!direction	0
!num_genes	500
!diffexp_method	chdir
!cutoff	500
!correction_method	None
!threshold	None
!organism	Homo sapiens
!cell_type	Skin
!drug_id	DB11569
!drug_name	Ixekizumab - 150mg
!organism	Human
!end_metadata
SPP1	-0.090799
IL19	-0.081246
SPRR2C	-0.077733
HLA-DQA1	0.077092
S100A12	-0.076896
IL37	0.075466
CHAC1	-0.075325
AADAC	0.066737
P2RX1	0.064743
VNN3	-0.064437
ACTC1	0.063582
STEAP4	-0.062403
RSAD2	-0.061760
SOAT1	-0.061654
CXCL13	-0.061116
TCN1	-0.059211
UPK1A	0.059186
CMA1	0.058660
CCL8	-0.056167
PLA2G2A	-0.055717
TDRD12	-0.055658
TNMD	0.055562
CXCL1	-0.054878
TNIP3	-0.054628
LAMC3	0.054590
GSTT1	-0.053883
C5AR1	-0.052737
RERGL	0.051991
FADS1	-0.051478
RPS4Y1	0.051286
PLIN1	0.050427
KRTAP9-9	0.050414
HLA-DRB4	-0.049815
CTSG	0.049754
SCGB2A2	-0.049496
KRT83	-0.048577
RHCG	-0.048356
KLK6	-0.048341
MX2	-0.048210
SMAD5-AS1	0.048007
KRTAP5-8	0.047960
PAMR1	0.047731
SAMD9	-0.047215
CH25H	-0.046729
KLK13	-0.046429
FADS2	-0.045859
IGJ	0.045840
SYT17	0.045546
SPRR3	-0.045312
OMD	0.045198
ISYNA1	0.045158
NR3C2	0.045110
GSTA3	0.044684
DSC2	-0.044521
GPRASP1	0.044478
CDCA8	-0.044442
DHRS9	-0.044243
LRP8	-0.044168
LRRC37A4P	-0.044032
CASQ2	0.043876
KIF20A	-0.043591
ANGPTL4	-0.042980
AQP9	0.042873
PRSS53	-0.042771
EDN1	0.042386
TMPRSS11D	-0.042310
HLA-DQB1	0.042105
LTF	-0.041949
CYP4F8	-0.041945
KIF4A	-0.041870
XIST	-0.041780
GSTT2	0.041670
ASGR2	0.041302
CIDEC	0.041243
CXCL8	-0.040795
MMP9	-0.040697
AUNIP	-0.040609
CYP2J2	0.040561
HYAL4	-0.040372
GLDC	-0.040304
APOL6	-0.039870
POLR3K	-0.039838
CCL5	0.039759
MDFI	-0.039317
MSMB	0.039302
MXD1	-0.039185
SPC25	-0.039036
SELP	0.038720
CD177	-0.038696
LRMP	0.038633
MOCOS	-0.038538
ISG15	-0.038410
PCP4	0.038319
HSD17B1	-0.038230
UBE2C	-0.037834
HSPB6	0.037697
CACNB4	0.037677
F10	0.037537
SCGB2A1	0.037511
PDGFRL	0.037508
CENPE	-0.037308
TMPRSS4	-0.037080
NEIL3	-0.037079
GZMK	0.037041
PLA2G7	-0.036794
CFH	0.036755
ACSM3	-0.036745
IGKC	0.036537
SOD3	0.036433
CTSF	0.036004
RBP4	0.035994
ZC3H12A	-0.035899
C1QB	-0.035829
HSPB2	0.035797
POU2AF1	0.035686
DLGAP5	-0.035521
KRT9	0.035494
OVOL1	-0.035446
PCSK2	0.035417
SHCBP1	-0.035361
SERPINA3	0.035350
OASL	-0.035239
IL1R2	0.035208
MKI67	-0.035123
ZNF204P	0.035111
AIM2	-0.035090
HIST1H3C	-0.035005
TTK	-0.034830
SCNN1B	0.034703
CPA3	0.034680
POMZP3	0.034613
TNNC1	0.034359
EPHB2	-0.034350
CDKN3	-0.034312
TMEM110	-0.034216
CHRNA9	0.034088
PER1	0.033934
FCGR3B	-0.033700
CCL18	-0.033693
PDE1A	0.033689
SERPINB4	-0.033390
SLC17A5	0.033385
KRT15	0.033359
CHODL	0.033309
CA6	0.033173
CHEK1	-0.033042
COCH	0.033025
CCDC102B	-0.032933
ATP12A	-0.032897
PLAT	-0.032776
CHIT1	-0.032655
PBK	-0.032586
CES1	0.032518
MST1	0.032425
NDC80	-0.032331
FAM124B	0.032328
WIF1	0.032285
CCNA2	-0.032279
GMPR	0.032226
ASF1B	-0.032094
CCNE1	-0.032006
CDCA3	-0.031849
IGLL3P	0.031800
LMNB2	-0.031565
CNN1	0.031556
RAD51AP1	-0.031554
GZMH	0.031551
GABRP	-0.031536
AURKA	-0.031273
C9orf9	0.031037
KDM5D	0.030960
NCAPH	-0.030877
IFI6	-0.030877
SLC6A14	-0.030839
CILP	0.030596
FXYD1	0.030564
LINC00302	0.030497
CARHSP1	-0.030465
KIF18B	-0.030411
TICAM1	-0.030410
LMOD1	0.030375
THSD7A	0.030374
SFRP4	-0.030296
GK3P	-0.030178
PPOX	0.030173
SLC22A18	0.030092
WISP2	0.030046
OAS2	-0.030045
APOBEC3C	0.030042
ELF3	-0.029986
BUB1B	-0.029972
RGP1	-0.029952
CENPN	-0.029941
CXCR2	-0.029856
VILL	0.029848
LCE2B	0.029728
ANG	0.029723
TRANK1	-0.029709
FMO5	0.029644
HMMR	-0.029541
FRZB	0.029512
MAL	0.029509
RRM2	-0.029501
UPP1	-0.029458
RARRES3	0.029282
CDK1	-0.029274
MLPH	0.029210
C1orf68	0.029179
CENPT	0.028950
NCAPG	-0.028845
CHP2	0.028780
SNX10	-0.028595
RIT1	-0.028562
EGFL6	-0.028490
SLC23A2	-0.028364
CTSV	0.028289
CTSW	0.028270
SAMHD1	-0.028195
CDC7	-0.028191
HPGDS	0.028167
EPHA2	-0.028157
PLP1	0.028137
PMEL	0.028122
LOC399491	0.028118
IL4R	-0.028089
APOBEC3A	0.028022
LOC100272216	0.027993
ZNF273	0.027985
ERICH1	0.027975
GAL	-0.027909
SCGB1D2	-0.027876
BPY2	-0.027869
CORIN	0.027868
APOC1	-0.027859
FOSL1	-0.027804
ATHL1	0.027800
TMC5	-0.027750
VSIG4	-0.027724
YBX2	0.027679
SERPINB13	-0.027639
ICAM2	0.027616
GLI3	0.027607
TPSAB1	0.027548
MELK	-0.027506
MGLL	0.027504
PDE9A	0.027476
NPIPB3	0.027457
GALNT14	0.027423
ACADSB	0.027407
TYMP	-0.027406
DDX3Y	0.027323
TRPV6	0.027318
EIF1AY	0.027295
CRELD1	0.027285
TRMT2B	0.027233
IGKV1OR2-108	0.027117
MICB	-0.027108
SULT1E1	0.027082
PTPN20B	0.027046
USP18	-0.026984
ACSF2	0.026959
LIPG	-0.026957
LPL	0.026921
HPGD	0.026898
CHL1	0.026885
OLFML1	0.026854
NLRP2	0.026844
MPZ	0.026837
CDC45	-0.026772
SMC2	-0.026762
NUP210	-0.026748
SLC16A6	-0.026706
COBL	0.026702
LSAMP	0.026627
MYEF2	0.026539
TRIP13	-0.026474
CCNO	-0.026420
CRYM	0.026419
TIE1	0.026348
MYO15B	0.026324
KIF2C	-0.026304
IL16	0.026303
TRAPPC6A	0.026281
SLC28A3	-0.026237
ADAM23	-0.026152
HJURP	-0.026150
DTL	-0.026091
SLCO3A1	0.026078
AURKB	-0.026069
FAR2	-0.025947
ZNF37BP	0.025891
TLE2	0.025886
ACKR1	0.025882
TSPAN7	0.025872
GUCY1A3	0.025872
ZNF177	0.025829
KCNJ15	-0.025820
HK2	-0.025801
AKR1B10	-0.025724
CLSTN3	-0.025689
LINC00667	0.025630
TWF1	-0.025607
PHYHIP	0.025597
MTMR11	0.025587
HS3ST3A1	-0.025582
ITGA8	0.025559
PLN	0.025557
PTGDS	0.025557
ZNF770	-0.025518
PRG4	-0.025493
CD48	0.025482
ACVRL1	0.025465
RPL23AP32	0.025383
ACP5	-0.025357
ERMAP	0.025357
ANXA3	0.025332
COX7A1	0.025255
MED31	-0.025253
IFI44L	-0.025226
ID1	-0.025187
WEE1	0.025156
CRAT	-0.025092
FOSB	0.025087
CYP2C18	-0.025044
ZNF280D	0.024916
UGGT1	-0.024895
XK	-0.024887
NOV	0.024881
TENC1	0.024840
HSPB7	0.024776
COL4A1	-0.024744
FGD6	0.024706
CERK	0.024668
INTS6	-0.024588
SQLE	-0.024482
CAPN3	0.024471
CA11	0.024403
PLK1	-0.024374
GAN	0.024349
ASMTL	0.024316
AGAP1	0.024315
CSNK2A2	0.024304
TYR	0.024295
PPP1R1A	0.024273
STAG3L1	0.024273
SERPINA5	0.024250
KIFC1	-0.024232
C1QA	-0.024223
VPS11	0.024216
ZAK	-0.024190
CST6	0.024143
SMCO4	-0.024140
MMP28	0.024089
CENPBD1P1	-0.024083
SLAMF7	-0.024008
TPSB2	0.024004
MYH11	0.024002
TDP1	-0.023950
ZFP30	0.023950
CYP4F2	-0.023916
CTSH	0.023862
NGFR	-0.023832
HRASLS	0.023800
ADRB2	0.023740
FRMPD1	0.023739
OAS3	-0.023737
HELLS	-0.023728
HPSE	-0.023704
CYP4F11	-0.023700
C12orf5	-0.023693
RBP1	0.023679
ZNF606	0.023654
IL13RA1	-0.023619
TK1	-0.023602
RNASE4	0.023589
DLG2	0.023550
AMIGO2	0.023481
POLE2	-0.023471
GAA	0.023451
LGALS2	0.023436
IFIT1	-0.023427
FAP	-0.023340
ATP1A2	0.023330
LOXL1	-0.023217
MAD2L1	-0.023182
GTF2H2B	0.023181
MPHOSPH8	0.023055
TMEM176B	0.023041
ASPM	-0.023010
OSR2	0.023006
HERC5	-0.022949
KCNK10	-0.022929
IPP	-0.022881
DKFZP564C152	-0.022880
FN3KRP	0.022873
EMX2	0.022827
HOXA10	0.022820
EMCN	0.022735
SAYSD1	0.022706
C10orf10	0.022671
ARHGEF40	0.022647
TGM1	-0.022636
TCHH	-0.022609
ZNF350	0.022598
ZNF34	0.022550
PRC1	-0.022477
FOXM1	-0.022462
PSORS1C2	0.022457
PC	-0.022455
PDSS1	-0.022395
CCNB1	-0.022375
SH3D21	-0.022360
TPPP	0.022348
PINLYP	0.022337
KRT81	-0.022335
HIST1H1D	-0.022327
DES	0.022285
ALOX15B	-0.022258
HHLA3	0.022225
PNMAL1	0.022213
KAL1	0.022190
C11orf68	0.022134
SCEL	0.022117
P4HTM	0.022096
FNDC3B	-0.022062
ORC6	-0.022024
ZNF329	0.022009
GEM	0.021995
HLA-DQB2	0.021984
CYBRD1	0.021953
SPATA20	0.021941
RAMP2	0.021926
EPHB6	0.021926
TTC9	-0.021926
KPNA3	-0.021894
STK10	0.021893
HAO2	-0.021892
PLA2G16	0.021881
EYA2	0.021853
CHEK2	-0.021844
ACTG2	0.021798
FGL2	0.021793
PECR	-0.021747
CDH19	0.021746
CRY2	0.021728
CPE	0.021694
MMP12	-0.021685
RUFY2	0.021676
ZNF573	0.021660
PDE8B	0.021653
ANKRD11	0.021623
MUC1	-0.021609
PPAN	-0.021600
CXCL2	-0.021598
HMGCS1	-0.021584
RGS20	-0.021534
KRT4	-0.021528
SRGAP2	0.021498
EGR2	0.021477
CLCN3	-0.021472
LRP5L	0.021470
FAM13A	0.021466
EPHX2	0.021447
ADRA2A	0.021446
PHF1	0.021402
GPALPP1	-0.021398
ENPP4	0.021373
LRCH3	0.021323
ZNF419	0.021275
BLM	-0.021263
SMU1	0.021261
DCT	0.021256
NRIP2	0.021245
ZSCAN16	0.021237
DUSP6	-0.021202
IFIT3	-0.021190
JAM2	0.021182
CMAHP	0.021181
DAZAP1	-0.021099
S100A1	0.021077
CDH3	-0.021057
PHLDA2	-0.021023
S100B	0.021021
CHI3L2	-0.020987
LRRC8E	0.020947
FAM173A	-0.020938
LOR	0.020920
BIRC5	-0.020915
MME	-0.020909
OVGP1	0.020857
FUT1	-0.020815
SERPINA1	-0.020814
COA7	-0.020806
UBE2S	-0.020754
SEMA4G	0.020731
ARNTL2	-0.020709
DDI2	-0.020709
CCL21	0.020647
VSTM4	0.020646
FAM193A	0.020631