!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Mus musculus
!ligand_name	17beta-estradiol
!ligand_id	CHEBI:16469
!cell_type	bone marrow (BM) c-kit+ stem cells (SCs)
!organism	mouse
!end_metadata
IL6	0.138688
IL12B	0.085071
CXCL10	0.081808
IRG1	0.077316
FOSB	0.072905
GEM	0.066102
MEFV	0.063634
RASGEF1B	0.063436
PTGS2	0.062520
CD69	0.062282
IL10	0.061473
NFKBIE	0.061462
MALT1	0.061201
CD40	0.061194
IL1B	0.059488
FLRT3	0.057919
PPP1R15A	0.057877
IL23A	0.057840
TRAF1	0.057797
CSRNP1	0.056378
FPR2	0.056183
IL1A	0.054992
CDC42EP2	0.054846
KDM6B	0.054439
FPR1	0.053950
IFIT1B	0.053839
SLC2A6	0.053310
MAFF	0.052995
GBP6	0.052821
ZNF263	0.052716
CPA3	0.052334
DUSP2	0.052158
EHD1	0.050704
ZC3H12C	0.049014
RAB20	0.048598
CD83	0.048041
HILPDA	0.047410
SOCS3	0.047330
INSIG1	0.046685
REL	0.046254
CD274	0.046150
IFNB1	0.046100
SLC7A11	0.045219
NR4A1	0.045011
PHLDB2	0.044738
OASL	0.044714
NUPR1	0.044230
CLEC4E	0.044106
FSTL1	0.044076
ARG2	0.044061
CSF2	0.044049
TRIM13	0.043904
PRDM1	0.043863
FRAT2	-0.043844
FAM26F	0.043318
SEMA4C	0.042855
DUSP4	0.042427
ICAM1	0.041658
CCRN4L	0.041475
PELI1	0.041086
RNF19B	0.041009
JUNB	0.040987
HOXA1	-0.040310
SPIC	0.040178
CAV1	0.039762
ARHGEF3	0.039737
CASP4	0.039120
CCL5	0.039071
TMEM88	0.039037
CCRL2	0.038449
ADORA2B	0.038047
RSAD2	0.038009
BIRC3	0.037903
OGN	0.037880
STX11	0.037863
GPR18	0.037803
CEBPB	0.037779
RALGDS	0.037667
ZFP36	0.037510
IFRD1	0.037227
IRF7	0.037171
MYL9	0.037159
BCL3	0.037008
MTHFS	0.037003
ADM	0.036855
JDP2	0.036795
IL1RN	0.036326
GADD45A	0.035938
P2RY2	0.035779
PLAC8	0.035706
TNIP1	0.035486
GADD45B	0.035370
GSG2	-0.035323
FAT1	0.035039
ORAI2	0.035029
CTGF	0.034984
MARCKSL1	0.034775
TNF	0.034696
GPR68	0.034344
CCL4	0.034250
GDF15	0.034080
PARP14	0.034062
GPR84	0.034026
ZNF408	-0.033866
GBP4	0.033746
HELZ2	0.033576
RBAK	-0.033330
MARCO	0.033292
IRF1	0.033173
TNFAIP3	0.033103
SNX18	0.032945
ZNF546	-0.032899
PROCR	0.032836
NFIL3	0.032815
NFKBIZ	0.032722
PDGFRB	0.032601
DUSP6	-0.032598
LPAR6	-0.032528
EGR1	0.032520
CD38	0.032486
GPR85	0.032454
TLR2	0.032409
OLR1	0.032364
PRMT1	0.032195
CXCR4	0.032114
MTERF	-0.032063
LSM14B	-0.031858
CXCL2	0.031699
EGR2	0.031495
SOWAHC	0.031448
DIAPH3	0.031370
HCAR2	0.031365
RAPGEF2	0.031364
IL17RA	0.031337
RNF19A	0.031299
ARRDC3	-0.031236
GPX8	0.031090
TSLP	0.030915
TGIF1	0.030902
BCL2L11	0.030796
LCN2	0.030775
LY9	0.030751
NFKBID	0.030541
PRR5L	0.030482
ZNF623	-0.030376
ZNF790	-0.030276
C3	0.030232
RELB	0.030157
CCL3L3	0.030029
LRP1	-0.029826
BORA	-0.029708
MMP14	0.029491
PIM3	0.029395
HTRA1	0.029382
DDIT4	0.029360
CDC42EP4	0.029204
SKIL	0.029198
PTGIR	0.029158
SLAMF8	0.029126
ZNF667	0.029025
GBP2	0.028971
ANKRD33B	0.028926
HEG1	0.028895
WDR53	-0.028749
ID3	0.028714
SUPT4H1	0.028667
CCDC122	0.028515
C8orf58	-0.028490
NLRP3	0.028486
BGN	0.028454
H19	0.028418
C10orf10	0.028290
CFLAR	0.028225
SERPINB2	0.028101
BTG1	0.028045
NUAK2	0.028041
ZC3H8	-0.027980
GCH1	0.027807
IGSF6	0.027585
TGM2	0.027584
TXNIP	-0.027546
TMA16	0.027514
AS3MT	0.027357
C14orf169	-0.027179
CLK1	0.027067
ARL5B	0.027065
FAM46C	0.027034
LIPT2	-0.027029
PLSCR1	0.026913
HIST1H3C	-0.026874
THBS1	0.026755
TTC30A	-0.026710
F10	0.026678
SGK1	0.026645
SDC1	0.026630
OSM	0.026593
RNF145	0.026449
MAP3K8	0.026432
C15orf65	-0.026396
ZNF764	-0.026307
MTMR14	0.026284
ZNF131	0.026239
RILPL2	0.026188
LGALS3BP	0.026136
MGP	0.026037
OPLAH	0.026032
MAPKAPK2	0.026020
F7	0.025936
AGFG2	-0.025928
SKA3	-0.025850
DPEP3	0.025841
SLC8B1	0.025813
THBD	-0.025785
TAL1	-0.025736
FAM20C	0.025427
CXCL12	0.025396
SOD2	0.025287
POLD4	-0.025251
ETS2	0.025212
BTG2	0.025179
VCAM1	0.025141
IQSEC3	0.025110
JAG1	0.025078
ZNF275	0.024987
BMP2	0.024970
MMP13	0.024877
ARRDC2	0.024812
C16orf54	-0.024675
HK2	0.024666
ITGB7	0.024615
CD55	0.024543
PDE4B	0.024497
SQSTM1	0.024476
HP	0.024441
STK16	-0.024373
GRAMD1A	0.024349
PLEK	0.024311
CCDC117	-0.024199
GGCT	0.024176
NXPE4	0.024067
MXD1	0.024035
PPAP2B	0.024032
DDHD1	0.024011
SH2B2	0.023936
PIK3R5	0.023914
C1QA	0.023901
HLA-DRB5	0.023876
SLC39A4	0.023767
SRC	0.023757
PIM1	0.023676
SDC4	0.023567
PLEKHF1	-0.023562
IPP	-0.023558
FOXN2	0.023553
BLNK	0.023551
IRS2	0.023535
XRCC6BP1	-0.023439
THBS2	0.023406
PER1	0.023321
IFIH1	0.023192
OSGIN2	0.023186
TRIM68	-0.023138
ZNF569	-0.023056
CTSC	0.023041
NOD1	0.023029
KLF7	0.023027
PTGER4	0.022969
TFEC	0.022934
TRAF2	0.022846
GPR34	-0.022825
TIPARP	0.022760
UCHL1	0.022760
RND1	0.022739
NFE2L1	0.022708
CMTM7	-0.022691
TNFAIP2	0.022594
SPATA13	0.022565
EXOSC7	-0.022510
MANSC1	0.022480
TRIM41	-0.022455
DKK3	0.022427
IFIT3	0.022370
SPARC	0.022363
SLC7A5	0.022280
FERMT2	0.022280
C9orf72	0.022217
IKBKE	0.022199
HAUS3	-0.022170
IRAK2	0.022153
NCK1	0.022149
FOXA1	0.022014
COL6A2	0.021967
PPP1R3D	-0.021914
TMEM260	-0.021907
IGIP	-0.021903
ZNF438	0.021880
IFIT2	0.021825
ID1	-0.021824
TTC30B	-0.021817
DENND2C	-0.021735
DUSP5	0.021704
BAG2	-0.021626
TSEN15	-0.021625
COL6A3	0.021607
HPN	0.021594
SPAG9	0.021592
ZC3H12A	0.021581
QPCT	-0.021532
C2orf81	-0.021451
VEGFA	0.021451
ZNF669	-0.021371
TRIM32	-0.021359
MYL6	-0.021354
MYLIP	0.021324
RABGEF1	0.021282
FRA10AC1	-0.021205
RTP4	0.021154
GBP7	0.021108
ZNF250	-0.021091
PABPC4	0.021023
ABHD17C	0.021006
MTRF1L	-0.020973
IFRD2	-0.020959
PLAUR	0.020955
NEIL3	-0.020903
C8orf48	-0.020873
IER2	0.020863
SEC61A2	-0.020830
CD300LB	-0.020812
IER3	0.020805
VGLL3	0.020791
ERBB2IP	0.020786
PCDHB14	0.020783
ARAP1	0.020783
TSPAN13	-0.020763
LRP12	0.020734
PLAT	0.020704
MTX3	-0.020698
EGR3	0.020689
CCNL1	0.020689
ZNF280B	-0.020660
SDE2	0.020656
CIRBP	0.020643
KLRD1	0.020618
C11orf54	-0.020598
EIF4A1	0.020529
SLC25A33	0.020520
HLA-DQA1	0.020473
SERPINE1	0.020457
TAF1B	0.020447
OVCA2	-0.020404
FAM20A	0.020393
SNX20	0.020373
EDA2R	0.020370
RECK	0.020368
CD34	-0.020331
ACADM	-0.020282
ZSCAN22	-0.020269
COQ10B	0.020249
LOX	0.020241
TANK	0.020232
CCDC172	0.020219
PARP11	-0.020218
RIPK2	0.020210
MRM1	-0.020157
ZNF697	0.020155
VPS72	-0.020119
DYRK2	0.020112
OPTN	0.020046
COL3A1	0.020034
CD14	0.020007
LNX2	-0.019999
PRX	-0.019991
SPINT2	0.019959
GCFC2	-0.019953
OSBPL3	0.019947
ZNF613	-0.019929
KCTD18	-0.019890
OAS3	0.019882
QRICH1	0.019783
CD74	0.019778
ARID5A	0.019766
EMD	-0.019723
SOCS6	-0.019694
BTLA	-0.019673
LCMT2	-0.019668
SMAD6	0.019605
C17orf85	-0.019581
ZNF775	-0.019546
RBM7	0.019515
CDH11	0.019475
SFRP2	0.019431
RUNDC3B	-0.019399
ZC3H18	0.019392
DCTN1	0.019380
RFFL	0.019364
DUSP8	0.019360
RGS1	0.019360
MRPL50	-0.019349
FGR	0.019344
SPRYD7	0.019343
HAUS7	0.019338
GJA1	0.019292
RHBDF2	0.019285
KBTBD7	-0.019282
ZMYM1	-0.019257
LRIF1	0.019244
SLAMF7	0.019241
EXTL2	0.019178
SERPINE2	0.019169
SERPINB8	0.019168
ST18	0.019125
COL5A2	0.019087
SLPI	0.019077
TAS1R1	0.019026
ENPP4	0.018985
MFSD2A	0.018965
ATF3	0.018965
NANP	-0.018942
GSAP	0.018942
RELA	0.018933
ZNF761	-0.018931
CCP110	-0.018894
HBEGF	0.018893
PILRA	0.018880
ZSWIM1	-0.018872
RALB	0.018872
IFITM2	0.018869
SLC2A1	0.018863
CDC42EP3	-0.018853
LY75	0.018844
CCDC105	0.018818
C9orf43	0.018803
IER5	0.018785
CCL13	0.018782
DUSP1	0.018748
ZNF322	-0.018742
SLC9A4	0.018741
TLR6	0.018737
ERRFI1	0.018736
ZNF717	-0.018697
CRY2	-0.018697
ZC3HAV1L	-0.018676
IFI16	0.018674
KIAA0586	-0.018643
ANGPTL4	-0.018631
C2orf69	-0.018543
GFI1	0.018539
PEX12	-0.018534
ALG6	-0.018523
HMGCS1	0.018499
HPS6	-0.018489
RCN2	-0.018484
C17orf49	0.018468
THUMPD1	-0.018442
DUSP16	0.018428
ADCK3	0.018425
NDUFAF1	-0.018419
LSM1	-0.018399
CCL2	0.018397
HIST1H2BJ	-0.018380
GAB3	-0.018378
AMMECR1	0.018361
LRP4	0.018352
EDNRB	0.018346
KTI12	-0.018335
USP18	0.018299
MCOLN2	0.018294
VASH1	0.018290
FBXO5	-0.018275
CDH2	0.018243
PRR3	-0.018229
STAT2	0.018221
HOXC8	0.018186
ZNF585A	-0.018180
IFI44	0.018152
PCF11	0.018146
C5orf46	-0.018140
P2RY12	-0.018125
NAGK	-0.018122
KCTD21	-0.018103
TP53INP2	0.018070
ZBTB42	-0.018053
EDEM3	-0.018048
S100A16	0.018023
CCL17	0.018007
PFKFB1	0.018007
MTA2	0.018004
SRFBP1	0.017993
ALKBH4	-0.017991
MCTP1	-0.017969
EID3	0.017932
CCDC88B	0.017897
RHOU	0.017873
SAMSN1	0.017860
CLIC1	-0.017819
GCDH	-0.017795
TRMT10B	-0.017767
ARHGAP22	0.017765
LHFP	0.017765