!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Rattus norvegicus
!drug_name	1-[3-(Trifluoromethyl)phenyl]piperazine
!smiles	C1CN(CCN1)C2=CC=CC(=C2)C(F)(F)F
!pubchem_cid	4296
!cell_type	Hepatocytes
!organism	rat
!end_metadata
FADS1	0.107018
FGF21	-0.093746
ACAT2	0.093696
MSMO1	0.092103
IDI1	0.087628
CYP1A1	0.080805
SQLE	0.079837
SULT2A1	-0.079740
HMGCS1	0.079678
CYP8B1	-0.075596
TM4SF4	-0.074892
HMGCS2	-0.073505
GPNMB	0.071419
CYP51A1	0.070612
FDFT1	0.069972
PCSK9	0.066702
DHCR24	0.066629
CYP26A1	-0.064192
FDPS	0.063563
SLC10A1	-0.062263
GYS2	-0.061713
DDAH1	-0.060932
IRF7	0.060493
BHMT	-0.057489
ISG15	0.057323
ACSM5	-0.056715
USP18	0.055672
CXCL3	-0.055141
TM7SF2	0.054805
DAO	-0.054778
IFI44L	0.053951
HMGCR	0.053666
GADD45A	-0.053561
IL1R2	0.053014
RRAGD	0.052909
FBP1	-0.052770
FTCD	-0.052474
FASN	0.052163
HAO2	-0.050609
IFIT3	0.049895
GPM6A	-0.049685
MTTP	-0.048805
VNN1	-0.048785
LSS	0.048770
AASS	-0.047789
TTC36	-0.047613
OAS1	0.047543
TRHDE	-0.047351
HSD17B7	0.047025
AQP9	-0.046737
ANGPTL4	-0.046306
RSAD2	0.046002
BHMT2	-0.045946
DPYSL2	0.044820
KYNU	-0.044386
ABCB11	-0.044369
ACSM1	-0.044024
CRELD2	-0.043937
CIDEC	-0.043726
NQO1	0.042629
RTP4	0.042413
HYKK	-0.042272
EVA1A	-0.042123
ACSS2	0.041722
CDKN3	0.041720
MAOB	-0.041620
GPD1	-0.041443
BHLHA15	-0.041093
ACSL3	0.041012
GLYAT	-0.040157
CNPPD1	0.040109
AGXT2	-0.040056
LOX	-0.039887
MLLT11	-0.039656
DPYD	-0.039432
CSRP3	0.039374
MAFB	-0.038324
AACS	0.038117
PDIA4	-0.037995
INHBE	-0.037901
ENPP3	-0.037646
ABCB1	-0.037539
GAS2	-0.037525
DMGDH	-0.037420
ACOX2	-0.037370
CLDN2	-0.037352
AGMAT	-0.037291
EPHX2	-0.037284
DECR1	-0.037195
SLC4A4	-0.036959
UPB1	-0.036925
ADH1C	0.036680
HSD17B2	-0.036652
SOAT1	0.036622
G6PC	-0.036377
INSIG1	0.036216
NIPSNAP1	-0.036210
MBL2	-0.036194
DYRK3	0.036029
GCAT	0.035894
DHCR7	0.035861
MGST3	-0.035789
SERPINA6	0.035760
TLCD1	0.035361
FAM111A	0.035187
GSTA3	-0.034945
ALDOB	-0.034731
DECR2	-0.034713
RBP7	-0.034488
CA14	-0.034338
HSPB1	-0.034244
SLC37A4	-0.034241
IDH2	-0.034240
SIRT3	-0.034055
PDP2	0.033971
LGALS3BP	0.033951
TMEM30B	-0.033716
ALDH1A1	-0.033639
MIOX	-0.033583
OTC	-0.033568
GSTK1	0.033255
GCKR	-0.033169
GEM	-0.033110
RABGAP1L	-0.033080
ECHDC1	0.033001
HERC6	0.032793
HGD	-0.032579
EBP	0.032555
RCAN2	-0.032391
AGMO	-0.032390
SERPINE1	-0.032334
RCAN1	-0.032300
NNMT	-0.031938
GAMT	-0.031923
CLDN1	-0.031891
FADS2	0.031866
ACAA2	-0.031862
FAM213A	0.031834
CASP4	-0.031568
STX3	0.031558
FBXO9	-0.031379
HSPH1	-0.031116
AKR1D1	-0.031112
ADORA2B	-0.031015
IFI44	0.031002
SLC26A1	-0.030985
ASGR1	-0.030979
PECR	-0.030834
DAK	-0.030731
NSDHL	0.030597
AMPD3	0.030552
MASP2	-0.030537
HSPA4L	-0.030466
AGXT	-0.030456
SULT1B1	-0.030406
IRF9	0.030326
HBEGF	-0.030276
GGCT	-0.030230
SH2D4A	0.030145
ADSSL1	-0.030080
LRP1	-0.029967
STARD4	0.029917
PMVK	0.029890
PAQR9	-0.029599
SNN	0.029530
SH3BGRL	-0.029494
FST	0.029456
HSD17B6	-0.029346
HAAO	-0.029269
RAPGEF4	-0.029231
HAO1	-0.029193
STAT2	0.028977
APOC2	-0.028935
ITPR1	-0.028852
TECR	0.028355
CMPK2	0.028210
LGALS3	0.028167
SAT2	0.028142
HES6	0.028110
SERPIND1	-0.028086
BAAT	-0.028064
GPX2	0.027957
NDRG2	-0.027938
ENPP2	-0.027921
ACOT4	-0.027845
SLC13A5	-0.027716
COQ5	-0.027685
CRYM	-0.027554
REEP6	-0.027546
ACY3	-0.027534
MCM6	0.027475
HMGB2	0.027462
MUM1	0.027409
PHYH	-0.027398
CLN5	0.027311
BAX	0.027309
ACAD11	-0.027266
OPN3	0.027227
MDH1	-0.027211
CYR61	-0.027122
G0S2	-0.027037
DUSP5	-0.026990
DCN	0.026854
SOD2	-0.026788
SEC14L2	-0.026731
CDS1	0.026690
LCAT	-0.026682
PEX11A	-0.026672
TRIM2	-0.026668
PSMB9	0.026658
RGN	-0.026612
DNAJB1	-0.026610
CXCL2	-0.026603
ESM1	-0.026567
MGP	0.026561
HSPA5	-0.026482
ACOT2	-0.026444
SLC25A33	0.026295
HSP90B1	-0.026191
MVD	0.026127
DHRS3	-0.026124
IFITM3	0.026092
NR1I3	-0.026052
DTX3L	0.026034
RUFY1	0.025970
FGGY	-0.025884
ROPN1L	0.025818
NPC2	0.025775
KIAA1217	-0.025752
C8A	-0.025714
ACSM3	-0.025637
EIF2AK2	0.025632
PPP1R3C	-0.025557
DUOXA1	0.025552
IFIT1B	0.025522
MAL2	-0.025518
MAB21L3	-0.025501
CREM	-0.025411
NUCB2	-0.025385
METRNL	0.025294
ETFB	-0.025215
RHBDD1	-0.025118
ATF3	-0.025074
TXNRD3	0.025061
CGNL1	-0.025047
ZFAND2A	-0.025035
UGT2B17	0.025006
CACNB4	0.024934
BPHL	-0.024933
PHLDA3	0.024930
ABCC6	-0.024921
IYD	-0.024901
MMD	-0.024819
LPCAT1	0.024818
PXMP2	-0.024788
AMY2B	0.024764
LIPC	0.024747
RND3	-0.024738
BBOX1	-0.024737
TEX264	0.024704
APPL2	-0.024681
SULT1C2	0.024676
TSR2	-0.024661
TMEM39A	-0.024540
TMEM55B	0.024513
RGS5	-0.024496
VEGFB	0.024481
APOB	-0.024450
CKS1B	-0.024414
TBC1D24	-0.024402
ACAT1	-0.024339
CTSF	0.024322
UAP1	-0.024303
GOLT1A	-0.024293
HADH	-0.024285
SCD	0.024260
DHX58	0.024235
SC5D	0.024231
PLSCR1	0.024173
PLIN5	-0.024160
EEPD1	0.024131
TMEM144	0.024103
GSTM3	-0.024095
SEL1L	-0.024059
AFP	-0.024042
SDF2L1	-0.024008
EGLN3	-0.024008
PLIN3	0.023923
DUSP1	-0.023921
ADI1	-0.023888
ALDOC	0.023855
CSTB	0.023813
OPLAH	-0.023810
PYGL	-0.023648
ADTRP	-0.023574
ABCC2	0.023562
PARP9	0.023489
GM2A	-0.023436
WNT4	0.023304
FLCN	0.023235
SREBF1	0.023202
SLC25A20	-0.023150
CYP2E1	-0.023125
SH3BP5L	0.023088
PDZK1	-0.023046
OCIAD2	-0.022881
MYH14	-0.022877
LAMTOR1	0.022856
TSKU	0.022845
YPEL2	0.022799
MANF	-0.022781
NPAS2	-0.022752
ANPEP	-0.022695
TECPR1	0.022690
FABP7	-0.022683
RAB30	0.022665
RNF213	0.022660
SSR3	-0.022622
KLF10	-0.022611
TCEA3	-0.022610
ODF2L	-0.022581
SLC22A1	-0.022558
FAM134A	0.022543
DDX58	0.022536
PALMD	-0.022477
SLC22A7	-0.022460
ECI2	-0.022422
PARP14	0.022403
DPP7	0.022399
LPCAT3	0.022388
ACADVL	-0.022373
IREB2	-0.022367
TMEM50B	0.022344
GALE	0.022328
LY6E	0.022316
EGR1	-0.022299
SCARA5	-0.022279
COPRS	0.022262
MAOA	-0.022246
GCGR	-0.022221
ANKS4B	-0.022189
MORC4	-0.022151
AQP8	-0.022148
TBCC	0.022114
SEC11C	-0.022081
ARRDC4	-0.022068
PTGFRN	0.022010
MIS12	-0.022006
FNDC3B	-0.021983
FMO5	0.021973
PHKB	-0.021942
CDH17	-0.021918
SECISBP2L	0.021908
PHGDH	-0.021888
LENG1	0.021857
NOP9	0.021820
ARG2	0.021804
SHC4	-0.021769
ACADM	-0.021691
HACL1	-0.021686
CALR	-0.021684
NUDT7	-0.021667
SLC16A10	0.021665
CDR2	-0.021657
ZFYVE26	0.021647
AADAT	-0.021631
TMEM97	0.021611
VIM	-0.021580
KLHL24	0.021543
AFMID	-0.021521
CEMIP	-0.021488
RAB3D	-0.021453
SLC30A1	-0.021408
DEF8	-0.021340
SHROOM2	0.021310
PIGR	-0.021293
NPW	-0.021266
SLC50A1	-0.021250
PLEKHH1	0.021240
BSPRY	0.021240
GREM2	-0.021229
AOX1	-0.021210
FAM114A1	-0.021187
GADD45G	-0.021184
CORO1B	0.021135
PON3	-0.021114
BCKDHB	-0.021100
SEC24D	-0.021099
TSPAN7	-0.021078
CST3	0.021073
CYP1A2	0.021041
SLC27A2	-0.021029
PCYT2	0.021009
ZBTB20	-0.021009
PYCR1	-0.020970
CMBL	-0.020967
TMEM106A	0.020919
MVK	0.020901
MGA	-0.020831
UAP1L1	0.020810
AZGP1	-0.020804
WDR38	0.020776
SORBS2	-0.020765
PLCB1	-0.020758
FUCA2	0.020732
BMP2	-0.020711
PKDCC	0.020695
HSPB6	-0.020636
EXD2	0.020584
CKAP2	0.020578
AS3MT	-0.020504
ZNF354A	-0.020448
CPEB1	-0.020442
GBP2	0.020417
GSTM1	-0.020416
PANK3	0.020331
GCDH	-0.020281
SLC10A2	-0.020254
ACAD10	-0.020244
HOMER3	0.020241
ATP6V1F	0.020228
RBCK1	0.020227
F2R	-0.020212
TSPYL4	-0.020210
MGLL	-0.020171
TM6SF2	-0.020159
CTH	-0.020145
ZDHHC18	0.020144
SEC63	-0.020139
SLC45A3	-0.020119
TMEM256	0.020046
NGFRAP1	0.020044
TBX15	-0.020035
SLC6A9	0.020010
ZNF25	-0.019964
GALK1	-0.019931
SLC5A6	0.019877
OFD1	-0.019872
INHBB	-0.019849
MITD1	0.019848
OGFR	0.019801
HIBCH	-0.019797
CABLES1	0.019774
PHF13	0.019730
ASNA1	0.019718
CENPV	0.019709
CSNK1G2	0.019705
SEC22B	-0.019700
PDIA6	-0.019627
CCNG2	0.019620
HAL	-0.019599
CES1	-0.019562
RINT1	-0.019505
GSTP1	0.019457
ADCK4	0.019448
PPM1H	0.019447
DOCK4	-0.019446
TMEM176B	-0.019431
GNPDA1	0.019431
MID1IP1	0.019404
DNAJB11	-0.019365
PTPN21	-0.019349
KHK	-0.019325
ANKRD37	-0.019310
MFSD2A	0.019274
RASL11B	-0.019269
TMEM98	-0.019238
ATP6V0B	0.019230
JUN	-0.019230
ALAS1	-0.019214
AGTR1	-0.019197
ZNF518A	0.019177
CD36	-0.019172
CLIC1	0.019171
DNASE2B	-0.019133
CC2D1B	0.019132
SMG8	0.019120
INSIG2	-0.019110
GDA	-0.019108
SLC27A5	-0.019088
CXCL10	0.019082
NUP210	-0.019069
EMR1	-0.019028
GNMT	-0.019027
SRP72	-0.019026
AGT	0.019025
SCFD1	-0.018967
ARFGAP3	-0.018940
PXMP4	-0.018901
CPED1	0.018882
SMAD2	0.018874
MMP19	-0.018840
SMYD4	0.018829
ABCB4	-0.018827
GSTM4	-0.018824
ORAI3	0.018822
TCF19	0.018807
PDE4B	-0.018799
TXK	0.018796
MYLK	-0.018740