!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	rat
!drug_name	NICKEL CHLORIDE
!smiles	Cl[Ni]Cl
!pubchem_cid	24385
!cell_type	H4-II-E-C3 LIVER-derived cell line - 140 uM
!organism	rat
!end_metadata
FABP1	-0.093926
HMOX1	0.079014
ITIH4	-0.075692
AZGP1	-0.070640
P4HA1	0.068637
ERO1L	0.068445
BNIP3	0.067597
SLC2A1	0.064137
ATF3	0.064043
MAFF	0.062477
PDK1	0.060185
MGARP	0.059051
PFKL	0.057971
LGALS2	-0.057099
CCDC181	0.056844
DDIT4	0.055927
ADM	0.051796
LDHA	0.051683
EGLN3	0.050735
TPI1	0.050617
SPSB2	-0.049968
TM4SF20	-0.047580
KDM3A	0.046878
HDC	-0.046412
ALDOC	0.046373
HAO1	-0.045687
ITIH2	-0.045382
ANGPTL3	-0.044538
C5	-0.044127
SCTR	-0.043970
OLFML3	-0.043941
PDZK1	-0.043932
LMNB2	0.043723
SLC2A2	-0.043636
WNT4	0.043528
STBD1	0.042599
KCTD15	0.041663
EHF	-0.041555
DDC	-0.041526
PIK3C2G	-0.040970
RGN	-0.040928
DDIT3	0.040640
BNIP3L	0.040579
PGK1	0.040503
DNAAF1	0.040382
JMJD6	0.040147
FRS3	0.039956
NDRG1	0.039699
PGM2	0.039615
HMGCS2	-0.039533
ALDOA	0.039520
SLC7A7	-0.039269
PON3	-0.039254
PTGR1	0.039135
BCS1L	0.038520
SPP2	-0.038494
NDRG2	0.038407
BAAT	-0.038193
ALDH1B1	-0.037571
HIGD1A	0.037540
GLIPR1	-0.037507
DCXR	-0.036359
PPP1R3C	0.036294
LOXL2	0.036046
MYOF	-0.035692
DUSP1	0.035411
AK4	0.035266
SP2	-0.035263
AKR1B10	0.035123
ALDOB	-0.035116
PLA2G1B	0.035013
TRIB3	0.035012
IGFBPL1	-0.035000
NAMPT	0.034812
FAM102B	-0.034696
PAQR8	-0.034670
ERRFI1	0.034475
SERPIND1	-0.034308
C8B	-0.034240
PPAP2B	-0.034196
APOBEC1	-0.033936
SLC13A4	-0.033773
GCLM	0.033633
JUN	0.033595
DAPL1	-0.033360
ONECUT2	0.033210
SLC17A2	-0.033168
ASL	-0.032972
LPAR6	-0.032906
MIF	0.032869
APLN	0.032525
TGM2	-0.032508
XPNPEP2	-0.032441
PLA2G16	-0.032389
NME3	-0.032300
C9	-0.032262
ABCA4	-0.032246
CDH17	-0.032193
CDHR5	-0.032112
CRYAB	-0.031903
RAD52	0.031751
SEMA3C	-0.031691
LGALS1	-0.031633
RINT1	0.031606
SPPL2A	-0.031531
MEX3B	0.031473
IFRD1	0.031199
KLF5	0.031171
DUSP12	0.031068
P2RY2	0.031020
HSD17B13	-0.030881
MYRF	-0.030832
ANKRD44	-0.030818
QRICH2	-0.030756
RLF	0.030753
SIGIRR	-0.030747
IL18	-0.030651
FETUB	-0.030620
ZFP36L1	0.030600
ACSS2	0.030576
GCLC	0.030543
UBE2L6	-0.030302
F10	-0.030260
LAMA3	-0.030090
ABCG5	-0.029971
SLCO1B3	-0.029953
MYLK	-0.029939
COL3A1	-0.029722
MYC	0.029718
PYGL	0.029678
CPPED1	-0.029606
ITIH1	-0.029601
GLRX	-0.029564
ZNF292	0.029558
LIG3	-0.029405
CLDN2	-0.029326
PPP1R36	-0.029323
RAB40B	0.029239
HPS3	0.029172
ARHGEF26	-0.029148
CIDEC	-0.029000
ZNF777	0.028969
AFP	-0.028952
PHLDB2	-0.028942
ANKRD37	0.028877
FGFBP3	0.028815
CAMKMT	-0.028800
SLC39A4	-0.028744
TRIM27	0.028725
ACKR4	-0.028697
SLC7A11	0.028578
GNAQ	-0.028560
ALDH1A1	-0.028515
ZNF143	-0.028478
PTOV1	-0.028435
ST7L	0.028427
GALNT4	-0.028401
KMO	-0.028316
VEGFA	0.028311
PLA2R1	-0.028250
SLC26A1	-0.028183
UBE2O	0.028166
HRSP12	-0.028131
BCMO1	-0.028118
SLC35E1	0.028027
RNASE1	-0.028010
AIDA	0.027996
A2M	-0.027968
PLAC8	-0.027961
NCOA7	-0.027907
RABL3	-0.027875
FGA	-0.027729
RHPN2	-0.027658
COA4	-0.027602
RTP4	-0.027589
MGLL	-0.027535
ENO1	0.027492
COPS7A	-0.027488
ABCG8	-0.027384
DHODH	0.027345
LGALS9B	-0.027337
CALML4	-0.027293
ECI2	-0.027283
DIXDC1	-0.027274
PPIP5K1	0.027230
OSGIN1	0.027195
UGCG	-0.027172
FBP1	-0.027104
CST6	-0.027084
CP	-0.027019
PHLDA2	-0.026840
MAP2K1	0.026738
TEN1	-0.026632
GZF1	0.026587
TRPT1	0.026576
RAPGEF4	-0.026561
CLRN3	-0.026558
KDM4B	0.026492
UAP1L1	-0.026379
GLOD5	-0.026343
PNPLA6	-0.026301
MAP3K1	0.026251
ACP2	-0.026171
LIMD2	-0.026162
CHDH	-0.026157
NMRK1	-0.026012
AMDHD2	-0.025948
MBL2	-0.025946
C11orf73	0.025920
ANKS4B	-0.025739
PIK3AP1	-0.025668
FABP2	-0.025659
RHBDD1	-0.025612
ADPRH	-0.025577
TPMT	-0.025563
PCGF5	0.025504
CHSY1	0.025494
NAA38	-0.025484
TBL2	0.025456
MBOAT1	-0.025451
CLN3	-0.025437
ADAMTS4	-0.025427
TMEM50B	-0.025248
PTGES2	0.025228
PHLDA1	-0.025186
SFXN5	-0.025183
SLC50A1	-0.025183
POC1B	-0.025168
MSH3	-0.025161
GJB1	-0.025153
PGAM1	0.025153
CPB2	-0.025066
SLC40A1	0.025058
MST1	-0.024941
ZNF330	0.024905
GDPD1	-0.024844
GALT	-0.024792
ARL6IP5	0.024791
AS3MT	-0.024785
GAMT	-0.024756
ZNF654	0.024685
ZNF629	0.024639
CTH	-0.024564
PRDX4	-0.024549
VBP1	-0.024514
EXD2	-0.024491
RNASEK	-0.024411
CTSC	-0.024288
ZKSCAN5	0.024286
PLA1A	-0.024191
NAPB	0.024129
RUFY1	-0.024110
SH3GLB2	-0.024098
CD36	-0.024046
AQP8	-0.024026
BAX	-0.024022
GGCT	0.024006
NAAA	-0.023983
ME1	0.023957
ABCA7	-0.023913
MET	-0.023887
KAZALD1	-0.023852
RFNG	-0.023780
KLHL41	-0.023735
ACADVL	-0.023722
TRAF3IP2	-0.023653
FGL1	-0.023620
RFX4	-0.023605
TATDN2	0.023604
GPR146	0.023585
FLOT1	-0.023565
AKR1D1	-0.023533
CYP27A1	-0.023480
TCEAL1	-0.023420
VPS13B	-0.023403
DEPDC7	-0.023390
HGFAC	-0.023371
UBE2D1	0.023341
MANSC1	-0.023271
ISPD	-0.023218
MMP11	0.023186
DTWD1	0.023181
ZSCAN12	0.023168
DSTYK	0.023055
MMP19	-0.023055
ZBTB10	0.023045
TMEM37	-0.023039
TTR	-0.023037
PROC	-0.023011
CCDC174	0.022965
SLC25A21	-0.022950
SULT2A1	-0.022902
LATS1	0.022867
FASN	-0.022843
SMTNL2	0.022836
MYZAP	-0.022832
TXNRD1	0.022823
ID2	-0.022818
FOXQ1	0.022735
PRKRIR	0.022723
COMT	0.022700
ZMYM2	0.022665
FAM171B	-0.022645
NEU2	-0.022630
APEH	-0.022583
NR1H4	-0.022577
TRIM59	0.022562
ABCC6	-0.022559
SOX6	-0.022515
ACY1	-0.022497
GNAT3	-0.022475
ZSCAN21	0.022474
CENPF	0.022474
PCTP	-0.022451
MACROD1	0.022420
NABP1	0.022347
TRAPPC1	-0.022346
EMP1	0.022338
ALDH1L2	-0.022307
TGFBR2	-0.022273
ADTRP	-0.022238
RIOK3	0.022205
SNAP29	-0.022165
IGFBP1	0.022158
TRIP10	0.022130
ADHFE1	-0.022125
IER3	0.022116
ARSA	-0.022107
SULT1B1	-0.022091
SCD	0.022090
KDSR	-0.022079
TNFSF13	-0.022049
HPS6	0.022049
SLC23A1	-0.022026
WHAMM	0.022019
C8G	-0.021936
RAMP2	-0.021898
PBLD	-0.021882
PEX26	0.021880
MAP2K6	-0.021875
RNF122	0.021810
F12	-0.021770
ABCA1	-0.021761
SPATA33	-0.021745
NFIL3	0.021723
HYKK	0.021672
SLC52A3	-0.021617
FGFR3	0.021566
HFE	-0.021542
DPP7	-0.021528
VPS4A	0.021510
DNAJB9	0.021450
ZFP36	-0.021429
AK1	-0.021428
FAM43A	0.021349
LRRC16A	-0.021349
CCNG1	-0.021333
KNG1	-0.021317
NEU3	-0.021305
TAF1B	0.021286
CA6	0.021215
ZCCHC9	-0.021212
DUSP8	0.021202
ACY3	-0.021199
PSMB8	-0.021197
PLOD1	0.021190
VIL1	-0.021155
IGSF5	-0.021136
PLCB1	-0.021119
LCAT	-0.021104
PFN2	-0.021100
SLC22A7	-0.021077
OCRL	0.021064
GULP1	-0.021063
GRB14	-0.021063
RAB32	-0.021054
PDZD11	-0.020966
ARSB	-0.020960
TLE6	-0.020959
DDAH1	-0.020941
HMHA1	-0.020937
TPRKB	-0.020882
NEIL1	-0.020863
PAPSS2	-0.020858
CPT2	-0.020848
CRY1	0.020808
FBXO30	0.020800
PPP1R13L	0.020785
TM6SF2	-0.020782
ARHGEF2	0.020744
GUSB	-0.020679
LSMEM2	0.020678
TEX10	0.020651
OTUD3	-0.020643
SLC22A18	-0.020639
RETSAT	-0.020630
ZNF335	-0.020629
CYTH1	-0.020622
KLF6	0.020622
MKLN1	0.020614
ANPEP	-0.020565
SNAPC1	0.020545
CHD6	0.020524
SQLE	0.020522
SH3BP5	-0.020499
CLCN7	-0.020478
UGDH	0.020473
UGT2B17	-0.020454
ELOVL6	-0.020453
PIDD	-0.020450
GPCPD1	-0.020438
NGEF	-0.020431
IFI44L	-0.020412
ST3GAL1	-0.020412
METTL22	0.020406
MGST3	-0.020397
GBA	-0.020382
TRMT12	0.020357
ENPP2	-0.020352
EMILIN1	0.020349
PRELID2	0.020339
SLC27A2	-0.020318
TMEM17	-0.020282
ENKD1	0.020276
ABCB1	-0.020234
TACC2	0.020232
CORO6	-0.020230
F5	-0.020216
GPM6A	-0.020194
GSTZ1	-0.020188
ASPA	-0.020187
DPYD	-0.020181
TNFRSF9	-0.020169
H1F0	0.020140
ZNF280B	0.020129
VPS28	-0.020080
GSTM1	-0.020056
BSCL2	-0.020055
POMK	-0.020046
CFI	-0.020022
B3GAT3	-0.019996
PIR	0.019896
TRAF6	0.019874
SUOX	-0.019860
FMO5	-0.019791
CYP51A1	0.019775
LGALS3BP	-0.019763
FKRP	0.019758
ACOX3	-0.019702
SLC22A17	-0.019668
TIMELESS	-0.019651
ZDHHC7	0.019624
GYS1	0.019620
NAGK	-0.019619
CCNL1	0.019613
RAB3D	-0.019611
TFPI	-0.019607
PPP1R15A	0.019594
RUVBL2	0.019593
PPP1R17	-0.019586
NARF	0.019581
KCNG3	-0.019568
TXNDC16	-0.019562
ZNHIT6	0.019560
ABCC4	0.019559
CIDEB	-0.019558
ZFAND2A	0.019543
LECT2	-0.019528
CNP	-0.019527
HEXA	-0.019519
TMEM256	-0.019515
FAM76B	0.019509
TBPL1	0.019502
GOLT1A	-0.019495
PALM	-0.019479
GABRA5	0.019478
FAM171A1	-0.019472
GLUL	-0.019469
ANXA2	0.019459
IL17RE	-0.019454
PKLR	-0.019438
MYO10	-0.019433
RASAL2	0.019416
OLFML2A	-0.019397
GAS2	-0.019359
COQ3	0.019343
ADAM9	-0.019342
PDK2	-0.019337
ZBTB39	0.019333
ACOT1	-0.019322
DCLRE1A	0.019321
SLC16A7	-0.019298
NPTX1	-0.019292
PPFIBP2	-0.019291
ITPR1	-0.019283
TIMM8B	-0.019277
MESDC1	0.019263
DHTKD1	-0.019261
TLE3	0.019192
LYST	0.019182