!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Mus musculus
!ligand_name	Interleukin-1 beta
!ligand_id	Drug Bank ID: BE0001051
!cell_type	embryonic fibroblasts from IRAK-4 kinase deficient mutants
!organism	mouse
!end_metadata
EGR1	0.409854
EGR2	0.268096
SGK1	0.192085
FOS	0.167855
EREG	0.143528
DUSP1	0.125309
ERRFI1	0.124753
JUN	0.121978
ST5	0.116936
EGR3	0.108605
KLF6	0.105887
PTGS2	0.089612
PDK4	0.086875
DUSP5	0.084331
CITED2	0.083392
DDIT4	-0.080065
KLHL9	0.073098
CFL1	0.072683
UBC	0.072529
TXNIP	-0.072305
CYR61	0.071652
IER3	0.069775
RPL3	0.069275
SERTAD4	0.064186
HSPH1	0.063462
RHEB	0.061739
TMEM55A	0.061674
OTUD1	0.060149
ISG20L2	0.059065
PSAT1	-0.058727
TUBB2B	-0.058597
RND3	0.058580
THBD	0.058161
SDPR	0.057812
FTH1	0.056359
CD81	0.056136
RPL27A	0.054806
SPRY2	0.054777
SPP1	0.053858
LGALS1	0.051627
CTGF	0.050327
DUSP22	0.050196
TMUB2	-0.049524
JDP2	-0.049102
ESYT2	-0.048986
MRFAP1	0.048932
GJB2	-0.048661
H19	0.047969
RPS2	0.047475
EIF4A2	0.046691
SEC23A	0.046285
RIN2	0.046200
FN1	0.046006
PHF13	-0.045703
WSB1	0.045700
FAM208A	0.045294
ADAM23	-0.044668
RHOB	0.044661
AMOTL2	0.044402
FSTL1	0.044247
WDR82	0.043750
CHFR	-0.043320
CHCHD2	-0.042816
LTBP2	-0.042736
MYL9	0.042578
ASAH1	0.042562
POLR3GL	0.042478
NFKBIA	0.042190
TSPAN31	0.041905
RNF111	0.041230
MORF4L2	-0.040952
INSIG1	0.040909
PHLDB2	-0.040873
ATP5G3	-0.040464
DUSP6	0.040387
NACA	0.040171
NUPR1	-0.039786
SAMD4A	-0.039441
SKIL	0.037741
RPL10	0.037527
MICAL3	0.037118
CCNL1	0.036954
NARS	-0.036786
HNRNPH2	0.036447
RPL23	0.036189
CHORDC1	0.036173
RPL8	-0.036057
CDH11	0.035925
HDGF	-0.035898
IGFBP5	0.035853
TMBIM6	0.035764
PROS1	0.035637
ZSCAN26	0.035618
SERPINH1	0.035298
RPS28	-0.035082
RPL27	0.035037
KBTBD2	0.034960
WBP5	0.034810
CAV1	-0.034737
CNN2	-0.034576
FHL1	-0.034408
SLC7A1	-0.034338
BSDC1	-0.033994
SPARC	0.033847
MEX3B	0.033532
RPL7A	0.033352
FBXO11	-0.033066
IL1RN	0.032997
ENO2	-0.032891
PLCB3	0.032881
GNB2L1	0.032450
BCL6	0.032124
COL4A2	-0.032074
ACTB	0.032001
MCL1	0.031952
HSP90AB1	0.031890
ARFIP1	-0.031776
RPS27A	-0.031455
DEK	-0.031359
BTG2	0.031283
RSL24D1	0.031249
DHRS3	0.031114
RPS5	0.031037
RBBP7	-0.030938
RPS23	0.030898
FOXC1	0.030886
HIVEP1	-0.030854
CPSF4	-0.030846
ASNS	-0.030823
PGRMC2	-0.030781
CST3	0.030720
SFXN3	-0.030596
SECISBP2L	0.030595
H2AFZ	-0.030558
FUBP3	-0.030360
HNRNPK	-0.030264
RBM39	0.030256
RPS8	-0.030128
CSTB	-0.030058
SENP3	0.029843
MRPL24	0.029779
HOXC4	-0.029777
RPL19	-0.029696
RPS24	0.029652
PTPLA	-0.029626
PTGES3	0.029405
PFN1	0.029309
TJP1	0.029275
ACTG2	-0.029189
RPL18A	0.029167
TIMMDC1	0.029151
PDGFA	-0.029126
NPM1	0.029032
S100A6	0.028944
PXDC1	0.028835
CEP170	0.028700
TIMP3	-0.028663
EFEMP1	-0.028653
YTHDF2	0.028640
CLK1	-0.028573
ZFP36L1	0.028366
CHSY1	0.028338
ZFC3H1	-0.028318
IRF2BP2	0.028297
RPL11	0.028232
C9orf40	-0.028168
HSPA5	0.028102
TUBA1B	-0.028090
DERL2	0.028056
FTL	-0.027612
SLC38A6	0.027582
CSTF2T	0.027555
ADRM1	-0.027507
ASPN	0.027502
COQ10B	0.027468
ID2	0.027445
SPCS1	0.027372
SNAI2	0.027289
FOSL2	0.027261
C18orf32	0.027141
GARS	-0.026872
PLK2	0.026849
FAM198B	-0.026824
IFRD1	0.026710
POMP	0.026685
ETS2	-0.026671
DSEL	-0.026662
SLC39A1	0.026608
RPS17	0.026441
MOB3A	0.026398
EIF2S3	0.026395
DDR1	-0.026320
NEDD9	0.026232
CTSV	0.026224
ITPRIPL2	-0.026182
RPL12	0.026167
CHMP1B	-0.026156
FAM84B	-0.026112
AGGF1	-0.025978
OTUD7B	-0.025929
TFE3	-0.025838
TGFB1I1	-0.025710
LRCH2	0.025696
TSC22D2	0.025622
ANKRD1	0.025563
HARS	-0.025474
SLC41A2	-0.025311
ZMAT3	0.025233
VKORC1L1	-0.025233
RPL26	0.025178
HIST1H2BI	0.025168
VBP1	0.024899
ACKR4	-0.024879
RRAGC	-0.024785
RPS21	0.024765
RPL28	0.024715
TMED9	0.024683
RBM3	-0.024583
KDM2B	-0.024543
TMEM86A	0.024417
PERP	0.024387
ANXA3	-0.024364
CKAP4	-0.024268
SEP15	0.024245
SLC7A5	-0.024176
NGF	0.024165
ARGLU1	-0.024081
LRP1	-0.023801
ADAMTS5	0.023782
DDX3X	-0.023757
NDUFA13	-0.023745
RALB	0.023646
SPATS2	0.023521
OAZ1	-0.023490
H2AFY2	0.023461
ZNF263	-0.023381
COL3A1	0.023317
ACVR2A	-0.023295
PTP4A2	0.023293
IER5	0.023165
HAX1	0.023011
LUC7L3	-0.023009
COX6A1	-0.022994
MTMR6	-0.022948
SORBS1	-0.022916
EHBP1	0.022911
H1F0	0.022794
SEPW1	-0.022760
COG3	-0.022747
DNAJB4	0.022611
PLAGL1	-0.022573
TCEAL8	0.022509
CDH2	-0.022460
OSBP	-0.022447
NRP1	0.022438
LPAR1	0.022378
FEM1B	-0.022365
ZBTB1	0.022337
LONRF1	-0.022325
PPIB	0.022324
HACE1	0.022306
ZFAND6	0.022297
LHFPL2	0.022249
TOMM34	0.022147
RPL7	-0.022075
CCNG1	0.021990
TOB2	-0.021973
RAN	-0.021956
FKBP9	-0.021912
SAT1	0.021869
PSMD6	-0.021843
SLC6A9	-0.021843
PSMB5	-0.021826
ZNF251	-0.021748
SNRNP27	0.021740
LAMTOR5	0.021734
TMOD1	-0.021672
RRN3	-0.021640
ZFHX4	0.021617
IDI1	-0.021572
PPP1R12A	0.021515
AKAP2	0.021456
ANTXR1	0.021443
COL4A5	0.021422
HCFC1R1	-0.021393
BRK1	-0.021361
VAT1	-0.021341
NR4A1	0.021337
SGTB	-0.021320
F3	0.021280
THBS1	-0.021123
KCTD9	-0.020912
ARL1	-0.020902
HMGCS1	0.020808
TOR1AIP2	0.020806
FMNL2	0.020788
LRRC8A	0.020758
LTBP1	-0.020752
ADM	0.020706
FAM76B	-0.020677
USMG5	-0.020667
FAM102B	0.020598
LIMA1	0.020508
RBAK	-0.020495
COX7A2	0.020479
FURIN	-0.020459
C9orf72	-0.020434
FIBIN	0.020342
PHLDA1	0.020342
ID1	0.020328
ZBTB18	-0.020326
AJUBA	-0.020321
DYRK2	-0.020320
ATP5J2-PTCD1	0.020294
MECOM	0.020278
CTNND1	0.020250
ZFP36	0.020218
IKBIP	-0.020132
HNRNPDL	-0.020038
GPR176	-0.020033
HADH	-0.019994
CYB5R1	-0.019994
ATP2B1	-0.019992
PCOLCE	0.019925
UBE2W	-0.019925
CSRNP2	-0.019870
SEPP1	0.019846
C15orf41	0.019775
RPS14	0.019720
TMEM123	-0.019697
COL4A1	-0.019664
HSPE1	0.019629
ZCCHC24	0.019564
RPSA	0.019554
RPL9	0.019548
BGN	-0.019482
TSPYL1	0.019448
PLEC	-0.019388
LSM14B	0.019375
RAB10	0.019350
DAPK1	0.019307
CSGALNACT1	0.019262
ELMOD2	0.019194
C3orf14	0.019189
RABL3	-0.019113
MFGE8	-0.019075
PCNP	-0.019070
GJA1	0.019039
PLA2G16	0.018972
RRAS2	-0.018960
GADD45G	0.018933
KIAA0247	0.018918
DEGS1	-0.018901
TNFRSF11B	-0.018858
ABRACL	-0.018855
PSMB7	-0.018792
TFDP1	0.018771
FNDC3B	0.018763
MDC1	0.018731
RAP2C	0.018725
MGP	0.018691
SOD1	0.018633
FYN	-0.018614
ARID5B	0.018610
RBMS3	0.018604
OSBPL11	-0.018551
COMMD10	-0.018483
TVP23B	0.018436
ATF4	-0.018394
TULP4	0.018392
SCAMP3	0.018383
BTF3	0.018305
ATP13A3	-0.018300
GLO1	0.018239
SERPINF1	0.018231
TNMD	-0.018230
OGN	0.018210
TAF13	0.018199
KDELR2	0.018179
GPC4	-0.018177
AP2M1	0.018115
PGRMC1	-0.018104
GRSF1	-0.018098
PSMC4	-0.018091
RPS4Y1	0.018019
ACOT9	-0.017993
LRRFIP1	-0.017979
SULF1	0.017938
NCK2	0.017920
EIF4G2	-0.017892
BRI3	-0.017870
TNPO1	-0.017800
FLNA	-0.017777
MEX3C	-0.017758
CNN3	-0.017740
RER1	0.017671
TWIST1	0.017656
TRIT1	-0.017641
PGD	-0.017612
TXNDC15	0.017579
PEG3	0.017573
FEM1C	0.017557
KDELC1	0.017524
MORC4	-0.017472
RAPGEF2	0.017429
NDUFV3	0.017395
THBS2	0.017390
CCT6A	-0.017332
RHOJ	-0.017317
ENC1	0.017303
BNC2	0.017299
SNX2	0.017280
FBLN5	0.017205
APLP2	0.017159
DDX6	0.017108
UGDH	-0.017065
MSRB3	-0.017057
TIMM21	0.017041
TMEFF1	-0.017018
TNFAIP6	-0.016951
GHR	-0.016931
BCAT1	-0.016923
TRA2A	0.016869
ROBO1	0.016853
KLF7	0.016848
ZNF329	-0.016797
RAB9A	0.016793
KIFAP3	0.016785
TCF4	0.016767
DNAJB11	0.016756
NEDD8	-0.016751
IRF2BPL	0.016738
EI24	0.016715
FAM96A	-0.016663
RAB1A	-0.016630
PPIA	0.016557
BMPR1A	0.016494
MICU2	0.016431
MAN1C1	0.016419
STON1	0.016419
CDK8	-0.016405
ICE1	-0.016370
TTC13	-0.016355
ARL4C	0.016313
UNC5C	-0.016227
RPL18	-0.016220
RPS18	0.016186
TMEM136	-0.016140
AK1	0.016108
ELAVL1	0.016058
TMED10	-0.016033
NRP2	0.016018
CAT	0.016017
ACTR2	0.016017
TDG	-0.016009
RHOC	-0.016006
GSTP1	0.015981
MAT2A	-0.015970
CALCRL	0.015957
ADCK3	-0.015924
DNPEP	-0.015918
SGMS2	-0.015909
ZNF559-ZNF177	-0.015882
KDM6B	0.015855
RPN1	0.015830
EDA2R	0.015806
TSPAN6	0.015802
MAP4K3	0.015794
SPTBN1	-0.015770
ATP6V0E1	0.015724
MMD	0.015710
VDAC3	0.015706
SPTSSA	0.015659
FERMT2	-0.015651
GSR	0.015633
ZBTB14	-0.015613
CFL2	0.015604
ZNF518A	0.015594
NME1	-0.015592
LYRM4	0.015590
MMACHC	0.015588
GJA3	-0.015567
MFAP5	-0.015551
WASF2	0.015550
SIAH1	0.015537
MYO1C	-0.015523
GPX8	0.015499
SMURF2	0.015459
SUCO	0.015421
PAPD5	-0.015401
SERP1	0.015352
RPS11	0.015338
HECA	-0.015328
TPRG1L	-0.015244
IFITM2	-0.015235
FBXL3	0.015212
FBXW11	0.015199
MGEA5	-0.015180
PDGFRB	0.015174
HIGD1A	-0.015173