF	0.028067
RABGGTA	0.028008
DGKZ	0.027819
GRM4	-0.027768
SPOCK3	-0.027717
TBR1	0.027704
GLTP	-0.027662
ADCY9	0.027532
SYNDIG1L	-0.027496
DDN	-0.027486
MAG	-0.027404
DNM1	0.027300
FKBP5	0.027299
SLC30A3	0.027294
PTPLA	-0.027280
ADAM21	-0.027274
RASL10B	-0.027257
UGGT2	-0.027000
CSF2RA	-0.026960
ELMOD1	-0.026917
DBI	-0.026898
RHOU	0.026822
SERPINE2	-0.026728
RPS28	-0.026624
JDP2	0.026618
ARL6IP5	-0.026592
ATP5J	-0.026571
ENPP2	-0.026538
COX7A2	-0.026425
RPL10A	-0.026399
GPR162	0.026344
CHMP4B	-0.026179
SERPINI1	0.026168
RESP18	-0.026071
TFEB	-0.026061
HMP19	-0.025947
LGMN	-0.025849
RBM3	0.025825
HSP90B1	-0.025721
NDN	-0.025629
NEUROD6	0.025624
SPHKAP	0.025602
R3HDM4	0.025555
MAN1A2	-0.025496
MYBPC1	0.025456
RIC8B	-0.025441
KLF9	0.025420
DARS2	-0.025402
CPLX1	0.025402
OXR1	0.025372
TRIM32	0.025319
ITGB1BP1	-0.025313
BHLHE40	0.025302
ARC	0.025302
HSD3B1	-0.025298
ZDBF2	-0.025232
PITPNA	0.025185
C1orf109	-0.025156
RAP1GAP2	0.025109
UGT8	-0.025008
MBOAT2	-0.024988
ATP5J2	-0.024949
ASIC4	-0.024948
DBP	-0.024848
KCNC2	0.024844
YWHAE	-0.024813
SNRPD2	-0.024779
KCNJ4	-0.024779
AMPH	0.024687
KHDRBS3	0.024665
MPPED1	0.024653
FBXO2	0.024634
VIP	0.024583
BRINP1	0.024514
GPR88	-0.024499
SLC24A2	0.024437
AHI1	-0.024422
GRM3	-0.024383
MERTK	0.024307
MIEN1	-0.024299
SEZ6L2	0.024284
KIFC2	-0.024283
PNMAL2	-0.024248
BCL11B	-0.024235
APLP1	-0.024217
PRKCB	0.024131
RELL2	0.024115
C14orf1	-0.024066
BHLHB9	-0.024006
PEA15	-0.023982
GPI	-0.023978
IVNS1ABP	-0.023970
PLXNB2	-0.023905
RGS2	-0.023893
COX6A1	-0.023892
BEX1	-0.023785
TMEM47	-0.023768
RNF208	0.023728
WFS1	0.023683
RPLP0	-0.023677
PRDM8	0.023668
PVALB	0.023631
CCDC90B	-0.023616
FAM19A2	0.023585
TMEM185A	-0.023449
LYPD4	-0.023347
GJB6	0.023343
ARL6	-0.023317
PGM2L1	0.023291
PPM1L	0.023280
OCIAD2	0.023264
TUBA3E	0.023242
ATP6V1A	0.023203
RPS8	-0.023106
TMEM38B	-0.023085
XBP1	-0.023056
EIF3F	-0.023007
GPR61	-0.022983
DCLK3	-0.022950
TRAPPC2L	-0.022944
RPL6	-0.022918
PRDX1	-0.022887
HNRNPH1	-0.022837
SYT13	0.022815
STMN3	0.022697
CAMK2N2	0.022673
FTH1	0.022607
STRN4	0.022595
CAMKK1	0.022593
PGK1	0.022577
CRY2	0.022565
KCNMB4	0.022556
RPL9	-0.022542
PFKFB4	-0.022427
NUAK1	0.022394
ZIC3	-0.022377
SPTAN1	0.022375
MKL1	0.022373
METTL9	-0.022339
SLC22A16	0.022334
SNX14	-0.022317
CCDC85B	0.022280
EIF4A1	-0.022204
FBXW7	0.022171
NT5DC3	0.022162
CCDC136	0.022117
SNAP25	0.022114
PPME1	0.022086
RPS23	-0.022068
ANKH	0.022046
ALDH1A1	0.022016
PHLDB1	-0.021981
HIVEP2	0.021966
SYBU	-0.021947
RPS13	-0.021931
RPS27A	-0.021910
ASCC1	-0.021852
DKK3	0.021848
MPC1	0.021843
LRRC3B	-0.021840
EIF2S3	0.021817
TRA2A	-0.021763
BCAS1	-0.021701
SST	0.021679
NDUFV3	-0.021610
ATP2B3	-0.021589
TTI2	-0.021465
RPL23	-0.021429
TMEM59L	0.021367
KIAA1462	-0.021318
PENK	-0.021316
APBB1	0.021252
ECEL1	-0.021228
RELT	0.021209
LRP12	-0.021207
ZFYVE19	-0.021203
GUCY1A3	-0.021169
SNRPF	-0.021162
MFSD2A	0.021145
NCALD	0.021057
KCNA1	0.021042
TRIM62	-0.021003
DUSP26	-0.020918
ARPC5L	-0.020917
SYT1	0.020889
APRT	0.020803
NDUFA4	-0.020800
KLHL7	-0.020776
HEXB	-0.020776
OLIG1	-0.020758
KRT78	0.020750
DNAJB2	-0.020682
RPH3A	0.020676
EZH2	-0.020614
SNX3	-0.020587
CAP1	-0.020574
ANXA11	0.020572
DMXL2	0.020521
CYB5A	-0.020508
MAP7D2	0.020482
RARG	-0.020465
LINGO1	0.020446
RSL24D1	-0.020442
PAK1	0.020317
FNBP1	-0.020310
HLF	0.020262
SDHB	-0.020251
GAD1	-0.020224
GOLGA7	-0.020209
MAL2	0.020096
LGI3	0.020095
CMTM5	-0.020090
S100A16	-0.020076
NDRG3	0.020060
AMER2	0.020045
CLSTN3	0.019985
NAT8L	0.019977
PRKCH	-0.019961
PFKM	0.019960
CHN1	0.019950
VSTM2A	-0.019929
COQ10B	-0.019904
PPP1R1B	-0.019895
GPRC5B	-0.019882
SERINC1	0.019878
CAT	-0.019843
MAFK	0.019789
FAM169A	0.019728
SLC39A11	-0.019724
FAM131A	0.019710
STRIP2	-0.019689
KCNA5	0.019673
GNG10	-0.019673
TF	-0.019668
ZNHIT1	-0.019645
RIN2	0.019598
BAI2	0.019595
PPFIA3	0.019592
NDUFA7	-0.019569
PDE10A	-0.019566
SPARC	-0.019560
TMEM160	0.019512
ARRDC2	0.019511
NOB1	-0.019497
ACSL5	0.019494
RGS4	-0.019454
RPS2	-0.019420
LYNX1	0.019409
HNRNPDL	0.019399
TCP1	-0.019380
HSP90AB1	-0.019369
MAT2B	0.019364
NEXN	-0.019356
RPL27A	-0.019321
UQCRB	-0.019304
NDRG2	-0.019285
BZRAP1	0.019263
PREX1	0.019245
HDC	-0.019234
RARB	-0.019215
TPPP	-0.019142
IFNLR1	-0.019101
FTL	-0.019094
MARCKSL1	-0.019080
HTRA1	0.019002
FXYD7	0.018978
NBEA	0.018976
CD9	-0.018953
ZSCAN26	0.018907
CPLX3	0.018885
ENO2	0.018871
HDAC5	-0.018866
C19orf60	0.018859
KCNJ10	-0.018804
FZD2	0.018775
C2orf49	-0.018772
NDUFA13	-0.018762
NTSR2	-0.018757
AP1B1	0.018757
ITIH3	-0.018712
ATP6AP1	0.018697
MBP	-0.018658
CPEB1	0.018642
SSH2	0.018634
SNPH	0.018590
WDR6	-0.018574
SNX24	0.018574
RAPGEF4	0.018567
ARHGAP44	0.018542
EFR3A	0.018539
CYFIP2	0.018506
SFPQ	-0.018485
SLC6A11	-0.018479
PLCXD2	0.018429
IDO1	-0.018423
RPRML	0.018402
GNG4	-0.018397