!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	mouse
!drug_name	Colistin
!smiles	CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)C(C)O
!drugbank_id	DB00803
!pubchem_cid	5311054
!cell_type	C57BL/6J kidneys
!organism	mouse
!end_metadata
DNASE1	-0.308432
NDRG1	0.194028
ASS1	-0.168231
INMT	-0.161535
NUDT19	0.150425
SPP1	0.138597
UMOD	0.134635
LGALS3	0.134553
G6PC	0.134028
SPINK1	-0.130876
DBP	-0.130093
OSBPL9	0.129803
ATP1B1	0.124900
ATP5B	0.120904
DBI	0.119092
NDUFA13	-0.118275
IGFBP5	-0.116059
TXNIP	-0.112551
PRNP	0.107151
ECH1	-0.093906
LGMN	0.093683
RPS27L	0.092778
NAT8	0.090120
CES1	0.089803
SLC51A	-0.089570
RETSAT	-0.088708
CFD	-0.087272
ATP5G3	0.087153
NUAK2	0.086948
CTGF	-0.086198
FTH1	-0.086056
LAMP1	0.084379
PPIA	0.082033
GPX1	-0.081404
FBP1	-0.081337
TMBIM6	-0.081042
TUBA1B	0.079713
HIST1H1C	-0.078081
CYTB	-0.076542
PVALB	-0.076445
RPS4Y1	0.072611
NEU1	-0.070480
ALDOB	-0.070205
CKB	-0.069364
TBCA	0.069319
SGK1	0.069231
WFDC2	0.069211
AKR1A1	0.068109
CHCHD10	-0.067578
TACSTD2	0.067388
IGFBP4	0.066998
HERPUD1	0.066201
MIOX	-0.065445
GUCA2B	0.064890
RPL39	-0.064050
SAMD9L	-0.063940
TTC36	-0.063703
EEF1A1	0.063121
HMGCS2	-0.060314
NAPSA	0.059302
TTR	0.058831
RPL38	0.056353
RPS26	0.056173
ODC1	-0.055422
LRPAP1	-0.055420
CYP24A1	-0.054436
F2R	-0.053820
KHK	-0.053116
PSAP	0.052847
RPS29	0.052772
UQCRHL	0.052769
NAT8B	-0.052609
HIBADH	-0.051423
NUDT4	0.050915
KLF9	0.050413
NDUFC1	-0.050217
CLDN2	0.048942
IDH1	-0.048775
BGN	-0.048771
RPS19	0.048444
SLC4A1	-0.048350
RPL9	0.047093
TMEM174	-0.047023
CYB5B	-0.046430
SLC12A3	-0.046351
PTTG1IP	-0.046215
NPM3	-0.045602
LDHA	0.045192
PPP1R1A	-0.045131
ESM1	-0.044599
PRDX5	-0.044207
PDZK1	-0.043534
UAP1L1	0.043106
MRPL42	0.042853
HSP90B1	0.042719
ITPR1	0.042587
ALDH2	-0.042169
HSPA9	0.041791
NDUFS8	-0.041766
SMPDL3A	0.041358
SPP2	-0.041198
ATP6V1E1	-0.040777
CSTB	0.040569
XBP1	0.040447
DEFB116	0.039947
DNAJB1	0.039654
APOM	-0.039521
HSPA8	0.039438
P4HB	-0.039033
ALDH4A1	-0.038557
MRPL12	-0.038475
HBB	0.038402
RPS7	0.038310
SLC34A1	0.038247
ERRFI1	0.038172
ACY3	0.038159
WBP5	0.037835
MIEN1	-0.037801
EEF1G	-0.037683
HIST1H2AM	0.037623
KLHL3	-0.037373
EMCN	-0.036967
GABARAPL1	-0.036818
FAM134B	0.036777
CYP4B1	-0.036639
RPS11	-0.036159
PLVAP	-0.035958
MFSD2A	-0.035940
COX6A1	-0.035749
SOD2	-0.035055
IER3	-0.034436
POLR2L	-0.033655
GABARAP	-0.033629
UQCR11	-0.033457
RAB2A	0.033404
CD81	-0.033300
COX4I1	-0.033276
LRP10	-0.032999
NOX4	-0.032800
HIST1H2AE	0.032632
SAP30	-0.031925
ABHD14B	-0.031835
CD164	0.031821
MDK	0.031518
TANGO2	-0.031417
TMEM86A	-0.030686
AK4	0.030608
ATP5J2	-0.030607
RPL28	-0.030424
SLC35E3	0.030234
RPS12	0.029973
LPL	-0.029753
HIST1H2AJ	0.029682
SLC25A5	0.029560
TMEM147	-0.029539
TMEM200B	-0.029403
VPS35	0.029321
SORD	0.029121
CCT6A	0.029077
ATPIF1	0.029008
TNFRSF21	0.028952
NR1H4	0.028781
DPP7	0.028611
PGAM2	-0.028490
BAG1	-0.027973
HGD	-0.027883
PRELP	-0.027526
PGPEP1	-0.027470
KCNK1	0.027410
RPS14	-0.027394
OAT	-0.027391
NDUFV1	-0.027008
HSPH1	0.026980
HIGD2A	-0.026946
MFGE8	-0.026484
TFCP2L1	0.026374
CTNNA1	-0.026349
NDUFB8	-0.026026
NPM1	0.026003
COX6B1	-0.025784
CHORDC1	0.025708
GGNBP2	0.025107
VPS28	-0.025022
AQP1	0.024999
HIST2H2AC	0.024832
CCS	-0.024708
NGDN	0.024611
ACSS1	-0.024149
CYP2E1	-0.024143
TMEM27	-0.024131
RPS2	0.024032
ANXA5	0.023856
ABCA3	-0.023214
NDUFA8	-0.023199
IVNS1ABP	0.023164
CA12	-0.022969
GSTM1	-0.022715
FAM102A	0.022537
SH3BGRL3	0.022528
GCNT1	-0.022417
PRDX1	-0.022397
PDZK1IP1	-0.022331
PBK	0.022192
SOWAHB	0.022146
ISCU	0.022102
CYP7B1	0.022070
SELT	0.021981
GPX3	-0.021960
ECM1	-0.021899
IRX3	-0.021859
SLC30A5	0.021787
GSTA3	-0.021712
ACTB	-0.021689
KLHDC2	0.021674
SOSTDC1	0.021594
ASCC1	-0.021580
LYPLA2	-0.021564
DAK	-0.021482
CYP4A11	-0.021336
AACS	0.021329
POLDIP2	-0.021324
NDUFA2	0.021254
ERP29	0.021243
EDF1	0.021211
SERPINA1	0.021055
ZFYVE21	-0.021003
SGK2	-0.020954
SULT1C2	-0.020869
TUBB	0.020834
PDHA1	0.020794
RPL36AL	0.020765
GM2A	0.020713
SERP1	0.020703
ISOC2	-0.020703
CCNG1	0.020653
GRB7	-0.020636
EGF	-0.020625
GADD45G	-0.020593
PI4KA	-0.020561
NDUFA10	-0.020494
ACOX2	-0.020460
UQCC2	-0.020370
ETHE1	-0.020266
PPP2CA	0.020234
ATP6V1D	0.020210
SPCS1	0.020115
ACAA2	-0.019816
SEPT11	-0.019752
HAT1	0.019734
GSTM3	0.019727
MAPK14	0.019691
YPEL3	-0.019679
EVI5	0.019460
SLC13A2	0.019457
GLRX	-0.019416
H2AFZ	0.019157
HINT1	-0.019152
BHLHE40	0.019124
ATP6AP1	-0.019116
SLC8A1	-0.019040
SLC22A18	0.018931
POMP	0.018839
CHPT1	0.018772
NDUFV3	-0.018613
DCXR	-0.018602
TUFM	-0.018544
NDUFA7	-0.018504
ATP6V0E1	-0.018417
NDUFA6	0.018401
MYL6	0.018281
PTER	0.018277
TMEM204	-0.018188
GLDC	0.018133
APMAP	-0.018079
RPL31	-0.018046
SLC6A8	-0.018042
SLC26A4	-0.018037
PPM1B	0.018006
RNF6	0.017908
DPEP1	-0.017853
ATP5D	-0.017789
SZRD1	-0.017765
SEPHS2	0.017743
VDAC3	0.017742
CYC1	-0.017694
BRI3	-0.017666
GAS6	0.017647
SDR39U1	-0.017621
TMEM252	0.017576
ATP5L	-0.017567
KIAA1033	0.017509
EGR1	-0.017491
NME1	-0.017405
RHOBTB1	0.017376
AQP3	-0.017325
EMP1	0.017183
TAGLN2	0.017179
CRYL1	-0.017156
ELTD1	-0.017100
MYEOV2	-0.017066
ALAS1	0.017022
PCBD1	-0.017021
C2orf80	-0.016960
BCL6	0.016882
GRHPR	-0.016881
SEMA4A	-0.016869
PSMA4	0.016861
ITGB6	-0.016814
SLC5A10	-0.016802
ATP5C1	0.016748
AKR7A2	-0.016743
PCBP2	0.016675
CELA1	-0.016647
OLFML3	-0.016606
TMEM205	-0.016550
MYLK	-0.016495
SLC47A1	0.016467
PPIC	0.016368
MIF	-0.016277
APP	-0.016233
UROC1	-0.016194
CIB1	0.016161
LCN2	0.016074
TNFAIP8	0.016057
STARD10	-0.016049
SERPING1	-0.016040
AIF1L	0.016037
ENO1	-0.016036
AMN	0.016024
APRT	-0.015981
SLC27A2	0.015951
JTB	0.015912
SSR4	-0.015829
SLC25A25	0.015804
TSC22D3	0.015794
RPS8	-0.015768
CCDC107	-0.015759
MORF4L2	0.015603
SLC25A30	0.015592
CPM	-0.015556
HSD11B1	0.015537
ZFP36	-0.015495
DDAH1	-0.015437
TIMP2	-0.015417
CDR2	0.015349
IRF2	-0.015343
HNF4A	0.015250
LRP2	0.015192
ALDH6A1	0.015180
DNAJC12	-0.015031
RSAD2	-0.014995
BNIP3L	0.014962
SCIN	0.014948
IDH3G	-0.014945
RARRES2	-0.014928
SPINK8	-0.014909
GPI	-0.014902
PLAU	-0.014874
MRPL14	-0.014866
TFRC	-0.014807
CCT4	0.014787
FKBP5	0.014749
FTL	0.014747
LMO4	-0.014715
NDUFAB1	-0.014701
RPL37	0.014653
UQCRC2	0.014606
PTP4A1	0.014534
C11orf31	0.014470
C18orf32	0.014426
DDRGK1	-0.014414
CCAR1	0.014407
HIST1H2AA	0.014398
ESAM	-0.014397
PSMD1	-0.014396
GLYAT	-0.014389
STRAP	0.014382
NDUFA1	0.014370
COX7A1	-0.014334
ETFA	0.014309
FMO1	-0.014119
TPRN	0.014103
CTSH	0.014088
PPP6C	0.014072
SLC51B	-0.014024
FARS2	-0.014016
IL11RA	-0.014010
NDUFA3	-0.013997
IGFBP3	-0.013975
DYNLL1	0.013956
ABCD3	0.013955
MAP2K3	0.013919
MRPS24	-0.013905
MRPS17	-0.013876
NDUFC2	-0.013844
GMPR	-0.013844
SDPR	-0.013833
ARGLU1	0.013831
TMBIM4	-0.013739
FKBP4	0.013688
SLC6A6	-0.013684
AURKAIP1	-0.013673
BTBD1	0.013665
PDPN	0.013659
UQCR10	-0.013622
HYPK	0.013585
RNF11	0.013552
ATP6	-0.013552
RNPEPL1	-0.013484
BDH2	0.013468
ST6GALNAC2	0.013468
TMEM120A	-0.013419
KL	-0.013411
ADH1C	0.013393
GRSF1	0.013351
SLC22A6	-0.013347
ACOT1	-0.013308
ASB9	-0.013305
ENPP6	0.013249
MRPS12	-0.013247
MRPS34	-0.013239
HMGN1	0.013202
MRPL50	-0.013196
HLA-DRB5	-0.013155
MRPS21	-0.013153
SEC11A	0.013119
AP1B1	-0.013055
IRS2	-0.013045
EHD4	-0.013007
C6orf203	-0.012983
MTCH1	-0.012974
APEH	-0.012963
EIF5	0.012936
UROD	-0.012906
UTP11L	0.012890
GSTK1	-0.012878
POLR2J	-0.012863
ARPC5	0.012838
ND4	-0.012797
DAB2	0.012772
GJA1	-0.012729
RPL35	0.012673
SLAMF9	-0.012659
AGTR1	-0.012655
GLRX5	-0.012653
SRSF1	0.012629
PREPL	-0.012623
ATOX1	0.012607
KCNK5	-0.012603
PER2	0.012581
GTPBP4	0.012579
HIST1H2AH	0.012561
ATP5J	0.012542
LLGL2	0.012537
SLC16A9	0.012527
ND1	0.012517
MAN2A1	0.012506
KRT8	0.012470
NXT2	0.012431
BSCL2	-0.012419
GLG1	-0.012413
TPD52	0.012356
SEC13	0.012344
CHUK	0.012304
SQSTM1	-0.012292
UQCRC1	-0.012277
ECI1	-0.012274
MAGED1	-0.012264
MGP	-0.012256
IGIP	0.012235
TPI1	-0.012228
NDUFA12	-0.012222
GSPT1	0.012204
MKNK2	0.012161
SLC9A3	-0.012145
DPP4	0.012138
TUBB4B	0.012087
ZCRB1	-0.012077
LMO2	-0.012051
RRAGC	0.011990
CALML4	0.011988
TMEM160	-0.011979
HLA-DQB1	-0.011924
TM2D2	-0.011912
NDFIP1	0.011911
TRIL	-0.011905
GLB1L2	0.011897
SLC25A3	-0.011799
PHOSPHO2	0.011791
RPS25	-0.011784
SLC15A2	0.011738
HNRNPC	0.011722
LBH	-0.011695
SEPT2	0.011656
NDUFA4	0.011611
EIF4H	0.011569
METTL7B	-0.011562
SUDS3	-0.011556
WSB2	0.011544
RPS16	0.011529