!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Methotrexate
!smiles	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
!drugbank_id	DB00563
!pubchem_cid	126941
!cell_type	granulocyte
!organism	human
!end_metadata
BTNL8	-0.132501
PCDH8	-0.065346
RNASE2	-0.064482
PPBP	0.063787
C4BPA	0.061127
LOC101928893	-0.060981
EGR1	0.059560
RNASE3	-0.058325
FAM3B	-0.055217
KDM5D	0.051015
KIAA1324	-0.050524
COL9A3	-0.050490
RGPD1	-0.050476
PMM2	0.047583
ORM1	0.046628
HIP1	0.044811
FGF13	0.043367
MIR646HG	0.043313
LYZ	0.042881
DSC2	0.042690
ZNF107	0.041334
BTNL3	0.041221
NUCB1	0.041104
HTATSF1P2	0.040425
PLA2G4A	-0.039945
PF4	0.038998
TMEM170B	-0.038953
ACCS	-0.038871
DDX17	-0.038843
MAB21L3	0.038685
LGSN	0.037474
CEP192	-0.037405
TMEM45B	-0.037252
NOD2	-0.037094
PI3	-0.036501
IDO1	-0.036480
LAP3	-0.036474
CYB5D1	0.035540
CYP26B1	0.035424
DAPK1-IT1	0.035271
ERO1L	-0.034993
CLEC12A	-0.034917
AKR1C3	0.034279
LTF	-0.034266
SNORA21	0.034043
TRPM6	0.033912
IFI44L	-0.033763
CHPT1	0.033739
CRIPAK	0.033724
SLC26A8	0.033608
GPX3	-0.033608
RPH3A	0.033560
VCAN	0.033252
NRN1	0.033237
LOC142937	0.033055
SLPI	-0.032997
MAL	0.032975
DUT	-0.032796
LRRC6	0.032789
ZNF431	0.032758
LINC01410	0.032702
HOXA5	-0.032659
LDHB	0.032654
CCBL2	-0.032261
MXRA7	-0.032121
DPYSL2	0.032080
EIF3C	0.031984
OVCH1-AS1	0.031969
JUP	0.031903
GIMAP6	0.031877
P2RY14	-0.031868
RSAD2	-0.031851
DERA	-0.031586
FOLR3	-0.031583
PF4V1	0.031376
LILRA3	-0.031315
CCR3	-0.031214
CHRM3-AS2	0.031210
KLHL15	-0.030970
NCKAP1L	-0.030896
SERPINB9P1	-0.030740
SNORA28	0.030617
RPA3OS	-0.030502
RAB33A	-0.030471
BAMBI	0.030468
TTC26	0.030416
CMPK2	-0.030384
SPCS2	0.030300
GPR171	-0.030186
APOBEC3B	-0.030164
SDHD	-0.029954
CPA3	0.029874
PPIP5K2	-0.029807
EIF1AY	0.029673
SECISBP2L	-0.029628
HSP90AB1	0.029619
GIMAP8	0.029496
SLC7A7	-0.029435
GZMM	-0.029434
TNF	0.029198
THBD	-0.028985
MCEMP1	-0.028946
PCED1B	0.028854
BRI3BP	-0.028743
RAPGEF1	-0.028667
ANKRD22	0.028636
RPS4Y1	0.028571
NRGN	0.028509
HTRA4	0.028450
RPL3	0.028384
FRY-AS1	-0.028312
CD93	-0.028183
HLA-DPA1	0.027935
SIGLEC5	0.027916
TRBV27	0.027899
CLASRP	-0.027882
SMCO4	-0.027753
LTA4H	0.027739
NLRP6	0.027423
OLFM4	-0.027322
PAM	0.027281
MIF	-0.027266
A2M-AS1	-0.027193
SLFN5	0.027147
RPS26	-0.027130
LIG4	-0.027108
PSPH	-0.027087
SPP1	-0.027058
MCOLN1	-0.027020
SLC2A3	0.026878
CCRL2	-0.026851
RPL36A	0.026768
SAMSN1	-0.026736
CECR6	0.026559
PITPNM1	-0.026534
CCL4	-0.026479
HPSE	-0.026436
PDZD8	-0.026425
C15orf40	-0.026404
PVRL2	-0.026334
TRIM6	0.026326
TRIM23	0.026285
ACADM	-0.026234
LRRC37A2	-0.026224
SF3A3	0.026145
DDX3Y	0.026105
SLFN12	-0.026063
MFSD9	0.026015
NPTN-IT1	-0.025966
APOL6	0.025945
MAPK14	0.025876
MSL2	0.025784
HNRNPU-AS1	-0.025597
CD48	-0.025591
DAAM2	0.025587
PLGLB2	-0.025538
MAFB	0.025519
CHST2	0.025506
DUSP5	0.025483
HIST1H4D	0.025372
SIRPB2	0.025324
METTL23	-0.025300
FAM177A1	-0.025259
LXN	-0.025255
GRAMD1C	-0.025231
NLRC3	0.025229
XIST	-0.024987
MYL9	0.024955
TAGLN2	-0.024937
GZMK	-0.024931
HCG27	-0.024895
SRPK1	0.024849
OLAH	0.024787
BMX	0.024772
C10orf32	-0.024731
FLVCR1	-0.024727
SLC7A5P2	0.024702
ANXA5	-0.024617
CD163	0.024512
NAIP	-0.024484
IL13RA1	0.024476
CCR7	0.024269
DNAJB6	0.024255
KLF10	0.024213
CBWD1	0.024147
AREG	-0.024114
DDX60	-0.024099
MX1	-0.024091
BATF2	0.024042
UHRF2	-0.024023
TMEM164	0.024011
TMEM63C	0.023975
GNA15	-0.023966
ACIN1	0.023950
CCNL1	0.023929
KIF28P	0.023908
ITGAE	-0.023843
ZNF267	-0.023840
LINC00294	0.023762
SCML4	0.023731
CISH	0.023727
GIMAP7	0.023717
MZT2A	0.023704
DENND4A	-0.023697
RPL22	0.023672
RTN1	0.023664
GPR183	-0.023632
LHFPL2	0.023604
SPAG1	-0.023427
LOC646626	0.023416
ADRB2	0.023382
ANXA4	-0.023364
UVSSA	0.023345
CLEC4A	-0.023337
EPSTI1	-0.023284
PPP1R15A	0.023263
XAF1	-0.023167
CHAC2	-0.023167
PIK3CD	0.023151
POC1B	-0.023150
ND6	0.023082
CXCL6	-0.023067
TMEM154	-0.023056
LMO2	0.023010
TEN1	-0.022987
ZCCHC8	-0.022985
ADARB2	0.022881
FLJ36848	-0.022829
LOC100506922	0.022827
CCR2	0.022726
SLC36A4	-0.022696
NMUR1	-0.022691
IFI6	-0.022599
UTS2	-0.022598
OXA1L	-0.022535
ZNF266	-0.022485
TUBB1	0.022475
JADE1	-0.022363
C8orf60	0.022297
ZNF746	0.022294
MAP2K6	0.022229
EIF4G3	0.022162
BRE-AS1	0.022153
DMTF1	-0.022135
STRN4	0.022123
MALAT1	-0.022119
SLC16A6	-0.022081
SKAP2	-0.022081
PRR12	0.022031
SUPT16H	0.022023
RPN2	-0.021982
GSKIP	-0.021937
BACE2	0.021919
SNORA68	0.021888
HERC5	-0.021815
HLA-DPB1	0.021780
ASRGL1	0.021742
PDCD10	-0.021676
RNF167	-0.021621
OR52K3P	0.021565
PTK2B	0.021534
CLPTM1	-0.021489
KLHL5	-0.021477
LOC158402	0.021367
C19orf40	-0.021336
SIPA1L2	0.021295
TAX1BP3	-0.021294
SNX16	-0.021268
ESCO1	-0.021224
PLK2	0.021211
PSMC6	-0.021203
RAVER1	0.021192
LOC729839	-0.021186
CLEC1A	-0.021148
C12orf5	-0.021123
DRAP1	0.021105
RSPH10B2	-0.021083
MED30	-0.021061
MTMR3	0.021050
BICD2	0.021043
TMEM123	-0.021041
ZNF630	0.021022
ALOX12	0.021010
TCFL5	-0.020994
HBD	0.020959
SORD	0.020926
SYNE1	0.020925
ZNF324	-0.020858
EXT2	-0.020817
ZNF654	-0.020765
BCL11A	-0.020730
ATHL1	-0.020709
AK3	-0.020692
TRIB2	0.020639
ALDH1A1	0.020623
SGMS1	-0.020622
PKD1P1	0.020603
PRUNE2	0.020579
COPB1	-0.020558
MRPS23	0.020551
GNAI2	-0.020536
RPS23	0.020534
KREMEN1	0.020514
RPS6KB2	-0.020514
S100A4	-0.020500
CLCN4	0.020457
MEN1	0.020452
LOC642361	-0.020450
CDC42EP3	0.020413
TMEM2	0.020361
MARCKSL1	-0.020353
RNF135	0.020339
PLEKHO2	0.020307
HIGD1A	-0.020278
PKN3	0.020246
GNL3L	0.020244
MAPK13	0.020237
HSPH1	0.020223
LINC00528	0.020205
ANKRA2	-0.020179
KLRG1	-0.020177
FUZ	-0.020173
MMP9	0.020163
SLC25A39	0.020142
DCP1A	-0.020097
TTC7B	0.020090
ZC3HAV1	0.020090
FAR2	-0.020080
ANXA6	-0.020054
LINC00493	0.019996
CA4	0.019993
RALGDS	-0.019981
MSRB2	-0.019963
CALCOCO1	0.019944
C1orf174	0.019941
SSPN	0.019924
VPS37B	0.019902
IL15	0.019894
TIAM1	0.019867
LOC101929681	0.019858
SPACA6P	-0.019840
KIAA1279	-0.019828
ZNHIT3	-0.019783
KCNH1	-0.019778
FNIP1	0.019774
SIK1	0.019762
NFKBIZ	0.019759
GZMH	-0.019744
SLC20A1	-0.019723
CYP4F12	0.019700
MRFAP1L1	0.019673
RAB5C	-0.019671
ANXA1	-0.019622
PTTG2	0.019548
AIM2	0.019528
ARSA	-0.019513
OTUD3	0.019475
DDIAS	0.019442
MICU2	-0.019430
HES4	-0.019422
SNHG16	0.019408
LOC93622	0.019404
LOC102724094	-0.019386
HCP5	-0.019381
PAGR1	0.019355
GSTT1	-0.019331
XPO1	-0.019316
TMEM106B	0.019307
FTX	0.019286
CAT	0.019257
PLD6	0.019242
MARCH2	-0.019240
CD7	0.019230
VAMP7	-0.019227
YBEY	-0.019217
CYP1B1	0.019216
LBH	0.019216
EID3	0.019190
NRROS	0.019181
GOLGA8B	0.019171
SEP15	-0.019164
IGJ	-0.019139
RNF4	-0.019136
TMX2	-0.019111
LINC00537	0.019074
KIAA0040	0.019062
SORT1	0.019061
PXN	0.019059
KCTD11	0.019012
ASMTL	0.019006
ADAT1	-0.018968
CD8A	-0.018956
TMEM71	-0.018938
SGK3	-0.018908
CASP5	0.018906
SNORD89	-0.018892
ENDOG	-0.018889
RANBP2	-0.018885
TMEM200B	-0.018868
DDX42	0.018866
CEP63	0.018854
RNASE6	-0.018829
SDSL	-0.018804
OLIG1	0.018797
DPY19L3	-0.018782
HDHD3	-0.018779
TP53	0.018764
TLX1	0.018763
PATL1	0.018732
LOC100630918	-0.018709
HHEX	0.018688
RNFT1	-0.018659
PRMT5-AS1	0.018657
SLBP	-0.018646
LSMEM1	0.018632
LGALS9	0.018625
CR1	0.018609
SLC24A4	0.018600
ACP5	-0.018589
YIPF5	-0.018562
UBE2J1	0.018536
SUSD1	0.018530
OSCP1	-0.018508
PLAGL1	-0.018497
CNNM3	0.018487
LOC403323	-0.018483
USP9Y	0.018457
NPIPB3	0.018453
USP32P2	-0.018442
UAP1	-0.018440
HIST1H2BG	-0.018439
TBL1Y	-0.018433
VCP	0.018432
ATXN2L	0.018417
GALM	0.018396
AOC2	0.018391
FBL	0.018388
CHST7	-0.018378
FAM187B	-0.018354
POLE3	0.018346
CIB1	-0.018332
FFAR3	0.018312
SMG1P1	0.018289
SIRT2	0.018273
FHDC1	0.018265
PPIB	-0.018262
YWHAQ	-0.018262
LOC100270804	-0.018233
LENG8	0.018220
RGS1	-0.018198
MTFR1L	-0.018181
TMEM88	-0.018179
ZBTB48	-0.018167
S100P	0.018162
CAMP	-0.018149
SACM1L	-0.018111
SYAP1	-0.018109
FAM172A	0.018082
GALNT6	0.018077
KLRD1	-0.018061
PER1	-0.018061
CD69	-0.018048
MLF2	0.017980
REV3L	-0.017969
SLC35B3	-0.017966
CMTM1	0.017957
GNLY	-0.017954
CEBPD	-0.017926
CD99	0.017924
TSHZ3	0.017913
FAM118A	0.017892
MLH1	-0.017871
SNAPC1	-0.017851
CXorf23	-0.017840
MID1IP1	0.017836
TET2	-0.017836
TBC1D10B	0.017813
PGAM2	-0.017809
LMNTD2	-0.017809
HMHA1	0.017801
IGKV4-1	-0.017784
MED18	0.017757
BCS1L	-0.017751
PLCL1	0.017749
TPST1	0.017742
SF3A2	0.017736
BARX1	-0.017711
TPK1	0.017708
DNMT1	0.017694
CEP170	-0.017680
LOC100506585	0.017675
WRB	-0.017595
GBP6	0.017579
MAP7	-0.017577
TIA1	-0.017576
LINC00926	-0.017576
ZDHHC20	-0.017576
JOSD1	-0.017563
FAM43B	-0.017539
ABRACL	-0.017518