!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Rattus norvegicus
!drug_name	Caerulein
!smiles	CC(C(C(=O)NCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)OS(=O)(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C5CCC(=O)N5)O
!pubchem_cid	16132921
!cell_type	Livers - 48 hours after exposure
!organism	rat
!end_metadata
INSIG1	-0.168846
COMT	-0.156161
A2M	0.133867
BHMT	0.128678
TDO2	0.122871
LCN2	0.119799
FGL1	0.118287
SCD	-0.116712
CYP8B1	0.112799
ALAS1	-0.110206
SDS	0.109218
APOA5	0.104017
CTSV	0.103994
UQCRQ	-0.100954
MIF	-0.098858
RETSAT	0.097024
CP	0.096884
TUBB2A	-0.095642
ERRFI1	-0.090225
SAT1	0.090111
PCK1	-0.087816
METTL7B	-0.085541
SAA2-SAA4	0.083301
HSD17B6	-0.082571
CHCHD10	-0.076482
TMEM176A	0.074674
PHYH	0.074329
GNMT	0.073924
ITIH4	0.071398
CEBPB	-0.071229
RCAN1	-0.069109
FTCD	0.068197
RPL35	-0.068076
TSKU	-0.067836
SULT1B1	0.066102
RPL27A	-0.065788
HP	0.063936
GOT1	0.063759
RPL31	-0.063706
FMO5	0.063663
TAT	-0.063517
RBP1	0.063427
HPX	0.062978
TMEM176B	0.062436
TXN	-0.061082
SEC61G	-0.060732
RPS17	-0.060728
ACSL4	0.059964
RPS28	-0.058617
FGA	0.058356
UPB1	0.056666
GLUL	0.056341
APOC4	-0.055846
FN1	0.055242
CPT1A	0.055153
ASL	0.055063
RPS15	-0.053629
THRSP	0.053627
CPB2	0.052789
GAPDH	-0.052578
TPT1	0.052252
SPTSSA	0.052188
MAT1A	0.052113
LBP	0.052016
CALR	-0.051597
CREG1	-0.051521
P4HB	-0.051481
FGG	0.051428
REEP6	0.051359
RPL38	-0.051282
ADH1C	0.051176
ATP5J2	-0.050746
GSTK1	-0.050620
AASS	0.050297
SCPEP1	0.050286
IRF2BP2	-0.050205
CA3	-0.049965
RPS12	-0.049811
SAR1B	0.049756
DNAJA1	0.049616
ARG1	0.049219
PDIA4	-0.049168
RPL27	-0.049144
CSAD	0.048460
CFH	0.047096
RPS26	-0.046437
DDX5	0.046227
HMGCS1	0.046050
RPS11	-0.045249
COX7A2	-0.045216
RPL37	-0.044868
RNASE4	0.044599
FADS1	-0.044540
CYP1A2	-0.044364
RPL5	0.044171
JUND	-0.044107
C3	0.044080
GABARAPL1	0.044047
SOD1	-0.043424
FABP5	-0.043262
F2	0.043058
GCK	-0.042671
SQRDL	0.042655
ECH1	0.042519
RPS23	-0.042305
C5	0.042257
HSPA8	-0.042142
CFB	0.042043
ND3	0.041944
IGFBP4	0.041593
TSC22D3	-0.041370
CFHR1	0.040836
NUDT4	0.040657
PIGR	0.040615
HSP90AA1	0.040379
NSDHL	-0.040322
C9	0.040276
CD81	0.040116
SLC37A4	0.040021
ALDH9A1	-0.039764
RPS21	-0.039675
APCS	0.039535
LONP2	-0.039500
PGPEP1	-0.039252
SERPINA6	-0.038999
ATP5A1	-0.038808
PPCS	0.038664
NDUFA11	-0.038461
FMO3	0.038099
RCL1	0.038081
KNG1	0.037978
GCKR	-0.037871
ACLY	-0.037779
APOC2	-0.037736
CD302	0.037622
USMG5	-0.037495
DPT	0.037465
UQCR10	-0.037451
AKR1A1	-0.037441
RPL19	-0.037407
NDUFB4	-0.037350
DAK	-0.037329
QDPR	0.037086
PSMB9	-0.037079
TTR	-0.037015
NDUFB11	-0.037004
COX1	-0.036911
MFGE8	-0.036881
TMEM30A	0.036651
RPS10	-0.036544
RPS3	-0.036503
IRF1	-0.036469
GUCD1	-0.036465
CNBP	0.036447
RPN1	-0.036217
TM7SF2	0.036180
WFDC2	-0.036083
HEBP1	-0.036080
RPS9	-0.035806
IVNS1ABP	0.035757
RTP4	-0.035711
ABCB11	0.035560
NDRG2	-0.035461
SERPINA3	0.035385
SLC10A1	0.035317
ACTG1	0.035249
ATOX1	-0.035238
PDHB	0.035206
EFNA1	0.035125
GJB1	0.034844
DDAH1	-0.034792
KLKB1	0.034693
CLPX	0.034631
SERPINA11	0.034576
HHEX	-0.034428
ATP5G1	-0.034391
RPL18	-0.034390
RPL7A	-0.034343
CD63	0.034308
DDT	-0.034080
APOH	0.034004
MAP1LC3B	0.033998
COX7B	-0.033787
PSMB3	-0.033704
ANGPTL3	0.033599
ZNF354A	-0.033514
ROMO1	-0.033506
GLUD1	0.033396
RPL15	-0.033387
FAU	-0.033373
FDPS	-0.033359
TOMM7	-0.033354
PPA1	-0.033273
PCSK9	-0.033231
HIBADH	0.033188
MFSD2A	-0.033184
GRHPR	-0.033035
TST	-0.032889
CYP7A1	0.032749
NDFIP1	0.032722
NDUFB5	-0.032709
SEC61B	-0.032545
ENO1	-0.032503
SGK1	-0.032499
ALDH2	-0.032404
INSIG2	-0.032308
APOA2	-0.032279
TSPAN31	-0.032269
RPL12	-0.032068
SERPING1	0.031916
SELK	-0.031892
RPS20	-0.031762
PKLR	-0.031751
MSMO1	0.031739
ITIH3	0.031533
PLA2G12A	0.031529
PARK7	-0.031385
EIF4EBP3	0.031273
RAB11A	0.031226
SLC3A2	0.031214
CITED2	0.031099
TMEM205	-0.030987
SULT2A1	-0.030907
GJB2	0.030870
NACA	0.030846
COPE	-0.030827
ATP5B	-0.030810
IGFBP3	-0.030666
RPS16	-0.030662
CLU	0.030592
SLC2A2	0.030585
RPL10A	-0.030436
NDUFB9	-0.030373
SLC27A5	0.030351
ACSL5	-0.030239
CTSH	0.030213
SOCS2	-0.030123
VKORC1	-0.029996
SURF4	-0.029990
RARRES2	-0.029927
LMAN2	-0.029780
HINT2	-0.029649
APOB	0.029614
DHCR24	0.029589
TOMM20	0.029515
POLG2	0.029489
ETFB	-0.029344
KPNA2	-0.029028
HAL	-0.028994
CERS2	-0.028925
MANF	-0.028891
HMOX1	0.028811
FBXO31	0.028780
DMGDH	0.028655
HAO2	0.028617
F9	0.028508
NDUFA4	-0.028480
TALDO1	-0.028455
CDH2	0.028333
FABP7	0.028132
RPS19	-0.028105
EDEM1	0.028074
NDUFB2	-0.027997
TUBB4B	-0.027993
G6PC	0.027983
PPP1R3C	-0.027971
SPINK1	0.027831
EPAS1	0.027797
HRSP12	0.027767
AHCY	0.027761
BSG	0.027624
RPL28	-0.027562
ADH5	0.027503
MYEOV2	-0.027390
EEF1B2	0.027356
SLC39A4	-0.027280
PTP4A1	0.027251
NCL	0.027223
NDUFB7	-0.027075
RPS29	-0.027055
GBE1	-0.026992
ZFAND6	0.026917
MOCS2	-0.026880
HAGH	-0.026820
C8A	0.026787
CLTA	0.026714
HERPUD1	-0.026645
PGRMC1	0.026571
ASGR2	0.026408
GCSH	0.026391
MID1IP1	-0.026319
SLC39A14	0.026197
ST6GAL1	0.026187
GCHFR	-0.026184
SLC25A15	0.026103
PAH	-0.026102
AGMO	-0.026030
CES1	-0.025884
AGT	-0.025756
MST1	-0.025702
PRKAB1	0.025674
NDUFV3	-0.025641
TMA7	-0.025359
ATP5O	-0.025343
HSPB1	0.025331
TRIM25	0.025176
RNASEK	-0.025091
SLC27A2	0.025085
SORD	-0.025050
AMBP	-0.024962
MKNK2	-0.024955
FADS2	-0.024915
PSMB4	-0.024799
PPAP2B	0.024795
LAPTM4A	0.024741
DSTN	0.024729
UBC	-0.024720
COX8A	-0.024536
LCMT1	-0.024525
SLC22A8	-0.024491
HSP90B1	-0.024473
APOM	-0.024456
ND2	-0.024452
FTH1	0.024370
TMEM256	-0.024317
NDUFA3	-0.024263
SLCO2A1	0.024250
LYZ	-0.024218
GSTM5	-0.024214
ATP5H	-0.024148
DCAF11	-0.024110
MDH2	-0.024066
SNRPD2	-0.023879
ASS1	-0.023832
HSPD1	0.023790
RPL11	-0.023687
AHSG	-0.023679
HSP90AB1	-0.023665
CTSB	0.023658
EBP	0.023564
HSPA5	-0.023539
TMEM258	-0.023532
HAO1	-0.023513
TUBA4A	-0.023501
HSD17B13	0.023470
ALDH6A1	0.023466
SERBP1	0.023435
LDHA	-0.023331
IRF7	-0.023275
CDC42EP4	-0.023169
TKT	-0.023121
RBM3	0.023115
NDUFB6	-0.023112
MRPL54	-0.023107
KRT8	-0.023077
PDIA6	-0.023063
GDE1	0.023047
FKBP11	-0.023037
BCAP31	-0.022981
AKR1D1	0.022946
CD164	-0.022934
SERPINF2	0.022886
SLC38A4	0.022877
NPM1	0.022858
PSENEN	-0.022857
UGDH	-0.022856
TTPA	0.022842
POLR2L	-0.022809
GAMT	0.022794
IRF2BP1	-0.022785
FAM134B	0.022751
SHMT2	-0.022727
SPTAN1	0.022716
OSGIN1	-0.022609
DBI	-0.022604
EPHX2	-0.022572
EIF3M	0.022513
BAAT	0.022449
EDF1	-0.022427
RPL22	-0.022411
STARD10	0.022390
TGFBI	-0.022380
GSTM2	0.022374
ADTRP	-0.022364
RAN	-0.022238
BDH1	-0.022211
COL3A1	-0.022204
PSMA7	-0.021962
ACAD11	0.021858
POR	0.021845
CLPTM1L	-0.021801
ISCU	0.021760
XBP1	0.021742
EGR1	-0.021664
ARHGAP17	-0.021512
CLEC4F	-0.021477
RBP4	-0.021452
HSD3B7	-0.021450
PSME2	-0.021449
KDELR2	-0.021447
MGP	-0.021352
SIGMAR1	-0.021286
SLC38A2	-0.021252
NET1	0.021236
PLIN2	0.021201
ECHDC3	-0.021195
TMCO1	0.021173
MIPEP	-0.021138
CNDP2	-0.021129
DNAJB11	-0.021118
VCP	-0.021097
GAS2	-0.021052
SV2B	-0.021004
VPS29	-0.020930
HNRNPAB	0.020902
USE1	-0.020849
LAMTOR4	-0.020847
UBE2L6	-0.020801
SSR4	-0.020777
SPCS1	-0.020773
TPST1	0.020672
COX4I1	-0.020667
THUMPD1	0.020664
LY6E	-0.020538
CAPNS1	-0.020458
NDUFS8	-0.020452
SQLE	0.020374
CTSD	0.020309
DAD1	-0.020294
NUCB2	-0.020258
DYNLL1	-0.020143
CAT	0.020123
APMAP	-0.020025
PPIB	-0.019975
RPS13	-0.019967
GPX1	-0.019896
PBLD	0.019777
EIF4A2	0.019765
RHOB	-0.019750
ATP6V0D1	-0.019748
ECHDC2	0.019737
MAGED1	-0.019655
HMGCR	-0.019443
HGFAC	0.019441
MBL2	-0.019359
ACOX1	0.019335
CLK1	0.019331
UQCRB	-0.019297
UGP2	0.019261
BLOC1S1	-0.019254
ATP5F1	0.019220
PMVK	-0.019218
RPL13A	-0.019157
SEC16B	0.019155
ETHE1	0.019145
MCFD2	0.019105
GLYCTK	0.019088
EIF3E	0.019074
RPS7	-0.019061
ATP5L	-0.019053
SERP1	-0.018971
HGD	-0.018943
PDIA5	0.018860
CTDSP1	-0.018832
GSTA5	-0.018801
CIAPIN1	0.018763
EIF2S2	0.018685
APOA1	-0.018662
CA8	0.018604
MRPL41	-0.018579
F5	0.018456
ALAD	-0.018421
ABHD14B	0.018407
TMEM97	-0.018394
M6PR	-0.018382
ASGR1	0.018382
SPCS2	-0.018373
CD14	-0.018336
FGB	0.018316
CYTB	0.018275
SDC2	0.018270
FBP1	-0.018253
DHRS1	0.018230
DNAJC22	-0.018160
CRELD2	-0.018117
SLCO1B3	0.018111
SPP2	0.018102
HSD17B2	0.018091
ALDOA	0.018028
UQCR11	-0.018028
ATP6V0C	0.017997
CYC1	-0.017971
RGN	0.017937
TMEM14C	0.017893
NCOA4	0.017864
FECH	-0.017831
SEPP1	0.017802
RPL9	-0.017762
DHRS3	-0.017756
ASPG	0.017755