!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Lapatinib
!smiles	CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
!drugbank_id	DB01259
!pubchem_cid	208908
!cell_type	lapatinib sensitive and lapatinib resistant ErbB2-positive breast cancer cells
!organism	human
!end_metadata
SCGB1D2	0.168370
HSPB1	-0.167693
S100A9	-0.155926
PAGE2	0.153656
OAZ1	0.148853
SNAR-A1	0.147643
RPS13	-0.146495
TUBA1B	0.130159
RPS19	0.129382
RPL39	-0.124989
PAGE2B	0.124248
BMP7	0.120444
SCIN	0.116616
H3F3A	-0.102449
PAGE5	0.101311
COX8A	0.097258
PRDX4	0.096841
ADIRF	0.095108
SUSD2	0.094963
RPS12	0.092790
TFRC	0.089548
XBP1	0.089547
RPS2	0.089513
RPS4X	-0.088086
RPL22	-0.086641
CPS1	0.084073
EEF1A2	-0.082482
CD81	0.082309
PPA1	-0.082198
UQCRHL	-0.081684
SEPT9	0.080714
RPL35A	-0.080642
EIF4A1	0.077291
S100A8	-0.075344
TMSB10	-0.074895
EEF1G	0.074820
S100A16	0.074635
NDUFS8	0.073883
KRT81	0.073192
RPL8	-0.073010
MDH2	-0.072498
RPL35	0.068814
FASN	0.067678
RPL27A	0.067568
RPL31	0.067190
MYL6	-0.065606
TMED3	0.063326
TRAM1	-0.063303
AP2S1	0.062904
HIST1H2BK	-0.062458
RN7SL1	-0.062377
GLTSCR2	-0.061400
H3F3AP4	-0.061061
CFL1	0.060988
ATP5L	0.060643
ENO1	0.060490
ACAT1	0.060255
TPT1	-0.060004
SRRM2	-0.059515
NDUFA8	0.058908
EZR	0.058327
ARL2	0.058235
ACTG1	-0.058133
NCCRP1	-0.057493
MIF	0.056647
LPCAT1	0.056551
EIF4A2	-0.056550
ATP5H	-0.054639
NFKBIA	-0.053991
DHRS2	0.053766
TMEM258	0.053752
NDUFA1	0.053318
MAL2	-0.051954
ANP32B	0.051273
GPX4	-0.050949
SDHA	0.050247
RPS10	-0.050193
RPLP2	0.050123
KRT19	0.049673
SAT1	-0.049537
LDHA	-0.048210
RPL38	-0.048165
ZMPSTE24	-0.047587
SLC9A3R1	0.047464
RPL13AP3	-0.047393
S100P	0.047243
UBA52	-0.046896
SSU72	-0.046857
PSMB1	0.046827
RPS16	-0.046448
AURKAIP1	-0.046430
RPS21	-0.046247
UQCRH	-0.046141
TUBA1C	0.045568
CA12	0.044442
ACTB	-0.044149
RPL10A	0.043980
NDUFA3	-0.043090
RPS11	-0.043079
RNA28S5	0.043061
ATOX1	0.042878
HSD17B7	-0.042166
TMEM59	-0.041938
JMJD8	0.041388
TXN	0.041106
PSMB10	-0.041073
HBE1	0.040808
TIMP2	0.040770
RPS24	0.040750
TMEM256	0.040611
CDKN2AIPNL	-0.040465
PPT1	0.040459
SLC25A51	-0.040359
TKT	0.039743
CAP1	-0.039579
PGM5	0.039282
LRRC26	0.039157
PPIAL4B	-0.038633
COX17	0.038540
VPS37C	0.038416
CDC42EP4	-0.038295
ORC6	0.037650
TAP1	-0.037435
STT3A	0.037223
COMT	0.037164
SLC7A5	0.036619
PSMA5	-0.036333
PTPRF	-0.035817
MAP1LC3A	0.035683
PDCD6	0.035551
SDF2L1	0.035462
EIF3H	0.035253
HYAL1	0.035136
ATP5B	-0.035091
HDDC2	0.034969
ATP6V1F	-0.034732
FAU	0.034729
TST	0.034622
MRPS17	-0.034589
S100A6	0.034322
RSL24D1	-0.034133
C9orf152	0.034014
TARP	0.033941
NDUFB5	-0.033543
RANGAP1	0.033185
RPL27	0.033094
RPL30	-0.032711
TALDO1	0.032567
MRPL36	0.032428
SCGB2A2	0.032251
RPL5	-0.032228
SLC25A5	0.032172
RPL13A	0.032139
ATP6AP2	0.032039
EIF2AK1	0.031768
VPS35	-0.031670
RPS14	-0.031606
DBI	-0.031549
ZNF549	-0.031511
PLOD1	0.031372
RPS18	-0.031235
SLIRP	-0.031198
RBM22	-0.031190
PTBP1	-0.031128
CKS2	0.030986
PURB	-0.030926
KLF2	0.030903
TMX2	0.030759
B4GALT5	-0.030549
COPS5	-0.030301
NDUFS3	-0.030280
RPS3	0.030194
SEC61B	0.030025
PGRMC1	-0.030006
ID3	0.029967
MBD4	-0.029910
LAMA5	-0.029893
RAB9A	0.029490
HIST1H4C	0.029455
IMP3	-0.029188
APOA1BP	0.029088
CAPZA2	-0.029087
ZNF486	-0.029066
CD151	0.029055
MUCL1	0.029041
AARS	0.028945
P4HB	0.028927
SEP15	-0.028913
PFN1	-0.028769
POLE3	0.028672
TMEM17	-0.028592
EFNA1	-0.028556
MLPH	0.028510
PCMT1	0.028489
FERMT2	-0.028397
IGFBP5	-0.028282
RPL18	-0.028251
STRA13	0.028157
CYC1	-0.028028
HSPE1	0.027877
OSBP	0.027847
HIST2H2AA3	-0.027371
EBNA1BP2	-0.027324
EPRS	-0.027200
YIF1A	0.027197
TK1	0.027194
AMY1C	-0.027148
ISG20	0.027109
COX6C	0.027041
DAD1	0.026987
INHBB	0.026843
CITED2	0.026674
ATP5F1	-0.026451
NDUFB2	0.026382
NLRP8	-0.026314
NOL11	-0.026138
PSMA6	-0.026112
RPL6	-0.026071
GPNMB	0.025995
SRRT	-0.025946
SOD1	0.025937
TACSTD2	-0.025913
EIF1	0.025912
ZC2HC1A	-0.025898
CLIC1	-0.025754
WASL	-0.025737
LDHB	0.025714
HADH	0.025634
CRACR2B	0.025437
GTPBP4	0.025328
KRT7	-0.025309
IL18	-0.025265
RPL9	-0.025247
SERBP1	-0.025219
C1orf64	0.025195
EIF3E	-0.025188
KAT2A	-0.025048
CYP1B1	-0.024941
MRPL13	-0.024894
MRPS22	-0.024713
CFD	-0.024602
TBATA	-0.024529
FAM120A	0.024409
MAGT1	-0.024323
CPNE3	-0.024161
HMG20B	0.023920
HNRNPAB	-0.023905
PTTG1IP	0.023842
ZHX2	0.023838
RPL18A	0.023749
MRPL32	-0.023741
VAMP8	0.023699
PSME1	-0.023626
MYL12A	-0.023616
DDX5	-0.023566
LACTB2	-0.023499
EEF2	0.023493
PRDX3	0.023489
KRT8	0.023455
KRTCAP2	0.023440
ETFA	0.023425
LEPREL1	0.023366
GPR56	-0.023344
TSPAN9	0.023322
DDB1	0.023285
PSMC2	-0.023244
RPL12	-0.023132
ZNF217	-0.023121
CMC2	0.023102
RPL36	-0.023091
AOC4P	-0.023009
UFC1	-0.022977
NPC2	0.022947
DENND2D	-0.022941
ATP5O	-0.022862
DUSP19	-0.022806
EIF3K	-0.022781
GNAS	0.022764
ATP6AP1	0.022716
SAE1	0.022686
PGAP3	-0.022555
MSH3	-0.022503
SRP9	-0.022474
MRPL41	0.022469
NDUFB10	0.022464
CD163L1	0.022425
EIF3L	-0.022338
USP49	-0.022264
SRSF2	-0.022177
ELF3	-0.022158
ITPR3	-0.022151
CLEC2D	-0.022056
NDUFV1	0.021966
TAX1BP1	-0.021926
CTSL	0.021904
ADM	-0.021888
C16orf58	0.021851
TMED10P1	0.021845
CPE	-0.021834
ARPC1A	-0.021826
TSPO	0.021771
SNRPG	-0.021730
RPSA	-0.021724
ODC1	0.021722
SUMO3	-0.021719
CIB1	0.021704
DDIT4	-0.021638
C8orf76	-0.021528
GNS	0.021493
MTSS1	-0.021484
ATP5J2	-0.021407
RPL24	0.021374
NDUFA13	-0.021371
PON2	-0.021329
RPL7	-0.021301
RDH10	-0.021292
CD2BP2	-0.021279
ATP6V1B1	-0.021256
ALPP	-0.021244
GGA1	-0.021115
CKS1B	0.021110
RPL3	0.021084
BAIAP2L2	0.021080
PITX1	0.021073
FBLN1	-0.021005
RPL39L	0.020997
KPNB1	-0.020987
NSA2	-0.020851
TYMP	-0.020833
RPS20	-0.020800
HSPH1	-0.020770
TUBA1A	0.020747
KLF9	0.020698
BRI3	0.020690
SFXN4	0.020574
HSP90AA1	-0.020564
VIPR1	-0.020563
SSBP1	-0.020522
FAF2	-0.020399
FAM213A	-0.020284
CALM2	-0.020270
NOP10	0.020267
THOC7	-0.020259
CRELD2	0.020158
MKRN1	-0.020127
RPL19	0.020111
ZNF14	-0.020102
DDIT4L	0.020090
ATP5D	0.020073
IMP4	0.020037
ROMO1	0.020036
ZNF704	-0.020024
IGF2R	0.019935
NDUFS5	-0.019876
FARSB	0.019792
MRPS24	-0.019773
PPP1CC	-0.019751
CITED4	-0.019701
IER3	-0.019661
PUF60	-0.019605
MT1A	0.019578
RPL23AP64	-0.019570
EFHD1	0.019561
OVOL2	-0.019539
CAPN1	0.019537
GABPB2	-0.019440
SF3B5	0.019432
GSDMB	0.019416
BRD2	-0.019411
MANF	0.019327
ATP6V1E1	0.019321
RARS	-0.019317
NOL7	-0.019316
PRDX5	0.019310
CDC20	-0.019162
HSPA1B	0.019111
PRDX6	0.019081
PTGES3	-0.019057
ANXA2	0.019040
MT2A	0.019000
CYBA	-0.018990
DUSP1	-0.018981
ARPC5	0.018890
SCYL1	0.018853
MAT2A	-0.018840
SGCE	-0.018724
PROM2	0.018714
RPLP1	0.018641
TCEB1	-0.018587
KYNU	0.018520
AHCYL1	-0.018468
DDX21	-0.018460
TRMT112	0.018423
YWHAQ	-0.018383
WWC1	-0.018383
LMNA	0.018368
PALLD	-0.018364
S100A14	0.018298
SIDT2	0.018236
TOB1	0.018162
CX3CL1	-0.018114
CRYZ	-0.018085
ZNF622	0.018085
TSPAN13	0.018080
MRPL37	-0.018053
ARHGDIA	0.018037
SARAF	-0.018033
MPC1	0.018023
UROS	0.017990
SNX3	-0.017964
DNMT1	0.017902
MRPS12	0.017896
TRIP6	-0.017862
PRDX1	0.017798
TRABD	0.017789
TUBB4B	0.017743
KHDRBS1	-0.017736
UHMK1	-0.017670
CCR6	-0.017575
ARGLU1	-0.017537
CTGF	-0.017477
ORM1	-0.017463
PTPLB	-0.017391
NDUFAF3	0.017389
HIST1H2BD	-0.017349
RHOA	0.017317
PSMB4	-0.017313
BLZF1	-0.017310
NOA1	-0.017307
RAB10	-0.017205
KIAA0101	0.017157
UBXN1	0.017146
CCDC6	-0.017061
TBCA	0.017053
CKMT1A	-0.017050
PTGES2	0.017042
NOP56	-0.017010
SHFM1	-0.017006
HIST1H1C	-0.016983
HSPA1A	0.016980
NDUFS4	-0.016959
UBE2M	0.016942
PPP1R14B	0.016876
NFKB1	-0.016823
NPM3	-0.016693
DKC1	-0.016651
CD24	-0.016639
IDH3B	-0.016605
RRAGA	0.016591
BTF3	-0.016574
MYO5C	0.016506
CLCN7	0.016497
DDX56	-0.016491
CTNNA1	-0.016478
EVL	0.016432
NUCB1	0.016427
POLE4	0.016421
CLINT1	-0.016390
TSKU	0.016366
SNRPB	0.016284
TFAM	-0.016274
MORF4L2	0.016248
PIEZO1	-0.016213
PTMA	-0.016208
EPCAM	-0.016199
TMBIM6	0.016171
PSME2	-0.016108
HARS	-0.016101
MRPL21	0.016087
PRPS1	0.016086
SLC7A5P2	0.016061
TMEM109	0.016050
RPN1	0.015998
SUCLG1	0.015976
GAR1	-0.015967
COX5A	0.015947
SLC25A3	-0.015936
DMC1	-0.015908
EID2B	-0.015880
EPAS1	0.015833
ESYT2	0.015791
SHROOM3	-0.015741
SPPL2A	-0.015725
STIP1	0.015719
CUTA	0.015713
NDUFA4	0.015704
EIF4A3	-0.015677
STOM	0.015675
PGD	0.015652
MRPL15	-0.015650
CAMK2G	-0.015645
KPNA4	-0.015601
XAGE2	0.015598
EIF3D	0.015589
SLC25A10	0.015589
ANXA1	-0.015526
CYP4B1	0.015522
CPD	-0.015461
ZNF69	-0.015448
GNB1	-0.015437