!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!drug_name	Estradiol
!smiles	CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
!drugbank_id	DB00783
!pubchem_cid	5757
!cell_type	Breast adenocarcinoma MCF-7 cell line
!organism	human
!end_metadata
EGR3	0.088823
WISP2	0.073748
PDZK1	0.069042
RBM24	0.066026
SYTL5	0.064058
IFI44L	-0.061936
ASB9	-0.059425
COL21A1	0.058748
PKIB	0.058501
SGK3	0.056110
ARHGAP36	0.054775
NPY5R	0.053108
PRSS23	0.052624
CXCL12	0.051717
RAB31	0.051338
SFXN2	0.051248
PGR	0.051210
MSMB	0.049200
ABCG1	-0.049032
ANKRD30A	-0.047958
APOD	-0.047636
MNS1	0.047201
TNFRSF11B	-0.046737
BLNK	-0.046581
C1orf226	0.046037
RERG	0.045103
HINT3	0.044414
IGSF1	0.044079
DDIT4	-0.044048
MME	-0.043205
SERPINA3	0.043120
PAQR5	-0.043113
SGK1	0.042792
ERC2	-0.042702
RBP7	0.042606
CAV1	0.042185
CDH26	0.042074
AGR3	0.041887
PGLYRP2	0.041855
TFPI2	0.041786
COL6A3	0.041594
BRINP3	-0.041483
PELI2	-0.041452
RAPGEFL1	0.041347
C8orf46	0.040984
JAK2	0.040778
GRHL3	-0.040464
FHL1	0.040379
IGFBP4	0.039996
TCF7L1	-0.039733
TFF1	0.038994
MYO16	0.038917
RAMP3	0.038715
IL1R1	-0.038713
TGFBI	0.038444
CELSR2	0.038171
FAM134B	-0.038003
KCNK6	0.037971
PMAIP1	0.037695
ELOVL2	0.037328
IFI44	-0.037275
CYP24A1	0.037256
LOC653602	-0.037225
KLK11	0.037138
RET	0.037071
UBE2QL1	-0.037066
CALCR	0.036918
GEM	0.036900
CTSD	0.036645
MATN2	-0.036605
GLA	0.036501
WNT2B	-0.036433
GREB1	0.036234
AHRR	-0.036204
C5orf34	0.036060
DRD1	-0.035552
GHR	-0.035454
CSTA	-0.035346
TMSB15A	0.035165
BTG2	-0.035137
PCP4	0.034819
PIK3R3	-0.034730
TPD52L1	0.034646
PCSK2	-0.034164
SALL4	-0.034018
ENC1	-0.033574
BCAR3	-0.033421
RUNDC3B	-0.033295
ISG20	0.033004
C12orf60	0.032982
BIK	-0.032913
KCNJ2	-0.032789
H19	0.032640
CREBRF	-0.032559
BMP5	0.032530
EFEMP1	-0.032282
TMEM164	0.032233
CDK6	-0.032210
IL17RB	0.032208
EFNA1	-0.031689
GPX8	0.031549
FAM107B	-0.031376
C6orf165	-0.031308
IFI6	-0.031135
B3GNT5	-0.030993
NDP	-0.030926
FGF13	-0.030746
C1QTNF6	0.030706
HIST2H2BE	-0.030705
LAMB1	-0.030638
SHCBP1	0.030625
HCRP1	-0.030514
S100A16	-0.030463
TMEM64	0.030429
TIAM1	0.030325
SYNPO2	0.030209
HS3ST3A1	0.030155
ABCC5	-0.030095
LINC00669	0.030050
EFHD1	-0.030016
FAM110C	-0.029995
HAUS1	0.029950
SLC39A8	0.029942
GDPD3	-0.029805
IFIT1	-0.029771
RPRM	-0.029730
SOX9	-0.029608
PNRC1	-0.029545
ORC1	0.029518
DEPDC1-AS1	0.029498
PMP22	-0.029206
C4orf46	0.029138
FHL2	0.029000
RAD51AP1	0.028998
LYN	-0.028958
ERBB4	-0.028920
NECAB1	0.028820
CMPK2	-0.028662
PGBD1	0.028608
RAI14	0.028593
C1orf106	0.028561
MB	-0.028543
CYP4F11	0.028448
NUAK1	-0.028363
BRCA2	0.028360
ZNF804A	-0.028322
DIO1	-0.028296
WDHD1	0.028216
AGTR1	-0.028183
SRPX	-0.028107
RNF43	-0.028076
TRERF1	-0.027759
C8orf88	0.027734
SYTL2	-0.027704
AGR2	0.027692
YPEL3	-0.027656
CDCA5	0.027614
FRK	0.027567
CCNYL1	0.027252
C1orf112	0.027181
CKAP2L	0.026999
EGR1	-0.026995
FABP5	0.026978
DDIAS	0.026971
PRTFDC1	0.026956
PCDHB16	0.026934
ZNF850	0.026735
TH	0.026711
GPER1	-0.026607
ATP6V0A4	-0.026447
HCAR1	-0.026417
PPL	-0.026266
CDCA2	0.026171
SMIM13	0.026138
PHLDA1	0.026089
SMTNL2	0.026078
ZNF750	-0.026069
SGK223	0.026060
XK	0.026050
CEP55	0.026017
DYNLT3	0.025986
KIF23	0.025932
TSPYL2	-0.025890
SMCO4	0.025889
COL28A1	-0.025826
CENPU	0.025822
C3orf70	0.025788
LINC01016	0.025687
RIBC2	0.025614
FEN1	0.025573
OSCP1	-0.025391
DIRAS2	0.025391
CENPQ	0.025376
STIL	0.025316
WDR76	0.025121
CDCA7	0.025082
FOXC1	0.025072
HEY2	0.025069
WFS1	0.025031
DHRS2	0.025004
DEPTOR	0.024948
TOP2A	0.024941
CDC6	0.024798
LHFPL2	-0.024698
HIST1H2BG	-0.024688
SYT17	-0.024626
CLEC2D	-0.024591
LOC81691	0.024579
C5AR2	0.024558
MX1	-0.024546
BST2	-0.024429
MND1	0.024415
TWIST1	-0.024409
TRAIP	0.024365
ST8SIA4	-0.024365
BRCA1	0.024357
CENPK	0.024330
NOS1AP	0.024255
ID1	-0.024251
TMA16	0.024251
C4orf19	0.024158
TMEM194A	0.024156
MASTL	0.024138
MAN1A1	0.024114
LINC01468	0.024107
RIPPLY3	0.024088
PBK	0.024082
ZNF467	-0.024055
RASA4	-0.023982
TUBB2A	0.023967
CYFIP2	-0.023961
MKNK2	-0.023929
GRB14	-0.023883
ARHGEF37	-0.023818
BRIP1	0.023811
NBEA	-0.023788
ACKR3	-0.023713
AUNIP	0.023706
SEMA3G	0.023640
CREB3L4	-0.023580
MTFR2	0.023571
PCOLCE2	0.023561
CCNG2	-0.023553
MGP	0.023511
LOXL1	0.023445
AREG	0.023419
THBS1	0.023402
CHAC2	0.023373
FKBP4	0.023369
PTGES	0.023364
HIST1H2AC	-0.023334
ARHGAP11A	0.023236
NRIP1	0.023226
FAM64A	0.023188
KIF28P	-0.023156
SELENBP1	-0.023141
RAB26	-0.023073
ARHGAP18	-0.023041
PSCA	-0.023012
EHHADH	0.023009
GBP3	0.023005
KIF11	0.022913
SFR1	0.022896
NPY1R	0.022886
HILPDA	-0.022885
SKA3	0.022866
NELL2	-0.022853
CPNE4	-0.022851
SKA1	0.022840
TMPRSS3	0.022820
HCAR3	-0.022743
JUP	-0.022710
FZD8	-0.022686
LINC01213	0.022659
ARL15	-0.022646
FKBP5	0.022583
EZH2	0.022568
ZNF641	-0.022560
MXD4	-0.022548
PLK4	0.022536
FAIM3	0.022533
NDC80	0.022499
SLC9A3R2	-0.022496
OIP5	0.022481
MDM1	0.022407
IFITM10	0.022381
ACACB	0.022357
PKDCC	0.022340
LOC729296	0.022258
OAS1	-0.022254
FAM214A	-0.022221
NTRK2	0.022220
YIPF1	-0.022213
GALNT4	0.022206
TRIB2	-0.022179
SERPINA1	0.022158
NBPF4	0.022139
LIG1	0.022118
SOX3	0.022100
ACAT2	0.022099
RSRP1	-0.022090
IFI27	-0.022045
SDC2	0.022005
RND3	-0.021986
LOC100506497	-0.021937
ANLN	0.021914
RILPL2	-0.021907
DTL	0.021886
CCNE2	0.021878
FTX	-0.021862
DSCAM	0.021839
OXTR	-0.021819
CDC45	0.021782
NEIL3	0.021767
CCDC146	-0.021766
TCF19	0.021744
GPR160	-0.021735
SUV39H2	0.021735
NAF1	0.021729
DPY19L2	0.021726
FAM105A	-0.021689
CUEDC1	0.021679
PALM3	-0.021646
YBEY	-0.021621
TST	0.021614
COX19	-0.021598
DDX60	-0.021596
CA5B	-0.021590
SGOL1	0.021528
MCM10	0.021527
NEK2	0.021476
MPPED2	0.021450
RAD54B	0.021440
SACS	0.021403
SEMA6D	-0.021380
NAV3	-0.021335
SEMA3C	0.021335
IRF9	-0.021323
CENPN	0.021308
UGDH	0.021234
ASPM	0.021198
SLC36A4	0.021161
INPP5J	-0.021133
SEC24D	0.021133
DEPDC1	0.021124
TNS3	-0.021115
RLN2	0.021062
DPY19L2P2	0.021050
AIM1	-0.021037
CHRNA5	0.021014
AURKB	0.020995
HELLS	0.020966
FANCI	0.020936
HJURP	0.020932
SAMD11	-0.020901
DUSP2	-0.020893
MYBL2	0.020886
DCAF4	-0.020885
ALDOC	0.020848
ACRC	-0.020838
SPOCD1	0.020835
ITPR1-AS1	-0.020832
FAM198B	0.020785
PLCB4	-0.020784
DOK7	0.020769
EXO1	0.020762
MREG	0.020758
RFX5	-0.020753
PCNA	0.020730
KLHL24	-0.020724
ACYP1	0.020704
CDK1	0.020701
CAP2	0.020697
ARHGEF39	0.020656
DNA2	0.020652
SERPINA5	0.020645
L1CAM	-0.020644
GLIS2	-0.020641
IL20	0.020641
DONSON	0.020640
FOXM1	0.020638
RIN2	-0.020600
PLCB1	0.020581
IGDCC3	-0.020546
MYOF	0.020536
LRRC49	0.020498
DEPDC1B	0.020474
TSPAN5	0.020466
GPR68	0.020414
TIPARP	0.020358
VRK1	0.020323
TPBG	0.020313
LGALS3	-0.020280
GINS4	0.020279
ADCY6	-0.020258
RASGRP1	0.020256
ENDOD1	0.020244
NCAPD2	0.020243
PMCH	0.020205
DLG5	0.020177
TUBB6	0.020140
SLC47A1	0.020122
GINS3	0.020110
GSAP	-0.020094
VIPR1	-0.020078
LOC101926996	-0.020067
XKRX	0.020063
CENPL	0.020053
BORA	0.020032
SPC25	0.020032
TMEM158	0.020007
MARCH2	-0.020005
CCND1	0.019993
EIF5A2	0.019935
RRM1	0.019903
MKI67	0.019896
CHSY1	0.019862
KCNK15	0.019837
TMPRSS4	0.019831
KIAA0895	0.019809
SLC27A2	0.019757
TRIP13	0.019748
GGH	0.019741
UNG	0.019732
TMEM180	0.019659
TEX14	0.019619
SMOC2	0.019602
TUBB3	0.019578
TTC39B	-0.019558
ATRNL1	0.019558
TMPO-AS1	0.019554
CYP1B1	0.019550
ST7L	-0.019545
PSD3	-0.019539
ZNF862	-0.019526
MYB	0.019488
PGM5	-0.019480
E2F1	0.019479
PCDHB8	0.019476
CALCOCO1	-0.019473
RAD51	0.019460
NVL	-0.019452
CHEK2	0.019446
CDCA8	0.019445
SEMA4C	-0.019432
DHCR7	0.019427
CAMK2N1	-0.019413
LDOC1	-0.019411
HAUS8	0.019406
SEPT3	0.019390
GRAMD1C	0.019355
HEBP1	-0.019349
KNTC1	0.019343
DHFR	0.019315
GPR37	-0.019299
SUSD4	0.019288
FAM83D	0.019283
CRIP2	-0.019281
CDR2	0.019278
S1PR3	-0.019238
SMG1P5	0.019225
TMEM45B	-0.019214
HSD17B6	0.019206
EPB41L5	-0.019200
SLIT2	-0.019198
PNP	0.019146
LOC100288911	-0.019146
FBXO5	0.019102
MAD2L1	0.019101
MCM6	0.019096
GAS2L3	0.019066
CPE	0.019054
ADRA2A	0.019036
TYMS	0.019024
TTK	0.019000
PRICKLE1	-0.018999
ZNRF2	0.018995
E2F8	0.018990
LOC100506098	0.018986
SDK2	0.018973
YPEL5	-0.018972
CBX6	-0.018956
LIMA1	-0.018955
LOC100506870	0.018954
PTPRG-AS1	0.018933
SLC29A1	0.018915
FZD2	-0.018900
PLEKHF2	-0.018882
KITLG	-0.018875
KIAA1147	-0.018864
C10orf82	-0.018849
TIFA	0.018847
EP300-AS1	0.018844
CD44	0.018826
HSPA2	0.018796
SLC7A5	0.018774
CDCA4	0.018765
C5orf42	-0.018736
KIF14	0.018732
CLHC1	-0.018730