!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	human
!drug_name	Morphine
!smiles	CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O
!drugbank_id	DB00295
!pubchem_cid	5288826
!cell_type	Striatum - C57BL/65 mice - Acute morphine treatment
!organism	mouse
!end_metadata
TTR	-0.171456
SGK1	0.166775
CCDC14	-0.145035
PTGDS	0.088194
PDE1B	-0.078685
TSC22D3	0.077641
BSG	-0.075392
EEF1A2	-0.074698
SCN4B	-0.073623
SLC2A1	0.073464
CA2	-0.070300
TF	-0.064729
APLP1	-0.063665
SEPW1	-0.061976
CTXN1	-0.061428
RPL28	-0.057392
ID4	-0.056441
THY1	-0.055804
NGEF	-0.054972
FAM107A	0.052366
SEPT4	-0.052218
RPL19	-0.051846
GJB6	0.048971
MAT2A	0.048182
ANKRD63	-0.048101
ZBTB16	0.047737
HRAS	-0.047372
PCP4	-0.046974
OSBPL8	-0.046440
PCSK1N	-0.046414
RPLP2	-0.046362
DDIT4	0.045671
SYNDIG1L	-0.045031
VTI1B	-0.044769
ACTG1	-0.044524
MTCH1	-0.044470
ERMN	-0.044095
MID1IP1	-0.043384
SLC22A16	0.042886
EGR1	-0.042606
ENPP2	-0.042362
RNF145	0.042245
DRD2	-0.042010
WFIKKN1	0.041604
LMO2	-0.041358
SOX2	-0.041076
ACOT7	-0.040706
FEZ1	-0.040540
TMEM88B	-0.040462
SH3BGRL3	-0.040319
MYO18A	-0.040199
QDPR	-0.039873
LYPD4	0.039782
PLEKHB1	-0.039682
PLTP	-0.039594
GPR155	-0.039469
UQCR11	-0.039460
PPP1CA	-0.039412
PDXP	-0.039285
RGS7BP	-0.039040
CLDN5	-0.038923
UQCRB	-0.038751
PPP1R1B	-0.038632
SNX3	-0.038565
CHST1	-0.038495
RPL6	-0.038256
NDUFA6	-0.038049
RTN1	-0.038037
LZTS3	-0.037992
PDE2A	-0.037965
PENK	-0.037714
LDHA	-0.037569
BCL11B	-0.037014
PHYHIP	-0.036672
HTRA1	0.036632
AES	-0.036611
SLC22A17	-0.036347
HNRNPU	-0.036073
AKR1A1	-0.035950
ITPR1	-0.035944
KCNJ10	-0.035670
MAG	-0.035652
MAL	-0.035543
PLLP	-0.035358
CNP	-0.035347
GSTP1	-0.035342
RND2	-0.035115
GPR37	-0.035050
VDAC2	-0.035035
INF2	-0.035019
IER3IP1	-0.034921
TRIM46	-0.034834
NDUFB10	-0.034814
CACNA2D3	-0.034795
NDUFV3	-0.034713
PSMD14	-0.034595
PEBP1	-0.034466
NFKBIA	0.034337
DBP	-0.034223
FTH1	-0.034174
TESC	-0.034136
RASL10B	-0.034123
NECAB2	-0.034099
CCK	0.034065
GNB2	-0.034040
S100A16	-0.033832
C15orf59	0.033717
RASD2	-0.033678
GNG3	-0.033620
SLCO1C1	-0.033538
COX4I1	-0.033536
SLC35D3	-0.033219
ASPHD2	-0.033123
MN1	-0.033079
LXN	-0.033065
GPI	-0.033040
PLD3	-0.033001
RXRG	-0.032980
DNAJB2	-0.032976
ST8SIA3	-0.032929
SARAF	-0.032925
TUBB4A	-0.032831
FKBP2	-0.032794
PFN1	-0.032777
C11orf87	-0.032267
TUSC3	-0.032031
UGT8	-0.031932
BRSK1	-0.031870
ACAT2	-0.031765
WASF1	-0.031724
RARB	-0.031721
NTSR2	-0.031672
CHCHD10	-0.031566
TCP1	-0.031552
CYP46A1	-0.031530
STMN4	-0.031497
RPS12	0.031416
GOT1	-0.031358
SMDT1	-0.031344
TIMM13	-0.031261
TPRG1L	-0.031196
LRRC58	0.031190
SMARCD3	-0.031163
SEPP1	0.031066
CDKN1A	0.030952
PRR18	-0.030925
SCG3	-0.030888
PPAP2B	-0.030852
BAI2	-0.030846
IGSF8	-0.030842
GPX4	-0.030817
TPST1	-0.030770
C1orf198	-0.030274
CST3	-0.030096
GRIPAP1	-0.030046
RAP1GAP	-0.030010
HSPH1	-0.029922
NUDT3	-0.029795
TMCC2	-0.029770
GATM	-0.029748
GNG7	-0.029736
TMEM130	-0.029713
PHPT1	-0.029700
ASPA	-0.029680
SST	-0.029666
MIEN1	-0.029642
CKB	-0.029627
MAP7D1	-0.029560
RGS4	-0.029515
GPR37L1	-0.029473
KRT78	0.029440
ATOH8	0.029431
GPS1	-0.029391
PAIP2	-0.029251
NDUFS3	-0.029229
NDUFB7	-0.029163
SIRT2	-0.029107
HEXB	-0.029054
TPPP	-0.028896
NME2	-0.028887
SHANK3	-0.028770
ITPKA	-0.028711
DUSP14	-0.028628
SPOCK2	-0.028583
UQCRFS1	-0.028536
GPR6	-0.028472
PHLPP1	-0.028228
CPLX2	-0.028228
NDN	-0.028182
NDUFA8	-0.028126
SMAP2	-0.028119
STMN2	-0.028104
ITM2A	-0.028100
NCKAP1	-0.028048
RASGEF1B	-0.028006
NDUFS8	-0.027961
LY6H	-0.027936
NDUFA13	-0.027923
REEP5	-0.027762
NDUFS7	-0.027728
PPP1R14A	-0.027687
BAIAP3	-0.027648
DCTN3	-0.027637
PSMB7	-0.027620
NEXN	-0.027563
LAMTOR1	-0.027562
FKBP8	-0.027553
CSPG5	-0.027547
SNAP47	-0.027467
GAP43	-0.027466
NFE2L1	-0.027437
PHLDB1	-0.027406
KCTD17	-0.027375
ELMOD1	-0.027340
GPR88	-0.027308
MAST3	-0.027296
PSMC5	-0.027261
FA2H	-0.027249
DCLK3	-0.027137
DUSP26	-0.026967
CCT7	-0.026898
TMEM151A	-0.026893
DAD1	-0.026795
ABHD8	-0.026767
CCP110	-0.026743
TUBA1A	0.026706
MBOAT2	0.026687
AP2S1	-0.026638
AATK	-0.026544
FAU	-0.026514
FAM127A	-0.026486
GPM6A	0.026449
PRMT8	-0.026437
DLGAP3	-0.026394
HDAC11	-0.026385
NDUFA4	-0.026366
ARHGAP33	-0.026339
SPCS3	-0.026282
GAA	-0.026144
SMIM3	0.026139
CYP4F8	0.026097
C1QC	-0.026077
NAA38	-0.026068
CFL1	-0.026040
CAMK1G	0.026031
TMBIM1	-0.025944
HSP90AB1	-0.025800
POMP	-0.025720
MOG	-0.025684
LAMP1	-0.025594
SEC61G	-0.025357
RPL4	-0.025287
ALCAM	-0.025270
ATP1B3	-0.025265
GRM3	-0.025212
TBCB	-0.025165
ATP5J	-0.025021
PRDX5	-0.025019
FKBP5	0.025017
BAG1	-0.025010
FAM213B	-0.024979
HPCA	-0.024967
RETN	0.024838
AP2M1	-0.024807
CALB2	0.024794
CROCC	-0.024732
DTX3	-0.024722
DDN	-0.024704
COA3	-0.024612
APOE	-0.024545
TKT	-0.024517
TST	-0.024501
KIFAP3	-0.024458
SLC25A11	-0.024429
RFTN1	0.024423
DENND5A	-0.024419
ARPP19	-0.024393
RPN1	-0.024387
RNF208	-0.024330
CA11	-0.024323
DNM1	-0.024306
TTC9B	-0.024284
OAT	-0.024270
RGS9	-0.024138
PDCD6	-0.024120
BRK1	-0.024104
MRPS33	-0.024096
FASN	-0.024085
LDHB	-0.024063
CTRB2	0.024034
EFNB3	-0.024033
TYRO3	-0.023986
ATP2B1	-0.023954
GSTM3	-0.023943
OMG	-0.023927
KCNAB1	-0.023801
HLF	-0.023778
VCP	-0.023751
FIS1	-0.023751
GMPR	-0.023740
RPL8	-0.023735
COX8A	-0.023726
ALDOA	-0.023714
LPPR4	-0.023670
CD9	-0.023661
TMEM98	-0.023637
JOSD2	-0.023634
GABARAP	-0.023631
TECR	-0.023610
TFEB	0.023555
GLRX5	-0.023544
SH2D5	-0.023543
PTPRN	-0.023504
SCG5	-0.023480
TRAPPC2L	-0.023467
RIC8B	-0.023437
LRPAP1	-0.023426
C14orf166	-0.023412
ATP5A1	-0.023393
PPP3CA	-0.023384
IFNLR1	0.023277
PRDX3	-0.023256
RPS17	-0.023245
ITIH3	-0.023231
CACNG4	-0.023230
NGFRAP1	-0.023219
HSPD1	-0.023211
RGS8	-0.023199
C14orf1	-0.023193
FAM102B	-0.023160
CFDP1	-0.023151
WNK1	-0.023144
SSBP4	-0.023105
LOC728392	-0.023070
GNMT	0.023053
GAB1	-0.023051
NNAT	-0.023018
CBX6	-0.023017
RESP18	-0.022995
MMP17	-0.022961
ATP1A3	-0.022953
EMC10	-0.022901
NDUFB3	-0.022900
NDUFS1	-0.022899
NDRG4	-0.022899
NUDT18	-0.022879
SARS	-0.022819
GHITM	-0.022726
PGK1	-0.022711
NDUFS2	-0.022707
SMIM13	-0.022700
CPE	0.022698
CSNK1G2	-0.022665
PSMC3	-0.022657
PRMT1	-0.022652
NDUFA1	-0.022604
STARD10	-0.022602
ATG9A	-0.022589
ZMAT3	-0.022574
DRAP1	-0.022570
CSRP1	-0.022569
AKAP11	-0.022569
LONRF1	-0.022567
NDUFB5	-0.022548
ADAM21	0.022510
SNX25	-0.022495
PPTC7	-0.022481
C4orf27	-0.022441
PLIN4	0.022383
HDAC5	-0.022369
PFKM	-0.022367
FABP7	0.022327
NDUFB11	-0.022296
PLCL2	-0.022294
GPX1	-0.022271
GRIK5	-0.022269
FNTA	-0.022235
TMEM256	-0.022205
GLUL	0.022199
MAP1LC3A	-0.022187
GNB5	-0.022179
SCAND1	-0.022143
UQCRHL	-0.022111
UFC1	-0.022094
SLC25A14	-0.022083
PPP1R16B	-0.022072
CACYBP	-0.022071
CAMKV	-0.022060
HIGD2A	-0.022059
CLPTM1L	-0.022044
CAPZA2	-0.022043
RPS13	-0.022000
EDF1	-0.021986
NBEA	-0.021976
LRRC4B	-0.021969
RPLP0	-0.021934
TIMM23	-0.021923
YWHAB	-0.021910
SLC22A23	-0.021895
SRM	-0.021890
ERP29	-0.021841
SYT11	-0.021832
HSPA8	0.021822
NUDC	-0.021811
TESK1	-0.021805
TRO	-0.021796
PHYHIPL	-0.021746
ARHGDIA	-0.021699
MCFD2	-0.021670
PSMA4	-0.021666
ADSS	-0.021656
ADORA2A	-0.021649
LYNX1	-0.021635
ARL2BP	-0.021627
DLG3	-0.021626
ALDH5A1	-0.021614
GATA1	0.021604
CPNE5	-0.021575
ARF5	-0.021552
KCTD1	-0.021549
RGS2	-0.021523
BAI1	-0.021519
PYGB	-0.021515
FAM98B	-0.021513
YPEL2	-0.021508
NDUFA2	-0.021441
SESN1	0.021441
MRPS34	-0.021438
MMD	-0.021429
MRPL24	-0.021425
RABGGTA	-0.021393
NETO1	-0.021352
SUPT5H	-0.021319
PRMT2	-0.021307
PTP4A2	-0.021301
EIF3K	-0.021285
RPL23	-0.021240
PPM1E	0.021221
CCT2	-0.021214
PTPRE	-0.021173
GABRD	-0.021159
EMC3	-0.021154
OPALIN	-0.021123
PPP2R1A	-0.021100
MYH10	-0.021097
LYRM4	-0.021066
VSTM2L	-0.021057
RGS10	-0.021052
SCRN1	-0.021049
HIST1H2BO	-0.021032
GABARAPL1	-0.021004
YPEL3	-0.020996
PPP1R9A	-0.020971
AAMP	-0.020931
FABP5	-0.020902
DRD1	-0.020895
RPL27A	-0.020863
GOLGA7	-0.020858
DDX5	0.020858
FBXO25	-0.020747
PCBP4	-0.020706
CASP14	0.020629
CHN1	-0.020604
NDUFS6	-0.020604
ARPC1A	-0.020595
SH3GLB2	-0.020526
PPP1R21	-0.020513
CACNG3	-0.020508
TMEM205	-0.020468
LSAMP	-0.020468
HSBP1	-0.020429
EI24	-0.020417
ATP6V0B	-0.020375
HECTD1	-0.020370
CALY	-0.020334
DPYSL2	-0.020333
MCAM	-0.020305
PHACTR3	0.020302
RPL22	-0.020298
SHFM1	-0.020281
S1PR1	-0.020274
PACSIN1	-0.020249
SYNGR3	-0.020207
SLC39A10	-0.020206
RPL37A	-0.020197
USMG5	-0.020193
LCMT1	-0.020182
UBE2D1	-0.020177
CCT5	-0.020170
LMBR1L	0.020164
KIAA1462	-0.020157
SRRT	-0.020136
ISCU	-0.020074
TMEM147	-0.020061
SQLE	-0.020010
UQCRC2	-0.019992
STX16	0.019991
NT5DC3	0.019988
HEXA	-0.019986
H2AFZ	-0.019973