!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!ligand_name	estradiol
!ligand_id	CHEBI:23965
!cell_type	MCF-7 cells
!organism	human
!end_metadata
MN1	0.141810
FOS	0.131919
KCNK5	0.129755
LINC00341	0.115215
FOXC1	0.104164
RASGRP1	0.101797
P2RY2	0.096727
FST	0.096306
SGK1	0.096110
CYP26A1	0.095744
HOXC6	0.094764
SERPINB9	0.089335
MYBL1	0.085681
TNFRSF11B	-0.085329
ID3	-0.084196
TIPARP	0.080985
CEMIP	0.078579
STC2	0.077169
EGR3	0.076740
C8orf4	-0.076669
HOXC5	0.076100
HOXC4	0.076093
EFNA1	-0.076046
DKK1	-0.075242
ARID5B	-0.075131
MTUS2	0.074419
PLAC1	0.073792
DUSP10	-0.073246
CCNG2	-0.072850
RNF43	-0.072298
EPB41L3	0.072223
VWF	0.071640
REEP1	0.071456
FZD7	0.068349
NRIP1	0.067389
SIAH2	0.066550
FAM13A	-0.065355
SAG	0.065128
TMPRSS3	0.064634
OLFML2A	0.064339
TSKU	0.063932
SMAD7	0.063399
PFKFB3	0.062194
CA12	0.061844
ABCG2	0.061686
SEMA3G	0.061202
PDP1	-0.061198
BIRC3	0.060655
ASB13	0.060626
PDZK1	0.060186
MYC	0.059722
WNT5B	0.059409
MMD	-0.058570
GADD45G	0.058264
WNT4	0.058111
GATA3	-0.058002
PRSS23	0.057483
OTUB2	0.057209
ARL4A	-0.057123
IGFBP4	0.056712
CLDN1	-0.056004
ID1	-0.054810
ANKRD2	0.053744
CXCL12	0.053231
PPP1R3C	-0.052708
BCL11B	0.052449
HILPDA	-0.052265
TRIB1	-0.052044
GAB2	0.051915
SYBU	0.051701
BCL6	0.051586
RWDD2A	-0.051523
TFF2	0.051358
GCNT1	-0.051295
HSPB8	0.050847
TGFB2	-0.050443
DDIT4	-0.050234
FAM63A	0.050153
TUBA3D	0.050109
HMOX1	-0.049808
ABTB2	0.049347
RARA	0.048422
PTGES	0.048025
GADD45B	0.048005
NR5A2	0.047291
VEGFC	-0.047215
PMAIP1	0.046838
CCDC88C	0.046347
KRT13	0.046277
INTS6	-0.045967
HEY2	0.045940
PITX1	0.045839
HEY1	-0.045544
SESN1	-0.044940
SMOX	0.044657
RGS16	0.044506
IL17RB	0.044259
CYR61	0.044114
LRP4	0.043910
HCAR3	-0.043904
CBFA2T3	0.043818
LRIG1	0.043582
CHST8	0.043430
RCL1	0.043400
ZNF552	0.043172
PLEKHO2	0.043157
MAP6D1	0.041733
JADE1	0.041513
JARID2	0.041476
CYP1B1	0.041391
SIK1	0.041108
INHBB	0.040974
GATA6	0.040891
PIM1	0.040843
SLC22A5	0.040799
IL10RA	0.040699
BLNK	-0.040662
FUT4	0.040613
MYLK	0.040447
MMRN2	0.040052
C14orf132	0.039997
MAP3K8	0.039925
SOCS1	0.039576
ASCL1	-0.039376
RNF144A	0.039233
NKX2-2	-0.039115
CRKL	0.039089
IRX5	-0.039086
CRISPLD2	0.038936
FFAR2	-0.038459
TRAF5	-0.038455
KIAA0226L	0.038442
IL24	0.038370
PGR	0.038311
RASL11B	-0.038204
MEIS1	0.038107
OPN3	0.038063
KLF4	0.037971
EGLN3	-0.037962
EFNA4	-0.037942
BHLHE41	0.037915
PXDC1	0.037694
C10orf2	0.037646
MAFF	0.037595
RHOBTB1	0.037568
SPSB1	0.037378
ADM	-0.037364
WNT16	0.037153
UPF1	0.037014
MCF2L-AS1	0.036920
KAZN	0.036855
ARHGAP32	-0.036708
TRIM36	-0.036666
SEC14L2	0.036613
SLC16A6	0.036574
GRAMD3	-0.036560
ERF	-0.036360
CXCR4	-0.036214
TOB2	-0.036139
CEP83	-0.036112
MICB	0.036011
KLF5	-0.035941
CBR4	-0.035909
PARD6B	0.035872
SBNO2	0.035845
SERTAD3	-0.035739
CASP7	0.035576
KCNJ3	-0.035329
LMO3	-0.035245
FJX1	0.035210
ARMCX6	0.035184
FHL2	0.035141
HHEX	-0.034895
BDKRB2	0.034770
RAB31	0.034673
SLC26A2	0.034585
ST8SIA4	-0.034516
CDC42EP1	0.034369
SEMA4C	-0.034297
ZBED8	-0.034223
TBX2	0.034117
ENC1	-0.034070
HIVEP2	-0.033996
SNAI1	0.033841
GREB1	0.033764
SOX3	0.033520
AKAP1	0.033466
IRS1	-0.033362
RHOBTB3	0.033299
ZNF184	-0.033071
PNRC1	-0.032959
KDM6A	-0.032956
MAP3K1	0.032800
ELOVL2	0.032781
ZNF750	-0.032558
TSPAN5	0.032366
MYB	0.032277
NEDD9	-0.032238
FAIM3	0.032113
SLC7A5	0.032071
S100PBP	-0.032031
ZFC3H1	-0.031791
RND3	-0.031766
HSD11B2	0.031750
C4orf19	0.031426
HIVEP1	-0.031372
SOX4	-0.031309
PLK2	-0.031170
SLCO4A1	0.030994
TBKBP1	0.030941
GRB14	-0.030940
CITED1	0.030834
EDN2	0.030826
KDM7A	0.030818
POM121L9P	0.030563
CHSY1	0.030504
MTCL1	-0.030329
CDKN1B	-0.030256
SPRY1	-0.030217
TLR5	0.030107
JRKL	-0.030013
SOX9	-0.029989
IRS2	0.029911
E2F6	0.029879
DLX2	-0.029691
FZD4	-0.029584
ADRB1	0.029571
WWC1	0.029502
FAM189A2	0.029390
RASL10A	0.029302
SH3TC1	0.029027
AEN	0.028979
GUSBP3	-0.028910
SLC25A24	0.028828
SKA1	0.028792
PAX9	0.028766
CGA	-0.028734
TWF2	0.028639
RPRM	-0.028375
LPIN2	-0.028364
TLN2	0.028318
MAF	0.028176
C3	0.028132
CAV1	0.028111
ACVR2A	-0.028078
ANXA9	0.027864
CREB5	-0.027848
THBD	0.027796
LRP5L	0.027783
ST3GAL5	0.027698
CHAC1	0.027501
TGIF2	0.027453
FOSL2	0.027294
GABBR1	-0.027204
RAB9A	-0.027151
CSRNP2	-0.027129
HOXC11	0.027016
PLA2G16	0.026879
NXT1	0.026783
PRUNE	0.026708
ACTG2	-0.026581
SLK	0.026570
DHRS2	0.026535
ELF3	0.026446
FZD2	-0.026405
ELF1	0.026344
DHRS3	0.026273
WEE1	-0.026261
TMPRSS2	0.026241
USP2	-0.026203
FAM118A	0.026128
PCYOX1	0.026122
GBP1	-0.025939
SNX16	-0.025900
KIAA0922	-0.025694
FCGR2B	0.025608
SHB	0.025523
PPIF	0.025521
MAMLD1	0.025492
KLF9	0.025292
TNFRSF21	-0.025250
ZNF217	-0.025206
USP36	0.025095
MYO1E	-0.025066
CXCL3	-0.025058
CASP8AP2	-0.025009
REL	-0.024882
ACVR1	-0.024840
LOC100272216	-0.024780
HOXC10	0.024750
RNF39	-0.024739
RET	0.024732
C1orf109	0.024728
GSAP	-0.024724
CLK4	-0.024710
RNF146	-0.024638
DSE	-0.024614
VAV3	-0.024581
SCYL3	-0.024579
CCND1	0.024562
BIK	-0.024527
WDR47	-0.024497
NR2F1	-0.024359
GAS1	-0.024341
ZNF606	-0.024252
IER2	-0.024234
ID2	-0.024114
VEGFA	0.024114
MYOT	0.024096
ZNF107	0.024071
C3orf52	-0.024046
RSRP1	-0.024042
TIMP2	-0.024005
ARID4A	0.023977
RPUSD2	0.023956
RAB20	-0.023929
CLDND1	-0.023917
CCR1	-0.023897
HOXC8	0.023831
PLEKHF2	-0.023800
MGLL	-0.023721
TRIB2	-0.023659
MAX	0.023603
FAM102A	0.023560
FURIN	-0.023538
KLHL21	0.023525
SERPINE2	0.023507
MREG	0.023461
PEX11A	0.023454
FRAT1	-0.023449
CTGF	-0.023389
SLC35C1	-0.023296
PAWR	-0.023252
IRF6	-0.023249
HK2	0.023113
AMIGO2	-0.023080
PMEPA1	0.023078
SNX24	0.023066
HOXC13	0.023065
CHD1	-0.023061
COA7	0.023042
DDX10	0.022998
FOXO1	0.022966
SOX2	-0.022957
GNAI1	-0.022880
CEBPB	0.022867
RAI14	0.022828
ITGB6	-0.022810
ARHGAP12	-0.022749
TRIM45	-0.022714
RELB	-0.022686
ZC2HC1C	0.022655
EHD1	0.022640
FAM134B	0.022631
KDM4B	0.022630
TRIM62	-0.022576
CD83	0.022485
METTL16	0.022452
MED23	-0.022392
JUNB	-0.022289
GFOD1	0.022274
TM4SF1	-0.022259
TGIF1	-0.022258
ZMIZ1	0.022249
DNAJB2	-0.022240
GEMIN4	0.022129
TAZ	0.022095
ZKSCAN4	-0.021861
SETD1B	-0.021809
SLC29A3	0.021804
PPP1R12A	-0.021801
OASL	-0.021748
GPC1	0.021736
TRIM68	-0.021726
EIF2AK3	-0.021631
LIMK2	-0.021614
FADS1	0.021598
NMRK1	0.021550
CHORDC1	-0.021542
NIP7	0.021528
WFS1	0.021516
AUTS2	0.021510
PIK3IP1	-0.021477
ZNF280D	-0.021472
UNC5C	-0.021450
EPHB3	0.021397
FAM46A	-0.021386
MAPK7	-0.021378
E2F8	-0.021306
NEIL3	-0.021229
PPRC1	0.021204
GTF2E1	-0.021142
BCL2L11	0.021112
ITGA6	0.021083
SEC14L5	-0.021043
ZCCHC24	-0.021031
SH3BP4	-0.021009
INSIG2	-0.020968
ZNF551	0.020927
ZBTB10	-0.020923
ETAA1	-0.020900
DHCR7	0.020896
ADCY9	0.020784
BTBD3	-0.020771
B3GNT3	0.020760
FOXA1	-0.020723
GGNBP2	-0.020698
LMO4	-0.020696
FAM69A	-0.020690
DDX28	0.020685
SLC22A4	0.020683
CXCL2	-0.020645
SERPINA5	0.020576
BBS10	-0.020570
ZNF292	-0.020509
WWTR1	-0.020499
GADD45A	-0.020483
PODXL	0.020425
ZNF254	0.020307
FKBP4	0.020296
AHR	-0.020257
ATXN2	-0.020253
CDK17	-0.020252
URB2	0.020251
CASD1	-0.020193
KITLG	-0.020182
MARCH3	0.020151
OLFML3	0.020096
ENPP2	0.020094
SLC6A6	0.020084
SAMD4A	-0.020062
NCF2	0.019973
SUSD4	0.019950
HEG1	0.019949
PIK3R3	-0.019887
RAB40C	0.019853
CLN8	0.019821
NFRKB	-0.019819
C19orf40	-0.019804
TMEM39B	-0.019774
KLF6	-0.019740
CDC42EP4	-0.019711
BRWD1	-0.019692
MISP	-0.019632
IFNGR1	-0.019591
TNS3	0.019569
ARHGEF10L	0.019554
BCOR	-0.019550
MOCS1	0.019542
ATF3	-0.019454
ZNF329	-0.019409
AREG	0.019377
FAM110B	-0.019338
ZFP36L2	-0.019283
TOB1	0.019218
KDM3A	-0.019203
LIN37	-0.019183
TPBG	0.019138
SATB1	-0.019131
PEX13	-0.019122
BTG2	-0.019095
MKNK1	0.018989
PPWD1	-0.018979
OSER1	-0.018896
NAV2	0.018881
CCDC68	0.018877
POLR1C	0.018877
ID4	-0.018873
GNA13	0.018829
RIPK4	0.018791
BCL7A	0.018771
RLF	-0.018732
FERMT2	-0.018725
PIKFYVE	-0.018684
PCP4	-0.018636
PLEKHO1	-0.018624
ZCCHC6	-0.018528
KIAA0907	-0.018506
LARP6	-0.018493
SH2D4A	-0.018450
ZNF85	-0.018440
ESRRG	-0.018405
BRD2	-0.018395
TFAP2A	-0.018348
TFAP2C	0.018325
RNF19B	-0.018188
FOXJ2	-0.018169
DMTF1	-0.018128
TRIM16	0.018109
DNMBP	0.018103
CARD14	-0.018097
MIR22HG	-0.018093
PPP1R15A	-0.018069
CALHM2	-0.018062
MEX3C	-0.018061
SNHG17	0.018061
CYP27B1	0.018056
FBXO34	0.018055
CPB1	-0.018052
A2M	-0.018002