!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!ligand_name	estradiol
!ligand_id	CHEBI:23965
!cell_type	endothelial cells
!organism	human
!end_metadata
RAB14	0.267782
MT2A	-0.182630
COX1	0.151209
ND2	-0.127817
ITGA5	-0.111899
PFN1	-0.102860
IGFBP4	-0.099580
MT1X	-0.099450
RPS3	0.095852
RPL39	0.095248
RPS4Y1	-0.095072
SH3BGRL3	-0.090384
RPS20	0.089847
PODXL	-0.088072
NACAP1	0.085763
MT1H	-0.083851
MT1HL1	-0.082785
TAGLN	-0.082092
RPL9	0.081287
COX2	0.075122
RPS2	0.074976
RPS8	0.074028
POTEKP	0.073946
BASP1	-0.073773
BGN	-0.072544
FLNA	-0.071224
HTRA1	-0.070006
RPS3A	0.069004
TMA7	0.068832
PKD1P1	-0.068424
MMRN1	0.067988
S100A6	-0.067485
ACTG1	0.067035
MYL9	-0.065670
CD81	-0.064122
CTGF	0.063786
RPS4X	0.063264
GSTP1	-0.063047
ZYX	-0.062151
HSPG2	-0.061765
PTPRO	-0.060249
TUBA1B	-0.060148
RPS26	-0.059144
FAM198B	0.058989
TUBA1C	-0.058819
PPIB	-0.058621
LTBP2	-0.057837
SLC25A3	-0.057799
RPL36	-0.057722
COL4A2	-0.056404
GNG5	-0.055418
ICAM2	-0.054198
SPARC	0.054078
ACTN4	-0.053651
NPIPA1	-0.053105
GNG11	0.052428
HSP90AB1	0.052087
EEF2	0.052085
RPS29	0.051973
B2M	0.051445
RPL41	0.051200
ARHGDIA	-0.050956
FN1	0.050809
RPL21	0.050580
EEF1A1	0.050498
RPL7A	0.049919
DKK1	-0.049729
CHCHD2	-0.049511
TFPI2	0.049125
MYH9	-0.048548
COL5A1	-0.048211
HLA-A	-0.048076
MIF	-0.047735
CD93	0.047699
NPC2	-0.047672
ENG	-0.047429
UBC	0.047232
GABARAP	-0.046892
S100A11	-0.046810
RPS13	0.046763
TUBB3	-0.046118
GPX1	-0.045848
COX6C	-0.045759
RPL34	0.045236
TIMP2	-0.045124
TTYH3	-0.045046
GJA1	0.044873
PPDPF	-0.044771
RPL28	0.044480
TFPI	0.044116
MSMO1	0.044110
PLOD1	-0.043030
RPS27	0.042962
CCL2	0.042770
RPS6	0.042691
LAP3	0.042406
SNRPD2	-0.042263
CALR	-0.042236
CD151	-0.041854
CD9	-0.041748
GBE1	-0.041622
RPS18	0.041311
ESM1	0.041281
IER3	0.041231
RPS14P3	0.041056
TSPO	-0.040877
PRKCSH	-0.040708
PTMA	0.040527
PEA15	-0.040520
TPM4	-0.040432
RPL19	-0.040381
SPATA20	-0.040285
MIB2	0.040158
EEF1G	0.040069
FAU	-0.040064
LINC00657	0.039752
TUBB4B	-0.039656
MVP	-0.039539
P4HB	-0.039521
TBCA	0.039460
MYL12A	0.039342
VAT1	-0.039172
ABHD17A	-0.039001
HHIP	-0.038839
MRPL32	0.038684
TMSB10	-0.038616
PPP1CC	0.038240
GJA5	0.038076
UQCRQ	-0.037928
CTHRC1	-0.037924
EFNA1	0.037822
HMGA1	-0.037547
IFI6	-0.037416
TPT1	0.037181
PIK3C2B	0.037139
HYAL2	-0.037065
RPS25	0.036862
EBPL	0.036821
GNB2	-0.036644
GNAI2	-0.036470
RPS17	0.036135
IGFBP2	-0.036084
SAT1	0.036002
ARF4	-0.036001
SRP14	0.035864
TUBA1A	-0.035804
OST4	-0.035783
GJA4	0.035543
XPO6	0.035139
FABP5	-0.035051
GPX4	-0.035022
RPS23	0.034999
PSMB6	-0.034735
FBLIM1	-0.034694
PSMB5	-0.034675
IL32	-0.034674
CDH13	0.034517
RPL3	0.034504
AMOTL2	0.034471
SPOCK1	-0.034294
FTH1	-0.034282
RPL11	0.034201
RPSA	0.033532
RTN4	-0.033347
S100A13	-0.033331
TRIM22	-0.033244
MT1E	-0.033021
PKM	-0.032986
NOP10	-0.032984
CAV1	0.032901
DENND5A	-0.032770
MCAM	-0.032743
TPI1	-0.032613
RCN1	-0.032593
ACTN1	-0.032452
PCBP1	-0.032140
COX7A2	0.031982
ECHS1	-0.031706
ALDH2	-0.031687
HIF1A	0.031619
FKBP1A	-0.031519
SULF1	0.031483
SGK1	-0.031251
YWHAE	-0.031204
GAS6	-0.031193
TXNIP	0.031151
HIGD2A	-0.031132
TGFB1	-0.031130
PLXND1	-0.031002
HYI	-0.030971
LOC285812	0.030790
XIST	0.030640
SEC24B	0.030605
DUSP23	-0.030555
ECH1	0.030554
PLK2	0.030551
EIF5A	-0.030550
WSB1	0.030372
RPS24	0.030367
PSMC6	0.030252
RPL7	0.030212
GRINA	-0.029951
CTSB	-0.029940
MTUS1	0.029930
NDUFA13	-0.029803
CAP1	-0.029784
NEAT1	0.029633
RPS16	0.029611
TSPYL4	0.029428
TUBB6	-0.029187
ANXA2	0.029154
ALCAM	-0.029107
TGFBI	-0.029084
IGFBP7	-0.029078
PDLIM1	0.029063
ITGA3	-0.029028
VIM	0.028841
SERPINE1	0.028731
IL33	0.028693
PLS3	0.028651
TM4SF1	0.028608
RAB13	0.028571
SLBP	0.028495
CD99	-0.028477
CYP51A1	0.028464
HAPLN3	0.028460
STEAP1	0.028438
RPS11	0.028425
AIM1	0.028324
MALAT1	0.028322
RPLP0	0.028272
SOD1	-0.028193
PSMD8	-0.027975
RPS14	0.027887
RPL22	0.027876
HIST1H4C	-0.027807
KCTD12	0.027717
TMEM30A	0.027664
DNAJB4	0.027651
CST3	-0.027618
TANK	0.027596
WWTR1	0.027547
BMX	0.027546
PSMA4	0.027427
ALDOA	-0.027335
RPL4	-0.027304
FSCN1	-0.027304
CLSTN1	-0.027163
SNHG6	0.027063
DUSP6	0.027041
FAM50A	-0.026804
COX3	0.026793
MTCH1	-0.026782
EGFL7	-0.026649
PEBP1	-0.026597
CLIC1	-0.026534
LDHA	-0.026447
PLD3	-0.026415
TUBB2A	-0.026397
RPL30	0.026384
PRSS23	-0.026303
TAGLN2	-0.026274
PLOD2	-0.026077
FBLN5	-0.025964
HN1	-0.025951
CLIC4	0.025937
TPM1	-0.025706
TMEM123	0.025642
ECE1	-0.025577
ADM	0.025507
RPL10A	0.025488
NPDC1	-0.025473
CDK17	0.025367
SRGN	-0.025359
TALDO1	-0.025240
RPS27A	0.025125
IRAK1	-0.025058
PTRF	-0.025004
RPS9	-0.025003
IFITM2	0.024950
PNMA1	0.024939
ROMO1	-0.024933
MANSC1	0.024900
TUBB	-0.024595
LOXL2	-0.024556
MGLL	-0.024531
GOLGA8H	0.024465
PLOD3	-0.024360
LOC643733	0.024264
RPL18	0.024247
SUB1	0.024241
NME4	-0.024189
SF3B1	0.024151
S100A10	-0.024148
ACTB	-0.024081
PIP5K1C	-0.023986
RPL6	0.023983
VPS51	-0.023943
DUT	0.023934
SDCBP	0.023845
LOC399491	-0.023810
RELL1	0.023795
UBA3	0.023788
RPL15	0.023734
DKK3	-0.023699
COX8A	-0.023599
NPTN	0.023598
MAFF	0.023501
TGFB1I1	-0.023449
CS	-0.023410
CLTA	-0.023296
TMEM147	-0.023278
DAD1	-0.023261
LAMTOR1	-0.023138
GARS	-0.023136
NDUFA12	-0.023125
PSMA1	-0.023106
LGALS1	0.023028
SEMA3G	-0.023024
MAP7D1	-0.022972
GNPAT	0.022970
RPS5	0.022929
SNHG19	0.022902
CAPN2	-0.022892
EFEMP1	0.022889
SERPINH1	-0.022882
ARL6IP5	0.022849
RHOB	-0.022819
RRAGA	-0.022796
ATP5E	-0.022759
ACTR10	0.022710
C14orf166	0.022553
GNG10	0.022454
MAGED2	-0.022417
CBWD1	0.022404
RPS7	0.022384
RPS10	-0.022380
OSTC	-0.022376
EOGT	0.022320
HGS	-0.022297
PTPRM	0.022287
FTO	0.022274
APLP2	-0.022261
RBBP7	0.022260
PPP1R14B	-0.022214
COX6A1	-0.022184
MYADM	-0.022174
EPB41L3	-0.022121
NDUFV2	-0.022107
MLLT11	-0.022092
ITGAV	0.022043
ATP5B	-0.022017
SEP15	-0.021932
SHC1	-0.021930
PIM3	0.021887
VOPP1	-0.021864
CNN3	0.021840
THBS1	0.021806
SRP9	0.021802
DTX3L	0.021697
PXDN	-0.021690
HSPA13	0.021649
ZFAS1	-0.021642
CD46	0.021628
RFK	0.021608
TRAM1	0.021592
HMGN2	0.021525
GAPDH	0.021502
SCOC	0.021467
NDEL1	0.021406
ATF4	0.021350
TMEM258	-0.021284
ARHGAP29	0.021250
SPNS2	0.021243
CISD1	-0.021236
COL4A1	0.021229
NDUFA3	-0.021226
EMP3	-0.021159
CFL1	-0.021141
NHP2	-0.021130
SEPHS2	0.021102
HMGN3	0.021026
EDN1	-0.020910
FURIN	-0.020899
IPO7	0.020826
NPLOC4	-0.020810
HSPA1A	0.020794
HNRNPA1	0.020767
UFC1	0.020740
STAB1	-0.020723
NDUFB5	0.020720
ILK	-0.020693
RRBP1	-0.020685
RALB	0.020685
FCGRT	-0.020665
CCNI	-0.020592
EXOC6	0.020582
OCIAD1	0.020542
ATP8B1	0.020522
ACVRL1	-0.020474
NTN4	-0.020438
EMC7	-0.020429
PCMTD2	0.020409
INHBA	-0.020385
TRAPPC1	-0.020356
FIBP	-0.020355
ESAM	-0.020352
NUAK1	0.020338
RPL5	0.020320
VDAC2	-0.020306
CKAP4	-0.020219
PFKP	-0.020211
PLAT	-0.020157
MYH10	0.020103
SHISA5	-0.020067
MARCKS	-0.020021
EIF4A2	0.019982
UGCG	-0.019981
AK9	0.019979
POLR2L	-0.019941
RSL24D1	0.019932
FAM127A	-0.019920
RPS28	0.019902
JAG2	-0.019901
LAMP1	-0.019861
EIF3E	0.019823
ATP13A2	-0.019797
PABPC3	0.019796
WASF2	-0.019787
TM6SF1	0.019781
LTBP1	-0.019778
EDF1	-0.019767
CHMP5	0.019748
EIF6	-0.019697
RPL38	-0.019680
SEPN1	-0.019676
HP1BP3	0.019624
SLIRP	-0.019562
CD59	-0.019534
C1D	0.019502
ELK3	0.019450
ISG15	-0.019417
RPL17	0.019411
CTSL	0.019409
FOLR1	-0.019331
YWHAG	-0.019235
FDFT1	0.019207
YIF1A	-0.019183
SEC13	-0.019120
CMBL	0.019081
TP53I3	-0.019019
SEC31A	-0.018997
CDC42EP1	-0.018994
TRAPPC5	-0.018984
CTDSP2	0.018954
CCDC47	0.018946
CYTL1	-0.018924
RPL23	0.018918
SELK	0.018896
SDF4	-0.018886
CSF2RB	0.018857
GNB1	-0.018716
UBA2	0.018607
PKN1	-0.018597
MX1	-0.018565
DDX5	0.018434
PRDX1	0.018403
MEIS2	0.018400
PROCR	0.018398
ERH	-0.018347
C12orf75	0.018345
FYTTD1	0.018226
PHPT1	-0.018199
FAM53C	0.018177
ECSCR	-0.018170
VASP	-0.018115
INSIG1	0.018112
ANKRD1	-0.018040
PLAGL1	0.017973
ATP6V0C	-0.017955
MAP1S	-0.017924
WARS	0.017870
FNBP1L	0.017868
FKBP9	-0.017865
EXOSC9	0.017819
SELM	-0.017799
SARAF	0.017775
EIF2S3	0.017739
VIPR2	-0.017707
NXN	0.017685
RPS27L	-0.017649
TMEM128	0.017627
ITM2B	0.017607
SMNDC1	0.017548
CDH2	-0.017529
KPNA2	0.017506
HHEX	0.017504
NAP1L1	-0.017501
HSPE1	0.017477
MAP4	-0.017442